Mitochondrial dysfunction in psychiatric and neurological diseases: cause(s), consequence(s), and implications of antioxidant therapy

scientific article published on 05 March 2013

Mitochondrial dysfunction in psychiatric and neurological diseases: cause(s), consequence(s), and implications of antioxidant therapy is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/BIOF.1093
P698PubMed publication ID23460132
P5875ResearchGate publication ID235787370

P2093author name stringSurendra S Katyare
Mahabaleshwar V Hegde
Deepak M Kasote
P2860cites workRole of mitochondrial dysfunction in the pathogenesis of Huntington's diseaseQ37557789
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Oxidative stress in psychiatric disorders: evidence base and therapeutic implicationsQ28265319
Supplementation of vitamin C with atypical antipsychotics reduces oxidative stress and improves the outcome of schizophreniaQ28269799
Huntington's diseaseQ28284355
Dynamin-related protein 1 and mitochondrial fragmentation in neurodegenerative diseasesQ28300234
Structural and functional alterations in mitochondrial membrane in picrotoxin-induced epileptic rat brainQ28571815
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Impaired balance of mitochondrial fission and fusion in Alzheimer's diseaseQ28854335
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Parkinson's disease brain mitochondrial complex I has oxidatively damaged subunits and is functionally impaired and misassembled.Q30440422
Origin and functional consequences of the complex I defect in Parkinson's diseaseQ30469425
Essential fatty acids, lipid membrane abnormalities, and the diagnosis and treatment of schizophreniaQ33179595
Neuroanatomical pattern of mitochondrial complex I pathology varies between schizophrenia, bipolar disorder and major depressionQ33383204
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Alpha-synuclein in Lewy body disease and Alzheimer's diseaseQ33750063
Melatonin as a pharmacological agent against neuronal loss in experimental models of Huntington's disease, Alzheimer's disease and parkinsonismQ33834203
Combination therapy with coenzyme Q10 and creatine produces additive neuroprotective effects in models of Parkinson's and Huntington's diseasesQ33837238
Creatine and its potential therapeutic value for targeting cellular energy impairment in neurodegenerative diseasesQ33917550
N-Acetylcysteine reverses mitochondrial dysfunctions and behavioral abnormalities in 3-nitropropionic acid-induced Huntington's diseaseQ45306350
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Quinone and oxyradical scavenging properties of N-acetylcysteine prevent dopamine mediated inhibition of Na+, K+-ATPase and mitochondrial electron transport chain activity in rat brain: implications in the neuroprotective therapy of Parkinson's diseQ46527836
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Loss of insulin receptor immunoreactivity from the substantia nigra pars compacta neurons in Parkinson's diseaseQ48216036
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Reduced Activities of Thiamine-Dependent Enzymes in the Brains and Peripheral Tissues of Patients With Alzheimer's DiseaseQ53192901
Effect of aluminium-induced Alzheimer like condition on oxidative energy metabolism in rat liver, brain and heart mitochondria.Q53232811
Desensitization of the neuronal insulin receptor: a new approach in the etiopathogenesis of late-onset sporadic dementia of the Alzheimer type (SDAT)?Q53264266
Effect of vitamin E administration on the elevated oxygen stress and the telomeric and subtelomeric status in Alzheimer's disease.Q53322100
Oxidative stress and heart failure in altered thyroid StatesQ58915024
Mitochondrial mechanisms of estrogen neuroprotectionQ33927797
beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's diseaseQ33947152
Glutathione, oxidative stress and neurodegenerationQ33994473
Melatonin as a potential therapeutic agent in psychiatric illness.Q34018192
Mitochondrial dysfunction and intracellular calcium dysregulation in ALSQ34103782
Age-related structural and functional changes of brain mitochondria.Q34104048
Mitochondrial complex I activity and oxidative damage to mitochondrial proteins in the prefrontal cortex of patients with bipolar disorderQ34108449
Mitochondrial dysfunction and pathology in bipolar disorder and schizophreniaQ34137363
Mitochondrial loss, dysfunction and altered dynamics in Huntington's diseaseQ34163054
N-acetyl cysteine restores brain glutathione loss in combined 2-cyclohexene-1-one and d-amphetamine-treated rats: relevance to schizophrenia and bipolar disorderQ34188115
DJ-1 null dopaminergic neuronal cells exhibit defects in mitochondrial function and structure: involvement of mitochondrial complex I assemblyQ34189590
Glucocorticoid receptor 1B and 1C mRNA transcript alterations in schizophrenia and bipolar disorder, and their possible regulation by GR gene variants.Q34199632
Therapeutic prospects for mitochondrial diseaseQ34205124
Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responsesQ34230044
Deceleration of fusion-fission cycles improves mitochondrial quality control during agingQ34325475
