Impaired spatial learning in the APPSwe + PSEN1DeltaE9 bigenic mouse model of Alzheimer's disease.

scientific article

Impaired spatial learning in the APPSwe + PSEN1DeltaE9 bigenic mouse model of Alzheimer's disease. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/J.1601-183X.2006.00221.X
P698PubMed publication ID17233641

P50authorFiona E. HarrisonQ53998031
Michael P. McDonaldQ55690457
P2093author name stringReiserer RS
Syverud DC
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectAlzheimer's diseaseQ11081
P304page(s)54-65
P577publication date2007-02-01
P1433published inGenes, Brain and BehaviorQ112067
P1476titleImpaired spatial learning in the APPSwe + PSEN1DeltaE9 bigenic mouse model of Alzheimer's disease
P478volume6

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cites work (P2860)
Q3382573617α-estradiol attenuates neuron loss in ovariectomized Dtg AβPP/PS1 mice.
Q397118422,2',4'-trihydroxychalcone from Glycyrrhiza glabra as a new specific BACE1 inhibitor efficiently ameliorates memory impairment in mice
Q43197086A GPCR/secretase complex regulates beta- and gamma-secretase specificity for Abeta production and contributes to AD pathogenesis.
Q34527792A comparative evaluation of treatments with 17β-estradiol and its brain-selective prodrug in a double-transgenic mouse model of Alzheimer's disease
Q48229419A dual magnetic resonance imaging/fluorescent contrast agent for Cathepsin-D detection
Q30455082APP transgenic mice for modelling behavioural and psychological symptoms of dementia (BPSD).
Q34218993Abnormal vibrissa-related behavior and loss of barrel field inhibitory neurons in 5xFAD transgenics.
Q99624207Acetylation of AMPA Receptors Regulates Receptor Trafficking and Rescues Memory Deficits in Alzheimer's Disease
Q92532068Activation of PPARA-mediated autophagy reduces Alzheimer disease-like pathology and cognitive decline in a murine model
Q28771517Activation of nicotinic α7 acetylcholine receptor enhances long term potentation in wild type mice but not in APPswe/PS1ΔE9 mice
Q34096125Adipose-derived mesenchymal stem cell transplantation promotes adult neurogenesis in the brains of Alzheimer's disease mice.
Q37813299Ageing and protein aggregation-mediated disorders: from invertebrates to mammals
Q38126026Aging, protein aggregation, chaperones, and neurodegenerative disorders: mechanisms of coupling and therapeutic opportunities
Q30493543Allele-specific RNAi mitigates phenotypic progression in a transgenic model of Alzheimer's disease
Q49524953Alzheimer's Disease Mutant Mice Exhibit Reduced Brain Tissue Stiffness Compared to Wild-type Mice in both Normoxia and following Intermittent Hypoxia Mimicking Sleep Apnea
Q35156207Aminostyrylbenzofuran directly reduces oligomeric amyloid-β and reverses cognitive deficits in Alzheimer transgenic mice
Q38843285Amniotic Mesenchymal Stem Cells Decrease Aβ Deposition and Improve Memory in APP/PS1 Transgenic Mice
Q34982983Amyloid β-induced impairments in hippocampal synaptic plasticity are rescued by decreasing mitochondrial superoxide
Q34414740An anterograde rabies virus vector for high-resolution large-scale reconstruction of 3D neuron morphology
Q47355534An exploratory investigation of brain-selective estrogen treatment in males using a mouse model of Alzheimer's disease
Q47244184Anesthetic Isoflurane or Desflurane Plus Surgery Differently Affects Cognitive Function in Alzheimer's Disease Transgenic Mice
Q30572684Angiotensin-converting enzyme overexpression in myelomonocytes prevents Alzheimer's-like cognitive decline
Q37061262Antioxidants and cognitive training interact to affect oxidative stress and memory in APP/PSEN1 mice
Q44328454Arctigenin effectively ameliorates memory impairment in Alzheimer's disease model mice targeting both β-amyloid production and clearance
Q60949629Assessment of spatial learning and memory in the Barnes maze task in rodents-methodological consideration
Q48901829Atorvastatin ameliorates cognitive impairment, Aβ1-42 production and Tau hyperphosphorylation in APP/PS1 transgenic mice
Q34074699Barnes maze testing strategies with small and large rodent models
Q37395530Behavioural Phenotyping of APPswe/PS1δE9 Mice: Age-Rrelated Changes and Effect of Long-Term Paroxetine Treatment
Q40053117Behavioural effects of PNU-282987 and stress in an animal model of Alzheimer's disease.
