Genetic causes of Parkinson's disease and their links to autophagy regulation

scientific article published on January 2014

Genetic causes of Parkinson's disease and their links to autophagy regulation is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/S1353-8020(13)70037-3
P8608Fatcat IDrelease_xagrpaxsxfftvjhdvigeeuqcte
P698PubMed publication ID24262170

P2093author name stringZhenyu Yue
Ping-Yue Pan
P2860cites workGaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathiesQ24307627
Parkin is recruited selectively to impaired mitochondria and promotes their autophagyQ24317471
Interplay of LRRK2 with chaperone-mediated autophagyQ24322747
Hereditary early-onset Parkinson's disease caused by mutations in PINK1Q24337084
Broad activation of the ubiquitin–proteasome system by Parkin is critical for mitophagyQ24339224
Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cellsQ24651391
LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular modelQ24656256
Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPaseQ28116395
Inhibition of LRRK2 kinase activity stimulates macroautophagyQ28118311
Identification of a candidate therapeutic autophagy-inducing peptideQ28593490
Drosophila pink1 is required for mitochondrial function and interacts genetically with parkinQ29547423
Autophagy: from phenomenology to molecular understanding in less than a decadeQ29614174
Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagyQ29614178
Autophagy gone awry in neurodegenerative diseasesQ29614849
Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseasesQ33613123
α-Synuclein impairs macroautophagy: implications for Parkinson's disease.Q35005567
α-Synuclein fate is determined by USP9X-regulated monoubiquitinationQ35558701
Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathwayQ35811884
Loss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration.Q36066469
Latrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brainQ36469322
Distinct RolesIn Vivofor the Ubiquitin–Proteasome System and the Autophagy–Lysosomal Pathway in the Degradation of α-SynucleinQ36653589
TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicityQ36835587
Lewy Body-like α-Synuclein Aggregates Resist Degradation and Impair MacroautophagyQ36873680
Metabolic activity determines efficacy of macroautophagic clearance of pathological oligomeric alpha-synucleinQ37278480
The Role of Autophagy in Parkinson's DiseaseQ37999796
Lysosome-dependent pathways as a unifying theme in Parkinson's disease.Q38038561
Advances in the genetics of Parkinson diseaseQ38121773
LRRK2 as a modulator of lysosomal calcium homeostasis with downstream effects on autophagyQ52735671
Dangerous duet: LRRK2 and α-synuclein jam at CMAQ54441670
P921main subjectParkinson's diseaseQ11085
autophagyQ288322
P304page(s)S154-7
P577publication date2014-01-01
P1433published inParkinsonism and Related DisordersQ15762600
P1476titleGenetic causes of Parkinson's disease and their links to autophagy regulation
P478volume20 Suppl 1

Reverse relations

cites work (P2860)
Q38212199Aberrant autophagy and parkinsonism: does correction rescue from disease progression?
Q47620111Age-Dependent Dopaminergic Neurodegeneration and Impairment of the Autophagy-Lysosomal Pathway in LRRK-Deficient Mice
Q28084605Autophagy in neurodegenerative diseases: from mechanism to therapeutic approach
Q35865171Can the disease course in Parkinson's disease be slowed?
Q27016100Chaperone-mediated autophagy: roles in neurodegeneration
Q38605280Dissecting the role of Engrailed in adult dopaminergic neurons--Insights into Parkinson disease pathogenesis
Q52689754Dysregulation of the autophagic-lysosomal pathway in Gaucher and Parkinson's disease
Q36284241Elevated GM3 plasma concentration in idiopathic Parkinson's disease: A lipidomic analysis
Q34585744Eryptosis as a marker of Parkinson's disease
Q38237560Genetic convergence of Parkinson's disease and lysosomal storage disorders
Q90012246Glucocerebrosidase Mutations and Synucleinopathies. Potential Role of Sterylglucosides and Relevance of Studying Both GBA1 and GBA2 Genes
Q58693990Glucocerebrosidase deficiency promotes protein aggregation through dysregulation of extracellular vesicles
Q46264470High Performance Liquid Chromatography-Mass Spectrometry (LC-MS) Based Quantitative Lipidomics Study of Ganglioside-NANA-3 Plasma to Establish Its Association with Parkinson's Disease Patients.
Q39404657Necroptosis in neurodegenerative diseases: a potential therapeutic target
Q42610191Necrostatin-1 protection of dopaminergic neurons
Q26779424Neuronal response in Alzheimer's and Parkinson's disease: the effect of toxic proteins on intracellular pathways
Q30369463Spermidine protects against α-synuclein neurotoxicity.
Q55399332TLR9 activation via microglial glucocorticoid receptors contributes to degeneration of midbrain dopamine neurons.
Q34513714The genetic background of Parkinson's disease: current progress and future prospects
Q91607344Trehalose as a promising therapeutic candidate for the treatment of Parkinson's disease
Q26739716Ubc13: the Lys63 ubiquitin chain building machine
Q38271411p600/UBR4 in the central nervous system

Search more.