Current and investigational pharmacotherapeutic approaches for modulating retinal angiogenesis

scientific article published on 03 March 2014

Current and investigational pharmacotherapeutic approaches for modulating retinal angiogenesis is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1586/17512433.2014.890047
P698PubMed publication ID24580084

P2093author name stringPaul Hahn
Glenn Yiu
Bozho Todorich
P2860cites workAngiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesisQ24313372
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1Q24316075
Treatment of leber congenital amaurosis due to RPE65 mutations by ocular subretinal injection of adeno-associated virus gene vector: short-term results of a phase I trialQ24608049
Efficacy of intravitreal bevacizumab for stage 3+ retinopathy of prematurityQ24609568
Ranibizumab and bevacizumab for neovascular age-related macular degenerationQ24616209
Ranibizumab and bevacizumab for treatment of neovascular age-related macular degeneration: two-year resultsQ24633874
Safety and efficacy of gene transfer for Leber's congenital amaurosisQ24634724
Human RPE65 gene therapy for Leber congenital amaurosis: persistence of early visual improvements and safety at 1 yearQ24634801
The time course changes of choroidal neovascularization in angioid streaks.Q50488474
EVEREST study: efficacy and safety of verteporfin photodynamic therapy in combination with ranibizumab or alone versus ranibizumab monotherapy in patients with symptomatic macular polypoidal choroidal vasculopathy.Q50500639
Intravitreal bevacizumab for exudative age-related macular degeneration after multiple treatments.Q50706391
Intravitreal aflibercept (VEGF trap-eye) in wet age-related macular degeneration.Q52886344
Complement factor H variant Y402H is a major risk determinant for geographic atrophy and choroidal neovascularization in smokers and nonsmokers.Q53555067
Astrocytes modulate retinal vasculogenesis: effects on endothelial cell differentiation.Q55480472
Photodynamic Therapy of Subfoveal Choroidal Neovascularization in Age-related Macular Degeneration With VerteporfinQ56812915
Astrocytes induce blood–brain barrier properties in endothelial cellsQ57318253
Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitorsQ24676378
Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cellsQ24679724
Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured Fab in complex with antigenQ27620162
VEGF-D promotes the metastatic spread of tumor cells via the lymphaticsQ28200072
Engineered antibodiesQ28201899
Laser photocoagulation for choroidal neovascular membrane associated with optic disc drusenQ28252627
High-affinity binders selected from designed ankyrin repeat protein librariesQ28257550
Primary intravitreal bevacizumab for subfoveal choroidal neovascularization in age-related macular degeneration: results of the Pan-American Collaborative Retina Study Group at 12 months follow-upQ28295656
Preretinal neovascularisation associated with choroidal melanomaQ28362436
Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryoQ28586040
Mechanisms of angiogenesisQ29547485
Abnormal blood vessel development and lethality in embryos lacking a single VEGF alleleQ29547733
Mechanisms of angiogenesis and arteriogenesisQ29617257
Ranibizumab for neovascular age-related macular degenerationQ29617549
Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancerQ29622818
The mouse retina as an angiogenesis modelQ30495106
Presumed ocular histoplasmosis syndrome: update on epidemiology, pathogenesis, and photodynamic, antiangiogenic, and surgical therapiesQ30773488
Prevention of experimental choroidal neovascularization with intravitreal anti-vascular endothelial growth factor antibody fragment.Q30824036
Intravitreal injection of bevacizumab (avastin) for treatment of stage 3 retinopathy of prematurity in zone I or posterior zone II.Q30844301
Human retinal molecular weight exclusion limit and estimate of species variationQ30919500
Designing repeat proteins: well-expressed, soluble and stable proteins from combinatorial libraries of consensus ankyrin repeat proteins.Q30979207
Photodynamic therapy of subfoveal choroidal neovascularization in pathologic myopia with verteporfin. 1-year results of a randomized clinical trial--VIP report no. 1.Q30988238
Maximum tolerated dose of a humanized anti-vascular endothelial growth factor antibody fragment for treating neovascular age-related macular degeneration.Q31172091
Use of intravitreal bevacizumab as a preoperative adjunct for tractional retinal detachment repair in severe proliferative diabetic retinopathyQ33249402
Angiogenic and antiangiogenic factors in proliferative diabetic retinopathy.Q33316526
Off-label use of intravitreal bevacizumab (Avastin) for salvage treatment in progressive threshold retinopathy of prematurity.Q33322288
Acute contraction of the proliferative membrane after an intravitreal injection of bevacizumab for advanced retinopathy of prematurityQ33322542
Endogenous VEGF is required for visual function: evidence for a survival role on müller cells and photoreceptorsQ33382103
The role of PGE2 receptor EP4 in pathologic ocular angiogenesisQ33459697
