Heterozygous CX3CR1 Deficiency in Microglia Restores Neuronal β-Amyloid Clearance Pathways and Slows Progression of Alzheimer's Like-Disease in PS1-APP Mice

scientific article published on 02 December 2019

Heterozygous CX3CR1 Deficiency in Microglia Restores Neuronal β-Amyloid Clearance Pathways and Slows Progression of Alzheimer's Like-Disease in PS1-APP Mice is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3389/FIMMU.2019.02780
P932PMC publication ID6900980
P698PubMed publication ID31849963

P2093author name stringJoseph El Khoury
Suzanne E Hickman
Elizabeth K Allison
Nathan D Kingery-Gallagher
Uwanda Coleman
P2860cites workDecreased atherosclerotic lesion formation in CX3CR1/apolipoprotein E double knockout mice.Q52549466
Roles of Microglial and Monocyte Chemokines and Their Receptors in Regulating Alzheimer's Disease-Associated Amyloid-β and Tau PathologiesQ58780923
The CX3C chemokine fractalkine in allergic asthma and rhinitisQ61895245
Microglia in neurodegenerationQ91786444
The neuroimmune system in Alzheimer's disease: the glass is half fullQ28270052
Mechanisms of mononuclear phagocyte recruitment in Alzheimer's diseaseQ28275105
A new class of membrane-bound chemokine with a CX3C motifQ28303204
Expression of fractalkine (CX3CL1) and its receptor, CX3CR1, during acute and chronic inflammation in the rodent CNSQ28570630
Amyloid precursor protein trafficking, processing, and functionQ29617429
Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertionQ29618089
Regulation of Tau Pathology by the Microglial Fractalkine ReceptorQ34179654
CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models.Q34254575
CX3CR1 in microglia regulates brain amyloid deposition through selective protofibrillar amyloid-β phagocytosisQ34796584
Decreased atherosclerosis in CX3CR1-/- mice reveals a role for fractalkine in atherogenesisQ34828549
Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivoQ35023290
CX3CR1 protein signaling modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer disease.Q35213298
CD36 mediates the innate host response to beta-amyloidQ36370903
Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease miceQ37003128
Abeta-degrading enzymes in Alzheimer's disease.Q37118130
The AbetaCs of Abeta-cleaving proteasesQ37250796
The microglial sensome revealed by direct RNA sequencingQ37341692
Fractalkine/CX3CR1: why a single chemokine-receptor duo bears a major and unique therapeutic potentialQ37670253
Role of the CX3CR1/p38 MAPK pathway in spinal microglia for the development of neuropathic pain following nerve injury-induced cleavage of fractalkineQ40325740
Matrix metalloproteinases MMP2 and MMP9 are upregulated by noradrenaline in the mouse neuroendocrine hypothalamusQ46684384
TGFβ directs gene expression of activated microglia to an anti‐inflammatory phenotype strongly focusing on chemokine genes and cell migratory genesQ47399868
Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like diseaseQ48247414
Impaired spatial learning in the APPSwe + PSEN1DeltaE9 bigenic mouse model of Alzheimer's disease.Q48306292
Exploratory activity, anxiety, and motor coordination in bigenic APPswe + PS1/DeltaE9 miceQ48521428
Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteinsQ48601563
Co-expression of multiple transgenes in mouse CNS: a comparison of strategiesQ48889458
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P921main subjectheterozygosityQ124059385
microgliaQ1622829
P304page(s)2780
P577publication date2019-12-02
P1433published inFrontiers in ImmunologyQ27723748
P1476titleHeterozygous CX3CR1 Deficiency in Microglia Restores Neuronal β-Amyloid Clearance Pathways and Slows Progression of Alzheimer's Like-Disease in PS1-APP Mice
P478volume10

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cites work (P2860)
Q96644586A new genetic strategy for targeting microglia in development and disease
Q99238383Distinct Residential and Infiltrated Macrophage Populations and Their Phagocytic Function in Mild and Severe Neonatal Hypoxic-Ischemic Brain Damage
Q97547766Microglial CX3CR1 production increases in Alzheimer's disease and is regulated by noradrenaline
Q97066909Reduced Fractalkine Levels Lead to Striatal Synaptic Plasticity Deficits in Huntington's Disease