Glucocorticoid receptor mRNA and protein isoform alterations in the orbitofrontal cortex in schizophrenia and bipolar disorderQ34343734
The other, forgotten genome: mitochondrial DNA and mental disordersQ34416941
Vitamin C enters mitochondria via facilitative glucose transporter 1 (Glut1) and confers mitochondrial protection against oxidative injuryQ34561378
Brain bioenergetics and response to triiodothyronine augmentation in major depressive disorderQ34587328
Mitochondrial dysfunction and molecular pathways of diseaseQ34604563
Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington's disease: implications for selective neuronal damageQ34627072
Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activityQ34634421
Assessing mitochondrial dysfunction in cells.Q34793639
Vitamin E therapy in Parkinson's diseaseQ35160394
Activation of the mitochondrial permeability transition pore modulates Ca2+ responses to physiological stimuli in adult neuronsQ35245867
Mitochondrial therapeutics in Alzheimer's disease and Parkinson's diseaseQ35579334
Mitochondrial fission in apoptosis, neurodegeneration and agingQ35595919
Mitochondrial medicine for aging and neurodegenerative diseasesQ35606693
Mitochondrial energetics and therapeuticsQ35632864
Mitochondrial DNA deletions and differential mitochondrial DNA content in Rhesus monkeys: implications for agingQ35645470
Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer's diseaseQ35660223
Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer's disease: implications to mitochondria-targeted antioxidant therapeuticsQ35737647
Mutant huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's diseaseQ35747131
Evidence for behavioral benefits of early dietary supplementation with CoEnzymeQ10 in a slowly progressing mouse model of Huntington's diseaseQ35754248
Abnormal mitochondrial dynamics and neurodegenerative diseasesQ37607449
Parkinson's disease and mitochondrial complex I: a perspective on the Ndi1 therapyQ37630973
Mitochondria-targeted antioxidant peptides.Q37778084
Nitrosylation and nitration of mitochondrial complex I in Parkinson's disease.Q37785104
Mitochondrial quality control and Parkinson's disease: a pathway unfoldsQ37814216
Parkinson's syndrome and Parkinson's disease in mitochondrial disordersQ37850755
Mitochondrial calcium homeostasis as potential target for mitochondrial medicineQ37907474
Elevation of glutathione as a therapeutic strategy in Alzheimer diseaseQ37947939
Parkin, PINK1 and mitochondrial integrity: emerging concepts of mitochondrial dysfunction in Parkinson's diseaseQ37953288
Estrogen and the regulation of mitochondrial structure and function in the brainQ37983332
Melatonin: an overlooked factor in schizophrenia and in the inhibition of anti-psychotic side effectsQ38004964
Mitochondria as sources and targets of damage in cellular agingQ38032465
Novel S-acyl glutathione derivatives prevent amyloid oxidative stress and cholinergic dysfunction in Alzheimer disease modelsQ39397930
PPARgamma rescue of the mitochondrial dysfunction in Huntington's disease.Q39476389
Perturbation in mitochondrial network dynamics and in complex I dependent cellular respiration in schizophreniaQ39577276
Melatonin treatment restores mitochondrial function in Alzheimer's mice: a mitochondrial protective role of melatonin membrane receptor signalingQ39585259
In vitro and in vivo neuroprotection by gamma-glutamylcysteine ethyl ester against MPTP: relevance to the role of glutathione in Parkinson's disease.Q40286709
Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progressionQ40301497
Mitochondria-targeted peptide prevents mitochondrial depolarization and apoptosis induced by tert-butyl hydroperoxide in neuronal cell linesQ40363556
Mutant huntingtin directly increases susceptibility of mitochondria to the calcium-induced permeability transition and cytochrome c releaseQ40551652
Supplementation with a combination of omega-3 fatty acids and antioxidants (vitamins E and C) improves the outcome of schizophreniaQ40577513
Superoxide production by the mitochondrial respiratory chainQ41488866
Glucagon stimulates ketone utilization by rat brain slicesQ41571757
Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's diseaseQ41945324
Bcl-2 SNP rs956572 associates with disrupted intracellular calcium homeostasis in bipolar I disorderQ42483967
Evidence for a mitochondrial oxidative phosphorylation defect in brains from patients with schizophreniaQ42501952
New evidence for the involvement of mitochondrial inheritance in schizophrenia: results from a cross-sectional study evaluating the risk of illness in relatives of schizophrenia patientsQ42643074
Is it time to reassess alpha lipoic acid and niacinamide therapy in schizophrenia?Q42937883
Randomized, double-blind, pilot evaluation of intravenous glutathione in Parkinson's diseaseQ43468224
Melatonin protects against 6-OHDA-induced neurotoxicity in rats: a role for mitochondrial complex I activityQ43517278
Localization of the glucocorticoid receptor in rat brain mitochondria.Q43613409
