Oligodeoxynucleotides inhibit retinal neovascularization in a murine model of proliferative retinopathy

scientific article published on May 1996

Oligodeoxynucleotides inhibit retinal neovascularization in a murine model of proliferative retinopathy is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode1996PNAS...93.4851R
P356DOI10.1073/PNAS.93.10.4851
P932PMC publication ID39368
P698PubMed publication ID8643492
P5875ResearchGate publication ID14556056

P50authorEric A PierceQ37385160
P2093author name stringL E Smith
R Webb
E Foley
S L Rook
G S Robinson
P2860cites workCleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Q25938983
Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivoQ29614729
Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesisQ29617644
Angiogenic factorsQ29620582
Oligodeoxynucleoside phosphoramidates and phosphorothioates as inhibitors of human immunodeficiency virusQ33650315
Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disordersQ34292807
Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathyQ34324536
Vascular endothelial growth factor/vascular permeability factor expression in a mouse model of retinal neovascularizationQ34749337
Antisense inhibition of oncogene expressionQ35226144
Antisense oligonucleotides as antiviral agentsQ35301174
Regulators of AngiogenesisQ36653534
Modulation of eukaryotic gene expression by complementary RNA or DNA sequencesQ38212410
Vasculotropin-VEGF stimulates retinal capillary endothelial cells through an autocrine pathway.Q38305663
Antisense oligodeoxynucleotides to GS protein alpha-subunit sequence accelerate differentiation of fibroblasts to adipocytesQ38327366
Recent advances in diabetic retinopathyQ40302190
Endothelial receptor tyrosine kinases involved in angiogenesis.Q40400431
Antisense oligonucleotides as therapeutic agents--is the bullet really magical?Q40834751
Effect of oxygen on developing retinal vessels with particular reference to the problem of retrolental fibroplasiaQ40935597
Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutantQ41488146
Vascular endothelial growth factor. Regulation by cell differentiation and activated second messenger pathwaysQ41608154
Pathogenesis of ascites tumor growth: angiogenesis, vascular remodeling, and stroma formation in the peritoneal lining.Q41664061
Antisense oligonucleotides inhibit intercellular adhesion molecule 1 expression by two distinct mechanismsQ41664990
Development of retinal vasculature is mediated by hypoxia-induced vascular endothelial growth factor (VEGF) expression by neurogliaQ41677354
Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo.Q44393459
Implication of RNA structure on antisense oligonucleotide hybridization kineticsQ45059437
Gene inhibition using antisense oligodeoxynucleotidesQ46429559
Pathogenesis of ascites tumor growth: vascular permeability factor, vascular hyperpermeability, and ascites fluid accumulation.Q50764794
Concerning antisense inhibition of the multiple drug resistance gene.Q54335272
A highly conserved vascular permeability factor secreted by a variety of human and rodent tumor cell linesQ69614850
Synthesis and secretion of vascular permeability factor/vascular endothelial growth factor by human retinal pigment epithelial cellsQ70764129
Oxygen tension regulates the expression of angiogenesis factor by macrophagesQ71015308
Oxygen-induced retinopathy in the mouseQ71608431
In vivo stability, disposition and metabolism of a “hybrid” oligonucleotide phosphorothioate in ratsQ71987560
A rapid method for quantitation of oligodeoxynucleotide phosphorothioates in biological fluids and tissuesQ72747306
Childhood diabetes. Its course, and influence on the second and third generationsQ79106106
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectneovascularizationQ1281049
murine modelQ122890741
P1104number of pages6
P304page(s)4851-4856
P577publication date1996-05-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleOligodeoxynucleotides inhibit retinal neovascularization in a murine model of proliferative retinopathy
P478volume93

Reverse relations

cites work (P2860)
Q370113895-Lipoxygenase metabolite 4-HDHA is a mediator of the antiangiogenic effect of ω-3 polyunsaturated fatty acids
Q38022991A brief history of anti-VEGF for the treatment of ocular angiogenesis
Q33820526A clinical prediction model to stratify retinopathy of prematurity risk using postnatal weight gain
Q34208338A novel antiangiogenic peptide derived from hepatocyte growth factor inhibits neovascularization in vitro and in vivo
Q40662746A peptide encoded by exon 6 of VEGF (EG3306) inhibits VEGF-induced angiogenesis in vitro and ischaemic retinal neovascularisation in vivo.
