N-Acetylcysteine reverses mitochondrial dysfunctions and behavioral abnormalities in 3-nitropropionic acid-induced Huntington's disease

scientific article

N-Acetylcysteine reverses mitochondrial dysfunctions and behavioral abnormalities in 3-nitropropionic acid-induced Huntington's disease is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1159/000334273
P698PubMed publication ID22327485
P5875ResearchGate publication ID221825918

P2093author name stringAditi Sood
Rajat Sandhir
Arpit Mehrotra
Sukhdev S Kamboj
P2860cites workRhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicityQ24317318
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.Q27860836
Assay for lipid peroxides in animal tissues by thiobarbituric acid reactionQ29616762
Mitochondrial control of cell deathQ29617739
N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial traffickingQ30486372
Effects of CAG repeat length, HTT protein length and protein context on cerebral metabolism measured using magnetic resonance spectroscopy in transgenic mouse models of Huntington's diseaseQ31002507
FK506 prevents mitochondrial-dependent apoptotic cell death induced by 3-nitropropionic acid in rat primary cortical culturesQ33209462
Neuroprotective effect of N-acetylcysteine on neuronal apoptosis induced by a synthetic gingerdione compound: involvement of ERK and p38 phosphorylationQ33258000
Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's diseaseQ33292417
N-acetyl cysteine supplementation prevents impairment of spatial working memory functions in rats following exposure to hypobaric hypoxiaQ33437587
Mitochondrial glutathione, a key survival antioxidantQ33649876
Effect of exogenous and endogenous antioxidants on 3-nitropionic acid-induced in vivo oxidative stress and striatal lesions: insights into Huntington's diseaseQ45301207
Striatal and extrastriatal atrophy in Huntington's disease and its relationship with length of the CAG repeatQ45302144
Oxidative stress parameters in plasma of Huntington's disease patients, asymptomatic Huntington's disease gene carriers and healthy subjects : a cross-sectional studyQ45306906
Role of HSP27 and reduced glutathione in modulating malathion-induced apoptosis of human peripheral blood mononuclear cells: ameliorating effect of N-acetylcysteine and curcumin.Q45927775
N-acetylcysteine prevents mitochondria from oxidative injury induced by conventional peritoneal dialysate in human peritoneal mesothelial cellsQ46047939
N-acetylcysteine suppresses oxidative stress in experimental rats with subarachnoid hemorrhageQ46098947
Astrocytic proliferation and mitochondrial dysfunction induced by accumulated glutaric acidemia I (GAI) metabolites: possible implications for GAI pathogenesisQ46310683
Neuroprotective effect of N-acetylcysteine in the development of diabetic encephalopathy in streptozotocin-induced diabetesQ46358585
Behavioural effects of parafascicular thalamic lesions in an animal model of parkinsonismQ46560087
Protection of cardiac mitochondria by overexpression of MnSOD reduces diabetic cardiomyopathyQ46966545
Lipid peroxidation associated cardiolipin loss and membrane depolarization in rat brain mitochondriaQ46970524
Correlation of morphologic brain lesions with physiologic alterations and blood-brain barrier impairment in 3-nitropropionic acid toxicity in ratsQ48250255
Cytochrome C is released from mitochondria into the cytosol after cerebral anoxia or ischemiaQ48307610
Do defecs in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases?Q48317832
Bergmann glia expression of polyglutamine-expanded ataxin-7 produces neurodegeneration by impairing glutamate transportQ48435478
Riluzole protects from motor deficits and striatal degeneration produced by systemic 3-nitropropionic acid intoxication in ratsQ48627086
Impairment of mitochondrial respiration after cerebral hypoxia-ischemia in immature rats: relationship to activation of caspase-3 and neuronal injuryQ49090197
Cyclosporin A protects striatal neurons in vitro and in vivo from 3-nitropropionic acid toxicity.Q52540884
Modulation of the mitochondrial permeability transition pore by pyridine nucleotides and dithiol oxidation at two separate sites.Q52547831
Studies on energy-linked reactions: modified mitochondrial ATPase of oligomycin-resistant mutants of Saccharomyces cerevisiae.Q54636781
Recent advances in understanding the pathogenesis of Huntington's diseaseQ33650539
Mitochondria, oxygen free radicals, disease and ageingQ33922972
Invited review: manganese superoxide dismutase in diseaseQ33944740
Energetics in the pathogenesis of neurodegenerative diseasesQ33944937
Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtinQ35013054
Preservation of cellular glutathione status and mitochondrial membrane potential by N-acetylcysteine and insulin sensitizers prevent carbonyl stress-induced human brain endothelial cell apoptosisQ35205624
Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?Q35254212
Reactive oxygen species and the central nervous systemQ35389986