Influence of vitamin E and C supplementation on lipoprotein oxidation in patients with Alzheimer's diseaseQ43680826
Ethanol impairs insulin-stimulated mitochondrial function in cerebellar granule neuronsQ43839526
State-dependent alterations in mitochondrial complex I activity in platelets: a potential peripheral marker for schizophreniaQ44194149
Pre-treatment with R-lipoic acid alleviates the effects of GSH depletion in PC12 cells: implications for Parkinson's disease therapyQ44214157
Substrate-specific stimulation by glucagon of isolated murine brain mitochondrial oxidative phosphorylationQ44440805
Ascorbate treatment attenuates the Huntington behavioral phenotype in miceQ44490151
Coenzyme Q10 reduces beta-amyloid plaque in an APP/PS1 transgenic mouse model of Alzheimer's diseaseQ44495822
Effect of corticosterone treatment on mitochondrial oxidative energy metabolism in developing rat brain.Q44574732
Decreased antioxidant enzymes and membrane essential polyunsaturated fatty acids in schizophrenic and bipolar mood disorder patientsQ44680500
Cell cycle activation linked to neuronal cell death initiated by DNA damageQ44774050
Protective effect of melatonin on 3-nitropropionic acid-induced oxidative stress in synaptosomes in an animal model of Huntington's diseaseQ45107385
Mitochondrial defect in Huntington's disease caudate nucleusQ45291734
Energy metabolism defects in Huntington's disease and effects of coenzyme Q10.Q45293805
Effect of coenzyme Q10 and vitamin E on brain energy metabolism in the animal model of Huntington's diseaseQ45299091
Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration.Q45302702
Decreased pyruvate dehydrogenase complex activity in Huntington and Alzheimer brainQ45304576
Mitochondria as a therapeutic target for aging and neurodegenerative diseasesQ35807409
Delaying the mitochondrial decay of agingQ35833024
The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer's disease.Q35908404
Mitochondrial decay in hepatocytes from old rats: membrane potential declines, heterogeneity and oxidants increaseQ36077271
Genetic inactivation of mitochondria-targeted redox enzyme p66ShcA preserves neuronal viability and mitochondrial integrity in response to oxidative challengesQ36106275
Progesterone and Cerebral Function during Emotion Processing in Men and Women with SchizophreniaQ36169081
Mitochondria and neurotransmission: evacuating the synapseQ36213274
Oxidative stress, α-tocopherol, ascorbic acid and reduced glutathione status in schizophrenicsQ36265242
Identification of glucagon receptors in rat brainQ36272209
Melatonin and Parkinson's diseaseQ36282830
The emerging role of coenzyme Q-10 in aging, neurodegeneration, cardiovascular disease, cancer and diabetes mellitusQ36352353
Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's diseaseQ36375845
The neurological disorder associated with thyroid autoimmunityQ36512186
The role of mitochondria in inherited neurodegenerative diseasesQ36521932
Targeting antioxidants to mitochondria by conjugation to lipophilic cations.Q36609730
A century of Alzheimer's diseaseQ36643414
Melatonin role in the mitochondrial function.Q36664479
Mitochondrial dysfunction, free radical generation and cellular stress response in neurodegenerative disordersQ36664537
Mitochondrial dysfunction in human pathologies.Q36664543
Progesterone and estrogen regulate oxidative metabolism in brain mitochondriaQ36692052
Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal gangliaQ36739461
The effects and mechanisms of mitochondrial nutrient alpha-lipoic acid on improving age-associated mitochondrial and cognitive dysfunction: an overviewQ36867029
Role of mitochondrial DNA in calcium signaling abnormality in bipolar disorder.Q37051703
Dynamic regulation of mitochondrial function by glucocorticoidsQ37087119
Parkinson's disease-associated DJ-1 mutations impair mitochondrial dynamics and cause mitochondrial dysfunctionQ37087927
Elevated cerebrospinal fluid lactate concentrations in patients with bipolar disorder and schizophrenia: implications for the mitochondrial dysfunction hypothesisQ37120081
The mitochondrial antioxidants MitoE(2) and MitoQ(10) increase mitochondrial Ca(2+) load upon cell stimulation by inhibiting Ca(2+) efflux from the organelleQ37177530
Glutathione: a novel treatment target in psychiatryQ37185741
Mitochondria in neuroplasticity and neurological disordersQ37216404
Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's diseaseQ37321251
Combined R-alpha-lipoic acid and acetyl-L-carnitine exerts efficient preventative effects in a cellular model of Parkinson's disease.Q37334961
Mitochondria: a therapeutic target in neurodegenerationQ37466059
Cause and consequence: mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases.Q37466088
Mitochondrial permeability transition pore in Alzheimer's disease: cyclophilin D and amyloid betaQ37555305
P433issue4
P304page(s)392-406
P577publication date2013-03-05
P1433published inBioFactorsQ15767404
P1476titleMitochondrial dysfunction in psychiatric and neurological diseases: cause(s), consequence(s), and implications of antioxidant therapy
P478volume39

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