| P2093 | author name string | Edward F Plow | |
| | Jun Qin | |
| | Mitali Das | |
| | Sujay Ithychanda | |
| P2860 | cites work | Talin contains a C-terminal calpain2 cleavage site important in focal adhesion dynamics | Q21134703 |
| | Layilin, a novel talin-binding transmembrane protein homologous with C-type lectins, is localized in membrane ruffles | Q22004003 |
| | Structural determinants of integrin recognition by talin | Q24292811 |
| | Structural basis of integrin activation by talin | Q24292977 |
| | Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation | Q24297812 |
| | Integrins β1 and β3 exhibit distinct dynamic nanoscale organizations inside focal adhesions | Q24299829 |
| | FAK promotes recruitment of talin to nascent adhesions to control cell motility | Q24303404 |
| | Identification of a repeated domain within mammalian alpha-synemin that interacts directly with talin | Q24311478 |
| | A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans | Q24313548 |
| | Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation | Q24313629 |
| | Cooperation between integrin alphavbeta3 and VEGFR2 in angiogenesis | Q24318607 |
| | The structure of the integrin alphaIIbbeta3 transmembrane complex explains integrin transmembrane signalling | Q24320948 |
| | Migfilin, a molecular switch in regulation of integrin activation | Q24328844 |
| | Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling | Q24553489 |
| | Integrin ligands at a glance | Q24600618 |
| | RIAM activates integrins by linking talin to ras GTPase membrane-targeting sequences | Q24652493 |
| | Dynamic membrane-cytoskeletal interactions: specific association of integrin and talin arises in vivo after phorbol ester treatment of peripheral blood lymphocytes | Q24655945 |
| | A new protein of adhesion plaques and ruffling membranes | Q24681303 |
| | A structural mechanism of integrin alpha(IIb)beta(3) "inside-out" activation as regulated by its cytoplasmic face | Q27639651 |
| | An integrin phosphorylation switch: the effect of beta3 integrin tail phosphorylation on Dok1 and talin binding | Q27649407 |
| | The structure of the C-terminal actin-binding domain of talin | Q27649413 |
| | NMR solution conformations and interactions of integrin alphaLbeta2 cytoplasmic tails | Q27653113 |
| | Single subunit chimeric integrins as mimics and inhibitors of endogenous integrin functions in receptor localization, cell spreading and migration, and matrix assembly | Q36234598 |
| | Integrin beta 3 cytoplasmic tail is necessary and sufficient for regulation of alpha 5 beta 1 phagocytosis by alpha v beta 3 and integrin-associated protein | Q36235842 |
| | Talin is required for integrin-mediated platelet function in hemostasis and thrombosis | Q36294415 |
| | A talin-dependent LFA-1 focal zone is formed by rapidly migrating T lymphocytes. | Q36320696 |
| | Integrin alpha v beta 3 differentially regulates adhesive and phagocytic functions of the fibronectin receptor alpha 5 beta 1. | Q36382983 |
| | The adhesion plaque protein, talin, is phosphorylated in vivo in chicken embryo fibroblasts exposed to a tumor-promoting phorbol ester | Q36734916 |
| | Differences in regulation of Drosophila and vertebrate integrin affinity by talin | Q36796913 |
| | beta1 integrin cytoplasmic domain residues selectively modulate fibronectin matrix assembly and cell spreading through talin and Akt-1. | Q37134457 |
| | Control of high affinity interactions in the talin C terminus: how talin domains coordinate protein dynamics in cell adhesions. | Q37185310 |
| | Interactions of platelet integrin alphaIIb and beta3 transmembrane domains in mammalian cell membranes and their role in integrin activation | Q37187555 |
| | Structural studies on full-length talin1 reveal a compact auto-inhibited dimer: implications for talin activation | Q37237654 |
| | Talin phosphorylation by Cdk5 regulates Smurf1-mediated talin head ubiquitylation and cell migration. | Q37271848 |