Clinical factors related to recurrence of anterior segment neovascularization after treatment including intravitreal bevacizumabQ33551829
Effects of intravitreal bevacizumab and laser in retinopathy of prematurity therapy on the development of peripheral retinal vesselsQ33555925
Reduced Choroidal Neovascular Membrane Formation in Cyclooxygenase-2 Null MiceQ33706172
Inhibition of choroidal neovascularization in a nonhuman primate model by intravitreal administration of an AAV2 vector expressing a novel anti-VEGF moleculeQ33729384
Digoxin inhibits retinal ischemia-induced HIF-1alpha expression and ocular neovascularizationQ33868764
Retinal and choroidal neovascularizationQ33980639
Polarized vascular endothelial growth factor secretion by human retinal pigment epithelium and localization of vascular endothelial growth factor receptors on the inner choriocapillaris. Evidence for a trophic paracrine relationQ40937602
Regulation of vascular endothelial growth factor expression by insulin-like growth factor I.Q41089071
Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. Flt-1, but not Flk-1/KDR, is up-regulated by hypoxia.Q41091104
Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumabQ42139247
Age-related macular degeneration histopathologic studies. The 1992 Lorenz E. Zimmerman LectureQ42483851
Vitrectomy after intravitreal bevacizumab (Avastin) for retinal detachment in retinopathy of prematurityQ43132463
Radiation retinopathy--clinical, histopathological, ultrastructural and experimental correlationsQ43634046
Treatment of idiopathic subfoveal choroidal neovascular lesions using photodynamic therapy with verteporfinQ44049073
Macrophages related to Bruch's membrane in age-related macular degenerationQ44289922
Chapter 6. Ocular models of angiogenesisQ44390529
Novel anti-VEGF chimeric molecules delivered by AAV vectors for inhibition of retinal neovascularization.Q44953303
Signaling vascular morphogenesis and maintenanceQ45058276
Treatment of diabetic macular edema with a designed ankyrin repeat protein that binds vascular endothelial growth factor: a phase I/II studyQ45148015
Pegaptanib for neovascular age-related macular degenerationQ45206481
Intravitreal triamcinolone acetonide compared with bevacizumab for the treatment of patients with macular edema secondary to central retinal vein occlusionQ45341379
Regression of retinal and iris neovascularization after intravitreal bevacizumab (Avastin) treatment.Q45959509
A variable-dosing regimen with intravitreal ranibizumab for neovascular age-related macular degeneration: year 2 of the PrONTO StudyQ46045838
Intraoperative bleeding during vitrectomy for diabetic tractional retinal detachment with versus without preoperative intravitreal bevacizumab (IBeTra study).Q46125936
Is there tachyphylaxis to intravitreal anti-vascular endothelial growth factor pharmacotherapy in age-related macular degeneration?Q46310363
Expression of cyclooxygenase-2 in choroidal neovascular membranes from age-related macular degeneration patientsQ46338018
An optical coherence tomography-guided, variable dosing regimen with intravitreal ranibizumab (Lucentis) for neovascular age-related macular degenerationQ46469410
Epimacular brachytherapy for neovascular age-related macular degeneration (CABERNET): fluorescein angiography and optical coherence tomographyQ46481610
Intravitreal bevacizumab (Avastin) in the treatment of proliferative diabetic retinopathyQ46493637
Systemic bevacizumab (Avastin) therapy for neovascular age-related macular degeneration twelve-week results of an uncontrolled open-label clinical studyQ46528410
Intravitreal bevacizumab to treat iris neovascularization and neovascular glaucoma secondary to ischemic retinal diseases in 41 consecutive cases.Q46623669
Ranibizumab combined with verteporfin photodynamic therapy in neovascular age-related macular degeneration (FOCUS): year 2 resultsQ46717705
Tractional retinal detachment following intravitreal bevacizumab (Avastin) in patients with severe proliferative diabetic retinopathyQ46927800
Vascular endothelial growth factor in aqueous humor before and after intravitreal injection of bevacizumab in eyes with diabetic retinopathyQ46960492
Intravitreal bevacizumab (Avastin) treatment of macular edema in central retinal vein occlusion: a short-term studyQ46969343
Ranibizumab versus Bevacizumab for Neovascular Age-related Macular Degeneration: Results from the GEFAL Noninferiority Randomized TrialQ47857376
Ranibizumab for choroidal neovascularization associated with adult-onset foveomacular vitelliform dystrophy: one-year results.Q50484068
Bevacizumab-induced tumor vessel remodeling in rhabdomyosarcoma xenografts increases the effectiveness of adjuvant ionizing radiationQ33995820
Vasculogenesis and angiogenesis as mechanisms of vascular network formation, growth and remodelingQ34178814
Choroidal neovascularization in pathological myopiaQ34262513
Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disordersQ34292807
Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathyQ34324536
VEGFR-1 and VEGFR-2: two non-identical twins with a unique physiognomyQ34333828
Inhibition of vascular endothelial growth factor prevents retinal ischemia-associated iris neovascularization in a nonhuman primateQ34369354
