Discovery of nitazoxanide-based derivatives as autophagy activators for the treatment of Alzheimer's disease

scientific article published on 29 July 2019

Discovery of nitazoxanide-based derivatives as autophagy activators for the treatment of Alzheimer's disease is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.APSB.2019.07.006
P932PMC publication ID7161708
P698PubMed publication ID32322468

P2093author name stringFei Mao
Jian Lu
Jian Li
Jiaying Wang
Lei Fan
Xu Shen
Jin Zhu
Wenwen Liu
Xiaokang Li
Xiaoxia Qiu
Baoli Li
Yixiang Xu
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The BACE1 inhibitor verubecestat (MK-8931) reduces CNS β-amyloid in animal models and in Alzheimer's disease patientsQ39222469
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Design, Synthesis, and Biological Evaluation of Orally Available First-Generation Dual-Target Selective Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5) for the Treatment of Alzheimer's Disease.Q47606444
Novel Vilazodone-Tacrine Hybrids as Potential Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease Accompanied with Depression: Design, Synthesis, and Biological EvaluationQ47777668
Assessing nest building in miceQ48218833
Impaired spatial learning in the APPSwe + PSEN1DeltaE9 bigenic mouse model of Alzheimer's disease.Q48306292
High throughput artificial membrane permeability assay for blood-brain barrierQ48349894
Discovery of the 3-Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)-A β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer's DiseaseQ48401163
Development of Multifunctional Pyrimidinylthiourea Derivatives as Potential Anti-Alzheimer AgentsQ48556634
Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's diseaseQ48820847
Novel Tadalafil Derivatives Ameliorates Scopolamine-Induced Cognitive Impairment in Mice via Inhibition of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5).Q52607974
An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.Q53207278
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Nitazoxanide, an anti-parasitic drug, efficiently ameliorates learning and memory impairments in AD model miceQ89999010
Rational Design of Novel Selective Dual-Target Inhibitors of Acetylcholinesterase and Monoamine Oxidase B as Potential Anti-Alzheimer's Disease AgentsQ90959660
P433issue4
P921main subjectautophagyQ288322
P304page(s)646-666
P577publication date2019-07-29
P1433published inActa Pharmaceutica Sinica BQ26854022
P1476titleDiscovery of nitazoxanide-based derivatives as autophagy activators for the treatment of Alzheimer's disease
P478volume10