Q37696351A review of clinical trials of anti-VEGF agents for diabetic retinopathy
Q46432751A single local injection of recombinant VEGF receptor 2 but not of Tie2 inhibits retinal neovascularization in the mouse
Q36618068Activated NAD(P)H oxidase from supplemental oxygen induces neovascularization independent of VEGF in retinopathy of prematurity model
Q38110394Algorithms for the prediction of retinopathy of prematurity based on postnatal weight gain
Q42456498An eye for discovery
Q24311459Angiogenesis promoted by vascular endothelial growth factor: regulation through alpha1beta1 and alpha2beta1 integrins
Q36424620Angiogenesis--a new target for future therapy
Q44654332Angiopoietin/Tek Interactions Regulate MMP-9 Expression and Retinal Neovascularization
Q24623508Annexin II regulates fibrin homeostasis and neoangiogenesis in vivo
Q53362175Anti-VEGF therapy for the treatment of glaucoma: a focus on ranibizumab and bevacizumab.
Q30666418Anti-angiogenic therapy of proliferative diabetic retinopathy
Q40960335Antisense oligonucleotides to the epidermal growth factor receptor
Q36003675Association of gene polymorphism with serum levels of inflammatory and angiogenic factors in Pakistani patients with age-related macular degeneration
Q35753400Basic fibroblast growth factor is neither necessary nor sufficient for the development of retinal neovascularization
Q35745444Blockade of vascular endothelial cell growth factor receptor signaling is sufficient to completely prevent retinal neovascularization
Q48580864Bowman Lecture 1998. Diabetic retinopathy: some cellular, molecular and therapeutic considerations
Q39661641Calpain inhibitors reduce retinal hypoxia in ischemic retinopathy by improving neovascular architecture and functional perfusion
Q44664918Captopril and vascular endothelial growth factor in a mouse model of retinopathy
Q30903366Cell injury unmasks a latent proangiogenic phenotype in mice with increased expression of FGF2 in the retina
Q43662174Circulating plasma vascular endothelial growth factor and microvascular complications of type 1 diabetes mellitus: the influence of ACE inhibition
Q33901062Combination of vascular endothelial growth factor receptor/platelet-derived growth factor receptor inhibition markedly improves the antiangiogenic efficacy for advanced stage mouse corneal neovascularization
Q38192060Current and investigational pharmacotherapeutic approaches for modulating retinal angiogenesis
Q37346456Decursin inhibits retinal neovascularization via suppression of VEGFR-2 activation
Q30631779Dramatic inhibition of retinal and choroidal neovascularization by oral administration of a kinase inhibitor
Q30724159Dynamics of phosphorothioate oligonucleotides in normal and laser photocoagulated retina
Q33868753Effect of brimonidine on retinal and choroidal neovascularization in a mouse model of retinopathy of prematurity and laser-treated rats
Q33185693Effective transfection of a cis element "decoy" of the nuclear factor-kappaB binding site into the experimental choroidal neovascularization
Q46891277Effects of the phosphatidylinositol 3-kinase inhibitor in a mouse model of retinal neovascularization
Q35566245Ethnic Variation in the Incidence and Severity of Retinopathy of Prematurity: Possible Explanations, Including Racial Differences in Illness Severity
Q34558870Experimental models of growth factor-mediated angiogenesis and blood-retinal barrier breakdown
Q35745334Expression of thrombospondin-1 in ischemia-induced retinal neovascularization
Q36397210Expression of vascular endothelial growth factor and its role in oncogenesis of human gastric carcinoma
Q28583644Expression of vascular endothelial growth factor and pigment epithelial-derived factor in a rat model of retinopathy of prematurity
Q35765120Expression of vascular endothelial growth factor in the human retina and in nonproliferative diabetic retinopathy.
Q28344709Gene transfer by viral vectors into blood vessels in a rat model of retinopathy of prematurity
Q28362039Glucose, VEGF-A, and diabetic complications
Q35648554Growth factors and protein kinase C inhibitors as novel therapies for the medical management diabetic retinopathy
Q40033199HIF-1α siRNA reduces retinal neovascularization in a mouse model of retinopathy of prematurity
Q43275526Hypothesis on the pathogenesis of retinopathy of prematurity--it is not VEGF alone but anatomical structures that are crucial
Q42155672Increased angiogenic factors associated with peripheral avascular retina and intravitreous neovascularization: a model of retinopathy of prematurity
Q35747297Inducible expression of vascular endothelial growth factor in adult mice causes severe proliferative retinopathy and retinal detachment
Q48086096Inhibition of VEGF mRNA by 2'-O,4'-C-ethylene-bridged nucleic acids (ENA) antisense oligonucleotides and their influence on off-target gene expressions
Q35088365Inhibition of platelet-derived growth factor B signaling enhances the efficacy of anti-vascular endothelial growth factor therapy in multiple models of ocular neovascularization
Q42794620Inhibition of proliferative retinopathy by the anti-vascular agent combretastatin-A4.
