Increased prion protein processing and expression of metabotropic glutamate receptor 1 in a mouse model of Alzheimer's disease.

scientific article published on 27 May 2013

Increased prion protein processing and expression of metabotropic glutamate receptor 1 in a mouse model of Alzheimer's disease. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/JNC.12296
P8608Fatcat IDrelease_xrlnzkhbljhjxi5qlwn4llndue
P698PubMed publication ID23651058
P5875ResearchGate publication ID236652416

P50authorAndré Luiz Sena GuimarãesQ42705054
Marco Antonio Maximo PradoQ44583422
Vania F PradoQ45827795
Vilma R MartinsQ45827808
Valeriy OstapchenkoQ62571142
P2093author name stringJue Fan
Monica Guzman
Flavio H Beraldo
Sanju Mishra
P2860cites workCellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomersQ22251089
beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathologyQ22253223
Stress-inducible protein 1 is a cell surface ligand for cellular prion that triggers neuroprotectionQ24534939
Group 1 mGluR-dependent synaptic long-term depression: mechanisms and implications for circuitry and diseaseQ24620534
Synthetic amyloid-beta oligomers impair long-term memory independently of cellular prion proteinQ24630045
Molecular cross talk between misfolded proteins in animal models of Alzheimer's and prion diseasesQ24633202
PrionsQ24633319
Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptakeQ24656613
Alzheimer's disease and insulin resistance: translating basic science into clinical applicationsQ26996487
Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretaseQ28188098
Physiology of the prion proteinQ28275220
Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomersQ28308082
Regulation of NMDA receptor trafficking by amyloid-betaQ28506085
Alzheimer's disease brain-derived amyloid-β-mediated inhibition of LTP in vivo is prevented by immunotargeting cellular prion proteinQ28771710
Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxinsQ29547593
A beta oligomers - a decade of discoveryQ29615152
Memory impairment in transgenic Alzheimer mice requires cellular prion proteinQ30032301
Elimination of the vesicular acetylcholine transporter in the striatum reveals regulation of behaviour by cholinergic-glutamatergic co-transmissionQ30472919
Deleterious effects of amyloid beta oligomers acting as an extracellular scaffold for mGluR5Q30500964
Cleavage of the amino terminus of the prion protein by reactive oxygen species.Q31520300
Neuroprotection against NMDA excitotoxicity by group I metabotropic glutamate receptors is associated with reduction of NMDA stimulated currentsQ33193869
Interplay among platelet-activating factor, oxidative stress, and group I metabotropic glutamate receptors modulates neuronal survival.Q33204967
Novel aspects of accumulation dynamics and A beta composition in transgenic models of AD.Q33206011
Peptide blockers of the inhibition of neuronal nicotinic acetylcholine receptors by amyloid betaQ33218208
Anti-PrPC monoclonal antibody infusion as a novel treatment for cognitive deficits in an Alzheimer's disease model mouseQ33718694
Endogenous proteolytic cleavage of disease-associated prion protein to produce C2 fragments is strongly cell- and tissue-dependentQ33795953
Novel strains of mice deficient for the vesicular acetylcholine transporter: insights on transcriptional regulation and control of locomotor behaviorQ33851514
Interaction between human prion protein and amyloid-beta (Abeta) oligomers: role OF N-terminal residuesQ34074414
Prion protein in Alzheimer's pathogenesis: a hot and controversial issueQ34130611
Probing the biology of Alzheimer's disease in miceQ34206962
Prion protein and Abeta-related synaptic toxicity impairmentQ34233877
Cellular prion protein: on the road for functionsQ34536249
Abeta toxicity in Alzheimer's disease: globular oligomers (ADDLs) as new vaccine and drug targetsQ34784378
Interaction between prion protein and toxic amyloid β assemblies can be therapeutically targeted at multiple sitesQ35166748
The distinct role of mGlu1 receptors in post-ischemic neuronal deathQ35216446
The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer's diseaseQ35327219
A naturally occurring C-terminal fragment of the prion protein (PrP) delays disease and acts as a dominant-negative inhibitor of PrPSc formation.Q35626193
α-Secretase-derived fragment of cellular prion, N1, protects against monomeric and oligomeric amyloid β (Aβ)-associated cell deathQ35763065
An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomersQ35858008
Cells release prions in association with exosomesQ36448448
Amyloid beta peptides and glutamatergic synaptic dysregulationQ37021970
Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta}Q37253971
Endocytosis of prion protein is required for ERK1/2 signaling induced by stress-inducible protein 1.Q37335792
Protein aggregation as a paradigm of agingQ37520024
α-secretase in Alzheimer's disease: molecular identity, regulation and therapeutic potentialQ37806286
mGluRs modulate strength and timing of excitatory transmission in hippocampal area CA3.Q37874147
Lack of a-disintegrin-and-metalloproteinase ADAM10 leads to intracellular accumulation and loss of shedding of the cellular prion protein in vivoQ39389999
Role of ADAMs in the ectodomain shedding and conformational conversion of the prion proteinQ39831418
alpha-cleavage of the prion protein occurs in a late compartment of the secretory pathway and is independent of lipid raftsQ39908845
The disintegrin ADAM9 indirectly contributes to the physiological processing of cellular prion by modulating ADAM10 activityQ40360129
A role for exosomes in the constitutive and stimulus-induced ectodomain cleavage of L1 and CD44Q40361195
Cleavage of L1 in exosomes and apoptotic membrane vesicles released from ovarian carcinoma cellsQ40438114
Alpha- and beta- cleavages of the amino-terminus of the cellular prion protein.Q40572421
Matrix metalloproteinase inhibition reduces oxidative stress associated with cerebral amyloid angiopathy in vivo in transgenic miceQ41230899
The alpha-secretase-derived N-terminal product of cellular prion, N1, displays neuroprotective function in vitro and in vivoQ42151993
The prion protein as a receptor for amyloid-beta.Q42692268
N-methyl-D-aspartate receptors are required for synaptic targeting of Alzheimer's toxic amyloid-β peptide oligomersQ42857361
Episodic-like memory deficits in the APPswe/PS1dE9 mouse model of Alzheimer's disease: relationships to beta-amyloid deposition and neurotransmitter abnormalitiesQ45310539
Amyloid-beta oligomers increase the localization of prion protein at the cell surfaceQ45827724
Impaired metabotropic glutamate receptor/phospholipase C signaling pathway in the cerebral cortex in Alzheimer's disease and dementia with Lewy bodies correlates with stage of Alzheimer's-disease-related changesQ46540225
Interaction of cellular prion and stress-inducible protein 1 promotes neuritogenesis and neuroprotection by distinct signaling pathways.Q46843638
Impaired spatial learning in the APPSwe + PSEN1DeltaE9 bigenic mouse model of Alzheimer's disease.Q48306292
PrP(C) homodimerization stimulates the production of PrPC cleaved fragments PrPN1 and PrPC1.Q48369828
Truncated forms of the human prion protein in normal brain and in prion diseasesQ48807964
Transgenic mice as a model of pre-clinical Alzheimer's disease.Q51027885
Metabotropic glutamate receptors transduce signals for neurite outgrowth after binding of the prion protein to laminin γ1 chain.Q51035911
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectprion protein familyQ24724413
P304page(s)415-425
P577publication date2013-05-27
P1433published inJournal of NeurochemistryQ6295643
P1476titleIncreased prion protein processing and expression of metabotropic glutamate receptor 1 in a mouse model of Alzheimer's disease.
P478volume127

