The cystic fibrosis of exocrine pancreas

scientific article published on May 2013

The cystic fibrosis of exocrine pancreas is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1101/CSHPERSPECT.A009746
P932PMC publication ID3633181
P698PubMed publication ID23637307

P50authorIvana NovakQ38322982
P2093author name stringMichael Wilschanski
P2860cites workPass the bicarb: the importance of HCO3– for mucin releaseQ22306298
Mapping of five new putative anion transporter genes in human and characterization of SLC26A6, a candidate gene for pancreatic anion exchangerQ24290545
IRBIT, an inositol 1,4,5-trisphosphate receptor-binding protein, specifically binds to and activates pancreas-type Na+/HCO3- cotransporter 1 (pNBC1)Q24293420
Genotype and phenotype correlations in patients with cystic fibrosis and pancreatitisQ78582128
DeltaF508 mutation results in impaired gastric acid secretionQ79441368
The cystic fibrosis transmembrane conductance regulator gene and ion channel function in patients with idiopathic pancreatitisQ81281959
Type of CFTR mutation determines risk of pancreatitis in patients with cystic fibrosisQ85159970
Distribution of aquaporin water channels AQP1 and AQP5 in the ductal system of the human pancreasQ24304463
Patterns of GI disease in adulthood associated with mutations in the CFTR geneQ24673570
Identification of the cystic fibrosis gene: cloning and characterization of complementary DNAQ28119124
Molecular cloning, chromosomal localization, tissue distribution, and functional expression of the human pancreatic sodium bicarbonate cotransporterQ28275417
Bicarbonate and fluid secretion evoked by cholecystokinin, bombesin and acetylcholine in isolated guinea-pig pancreatic ductsQ28354110
IRBIT coordinates epithelial fluid and HCO3- secretion by stimulating the transporters pNBC1 and CFTR in the murine pancreatic ductQ28504720
IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathwayQ28512680
TMEM16A confers receptor-activated calcium-dependent chloride conductanceQ28590097
Mechanism of direct bicarbonate transport by the CFTR anion channelQ28941788
Identification of the cystic fibrosis gene: genetic analysisQ29614402
The solute carrier 26 family of proteins in epithelial ion transportQ31152083
Dynamic regulation of CFTR bicarbonate permeability by [Cl-]i and its role in pancreatic bicarbonate secretionQ33348947
Expression cloning of TMEM16A as a calcium-activated chloride channel subunitQ33370813
Pathology of gastrointestinal organs in a porcine model of cystic fibrosisQ33703755
New horizons in the treatment of cystic fibrosisQ33756002
Chloride channels: often enigmatic, rarely predictableQ33775731
Cyclic AMP potentiates Ca2+-dependent exocytosis in pancreatic duct epithelial cellsQ33814299
Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birthQ33929671
An animal model for cystic fibrosis made by gene targetingQ33970549
Purinergic receptors in airway epitheliaQ34016545
Emerging treatments in cystic fibrosisQ34019357
Inhibition of acinar apoptosis occurs during acute pancreatitis in the human homologue DeltaF508 cystic fibrosis mouseQ34085307
Disease phenotype of a ferret CFTR-knockout model of cystic fibrosis.Q34090196
Neural hormonal regulation of exocrine pancreatic secretionQ34139137
Localization of the cystic fibrosis transmembrane conductance regulator in pancreasQ34195125
Secretin causes H+/HCO3- secretion from pig pancreatic ductules by vacuolar-type H(+)-adenosine triphosphataseQ34319825
The relation between genotype and phenotype in cystic fibrosis--analysis of the most common mutation (delta F508).Q34635892
TMEM16A, a membrane protein associated with calcium-dependent chloride channel activityQ34821709
Relationship of a non-cystic fibrosis transmembrane conductance regulator-mediated chloride conductance to organ-level disease in Cftr(-/-) miceQ34978226
Characteristic multiorgan pathology of cystic fibrosis in a long-living cystic fibrosis transmembrane regulator knockout murine modelQ35097413
Slc26a6 regulates CFTR activity in vivo to determine pancreatic duct HCO3- secretion: relevance to cystic fibrosisQ35121200
Genetic determination of exocrine pancreatic function in cystic fibrosisQ35195369
Combined bicarbonate conductance-impairing variants in CFTR and SPINK1 variants are associated with chronic pancreatitis in patients without cystic fibrosisQ35209665
A mouse model for the delta F508 allele of cystic fibrosis.Q35765143