Q44763476Inhibition of retinal neovascularisation by gene transfer of soluble VEGF receptor sFlt-1.
Q40753765Inhibitory effects of EGFR antisense oligodeox ynucleotide in human colorectal cancer cell line.
Q40692956Inhibitory mechanism of vascular endothelial growth factor (VEGF) by bucillamine
Q35813635Insulin like growth factor-1 and insulin-like growth factor binding proteins: their possible roles in both maintaining normal retinal vascular function and in promoting retinal pathology
Q43637135Intravitreal VEGF and bFGF produce florid retinal neovascularization and hemorrhage in the rabbit
Q45224240Intravitreal injection of specific receptor tyrosine kinase inhibitor PTK787/ZK222 584 improves ischemia-induced retinopathy in mice
Q42453872Intravitreal triamcinolone does not alter basal vascular endothelial growth factor mRNA expression in rat retina
Q40642055Intravitreous anti-raf-1 kinase antisense oligonucleotide as an angioinhibitory agent in porcine preretinal neovascularization
Q33219678Long-term evaluation of AAV-mediated sFlt-1 gene therapy for ocular neovascularization in mice and monkeys
Q35897076Low IGF-I suppresses VEGF-survival signaling in retinal endothelial cells: direct correlation with clinical retinopathy of prematurity.
Q37578873Mast cell chymase and tryptase as targets for cardiovascular and metabolic diseases
Q38069895Mechanisms and management of retinopathy of prematurity
Q42717540Moderate GSK-3β inhibition improves neovascular architecture, reduces vascular leakage, and reduces retinal hypoxia in a model of ischemic retinopathy
Q34238103Moderation of calpain activity promotes neovascular integration and lumen formation during VEGF-induced pathological angiogenesis
Q42803718Molecular framework for angiogenesis: a complex web of interactions between extravasated plasma proteins and endothelial cell proteins induced by angiogenic cytokines
Q28362790More weapons in the arsenal against ischemic retinopathy
Q37942156Nano-vectors for the Ocular Delivery of Nucleic Acid-based Therapeutics.
Q38913007Neurovascular cross talk in diabetic retinopathy: Pathophysiological roles and therapeutic implications
Q41829449Neutralizing antibody to VEGF reduces intravitreous neovascularization and may not interfere with ongoing intraretinal vascularization in a rat model of retinopathy of prematurity.
Q37777001New Approaches to Blockade of the Renin–Angiotensin–Aldosterone System: Chymase as an Important Target to Prevent Organ Damage
Q39755127Norrin promotes vascular regrowth after oxygen-induced retinal vessel loss and suppresses retinopathy in mice.
Q34805398Novel protective properties of IGFBP-3 result in enhanced pericyte ensheathment, reduced microglial activation, increased microglial apoptosis, and neuronal protection after ischemic retinal injury.
Q52172692Oligonucleotide-based inhibition of embryonic gene expression.
Q35140846Ophthalmic drug discovery
Q45151519Overexpression of VEGF-A induces neovascularization and increased vascular leakage in rabbit eye after intravitreal adenoviral gene transfer
Q34805909PEI-g-PEG-RGD/small interference RNA polyplex-mediated silencing of vascular endothelial growth factor receptor and its potential as an anti-angiogenic tumor therapeutic strategy
Q51568377POSTNATAL SERUM INSULIN-LIKE GROWTH FACTOR I AND RETINOPATHY OF PREMATURITY.
Q34546104Pathogenesis of retinopathy of prematurity
Q41853291Pharmacologic and genetic manipulation of MMP-2 and -9 affects retinal neovascularization in rodent models of OIR.
Q33194915Pharmacologic therapy for diabetic retinopathy
Q33997311Pharmacological treatment for retinopathy of prematurity
Q31065469Potential long-term inhibition of ocular neovascularisation by recombinant adeno-associated virus-mediated secretion gene therapy
Q34626222Potential new medical therapies for diabetic retinopathy: protein kinase C inhibitors
Q32063152Preclinical evaluation of a phosphorothioate oligonucleotide in the retina of rhesus monkey
Q34477473Prevention of ischemia-induced retinopathy by the natural ocular antiangiogenic agent pigment epithelium-derived factor
Q35787073Pro-inflammatory cytokines induce expression of matrix-metabolizing enzymes in human cervical smooth muscle cells
Q35156007RNA interference-based therapy for spinocerebellar ataxia type 7 retinal degeneration.
