| P50 | author | Ehud Cohen | Q37834766 |
| P2860 | cites work | Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice | Q22242267 |
| | A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline | Q22251083 |
| | Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory | Q24645499 |
| | Association of FOXO3A variation with human longevity confirmed in German centenarians | Q24646035 |
| | FOXO3A genotype is strongly associated with human longevity | Q24647408 |
| | TDP-1/TDP-43 regulates stress signaling and age-dependent proteotoxicity in Caenorhabditis elegans | Q27332459 |
| | Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans | Q27860971 |
| | A C. elegans mutant that lives twice as long as wild type | Q27861054 |
| | Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide | Q28131750 |
| | Adapting proteostasis for disease intervention | Q28131818 |
| | Huntingtin aggregation and toxicity in Huntington's disease | Q28204163 |
| | Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice | Q28252794 |
| | Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice | Q28505715 |
| | Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations | Q28506710 |
| | daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans | Q28611331 |
| | Daf-2 signaling modifies mutant SOD1 toxicity in C. elegans | Q28731030 |
| | Molecular chaperones in protein folding and proteostasis | Q29547715 |
| | Extended longevity in mice lacking the insulin receptor in adipose tissue | Q29614549 |
| | The IRS2 Gly1057Asp variant is associated with human longevity. | Q54456152 |
| | Linkage of a gene causing familial amyotrophic lateral sclerosis to chromosome 21 and evidence of genetic-locus heterogeneity | Q70142305 |
| | Alzheimer's disease | Q84113248 |
| | A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity | Q29614550 |
| | Autophagy gone awry in neurodegenerative diseases | Q29614849 |
| | TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis | Q29615597 |
| | IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice | Q29616382 |
| | The plasticity of aging: insights from long-lived mutants | Q29616584 |
| | Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans | Q29619580 |
| | Opposing activities protect against age-onset proteotoxicity | Q29619758 |
| | Regulation of Aging and Age-Related Disease by DAF-16 and Heat-Shock Factor | Q29619759 |
| | The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans | Q29619760 |
| | The effect of retarded growth upon the length of life span and upon the ultimate body size. 1935 | Q29620325 |
| | Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans | Q30488783 |
| | Reduced IGF-1 signaling delays age-associated proteotoxicity in mice | Q30497845 |
| | Neuron-specific proteotoxicity of mutant ataxin-3 in C. elegans: rescue by the DAF-16 and HSF-1 pathways | Q30502208 |
| | Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans | Q33902367 |
| | Small heat shock proteins potentiate amyloid dissolution by protein disaggregases from yeast and humans | Q34313725 |
| | Amyloid beta-protein dimers rapidly form stable synaptotoxic protofibrils | Q34330681 |
| | Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease | Q34460984 |
| | Functionally significant insulin-like growth factor I receptor mutations in centenarians | Q34757952 |
| | TDP-43 neurotoxicity and protein aggregation modulated by heat shock factor and insulin/IGF-1 signaling | Q34829446 |
| | The mechanism of γ-Secretase dysfunction in familial Alzheimer disease | Q36000134 |
| | Lysosomal calcium homeostasis defects, not proton pump defects, cause endo-lysosomal dysfunction in PSEN-deficient cells. | Q36085273 |
| | The ubiquitin proteolytic system: from a vague idea, through basic mechanisms, and onto human diseases and drug targeting | Q36375898 |
| | Mechanisms of Parkinson's disease linked to pathological alpha-synuclein: new targets for drug discovery | Q36610346 |
| | HSF-1 regulators DDL-1/2 link insulin-like signaling to heat-shock responses and modulation of longevity | Q36737237 |
| | Aging and survival: the genetics of life span extension by dietary restriction. | Q37121798 |
| | FOXO3a is broadly neuroprotective in vitro and in vivo against insults implicated in motor neuron diseases | Q37356513 |
| | A kinetic assessment of the C. elegans amyloid disaggregation activity enables uncoupling of disassembly and proteolysis | Q39953074 |
| | Mutations of the presenilin I gene in families with early-onset Alzheimer's disease | Q41263613 |
| | Temporal requirements of insulin/IGF-1 signaling for proteotoxicity protection | Q41769831 |
| | Temporal requirements of heat shock factor-1 for longevity assurance | Q43175674 |
| | Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans | Q43799857 |
| | Rates of behavior and aging specified by mitochondrial function during development | Q44242015 |
| | Hsp104 catalyzes formation and elimination of self-replicating Sup35 prion conformers | Q44904974 |
| | Neuronal IGF-1 resistance reduces Abeta accumulation and protects against premature death in a model of Alzheimer's disease. | Q45987250 |
| | Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway | Q46102898 |
| | Conformational disease | Q46332791 |
| | Impaired spatial learning in the APPSwe + PSEN1DeltaE9 bigenic mouse model of Alzheimer's disease. | Q48306292 |
| | Co-expression of multiple transgenes in mouse CNS: a comparison of strategies | Q48889458 |
| | Chaperonin TRiC promotes the assembly of polyQ expansion proteins into nontoxic oligomers. | Q50715387 |
| | Aging as a major risk for degenerative diseases of the central nervous system. | Q53314938 |
| P433 | issue | 4 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | neurodegeneration | Q1755122 |
| | protein aggregation | Q7251455 |
| | molecular chaperones | Q422496 |
| P304 | page(s) | e0021 | |
| P577 | publication date | 2012-10-31 | |
| P1433 | published in | Rambam Maimonides Medical Journal | Q18209815 |
| P1476 | title | Aging, protein aggregation, chaperones, and neurodegenerative disorders: mechanisms of coupling and therapeutic opportunities | |
| P478 | volume | 3 | |