Mutations in the cystic fibrosis transmembrane regulator gene and in vivo transepithelial potentialsQ43173791
Ducts isolated from the pancreas of CFTR-null mice secrete fluidQ43298556
Visualization of ATP release in pancreatic acini in response to cholinergic stimulus. Use of fluorescent probes and confocal microscopyQ43626724
Pancreatic acinar cell dysfunction in CFTR(-/-) mice is associated with impairments in luminal pH and endocytosisQ43770471
Two types of chloride channel on duct cells cultured from human fetal pancreasQ43995113
Secretion of electrolytes by the pancreas of the anaestetized ratQ44203166
Where have all the Na+ channels gone? In search of functional ENaC in exocrine pancreasQ44209009
Omeprazole, a proton pump inhibitor, improves residual steatorrhoea in cystic fibrosis patients treated with high dose pancreatic enzymesQ44589197
Acidic duodenal pH alters gene expression in the cystic fibrosis mouse pancreasQ44830083
Production of a severe cystic fibrosis mutation in mice by gene targetingQ45868497
Fluid secretion in interlobular ducts isolated from guinea-pig pancreasQ46292509
P2Y2 and P2Y4 receptors regulate pancreatic Ca(2+)-activated K+ channels differentlyQ46630784
A proinflammatory, antiapoptotic phenotype underlies the susceptibility to acute pancreatitis in cystic fibrosis transmembrane regulator (-/-) miceQ46637437
Cystic fibrosis transmembrane conductance regulator currents in guinea pig pancreatic duct cells: inhibition by bicarbonate ionsQ46702578
Pancreatitis among patients with cystic fibrosis: correlation with pancreatic status and genotype.Q47831516
Long-term survival of the exon 10 insertional cystic fibrosis mutant mouse is a consequence of low level residual wild-type Cftr gene expressionQ48080544
The severe G480C cystic fibrosis mutation, when replicated in the mouse, demonstrates mistrafficking, normal survival and organ-specific bioelectricsQ48869835
WNK1 and WNK4 modulate CFTR activity.Q50640928
Phase 2 randomized safety and efficacy trial of nebulized denufosol tetrasodium in cystic fibrosis.Q51021959
Twenty-four hour ambulatory gastric and duodenal pH profiles in cystic fibrosis: effect of duodenal hyperacidity on pancreatic enzyme function and fat absorption.Q51580760
Gastric acid hypersecretion in cystic fibrosis.Q51652242
A severe phenotype in mice with a duplication of exon 3 in the cystic fibrosis locus.Q52507286
Renal function and renotropic effects of secretin in cystic fibrosis.Q52997543
Purinoceptors evoke different electrophysiological responses in pancreatic ducts. P2Y inhibits K(+) conductance, and P2X stimulates cation conductance.Q53922809
Effect of bicarbonate on potassium conductance of isolated perfused rat pancreatic ducts.Q54290847
Modification of pancreatic lipase properties by directed molecular evolution.Q54390616
Relation between mutations of the cystic fibrosis gene and idiopathic pancreatitis.Q55067851
Successful targeting of the mouse cystic fibrosis transmembrane conductance regulator gene in embryonal stem cellsQ57557425
Duodenal pH in cystic fibrosis and its relationship to fat malabsorptionQ58385527
An intermediate-conductance Ca2+-activated K+ channel is important for secretion in pancreatic duct cellsQ61640378
Effect of vasoactive intestinal peptide, carbachol and other agonists on the membrane voltage of pancreatic duct cellsQ61640418
Electrophysiological study of transport systems in isolated perfused pancreatic ducts: properties of the basolateral membraneQ61640427
Properties of the luminal membrane of isolated perfused rat pancreatic ductsQ61640430
Changes in the exocrine pancreas secondary to altered small intestinal function in the CF mouse.Q64892494
Recurrent acute pancreatitis in patients with cystic fibrosis with normal pancreatic enzymesQ66907681
Potentiation effect of cholecystokinin-octapeptide on pancreatic bicarbonate secretion stimulated by a physiologic dose of secretin in humansQ67294747
Regulation of maxi-K+ channels on pancreatic duct cells by cyclic AMP-dependent phosphorylationQ67665178
Pancreatic, hepatic, and duodenal mucosal bicarbonate secretion during infusion of secretin and cholecystokinin. Evidence of the importance of hepatic bicarbonate in the neutralization of acid in the duodenum of anaesthetized pigsQ68053197
Impaired chloride secretion, as well as bicarbonate secretion, underlies the fluid secretory defect in the cystic fibrosis pancreasQ68434984