Vascular endothelial growth factor is sufficient to produce iris neovascularization and neovascular glaucoma in a nonhuman primateQ34387729
Intravitreous injections of vascular endothelial growth factor produce retinal ischemia and microangiopathy in an adult primateQ34409210
Highly potent VEGF-A-antagonistic DARPins as anti-angiogenic agents for topical and intravitreal applicationsQ34415658
Intravitreal bevacizumab (Avastin) treatment of proliferative diabetic retinopathy complicated by vitreous hemorrhageQ34498424
Rapid improvement of rubeosis iridis from a single bevacizumab (Avastin) injectionQ34498429
Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular diseaseQ34499843
Clinical and differential utility of VEGF inhibitors in wet age-related macular degeneration: focus on afliberceptQ34642583
Preclinical pharmacokinetics of Ranibizumab (rhuFabV2) after a single intravitreal administrationQ34650239
Ranibizumab versus verteporfin for neovascular age-related macular degeneration.Q34652928
Vascular endothelial growth factor/vascular permeability factor expression in a mouse model of retinal neovascularizationQ34749337
Treatment of subfoveal choroidal neovascularization associated with multifocal choroiditis and panuveitis with photodynamic therapyQ35004137
Animal models of oxygen-induced retinopathyQ35109399
A new model of experimental choroidal neovascularization in the rat.Q35125744
A model of subretinal neovascularization in the pigmented rat.Q35135509
Cellular mechanisms in retinal vascular developmentQ35174073
Lasting controversy on ranibizumab and bevacizumabQ35641933
An outbreak of streptococcus endophthalmitis after intravitreal injection of bevacizumabQ35697390
Risks of intravitreous injection: a comprehensive reviewQ35922099
Retinal angiogenesis in development and diseaseQ36342347
Glaucoma following retinal detachment operationsQ36456275
Current status of angiogenesis inhibitors combined with radiation therapyQ36483330
Nonsteroidal anti-inflammatory drugs for retinal diseaseQ36567310
Subretinal neovascularization. Natural history of an experimental modelQ36590902
Antivascular endothelial growth factor agents and their development: therapeutic implications in ocular diseases.Q36608661
Intravitreal injection of bevacizumab (Avastin) as adjunctive treatment of proliferative diabetic retinopathyQ36608675
Combined vascular endothelial growth factor-targeted therapy and radiotherapy for rectal cancer: theory and clinical practiceQ36673500
Anti-VEGF aptamer (pegaptanib) therapy for ocular vascular diseasesQ36673663
Review of the pericyte during angiogenesis and its role in cancer and diabetic retinopathyQ36680668
VEGF-targeted cancer therapy strategies: current progress, hurdles and future prospectsQ36803200
Nuclease-resistant nucleic acid ligands to vascular permeability factor/vascular endothelial growth factorQ36893265
Pazopanib, a potent orally administered small-molecule multitargeted tyrosine kinase inhibitor for renal cell carcinomaQ37071204
Quantitative subanalysis of optical coherence tomography after treatment with ranibizumab for neovascular age-related macular degeneration.Q37169291
Levels of vascular endothelial growth factor are elevated in the vitreous of patients with subretinal neovascularisationQ37319826
A systematic analysis of the off-label use of bevacizumab for severe retinopathy of prematurityQ37574523
Oligodeoxynucleotides inhibit retinal neovascularization in a murine model of proliferative retinopathyQ37607034
Therapeutic antibodies in ophthalmology: old is new againQ37848065
Avastin doesn't blind people, people blind peopleQ37977621
Ranibizumab versus bevacizumab to treat neovascular age-related macular degeneration: one-year findings from the IVAN randomized trialQ38009430
Epimacular brachytherapy for neovascular age-related macular degeneration: a randomized, controlled trial (CABERNET).Q38061782
Aflibercept therapy for exudative age-related macular degeneration resistant to bevacizumab and ranibizumab.Q38109282
Topical nonsteroidal anti-inflammatory drugs for macular edema.Q38162433
2'-Fluoropyrimidine RNA-based aptamers to the 165-amino acid form of vascular endothelial growth factor (VEGF165). Inhibition of receptor binding and VEGF-induced vascular permeability through interactions requiring the exon 7-encoded domainQ38335060
Initial exploration of oral pazopanib in healthy participants and patients with age-related macular degeneration.Q38443158
Honokiol inhibits pathological retinal neovascularization in oxygen-induced retinopathy mouse modelQ39114467
A Phase IIIb study to evaluate the safety of ranibizumab in subjects with neovascular age-related macular degenerationQ39959029
Ocular neovascularization with retinal vascular occlusion. II. Occurrence in central and branch retinal artery occlusionQ40104796
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectangiogenesisQ539568
P304page(s)375-391
P577publication date2014-03-03
P1433published inExpert Review of Clinical PharmacologyQ15793519
P1476titleCurrent and investigational pharmacotherapeutic approaches for modulating retinal angiogenesis
P478volume7