Huperzine A alleviates synaptic deficits and modulates amyloidogenic and nonamyloidogenic pathways in APPswe/PS1dE9 transgenic mice

scientific article published on 17 October 2011

Huperzine A alleviates synaptic deficits and modulates amyloidogenic and nonamyloidogenic pathways in APPswe/PS1dE9 transgenic mice is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/JNR.22775
P698PubMed publication ID22002568

P2093author name stringYing Wang
Hai Yan Zhang
Xi Can Tang
P2860cites workRelease of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptorsQ24294213
Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memoryQ24645499
Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's diseaseQ24670696
Multiple events lead to dendritic spine loss in triple transgenic Alzheimer's disease miceQ27312360
The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeuticsQ27860914
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptideQ28131750
Interleukin-1beta enhances nucleotide-induced and alpha-secretase-dependent amyloid precursor protein processing in rat primary cortical neurons via up-regulation of the P2Y(2) receptorQ28574838
Development and Regulation of Dendritic Spine SynapsesQ29029261
Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's diseaseQ29617986
Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivoQ29619108
Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaquesQ30486499
Spatial relationship between synapse loss and beta-amyloid deposition in Tg2576 miceQ33263907
Amyloid beta induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activationQ33740340
Correlated memory defects and hippocampal dendritic spine loss after acute stress involve corticotropin-releasing hormone signalingQ34059155
Human intravenous immunoglobulin provides protection against Aβ toxicity by multiple mechanisms in a mouse model of Alzheimer's diseaseQ34419295
Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenesQ34452028
Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's diseaseQ34460984
Huperzine A activates Wnt/β-catenin signaling and enhances the nonamyloidogenic pathway in an Alzheimer transgenic mouse modelQ34797526
Age-related loss of synaptophysin immunoreactive presynaptic boutons within the hippocampus of APP751SL, PS1M146L, and APP751SL/PS1M146L transgenic miceQ35084882
Emerging role for ERK as a key regulator of neuronal apoptosisQ35895210
Impaired spine stability underlies plaque-related spine loss in an Alzheimer's disease mouse modelQ36007461
Neprilysin and amyloid beta peptide degradationQ37130680
Structure-neurotoxicity relationships of amyloid beta-protein oligomersQ37329557
Synaptotagmins in neurodegenerationQ37640006
l-3-n-Butylphthalide regulates amyloid precursor protein processing by PKC and MAPK pathways in SK-N-SH cells over-expressing wild type human APP695Q39640944
ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neuronsQ39672952
Huperzine A regulates amyloid precursor protein processing via protein kinase C and mitogen-activated protein kinase pathways in neuroblastoma SK-N-SH cells over-expressing wild type human amyloid precursor protein 695.Q40065891
Involvement of M1-muscarinic acetylcholine receptors, protein kinase C and mitogen-activated protein kinase in the effect of huperzine A on secretory amyloid precursor protein-alphaQ40147094
Interleukin-1alpha stimulates non-amyloidogenic pathway by alpha-secretase (ADAM-10 and ADAM-17) cleavage of APP in human astrocytic cells involving p38 MAP kinase.Q40275439
P2Y2 nucleotide receptors enhance alpha-secretase-dependent amyloid precursor protein processing.Q40444970
Huperzine A enhances the level of secretory amyloid precursor protein and protein kinase C-alpha in intracerebroventricular beta-amyloid-(1-40) infused rats and human embryonic kidney 293 Swedish mutant cellsQ40567243
Human neprilysin is capable of degrading amyloid beta peptide not only in the monomeric form but also the pathological oligomeric formQ40634900
Synaptic vesicle traffic: rush hour in the nerve terminalQ40918904
Cleavage of amyloid beta peptide during constitutive processing of its precursorQ41852594
Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopyQ42087146
Proteolytic shedding of ST6Gal-I by BACE1 regulates the glycosylation and function of alpha4beta1 integrinsQ42748675
Effect of huprine X on β-amyloid, synaptophysin and α7 neuronal nicotinic acetylcholine receptors in the brain of 3xTg-AD and APPswe transgenic miceQ42944835
Increased expression of the amyloid precursor beta-secretase in Alzheimer's diseaseQ44060098
Muscarine enhances soluble amyloid precursor protein secretion in human neuroblastoma SH-SY5Y by a pathway dependent on protein kinase C(alpha), src-tyrosine kinase and extracellular signal-regulated kinase but not phospholipase C.Q44111144
Dendrite and dendritic spine alterations in Alzheimer modelsQ45099584
Amyloid-beta causes memory impairment by disturbing the JAK2/STAT3 axis in hippocampal neurons.Q46350343
Effects of huperzine A on secretion of nerve growth factor in cultured rat cortical astrocytes and neurite outgrowth in rat PC12 cellsQ46509880
Dendritic spine loss in the hippocampus of young PDAPP and Tg2576 mice and its prevention by the ApoE2 genotypeQ47711160
Abeta oligomer-mediated long-term potentiation impairment involves protein phosphatase 1-dependent mechanisms.Q48103179
The levels of soluble versus insoluble brain Abeta distinguish Alzheimer's disease from normal and pathologic agingQ48156883
Regulation of amyloid precursor protein cleavageQ48292877
Huperzine A in rat plasma and CSF following intranasal administrationQ48301461
Impaired spatial learning in the APPSwe + PSEN1DeltaE9 bigenic mouse model of Alzheimer's disease.Q48306292
Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer diseaseQ48400715
Synaptotagmin: a calcium sensor on the synaptic vesicle surfaceQ48480063
Differential expression of synaptic proteins in the frontal and temporal cortex of elderly subjects with mild cognitive impairmentQ48493675
Low-density lipoprotein receptor-related protein promotes amyloid precursor protein trafficking to lipid rafts in the endocytic pathway.Q50687332
Phenylbutyric acid reduces amyloid plaques and rescues cognitive behavior in AD transgenic mice.Q51021977
Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches.Q52560574
P433issue2
P304page(s)508-517
P577publication date2011-10-17
P1433published inJournal of Neuroscience ResearchQ6295654
P1476titleHuperzine A alleviates synaptic deficits and modulates amyloidogenic and nonamyloidogenic pathways in APPswe/PS1dE9 transgenic mice
P478volume90