Secretin-regulated chloride channel on the apical plasma membrane of pancreatic duct cellsQ69051907
Pancreatic fluid secretion and protein hyperconcentration in cystic fibrosisQ70053115
Immunohistochemical localization of carbonic anhydrase isoenzymes in the human pancreasQ71538117
Exocrine pancreatic alterations in long-lived surviving cystic fibrosis miceQ71581608
CFTR and calcium-activated chloride currents in pancreatic duct cells of a transgenic CF mouseQ71609179
Accumulation of intracellular HCO3- by Na(+)-HCO3- cotransport in interlobular ducts from guinea-pig pancreasQ71673993
Increased expression of sulfated gp300 and acinar tissue pathology in pancreas of CFTR(-/-) miceQ71690764
Calcium-activated chloride conductance is not increased in pancreatic duct cells of CF miceQ71709185
Interactions between secretin and acetylcholine in the regulation of fluid secretion by isolated rat pancreatic ductsQ71762759
The cystic fibrosis transmembrane conductance regulator as a marker of human pancreatic duct developmentQ73676025
Significant cholinergic role in secretin-stimulated exocrine secretion in isolated rat pancreasQ74255007
Synergistic effects of cAMP- and calcium-mediated amylase secretion in isolated pancreatic acini from cystic fibrosis miceQ77324279
Luminal ATP stimulates fluid and HCO3- secretion in guinea-pig pancreatic ductQ78157388
Cystic fibrosis mice carrying the missense mutation G551D replicate human genotype-phenotype correlations.Q35844736
Processing and function of CFTR-DeltaF508 are species-dependentQ35991100
Membrane localization of H+ and HCO3- transporters in the rat pancreatic ductQ36435278
Dynamics intrinsic to cystic fibrosis transmembrane conductance regulator function and stabilityQ36629079
Review article: duodenal bicarbonate - mucosal protection, luminal chemosensing and acid-base balanceQ36702146
Confocal microscopic analysis of intracellular pH regulation in isolated guinea pig pancreatic ductsQ36847208
Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigsQ36944556
No potassium, no acid: K+ channels and gastric acid secretionQ36967648
Sodium channels and cystic fibrosisQ36999398
Purinergic receptors in the endocrine and exocrine pancreas.Q37119875
CFTR functions as a bicarbonate channel in pancreatic duct cellsQ37124268
Cystic fibrosis and nutrition: linking phospholipids and essential fatty acids with thiol metabolismQ37170937
Functional coupling of apical Cl-/HCO3- exchange with CFTR in stimulated HCO3- secretion by guinea pig interlobular pancreatic ductQ37231297
Cystic fibrosis: impaired bicarbonate secretion and mucoviscidosisQ37233641
Normal mouse intestinal mucus release requires cystic fibrosis transmembrane regulator-dependent bicarbonate secretionQ37328491
Update on the Mechanisms of Gastric Acid SecretionQ37785842
Purinergic signalling in epithelial ion transport: regulation of secretion and absorptionQ37809120
Cystic fibrosis transmembrane regulator correctors and potentiatorsQ38118742
Mutations of the cystic fibrosis gene in patients with chronic pancreatitisQ38502091
Purinergic regulation of CFTR and Ca(2+)-activated Cl(-) channels and K(+) channels in human pancreatic duct epitheliumQ39201947
Effect of duramycin on chloride transport and intracellular calcium concentration in cystic fibrosis and non‐cystic fibrosis epitheliaQ39629752
Pattern of Ca2+ increase determines the type of secretory mechanism activated in dog pancreatic duct epithelial cellsQ40253019
Characterization of vectorial chloride transport pathways in the human pancreatic duct adenocarcinoma cell line HPAFQ40652671
Ca2+ activates cystic fibrosis transmembrane conductance regulator- and Cl- -dependent HCO3 transport in pancreatic duct cellsQ40693281
Downregulated in adenoma and putative anion transporter are regulated by CFTR in cultured pancreatic duct cellsQ40773534
A mouse model for the cystic fibrosis delta F508 mutation.Q40789334
Regulatory interaction between the cystic fibrosis transmembrane conductance regulator and HCO3- salvage mechanisms in model systems and the mouse pancreatic ductQ40816480
Aberrant CFTR-dependent HCO3- transport in mutations associated with cystic fibrosisQ40821697
Cystic fibrosis transmembrane conductance regulator regulates luminal Cl-/HCO3- exchange in mouse submandibular and pancreatic ductsQ40954140
Concurrent and independent HCO3- and Cl- secretion in a human pancreatic duct cell line (CAPAN-1).Q41025755