Q40625519Blocking IGF Signaling in Adult Neurons Alleviates Alzheimer's Disease Pathology through Amyloid-β Clearance.
Q41444056Characterization of AD-like phenotype in aged APPSwe/PS1dE9 mice
Q50472663Cholinergic Modification of Neurogenesis and Gliosis Improves the Memory of AβPPswe/PSEN1dE9 Alzheimer's Disease Model Mice Fed a High-Fat Diet.
Q35827454Chronic IL-1β-mediated neuroinflammation mitigates amyloid pathology in a mouse model of Alzheimer's disease without inducing overt neurodegeneration
Q47794929Chronic cannabidiol treatment improves social and object recognition in double transgenic APPswe/PS1∆E9 mice
Q48431434Circadian system functionality, hippocampal oxidative stress, and spatial memory in the APPswe/PS1dE9 transgenic model of Alzheimer disease: effects of melatonin or ramelteon.
Q90587999Cognitive and emotional alterations in App knock-in mouse models of Aβ amyloidosis
Q36997908Comprehensive behavioral characterization of an APP/PS-1 double knock-in mouse model of Alzheimer's disease
Q42544187Cox-2 Plays a Vital Role in the Impaired Anxiety Like Behavior in Colchicine Induced Rat Model of Alzheimer Disease
Q46655961Decreased hippocampal cell proliferation correlates with increased expression of BMP4 in the APPswe/PS1DeltaE9 mouse model of Alzheimer's disease
Q36717090Deficits in hippocampal-dependent transfer generalization learning accompany synaptic dysfunction in a mouse model of amyloidosis
Q36582377Delayed amyloid plaque deposition and behavioral deficits in outcrossed AβPP/PS1 mice
Q47351358Detection of β-Amyloid by Sialic Acid Coated Bovine Serum Albumin Magnetic Nanoparticles in a Mouse Model of Alzheimer's Disease
Q35589042Differential proteomic and behavioral effects of long-term voluntary exercise in wild-type and APP-overexpressing transgenics.
Q59758209Direct reprogramming of fibroblasts into neural stem cells by single non-neural progenitor transcription factor Ptf1a
Q93166438Discovery of nitazoxanide-based derivatives as autophagy activators for the treatment of Alzheimer's disease
Q37458204Disrupted-in-Schizophrenia-1 Attenuates Amyloid-β Generation and Cognitive Deficits in APP/PS1 Transgenic Mice by Reduction of β-Site APP-Cleaving Enzyme 1 Levels
Q51759819Dynamic SAP102 expression in the hippocampal subregions of rats and APP/PS1 mice of various ages.
Q50422373Early Presymptomatic Changes in the Proteome of Mitochondria-Associated Membrane in the APP/PS1 Mouse Model of Alzheimer's Disease.
Q51038505Early temporal short-term memory deficits in double transgenic APP/PS1 mice
Q37154745Effects of an alpha7 nicotinic receptor agonist and stress on spatial memory in an animal model of Alzheimer's disease
Q36953692Elevated oxidative stress and sensorimotor deficits but normal cognition in mice that cannot synthesize ascorbic acid
Q28247764Elevation of brain magnesium prevents synaptic loss and reverses cognitive deficits in Alzheimer's disease mouse model
Q90441714Ellagic acid ameliorates learning and memory impairment in APP/PS1 transgenic mice via inhibition of β-amyloid production and tau hyperphosphorylation
Q43152844Endogenous anxiety and stress responses in water maze and Barnes maze spatial memory tasks
Q36019557Enhanced penetration of exogenous EPCs into brains of APP/PS1 transgenic mice
Q30420041Epidermal growth factor receptor is a preferred target for treating amyloid-β-induced memory loss
Q50034406Expression Profiling of Cytokine, Cholinergic Markers, and Amyloid-β Deposition in the APPSWE/PS1dE9 Mouse Model of Alzheimer's Disease Pathology.
