Do t-tubules play a role in arrhythmogenesis in cardiac ventricular myocytes?

scientific article published on 07 May 2013

Do t-tubules play a role in arrhythmogenesis in cardiac ventricular myocytes? is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1113/JPHYSIOL.2013.254540
P932PMC publication ID3779108
P698PubMed publication ID23652596
P5875ResearchGate publication ID236653849

P50authorAndrew F. JamesQ69846071
P2093author name stringC H Orchard
S M Bryant
P2860cites workLoss of T-tubules and other changes to surface topography in ventricular myocytes from failing human and rat heartQ33426244
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Mechanisms by which cytoplasmic calcium wave propagation and alternans are generated in cardiac atrial myocytes lacking T-tubules-insights from a simulation studyQ35866809
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Organization of ryanodine receptors, transverse tubules, and sodium-calcium exchanger in rat myocytes.Q42183362
Protein kinase A hyperphosphorylation increases basal current but decreases beta-adrenergic responsiveness of the sarcolemmal Na+-Ca2+ exchanger in failing pig myocytesQ42439302
Ca efflux via the sarcolemmal Ca ATPase occurs only in the t-tubules of rat ventricular myocytesQ42478820
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Na+-Ca2+ exchange activity is localized in the T-tubules of rat ventricular myocytesQ44112807
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Ca2+ scraps: local depletions of free [Ca2+] in cardiac sarcoplasmic reticulum during contractions leave substantial Ca2+ reserveQ44468965
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beta-adrenergic stimulation restores the Ca transient of ventricular myocytes lacking t-tubulesQ44761699
Functional consequences of detubulation of isolated rat ventricular myocytesQ44906500
Differential modulation of L-type Ca2+ current by SR Ca2+ release at the T-tubules and surface membrane of rat ventricular myocytesQ44932505
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Theoretical study of L-type Ca(2+) current inactivation kinetics during action potential repolarization and early afterdepolarizationsQ46393948
Spatiotemporal characteristics of SR Ca(2+) uptake and release in detubulated rat ventricular myocytesQ46730851
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Stimulation of Ca-induced Ca release only transiently increases the systolic Ca transient: measurements of Ca fluxes and sarcoplasmic reticulum Ca.Q47863936
No apparent requirement for neuronal sodium channels in excitation-contraction coupling in rat ventricular myocytesQ48721215
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Diastolic spontaneous calcium release from the sarcoplasmic reticulum increases beat-to-beat variability of repolarization in canine ventricular myocytes after β-adrenergic stimulation.Q54471951
Sarcoplasmic Reticulum Ca2+ Release Causes Myocyte Depolarization : Underlying Mechanism and Threshold for Triggered Action PotentialsQ55983199
The relative contributions of different intracellular and sarcolemmal systems to relaxation in rat ventricular myocytesQ60182092
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Similarities between early and delayed afterdepolarizations induced by isoproterenol in canine ventricular myocytesQ73471651
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Density and sub-cellular distribution of cardiac and neuronal sodium channel isoforms in rat ventricular myocytesQ80099104
T-tubule disorganization and reduced synchrony of Ca2+ release in murine cardiomyocytes following myocardial infarctionQ83367125
Role of t-tubules in the control of trans-sarcolemmal ion flux and intracellular Ca2+ in a model of the rat cardiac ventricular myocyteQ83786010
Microdomain [Ca²⁺] near ryanodine receptors as reported by L-type Ca²⁺ and Na+/Ca²⁺ exchange currentsQ83842163
P433issue17
P407language of work or nameEnglishQ1860
P1104number of pages7
P304page(s)4141-4147
P577publication date2013-05-07
P1433published inJournal of PhysiologyQ7743612
P1476titleDo t-tubules play a role in arrhythmogenesis in cardiac ventricular myocytes?
P478volume591

Reverse relations

cites work (P2860)
Q39123722Altered Na/Ca exchange distribution in ventricular myocytes from failing hearts.
Q46725989Arrhythmia: 100 years on from George Ralph Mines
Q60960134Dyadic Plasticity in Cardiomyocytes
Q34368724Functional cardiac imaging by random access microscopy
Q36046902Heterogeneity of T-Tubules in Pig Hearts.
Q35815908High speed sCMOS-based oblique plane microscopy applied to the study of calcium dynamics in cardiac myocytes
Q58556671Interplay Between Sub-Cellular Alterations of Calcium Release and T-Tubular Defects in Cardiac Diseases
Q33653885Regulation of Cardiomyocyte T-Tubular Structure: Opportunities for Therapy
Q39435932Remodeling of the transverse tubular system after myocardial infarction in rabbit correlates with local fibrosis: A potential role of biomechanics.
Q35069142T-tubule disruption promotes calcium alternans in failing ventricular myocytes: mechanistic insights from computational modeling
Q46241479Transverse tubular network structures in the genesis of intracellular calcium alternans and triggered activity in cardiac cells
Q51075465Variable t-tubule organization and Ca2+ homeostasis across the atria.

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