Reverse relations

cites work (P2860)
Q35546911A genome wide association study links glutamate receptor pathway to sporadic Creutzfeldt-Jakob disease risk
Q51531026Ambient Glutamate Promotes Paroxysmal Hyperactivity in Cortical Pyramidal Neurons at Amyloid Plaques via Presynaptic mGluR1 Receptors.
Q89486165Amyloid Fibril-Induced Astrocytic Glutamate Transporter Disruption Contributes to Complement C1q-Mediated Microglial Pruning of Glutamatergic Synapses
Q34391341Cellular prion protein and NMDA receptor modulation: protecting against excitotoxicity
Q61818017Detection of Active Caspase-3 in Mouse Models of Stroke and Alzheimer's Disease with a Novel Dual Positron Emission Tomography/Fluorescent Tracer [Ga]Ga-TC3-OGDOTA
Q38808517Exosomal cellular prion protein drives fibrillization of amyloid beta and counteracts amyloid beta-mediated neurotoxicity.
Q57156403Fragile X and APP: a Decade in Review, a Vision for the Future
Q47099606Inhibition of group-I metabotropic glutamate receptors protects against prion toxicity.
Q30580280Metabotropic glutamate receptor 5 knockout reduces cognitive impairment and pathogenesis in a mouse model of Alzheimer's disease
Q38193084Neuron-specific regulation of class I PI3K catalytic subunits and their dysfunction in brain disorders
Q49957320Prion Proteins Without the Glycophosphatidylinositol Anchor: Potential Biomarkers in Neurodegenerative Diseases
Q54224345Prions, prionoids and protein misfolding disorders.
Q40562510Regulation of Amyloid β Oligomer Binding to Neurons and Neurotoxicity by the Prion Protein-mGluR5 Complex
Q38802640Synaptic signalling and its interface with neuropathologies: snapshots from the past, present and future
Q38171006Taking advantage of physiological proteolytic processing of the prion protein for a therapeutic perspective in prion and Alzheimer diseases.
Q38186552The GPI-anchoring of PrP: implications in sorting and pathogenesis.
Q48106243The Transient Receptor Potential Melastatin 2 (TRPM2) Channel Contributes to β-Amyloid Oligomer-Related Neurotoxicity and Memory Impairment.
Q38623320The pathogenesis of soluble PrP fragments containing Aβ binding sites
Q44331418The prion protein ligand, stress-inducible phosphoprotein 1, regulates amyloid-β oligomer toxicity.
Q35137829The sheddase ADAM10 is a potent modulator of prion disease.
Q64084664Unchanged type 1 metabotropic glutamate receptor availability in patients with Alzheimer's disease: A study using C-ITMM positron emission tomography

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