| | Membrane-mediated structural transitions at the cytoplasmic face during integrin activation | Q37356532 |
| | Mechanisms that regulate adaptor binding to beta-integrin cytoplasmic tails | Q37360853 |
| | Trans-dominant inhibition of integrin function. | Q37383759 |
| | Beta integrin tyrosine phosphorylation is a conserved mechanism for regulating talin-induced integrin activation | Q37479464 |
| | The tail of integrins, talin, and kindlins | Q37483142 |
| | Kindling the flame of integrin activation and function with kindlins | Q37530251 |
| | Kindlins in FERM adhesion. | Q37708950 |
| | Crosstalk between integrin and receptor tyrosine kinase signaling in breast carcinoma progression | Q37761401 |
| | Structural Determinants of Integrin Binding to the Talin Rod | Q27653581 |
| | The Structure of an Interdomain Complex That Regulates Talin Activity | Q27654202 |
| | The structure of an integrin/talin complex reveals the basis of inside-out signal transduction. | Q27657634 |
| | Structure of an integrin IIb 3 transmembrane-cytoplasmic heterocomplex provides insight into integrin activation | Q27657684 |
| | Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation | Q27659768 |
| | Central Region of Talin Has a Unique Fold That Binds Vinculin and Actin | Q27663253 |
| | The Structure of the Talin Head Reveals a Novel Extended Conformation of the FERM Domain | Q27665036 |
| | Mechanism for KRIT1 Release of ICAP1-Mediated Suppression of Integrin Activation | Q27675893 |
| | RIAM and Vinculin Binding to Talin Are Mutually Exclusive and Regulate Adhesion Assembly and Turnover | Q27676229 |
| | A novel membrane-dependent on/off switch mechanism of talin FERM domain at sites of cell adhesion | Q27681229 |
| | Integrins: bidirectional, allosteric signaling machines | Q27860700 |
| | Integrin signaling | Q28142010 |
| | The phosphotyrosine binding-like domain of talin activates integrins | Q28212748 |
| | Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin | Q28214335 |
| | Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions | Q28214350 |
| | Increased filamin binding to beta-integrin cytoplasmic domains inhibits cell migration | Q28214955 |
| | Interaction of plasma membrane fibronectin receptor with talin--a transmembrane linkage | Q28285095 |
| | RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion | Q28286523 |
| | Interaction of focal adhesion kinase with cytoskeletal protein talin | Q28294149 |
| | Sequence and domain structure of talin | Q28302349 |
| | Kindlin-2 controls bidirectional signaling of integrins | Q28507652 |
| | Kindlin-3 is essential for integrin activation and platelet aggregation | Q28595084 |
| | Integrin alpha(IIb)beta(3) signaling in platelet adhesion and aggregation | Q28610108 |
| | Alpha v beta 1 is a receptor for vitronectin and fibrinogen, and acts with alpha 5 beta 1 to mediate spreading on fibronectin | Q28645705 |
| | Functional atlas of the integrin adhesome | Q29617077 |
| | Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice | Q29617498 |
| | c-Src enhances the spreading of src-/- fibroblasts on fibronectin by a kinase-independent mechanism | Q30193362 |
| | Matrix-specific suppression of integrin activation in shear stress signaling. | Q30441401 |
| | Talin depletion reveals independence of initial cell spreading from integrin activation and traction | Q30490335 |
| | Clustering of alpha(5)beta(1) integrins determines adhesion strength whereas alpha(v)beta(3) and talin enable mechanotransduction | Q30490566 |
| | Quantitative proteomics of the integrin adhesome show a myosin II-dependent recruitment of LIM domain proteins | Q30498837 |
| | Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation | Q30514206 |
| | Integrin-dependent force transmission to the extracellular matrix by α-actinin triggers adhesion maturation | Q30538811 |
| | Two modes of integrin activation form a binary molecular switch in adhesion maturation | Q30539304 |