Q48753034Expression of δNp73 in hippocampus of APP/PS1 transgenic mice following GFP-BMSCs transplantation
Q21133775Galactic cosmic radiation leads to cognitive impairment and increased aβ plaque accumulation in a mouse model of Alzheimer's disease
Q92072136Heterozygous CX3CR1 Deficiency in Microglia Restores Neuronal β-Amyloid Clearance Pathways and Slows Progression of Alzheimer's Like-Disease in PS1-APP Mice
Q92363257High Dietary Iron Disrupts Iron Homeostasis and Induces Amyloid-β and Phospho-τ Expression in the Hippocampus of Adult Wild-Type and APP/PS1 Transgenic Mice
Q55262808Huatuo Zaizao pill ameliorates cognitive impairment of APP/PS1 transgenic mice by improving synaptic plasticity and reducing Aβ deposition.
Q39457273Huperzine A alleviates synaptic deficits and modulates amyloidogenic and nonamyloidogenic pathways in APPswe/PS1dE9 transgenic mice
Q51013962Increased prion protein processing and expression of metabotropic glutamate receptor 1 in a mouse model of Alzheimer's disease.
Q47102588Intermittent Fasting Protects against Alzheimer's Disease Possible through Restoring Aquaporin-4 Polarity
Q50719528Intracerebral transplantation of adipose-derived mesenchymal stem cells alternatively activates microglia and ameliorates neuropathological deficits in Alzheimer's disease mice.
Q34110890Intracranial V. cholerae sialidase protects against excitotoxic neurodegeneration
Q37235613Intranasal insulin alleviates cognitive deficits and amyloid pathology in young adult APPswe/PS1dE9 mice
Q35621563Intraneuronal APP and extracellular Aβ independently cause dendritic spine pathology in transgenic mouse models of Alzheimer's disease
Q37693458Intravenous ascorbate improves spatial memory in middle-aged APP/PSEN1 and wild type mice.
Q47771892Kalirin reduction rescues psychosis-associated behavioral deficits in APPswe/PSEN1dE9 transgenic mice
Q46158936Low-dose proton radiation effects in a transgenic mouse model of Alzheimer's disease - Implications for space travel.
Q36715856MPTP-induced executive dysfunction is associated with altered prefrontal serotonergic function
Q30823245Measuring discrimination- and reversal learning in mouse models within 4 days and without prior food deprivation.
Q53413215Memory deficiency, cerebral amyloid angiopathy, and amyloid-β plaques in APP+PS1 double transgenic rat model of Alzheimer's disease.
Q47280341Mesenchymal Stem Cell-Derived Extracellular Vesicles Suppresses iNOS Expression and Ameliorates Neural Impairment in Alzheimer's Disease Mice
Q30419141Metformin attenuates Alzheimer's disease-like neuropathology in obese, leptin-resistant mice
Q93129413Minor ginsenoside F1 improves memory in APP/PS1 mice
Q90718217Mossy cell synaptic dysfunction causes memory imprecision via miR-128 inhibition of STIM2 in Alzheimer's disease mouse model
Q46912904NAD attenuates oxidative DNA damages induced by amyloid beta-peptide in primary rat cortical neurons
Q36579852Neprilysin: an enzyme candidate to slow the progression of Alzheimer's disease
Q33768246Neuroinflammation and M2 microglia: the good, the bad, and the inflamed.
Q36465116Neuroinflammation impairs adaptive structural plasticity of dendritic spines in a preclinical model of Alzheimer's disease
Q46185330Neuroprotective Effect of Ligustilide through Induction of α-Secretase Processing of Both APP and Klotho in a Mouse Model of Alzheimer's Disease
Q47098610Neuroprotective effects of bajijiasu against cognitive impairment induced by amyloid-β in APP/PS1 mice
Q89999010Nitazoxanide, an anti-parasitic drug, efficiently ameliorates learning and memory impairments in AD model mice
Q35101132Novel age-dependent learning deficits in a mouse model of Alzheimer's disease: implications for translational research.
Q61796294Opposing Roles of apolipoprotein E in aging and neurodegeneration
Q37213608Overexpression of Hsp27 ameliorates symptoms of Alzheimer's disease in APP/PS1 mice
Q34299310Overexpression of human apolipoprotein A-I preserves cognitive function and attenuates neuroinflammation and cerebral amyloid angiopathy in a mouse model of Alzheimer disease.
Q26747019Palmitoylation in Alzheimer's disease and other neurodegenerative diseases
Q51021977Phenylbutyric acid reduces amyloid plaques and rescues cognitive behavior in AD transgenic mice.