Calcium-activated chloride conductance in a pancreatic adenocarcinoma cell line of ductal origin (HPAF) and in freshly isolated human pancreatic duct cellsQ41035207
Phosphorylation-regulated low-conductance Cl- channels in a human pancreatic duct cell lineQ41525891
Pancreatic bicarbonate secretion involves two proton pumps.Q41556981
High intracellular pH in CFPAC: A pancreas cell line from a patient with cystic fibrosis is lowered by retrovirus-mediated CFTR gene transferQ41661082
Phosphorylation-regulated CI− channel in CHO cells stably expressing the cystic fibrosis geneQ41669744
Apoptosis participates in the remodeling of the endocrine pancreas in the neonatal rat.Q42436119
Cystic fibrosis gene mutation reduces epithelial cell acidification and injury in acid-perfused mouse duodenumQ42469051
Effect of ATP, carbachol and other agonists on intracellular calcium activity and membrane voltage of pancreatic ductsQ42476129
cAMP-regulated whole cell chloride currents in pancreatic duct cellsQ42482968
Effect of Slc26a6 deletion on apical Cl-/HCO3- exchanger activity and cAMP-stimulated bicarbonate secretion in pancreatic ductQ42499589
Loss of TMEM16A causes a defect in epithelial Ca2+-dependent chloride transportQ42660614
Protons released during pancreatic acinar cell secretion acidify the lumen and contribute to pancreatitis in miceQ42944148
Effect of P2X(7) receptor knockout on exocrine secretion of pancreas, salivary glands and lacrimal glandsQ42965444
ATP storage and uptake by isolated pancreatic zymogen granulesQ43074659
P433issue5
P921main subjectcystic fibrosisQ178194
pancreasQ9618
P304page(s)a009746
P577publication date2013-05-01
P1433published inCold Spring Harbor Perspectives in MedicineQ21042440
P1476titleThe cystic fibrosis of exocrine pancreas
P478volume3

Reverse relations

cites work (P2860)
Q26998861Acid-base transport in pancreas-new challenges
Q38265305Acid-base transport in pancreatic cancer: molecular mechanisms and clinical potential.
Q99551734Advances in Ca2+ modulation of gastrointestinal anion secretion and its dysregulation in digestive disorders (Review)
Q39261074Alternating pH landscapes shape epithelial cancer initiation and progression: Focus on pancreatic cancer.
Q60920753Animal Models in the Pathophysiology of Cystic Fibrosis
Q49958195CFTR mutation enhances Dishevelled degradation and results in impairment of Wnt-dependent hematopoiesis.
Q38134726Cell volume regulation in epithelial physiology and cancer
Q64980440Contribution of pancreatic enzyme replacement therapy to survival and quality of life in patients with pancreatic exocrine insufficiency.
Q55376866Cystic Fibrosis-Related Diabetes.
Q92697837Cystic Fibrosis-Related Diabetes: Pathophysiology and Therapeutic Challenges
Q64941190Deconstructing the principles of ductal network formation in the pancreas.
Q48108670Electrophysiological properties of anion exchangers in the luminal membrane of guinea pig pancreatic duct cells.
Q26744381Epithelial Anion Transport as Modulator of Chemokine Signaling
Q52739000Evolving Mechanistic Views and Emerging Therapeutic Strategies for Cystic Fibrosis-Related Diabetes.
Q38832770Genophenotypic Analysis of Pediatric Patients With Acute Recurrent and Chronic Pancreatitis
Q48342582In silico analysis of the transportome in human pancreatic ductal adenocarcinoma
Q51710619Ivacaftor: from bench to bedside... and back again.
Q58722211KRAS and TP53 Cooperate to Induce Pancreatic Ductal Adenocarcinoma in Sus scrofa Pigs
Q27302962Loss of cftr function leads to pancreatic destruction in larval zebrafish.
Q38130386Molecular basis of potassium channels in pancreatic duct epithelial cells
Q49795312Pancreatic and Islet Remodeling in Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Knockout Ferrets
Q36424575Pancreatic pathophysiology in cystic fibrosis
Q38317614Pancreatitis in dogs and cats: definitions and pathophysiology.
Q91936416Patient-derived pancreas-on-a-chip to model cystic fibrosis-related disorders
Q35636415Proton Pump Inhibitors Inhibit Pancreatic Secretion: Role of Gastric and Non-Gastric H+/K+-ATPases.
Q41302801Stem cell-derived organoids to model gastrointestinal facets of cystic fibrosis
Q37092681The adenosine A2B receptor is involved in anion secretion in human pancreatic duct Capan-1 epithelial cells
Q37122355The cystic fibrosis intestine
Q47318866The long and winding road: stem cells for cystic fibrosis

Search more.