Q37256549Recent perspectives in ocular drug delivery
Q45858295Reduction of fibronectin expression by intravitreal administration of antisense oligonucleotides.
Q73226153Regulation of vascular endothelial growth factor-dependent retinal neovascularization by insulin-like growth factor-1 receptor
Q64937118Retinal Vasculature in Development and Diseases.
Q35566836Retinal and choroidal angiogenesis: pathophysiology and strategies for inhibition
Q41520625Retinal development: Communication helps you see the light
Q33606227Retinopathy of prematurity: current concepts in molecular pathogenesis
Q34475449Review of therapeutic advances in diabetic retinopathy
Q35300661Role of vascular permeability factor/vascular endothelial growth factor in eye disease
Q24531302Selective induction of neuropilin-1 by vascular endothelial growth factor (VEGF): a mechanism contributing to VEGF-induced angiogenesis
Q55472739Structure and inhibitory effects on angiogenesis and tumor development of a new vascular endothelial growth inhibitor.
Q33787955Studies on the pathogenesis of avascular retina and neovascularization into the vitreous in peripheral severe retinopathy of prematurity (an american ophthalmological society thesis)
Q38373964Study protocol: safety and efficacy of propranolol 0.2% eye drops in newborns with a precocious stage of retinopathy of prematurity (DROP-ROP-0.2%): a multicenter, open-label, single arm, phase II trial.
Q33379554Suppression of retinal neovascularization by erythropoietin siRNA in a mouse model of proliferative retinopathy
Q46318087Suppression of retinal neovascularization by shRNA targeting HIF-1alpha
Q46081402Suppression of retinal neovascularization by the iNOS inhibitor aminoguanidine in mice of oxygen-induced retinopathy
Q37835286Targets of chymase inhibitors
Q35643535Temporal and spatial changes in VEGF, αA- and αB-crystallin expression in a mouse model of oxygen-induced retinopathy
Q28504605The 67-kd laminin receptor is preferentially expressed by proliferating retinal vessels in a murine model of ischemic retinopathy
Q38110390The biology of retinopathy of prematurity: how knowledge of pathogenesis guides treatment
Q37565247The effects of oxygen stresses on the development of features of severe retinopathy of prematurity: knowledge from the 50/10 OIR model
Q30495106The mouse retina as an angiogenesis model
Q34658478The pathogenesis of diabetic retinopathy: old concepts and new questions
Q38101684The pathophysiology of retinopathy of prematurity: an update of previous and recent knowledge
Q31123344The potential role of PKC beta in diabetic retinopathy and macular edema
Q31061150The role of angiogenesis in the development of proliferative diabetic retinopathy: impact of intravitreal anti-VEGF treatment
Q27021701Therapeutic interventions against inflammatory and angiogenic mediators in proliferative diabetic retinopathy
Q35028866Tranilast inhibits protein kinase C-dependent signalling pathway linked to angiogenic activities and gene expression of retinal microcapillary endothelial cells
Q38335452Transcription factors Sp1 and Sp3 alter vascular endothelial growth factor receptor expression through a novel recognition sequence
Q35763708Transgenic mice with increased expression of vascular endothelial growth factor in the retina: a new model of intraretinal and subretinal neovascularization
Q45264621Upregulation of placental growth factor by vascular endothelial growth factor via a post-transcriptional mechanism.
Q34451927VEGF antagonists
Q35950867Vascular Endothelial Growth Factor and Diabetic Retinal Disease
Q34280300Vascular endothelial growth factor and diabetic retinopathy: pathophysiological mechanisms and treatment perspectives.
Q35763668Vascular endothelial growth factor and ocular neovascularization.
Q48605197Vascular endothelial growth factor and severity of nonproliferative diabetic retinopathy mediate retinal hemodynamics in vivo: a potential role for vascular endothelial growth factor in the progression of nonproliferative diabetic retinopathy
Q36502592Vascular endothelial growth factor antisense oligodeoxynucleotides with lipiodol in arterial embolization of liver cancer in rats.
Q38153731Vascular endothelial growth factor gene polymorphisms and vitreous proteome changes in diabetic retinopathy
Q46219956[Pathogenesis of retinopathy of prematurity].

Search more.