Q37220808Progesterone reduces depression-like behavior in a murine model of Alzheimer's Disease
Q28551173Protective Effects of Dietary Supplementation with a Combination of Nutrients in a Transgenic Mouse Model of Alzheimer's Disease
Q30423207Pyrrolidine dithiocarbamate attenuates brain Aβ increase and improves long-term neurological outcome in rats after transient focal brain ischemia
Q44968491RETRACTED: Elevation of brain magnesium prevents and reverses cognitive deficits and synaptic loss in Alzheimer's disease mouse model.
Q57192805RPS23RG1 Is Required for Synaptic Integrity and Rescues Alzheimer's Disease-Associated Cognitive Deficits
Q30497845Reduced IGF-1 signaling delays age-associated proteotoxicity in mice
Q89640703Retinal analysis of a mouse model of Alzheimer's disease with multicontrast optical coherence tomography
Q93035932Revealing brain pathologies with multimodal visible light optical coherence microscopy and fluorescence imaging
Q24601406SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10.
Q26784170Shared Neuropathological Characteristics of Obesity, Type 2 Diabetes and Alzheimer's Disease: Impacts on Cognitive Decline
Q92714088Small interfering RNA delivery to the neurons near the amyloid plaques for improved treatment of Alzheimer׳s disease
Q36115392Small molecule LX2343 ameliorates cognitive deficits in AD model mice by targeting both amyloid β production and clearance
Q34489284Smart Soup, a traditional Chinese medicine formula, ameliorates amyloid pathology and related cognitive deficits
Q35612961Spatial and nonspatial escape strategies in the Barnes maze
Q39577346Spectral unmixing imaging of wavelength-responsive fluorescent probes: an application for the real-time report of amyloid Beta species in Alzheimer's disease
Q49361337Subtle Alterations in Spatial Memory Induced by Amyloid Peptides Infusion in Rats.
Q89813314Synergic Effects of Berberine and Curcumin on Improving Cognitive Function in an Alzheimer's Disease Mouse Model
Q53081269Targeting glucocorticoid receptors prevents the effects of early life stress on amyloid pathology and cognitive performance in APP/PS1 mice.
Q28833244Targeting the γ-/β-secretase interaction reduces β-amyloid generation and ameliorates Alzheimer's disease-related pathogenesis
Q49804395The Cyanthin Diterpenoid and Sesterterpene Constituents of Hericium erinaceus Mycelium Ameliorate Alzheimer's Disease-Related Pathologies in APP/PS1 Transgenic Mice
Q59806753The Emerging Role of Altered Cerebellar Synaptic Processing in Alzheimer's Disease
Q48785645The Synergistic Roles of the Chronic Prenatal and Offspring Stress Exposures in Impairing Offspring Learning and Memory
Q46342780The diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology.
Q90086183The expanding phenotypes of cohesinopathies: one ring to rule them all!
Q39497033The human-specific CASP4 gene product contributes to Alzheimer-related synaptic and behavioural deficits
Q42503378Therapeutic effects of human amniotic epithelial cell transplantation on double-transgenic mice co-expressing APPswe and PS1ΔE9-deleted genes.
Q28550590Traditional Chinese Nootropic Medicine Radix Polygalae and Its Active Constituent Onjisaponin B Reduce β-Amyloid Production and Improve Cognitive Impairments
Q36950042Transgenic models of Alzheimer's disease: better utilization of existing models through viral transgenesis
Q38956724Translational Assays for Assessment of Cognition in Rodent Models of Alzheimer's Disease and Dementia.
Q33828868Type 1 diabetes exaggerates features of Alzheimer's disease in APP transgenic mice
Q34418781Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models
Q35764820Vitamin C deficiency in the brain impairs cognition, increases amyloid accumulation and deposition, and oxidative stress in APP/PSEN1 and normally aging mice
Q33688727Vitamin C deficiency increases basal exploratory activity but decreases scopolamine-induced activity in APP/PSEN1 transgenic mice
Q37301622Vitamin C reduces spatial learning deficits in middle-aged and very old APP/PSEN1 transgenic and wild-type mice
Q28534524Vitamin D2-enriched button mushroom (Agaricus bisporus) improves memory in both wild type and APPswe/PS1dE9 transgenic mice
Q48284096Voluntary Running Attenuates Memory Loss, Decreases Neuropathological Changes and Induces Neurogenesis in a Mouse Model of Alzheimer's Disease.
Q33715454YXQN Reduces Alzheimer's Disease-Like Pathology and Cognitive Decline in APPswePS1dE9 Transgenic Mice