| | The C terminus of talin links integrins to cell cycle progression. | Q35503801 |
| | Affinity of talin-1 for the β3-integrin cytosolic domain is modulated by its phospholipid bilayer environment. | Q35735180 |
| | Alpha-actinin revisited: a fresh look at an old player | Q35745364 |
| | Molecular and mechanical synergy: cross-talk between integrins and growth factor receptors. | Q35846893 |
| | Subcellular localization of talin is regulated by inter-domain interactions | Q35922268 |
| | Talin activates integrins by altering the topology of the β transmembrane domain | Q36002154 |
| | The I/LWEQ module: a conserved sequence that signifies F-actin binding in functionally diverse proteins from yeast to mammals | Q36155573 |
| | Evidence for the selective association of a subpopulation of GPIIb-IIIa with the actin cytoskeletons of thrombin-activated platelets | Q36232933 |
| | Talin anchors and nucleates actin filaments at lipid membranes. A direct demonstration | Q67599603 |
| | Phosphorylation of high molecular weight proteins in platelets treated with 12-O-tetradecanoylphorbol-13-acetate | Q68800318 |
| | The role of phosphorylation and limited proteolytic cleavage of talin and vinculin in the disruption of focal adhesion integrity | Q69352160 |
| | Phosphorylation of the cytoskeletal protein talin by protein kinase C | Q70276946 |
| | Integrin activation and cytoskeletal interaction are essential for the assembly of a fibronectin matrix | Q70787146 |
| | Talin can crosslink actin filaments into both networks and bundles | Q70900726 |
| | Direct binding of the platelet integrin alphaIIbbeta3 (GPIIb-IIIa) to talin. Evidence that interaction is mediated through the cytoplasmic domains of both alphaIIb and beta3 | Q71143866 |
| | Platelet talin is phosphorylated by calyculin A | Q72168090 |
| | Talin distribution and phosphorylation in thrombin-activated platelets | Q72288101 |
| | Identification of functional domains in the cytoskeletal protein talin | Q72715640 |
| | Interaction of talin with actin: sensitive modulation of filament crosslinking activity | Q77767343 |
| | A C-terminal dimerization motif is required for focal adhesion targeting of Talin1 and the interaction of the Talin1 I/LWEQ module with F-actin | Q80851261 |
| | Calpain cleavage promotes talin binding to the beta 3 integrin cytoplasmic domain | Q30671443 |
| | Localization of an integrin binding site to the C terminus of talin | Q30717116 |
| | Loss of Kindlin-1 causes skin atrophy and lethal neonatal intestinal epithelial dysfunction | Q33389852 |
| | Integrin alphaIIbbeta3 activation in Chinese hamster ovary cells and platelets increases clustering rather than affinity | Q33581938 |
| | New PI(4,5)P2- and membrane proximal integrin-binding motifs in the talin head control beta3-integrin clustering | Q33590915 |
| | Cytoskeletal interactions with the leukocyte integrin beta2 cytoplasmic tail. Activation-dependent regulation of associations with talin and alpha-actinin | Q33662882 |
| | The Talin head domain binds to integrin beta subunit cytoplasmic tails and regulates integrin activation | Q33874977 |
| | Disruption of the talin gene arrests mouse development at the gastrulation stage | Q33925712 |
| | Migfilin and filamin as regulators of integrin activation in endothelial cells and neutrophils | Q34063691 |
| | Structural diversity in integrin/talin interactions | Q34153526 |
| | Properties of talin from chicken gizzard smooth muscle. | Q34166218 |
| | Studies on the morphology and spreading of human endothelial cells define key inter- and intramolecular interactions for talin1. | Q34218072 |
| | Spatial coordination of kindlin-2 with talin head domain in interaction with integrin β cytoplasmic tails | Q34286961 |
| | A fluorescence cell biology approach to map the second integrin-binding site of talin to a 130-amino acid sequence within the rod domain | Q34307039 |
