Emerging cell and cytokine targets in rheumatoid arthritis

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Emerging cell and cytokine targets in rheumatoid arthritis is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1050122441
P356DOI10.1038/NRRHEUM.2013.168
P698PubMed publication ID24217582

P50authorGerd-Rüdiger BurmesterQ47261275
P2093author name stringThomas Dörner
Eugen Feist
P2860cites workTACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune diseaseQ22254041
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BLyS and APRIL form biologically active heterotrimers that are expressed in patients with systemic immune-based rheumatic diseasesQ28205999
Anti-IL-20 monoclonal antibody inhibits the differentiation of osteoclasts and protects against osteoporotic bone lossQ28245637
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The expression of IL-20 and IL-24 and their shared receptors are increased in rheumatoid arthritis and spondyloarthropathyQ28260108
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Induced T regulatory cells suppress osteoclastogenesis and bone erosion in collagen-induced arthritis better than natural T regulatory cells.Q33684899
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Th17 plasticity in human autoimmune arthritis is driven by the inflammatory environmentQ34093086
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Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren's syndromeQ34108411
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JAKs and STATs in immunity, immunodeficiency, and cancerQ34321767
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CD25+ cell depletion hastens the onset of severe disease in collagen-induced arthritis.Q34533631
Early rheumatoid arthritis is associated with a deficit in the CD4+CD25high regulatory T cell population in peripheral bloodQ34566056
IPEX, FOXP3 and regulatory T-cells: a model for autoimmunity.Q34583514
Epratuzumab targeting of CD22 affects adhesion molecule expression and migration of B-cells in systemic lupus erythematosus.Q34613920
Mechanisms of impaired regulation by CD4(+)CD25(+)FOXP3(+) regulatory T cells in human autoimmune diseasesQ34615216
Immunity to citrullinated proteins in rheumatoid arthritisQ34732863
Th17 and natural Treg cell population dynamics in systemic lupus erythematosusQ34978528
The role of B cells in rheumatoid arthritis: mechanisms and therapeutic targetsQ35111838
Expression of cell surface markers after human B lymphocyte activationQ35386633
Ofatumumab, a fully human anti-CD20 monoclonal antibody, in biological-naive, rheumatoid arthritis patients with an inadequate response to methotrexate: a randomised, double-blind, placebo-controlled clinical trialQ35540009
Safety and efficacy of ocrelizumab in combination with methotrexate in MTX-naive subjects with rheumatoid arthritis: the phase III FILM trialQ36094059
CD22: a multifunctional receptor that regulates B lymphocyte survival and signal transductionQ36287462
Increased apoptotic chondrocytes in articular cartilage from adult heterozygous SirT1 mice.Q36390894
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Monoclonal IgG antibodies generated from joint-derived B cells of RA patients have a strong bias toward citrullinated autoantigen recognitionQ36694143
Mechanisms of killing by anti-CD20 monoclonal antibodies.Q36927853
CD4+CD25high T cell numbers are enriched in the peripheral blood of patients with rheumatoid arthritis.Q36978507
The central role of T cells in rheumatoid arthritisQ36988984
Interleukin-2 and regulatory T cells in graft-versus-host diseaseQ37055805
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Therapeutic potential of Tregs to treat rheumatoid arthritisQ37924394
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MicroRNAs in rheumatoid arthritis: potential role in diagnosis and therapyQ38001790
Autoimmune arthritis: the interface between the immune system and jointsQ38011356
B-cell depletion in the treatment of lupus nephritisQ38026784
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Anti-A2/RA33 autoantibodies are directed to the RNA binding region of the A2 protein of the heterogeneous nuclear ribonucleoprotein complex. Differential epitope recognition in rheumatoid arthritis, systemic lupus erythematosus, and mixed connectiveQ38344731
Fibroblast-like synoviocytes of mesenchymal origin express functional B cell-activating factor of the TNF family in response to proinflammatory cytokines.Q40474288
Specific autoantibodies precede the symptoms of rheumatoid arthritis: a study of serial measurements in blood donorsQ40532147
Secretion of gelatinases and activation of gelatinase A (MMP-2) by human rheumatoid synovial fibroblastsQ40765877
A multitude of kinases--which are the best targets in treating rheumatoid arthritis?Q40840109
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Foxp3+ Helios+ regulatory T cells are expanded in active systemic lupus erythematosusQ42518281
Rituximab versus cyclophosphamide in ANCA-associated renal vasculitisQ42963758
Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapyQ42971266
Regulatory T-cell responses to low-dose interleukin-2 in HCV-induced vasculitisQ43048001
CD19+CD24hiCD38hi B cells maintain regulatory T cells while limiting TH1 and TH17 differentiationQ43406136
Chemokine receptor CCR1 antagonist CCX354-C treatment for rheumatoid arthritis: CARAT-2, a randomised, placebo controlled clinical trialQ43696394
CD22 ligation inhibits downstream B cell receptor signaling and Ca(2+) flux upon activationQ44173489
Characterization of a human B lymphocyte-specific antigen.Q44191670
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Potent in vitro and in vivo activity of an Fc-engineered anti-CD19 monoclonal antibody against lymphoma and leukemiaQ46280969
The pathogenesis of rheumatoid arthritis: new insights from old clinical data?Q48029200
Interleukin-21 promotes osteoclastogenesis in humans with rheumatoid arthritis and in mice with collagen-induced arthritis.Q54292098
Function of interleukin-20 as a proinflammatory molecule in rheumatoid and experimental arthritis.Q54584374
CD4+ CD25+ T cells with the phenotypic and functional characteristics of regulatory T cells are enriched in the synovial fluid of patients with rheumatoid arthritisQ56902845
Increased Interleukin 21 (IL-21) and IL-23 Are Associated with Increased Disease Activity and with Radiographic Status in Patients with Early Rheumatoid ArthritisQ56974064
Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren’s syndromeQ57212191
Antibody specificity controls in vivo effector mechanisms of anti-CD20 reagentsQ57271792
Isolation and functional characterization of regulatory CD25brightCD4+ T cells from the target organ of patients with rheumatoid arthritisQ57350588
Pulmonary Alveolar ProteinosisQ57749775
Anti–Interleukin-17 Monoclonal Antibody Ixekizumab in Chronic Plaque PsoriasisQ58466080
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectrheumatoid arthritisQ187255
P304page(s)77-88
P577publication date2013-11-12
P1433published inNature Reviews RheumatologyQ2107227
P1476titleEmerging cell and cytokine targets in rheumatoid arthritis
P478volume10

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