The effects of stress and aging on glutathione metabolismQ36151893
3-Nitropropionic acid: a mitochondrial toxin to uncover physiopathological mechanisms underlying striatal degeneration in Huntington's disease.Q36318579
Antioxidant and anti-inflammatory efficacy of NAC in the treatment of COPD: discordant in vitro and in vivo dose-effects: a reviewQ36386914
Selective neuronal degeneration in Huntington's diseaseQ36597920
Mechanisms of neurodegeneration in Huntington's disease.Q37202865
Watching the watcher: regulation of p53 by mitochondriaQ37401359
3-Nitropropionic acid as a tool to study the mechanisms involved in Huntington's disease: past, present and future.Q37718532
Neural mechanisms of ageing and cognitive declineQ37718609
Mitochondrial dysfunction: a potential link between neuroinflammation and neurodegeneration?Q37767300
Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutaseQ39184357
3-Nitropropionic acid exacerbates N-methyl-D-aspartate toxicity in striatal culture by multiple mechanisms.Q39449440
Stress-induced activation of the p53 tumor suppressor in leukemia cells and normal lymphocytes requires mitochondrial activity and reactive oxygen species.Q40459745
Mutant huntingtin directly increases susceptibility of mitochondria to the calcium-induced permeability transition and cytochrome c releaseQ40551652
An electron-transport system associated with the outer membrane of liver mitochondria. A biochemical and morphological studyQ41093578
Excitotoxicity is required for induction of oxidative stress and apoptosis in mouse striatum by the mitochondrial toxin, 3-nitropropionic acidQ41711372
p53 regulates mitochondrial membrane potential through reactive oxygen species and induces cytochrome c-independent apoptosis blocked by Bcl-2.Q42125448
Oxidative damage and metabolic dysfunction in Huntington's disease: selective vulnerability of the basal ganglia.Q42438521
Discriminative behavioral assessment unveils remarkable reactive astrocytosis and early molecular correlates in basal ganglia of 3-nitropropionic acid subchronic treated ratsQ42460820
Basal ganglia degeneration, myelin alterations, and enzyme inhibition induced in mice by the plant toxin 3-nitropropanoic acidQ42464071
Perseverative behavior underlying attentional set-shifting deficits in rats chronically treated with the neurotoxin 3-nitropropionic acid.Q42512046
Lycopene prevents 3-nitropropionic acid-induced mitochondrial oxidative stress and dysfunctions in nervous systemQ42965732
Inhibition of mitochondrial respiratory chain in the brain of rats after renal ischemia is prevented by N-acetylcysteine and deferoxamineQ43083214
N-acetylcysteine prevents memory deficits, the decrease in acetylcholinesterase activity and oxidative stress in rats exposed to cadmiumQ43095424
N-acetylcysteine increases manganese superoxide dismutase activity in septic rat diaphragmsQ43478194
Therapeutic potential of N-acetylcysteine in age-related mitochondrial neurodegenerative diseasesQ43599271
Behavioral and biochemical effects of glutathione depletion in the rat brainQ43698402
Specific modification of mitochondrial protein thiols in response to oxidative stress: a proteomics approachQ43893354
Involvement of superoxide in excitotoxicity and DNA fragmentation in striatal vulnerability in mice after treatment with the mitochondrial toxin, 3-nitropropionic acid.Q44079753
Proteomic and oxidative stress analysis in human brain samples of Huntington disease.Q44737699
Mitochondrial calcium, oxidative stress and apoptosis in a neurodegenerative disease model induced by 3-nitropropionic acidQ44792354
Increased formation of reactive oxygen species, but no changes in glutathione peroxidase activity, in striata of mice transgenic for the Huntington's disease mutationQ44852260
Utility of an elevated plus-maze for dissociation of amnesic and behavioral effects of drugs in miceQ45252402
Mitochondrial defect in Huntington's disease caudate nucleusQ45291734
p53 mediates cellular dysfunction and behavioral abnormalities in Huntington's diseaseQ45297400
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectHuntington's diseaseQ190564
acetylcysteineQ375613
P304page(s)145-157
P577publication date2012-02-09
P1433published inNeurodegenerative DiseasesQ15764918
P1476titleN-Acetylcysteine reverses mitochondrial dysfunctions and behavioral abnormalities in 3-nitropropionic acid-induced Huntington's disease
P478volume9

Reverse relations

cites work (P2860)
Q453031594-hydroxy tempo improves mitochondrial and neurobehavioral deficits in experimental model of Huntington's disease.
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Q45290091N-Acetylcysteine for Huntington's?
Q90394758N-Acetylcysteine protects against intrauterine growth retardation-induced intestinal injury via restoring redox status and mitochondrial function in neonatal piglets
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Q87241483[Huntington's disease]

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