| | Probing actin and liposome interaction of talin and talin-vinculin complexes: a kinetic, thermodynamic and lipid labeling study | Q34316463 |
| | Talin1 has unique expression versus talin 2 in the heart and modifies the hypertrophic response to pressure overload. | Q34319557 |
| | Native talin is a dumbbell-shaped homodimer when it interacts with actin | Q34330217 |
| | Interaction of NBD-talin with lipid monolayers. A film balance study | Q34365970 |
| | Intrasteric inhibition mediates the interaction of the I/LWEQ module proteins Talin1, Talin2, Hip1, and Hip12 with actin | Q34373785 |
| | Transmembrane and cytoplasmic domains in integrin activation and protein-protein interactions (review). | Q34400650 |
| | Talin contains three actin-binding sites each of which is adjacent to a vinculin-binding site | Q34408635 |
| | Integrin beta 1 cytoplasmic domain dominant negative effects revealed by lysophosphatidic acid treatment | Q34445932 |
| | Integrin and growth factor receptor crosstalk. | Q34460850 |
| | Talin phosphorylation sites mapped by mass spectrometry | Q34463527 |
| | The integrin binding site 2 (IBS2) in the talin rod domain is essential for linking integrin beta subunits to the cytoskeleton | Q34618626 |
| | Talin-dependent integrin activation is required for fibrin clot retraction by platelets | Q34667580 |
| | Loss of talin1 in platelets abrogates integrin activation, platelet aggregation, and thrombus formation in vitro and in vivo | Q34726698 |
| | The talin rod IBS2 alpha-helix interacts with the beta3 integrin cytoplasmic tail membrane-proximal helix by establishing charge complementary salt bridges | Q34788810 |
| | The tail of integrin activation | Q34804460 |
| | Biochemical and structural properties of the integrin-associated cytoskeletal protein talin | Q34979246 |
| | Loss of Kindlin-3 in LAD-III eliminates LFA-1 but not VLA-4 adhesiveness developed under shear flow conditions | Q34992989 |
| | Talin 1 and 2 are required for myoblast fusion, sarcomere assembly and the maintenance of myotendinous junctions | Q35005808 |
| | Talin1 regulates integrin turnover to promote embryonic epithelial morphogenesis | Q35139916 |
| | ??? | Q28144953 |
| | Cooperation between integrins and growth factor receptors in signaling and endocytosis | Q37887791 |
| | Integrin signaling in vascular function. | Q38001325 |
| | Talin-1 and kindlin-3 regulate alpha4beta1 integrin-mediated adhesion stabilization, but not G protein-coupled receptor-induced affinity upregulation | Q39475082 |
| | A potential role for α-actinin in inside-out αIIbβ3 signaling | Q39645121 |
| | The NPIY motif in the integrin beta1 tail dictates the requirement for talin-1 in outside-in signaling | Q39863533 |
| | Integrin adhesion and force coupling are independently regulated by localized PtdIns(4,5)2 synthesis | Q39938242 |
| | Kindlin-2 (Mig-2): a co-activator of beta3 integrins. | Q39985157 |
| | A NPxY-independent beta5 integrin activation signal regulates phagocytosis of apoptotic cells. | Q40061608 |
| | Activation of LFA-1 by ionomycin is independent of calpain-mediated talin cleavage | Q40163500 |
| | Phospholipase C, calcium, and calmodulin are critical for alpha4beta1 integrin affinity up-regulation and monocyte arrest triggered by chemoattractants | Q40234289 |
| | The mechanisms and dynamics of (alpha)v(beta)3 integrin clustering in living cells | Q40358354 |
| | Calpain-mediated proteolysis of talin regulates adhesion dynamics | Q40510946 |
| | Integrin-induced epidermal growth factor (EGF) receptor activation requires c-Src and p130Cas and leads to phosphorylation of specific EGF receptor tyrosines | Q40760846 |
| | The alphavbeta3 integrin regulates alpha5beta1-mediated cell migration toward fibronectin | Q41079791 |
| | The structure of a receptor with two associating transmembrane domains on the cell surface: integrin alphaIIbbeta3. | Q41543290 |
| | Integrin αIIbβ3 inside-out activation: an in situ conformational analysis reveals a new mechanism | Q41952463 |
