Memory deficiency, cerebral amyloid angiopathy, and amyloid-β plaques in APP+PS1 double transgenic rat model of Alzheimer's disease.

scientific article published on 11 April 2018

Memory deficiency, cerebral amyloid angiopathy, and amyloid-β plaques in APP+PS1 double transgenic rat model of Alzheimer's disease. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PONE.0195469
P932PMC publication ID5895023
P698PubMed publication ID29641600

P50authorDiana KlakotskaiaQ87046069
Yuksel AgcaQ87843312
P2093author name stringTodd R Schachtman
Edward G Stopa
Yuksel Agca
Rachel A Richardson
P2860cites workCerebral amyloid angiopathy: amyloid beta accumulates in putative interstitial fluid drainage pathways in Alzheimer's diseaseQ24682442
Homeostatic capabilities of the choroid plexus epithelium in Alzheimer's diseaseQ24798001
Fiji: an open-source platform for biological-image analysisQ27860912
Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunctionQ29547778
Are the dorsal and ventral hippocampus functionally distinct structures?Q29619734
BACE1: the beta-secretase enzyme in Alzheimer's diseaseQ33202614
Development of transgenic rats producing human beta-amyloid precursor protein as a model for Alzheimer's disease: transgene and endogenous APP genes are regulated tissue-specificallyQ33321335
Early neurovascular dysfunction in a transgenic rat model of Alzheimer's diseaseQ33555571
Cerebral amyloid angiopathy: accumulation of A beta in interstitial fluid drainage pathways in Alzheimer's diseaseQ33922686
Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis.Q34341174
Cortical and leptomeningeal cerebrovascular amyloid and white matter pathology in Alzheimer's diseaseQ34520661
Neuroinflammation and neuronal loss precede Aβ plaque deposition in the hAPP-J20 mouse model of Alzheimer's disease.Q34656208
A shortened Barnes maze protocol reveals memory deficits at 4-months of age in the triple-transgenic mouse model of Alzheimer's diseaseQ35043942
Alzheimer's disease, normal-pressure hydrocephalus, and senescent changes in CSF circulatory physiology: a hypothesisQ35183975
Cerebral amyloid angiopathy in traumatic brain injury: association with apolipoprotein E genotypeQ35486023
Prominent cerebral amyloid angiopathy in transgenic mice overexpressing the london mutant of human APP in neurons.Q35745836
Role of Liver X Receptor in AD Pathophysiology.Q35882575
A behavioral assessment of hippocampal function based on a subregional analysisQ35969734
Presenilin 1 transgene addition to amyloid precursor protein overexpressing transgenic rats increases amyloid beta 42 levels and results in loss of memory retention.Q36070202
[Hippocampal and cognitive alterations precede amyloid deposition in a mouse model for Alzheimer's disease].Q50782883
Gender, sex steroid hormones, and Alzheimer's disease.Q36146996
Sporadic cerebral amyloid angiopathy: pathology, clinical implications, and possible pathomechanisms.Q36260752
A transgenic Alzheimer rat with plaques, tau pathology, behavioral impairment, oligomeric aβ, and frank neuronal lossQ37037738
Microvasculature changes and cerebral amyloid angiopathy in Alzheimer's disease and their potential impact on therapy.Q37398713
Cerebral amyloid angiopathy in the aetiology and immunotherapy of Alzheimer diseaseQ37613107
Which memory task for my mouse? A systematic review of spatial memory performance in the Tg2576 Alzheimer's mouse modelQ37874061
Memory deficits associated with senescence: A neurophysiological and behavioral study in the ratQ40232008
Cerebral microvascular alterations in aging, leukoaraiosis, and Alzheimer's diseaseQ41611048
Suppression of glymphatic fluid transport in a mouse model of Alzheimer's diseaseQ42364356
Kaolin-induced chronic hydrocephalus accelerates amyloid deposition and vascular disease in transgenic rats expressing high levels of human APP.Q43074615
Amyloid-beta(25-35)-induced memory impairments correlate with cell loss in rat hippocampusQ44776973
Understanding white matter disease: imaging-pathological correlations in vascular cognitive impairmentQ45007669
Cognitive and emotional alterations in young Alzheimer's disease (3xTgAD) mice: effects of neonatal handling stimulation and sexual dimorphismQ47703872
Early detection of cognitive deficits in the 3xTg-AD mouse model of Alzheimer's disease.Q47712319
Beneficial effects of dietary EGCG and voluntary exercise on behavior in an Alzheimer's disease mouse modelQ47799205
Environmental enrichment eliminates the anxiety phenotypes in a triple transgenic mouse model of Alzheimer's diseaseQ47803101
Visuo-spatial learning and memory deficits on the Barnes maze in the 16-month-old APPswe/PS1dE9 mouse model of Alzheimer's diseaseQ47842990
Spatial learning and memory impairment and increased locomotion in a transgenic amyloid precursor protein mouse model of Alzheimer's disease.Q48145768
Characterization of the 3xTg-AD mouse model of Alzheimer's disease: part 2. Behavioral and cognitive changesQ48161518
Impaired spatial learning in the APPSwe + PSEN1DeltaE9 bigenic mouse model of Alzheimer's disease.Q48306292
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectcerebral amyloid angiopathyQ191562
P304page(s)e0195469
P577publication date2018-04-11
P1433published inPLOS OneQ564954
P1476titleMemory deficiency, cerebral amyloid angiopathy, and amyloid-β plaques in APP+PS1 double transgenic rat model of Alzheimer's disease.
P478volume13

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cites work (P2860)
Q90399180Potential Role of Venular Amyloid in Alzheimer's Disease Pathogenesis
Q91890979Preclinical Models of Alzheimer's Disease: Relevance and Translational Validity
Q92819641White matter inflammation and cognitive function in a co-morbid metabolic syndrome and prodromal Alzheimer's disease rat model