Reverse relations

cites work (P2860)
Q485017443,4-dihydroxyphenylethanol attenuates spatio-cognitive deficits in an Alzheimer's disease mouse model: modulation of the molecular signals in neuronal survival-apoptotic programs
Q36308567A novel assay to determine acetylcholinesterase activity: The application potential for screening of drugs against Alzheimer's disease
Q38532717Brain Food for Alzheimer-Free Ageing: Focus on Herbal Medicines
Q27333843Diminished CRE-Induced Plasticity is Linked to Memory Deficits in Familial Alzheimer's Disease Mice
Q46330122Huperzine A alleviates neuroinflammation, oxidative stress and improves cognitive function after repetitive traumatic brain injury
Q92860670Huperzine A ameliorates obesity-related cognitive performance impairments involving neuronal insulin signaling pathway in mice
Q35646336Involvement of Intracellular and Mitochondrial Aβ in the Ameliorative Effects of Huperzine A against Oligomeric Aβ42-Induced Injury in Primary Rat Neurons
Q64096408Mutations of beta-amyloid precursor protein alter the consequence of Alzheimer's disease pathogenesis
Q37098664Natural products as promising drug candidates for the treatment of Alzheimer's disease: molecular mechanism aspect
Q38162960Nature as a source of metabolites with cholinesterase-inhibitory activity: an approach to Alzheimer's disease treatment.
Q96306586Neurodegenerative pathways as targets for acquired epilepsy therapy development
Q38127470Novel disease-modifying therapeutics for the treatment of Alzheimer's disease.
Q37508249Pharmacotherapy of traumatic brain injury: state of the science and the road forward: report of the Department of Defense Neurotrauma Pharmacology Workgroup
Q33963659RanBP9 overexpression accelerates loss of dendritic spines in a mouse model of Alzheimer's disease
Q89747430Rivastigmine modifies the α-secretase pathway and potentially early Alzheimer's disease
Q43245833The effects of huperzine A on gastrointestinal acetylcholinesterase activity and motility after single and multiple dosing in mice
Q36689057Traditional Chinese medicine: a promising candidate for the treatment of Alzheimer's disease

Search more.