| | Collagen-induced platelet activation mainly involves the protein kinase C pathway | Q42024590 |
| | Talin binds to actin and promotes filament nucleation | Q42091581 |
| | Structural basis for the autoinhibition of talin in regulating integrin activation | Q42410877 |
| | Talin is essential for integrin function in Drosophila | Q42527426 |
| | Endothelial cell talin1 is essential for embryonic angiogenesis. | Q42577942 |
| | The structure of the talin/integrin complex at a lipid bilayer: an NMR and MD simulation study | Q42588609 |
| | Integrin cross talk: activation of lymphocyte function-associated antigen-1 on human T cells alters alpha4beta1- and alpha5beta1-mediated function. | Q42795898 |
| | The molecular basis of filamin binding to integrins and competition with talin | Q42805546 |
| | Protein interactions with the platelet integrin alpha(IIb) regulatory motif | Q43058879 |
| | Protein kinase A regulates Rac and is required for the growth factor-stimulated migration of carcinoma cells | Q43770508 |
| | Domain-specific interactions of talin with the membrane-proximal region of the integrin beta3 subunit. | Q44503664 |
| | Talin loss-of-function uncovers roles in cell contractility and migration in C. elegans | Q44547425 |
| | Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins | Q44590985 |
| | Competition for talin results in trans-dominant inhibition of integrin activation | Q44895867 |
| | PKC-theta selectively controls the adhesion-stimulating molecule Rap1. | Q45124437 |
| | Structural basis for phosphatidylinositol phosphate kinase type Igamma binding to talin at focal adhesions | Q45204971 |
| | Identification of the beta1-integrin binding site on alpha-actinin by cryoelectron microscopy | Q45274770 |
| | LAD-1/variant syndrome is caused by mutations in FERMT3. | Q46209404 |
| | Integrin beta cytoplasmic domains differentially bind to cytoskeletal proteins. | Q46376510 |
| | Reconstructing and deconstructing agonist-induced activation of integrin alphaIIbbeta3. | Q46619229 |
| | Protein kinase D1 and the beta 1 integrin cytoplasmic domain control beta 1 integrin function via regulation of Rap1 activation. | Q46659681 |
| | Mapping and consensus sequence identification for multiple vinculin binding sites within the talin rod. | Q46681141 |
| | Cooperative role of the membrane-proximal and -distal residues of the integrin beta3 cytoplasmic domain in regulation of talin-mediated alpha IIb beta3 activation | Q46824116 |
| | The N-terminal domains of talin cooperate with the phosphotyrosine binding-like domain to activate beta1 and beta3 integrins | Q46828504 |
| | Multiple factors contribute to integrin-talin interactions in vivo. | Q47070092 |
| | Purification and properties of human platelet P235. A high molecular weight protein substrate of endogenous calcium-activated protease(s) | Q47267323 |
| | Phosphatidylinositol phosphate kinase type 1gamma and beta1-integrin cytoplasmic domain bind to the same region in the talin FERM domain | Q48292433 |
| | An interaction between integrin and the talin FERM domain mediates integrin activation but not linkage to the cytoskeleton. | Q48547650 |
| | Talin at a glance | Q50335781 |
| | In vivo functional analysis reveals specific roles for the integrin-binding sites of talin. | Q50521001 |
| | Gene duplication and functional divergence during evolution of the cytoskeletal linker protein talin. | Q53654172 |
| | Energy-filtered electron microscopy reveals that talin is a highly flexible protein composed of a series of globular domains. | Q54397824 |
| | Characterization of an Actin-binding Site within the Talin FERM Domain | Q58321657 |
| P433 | issue | 2 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 579-588 | |
| P577 | publication date | 2013-07-24 | |
| P1433 | published in | Biochimica et Biophysica Acta | Q864239 |
| P1476 | title | Mechanisms of talin-dependent integrin signaling and crosstalk | |
| P478 | volume | 1838 | |