Dynamics between actin and the VE-cadherin/catenin complex: novel aspects of the ARP2/3 complex in regulation of endothelial junctions

scientific article published on March 2014

Dynamics between actin and the VE-cadherin/catenin complex: novel aspects of the ARP2/3 complex in regulation of endothelial junctions is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.4161/CAM.28243
P932PMC publication ID4049858
P698PubMed publication ID24621569

P2093author name stringAbdallah Abu Taha
Hans-J Schnittler
P2860cites workSingle molecule imaging of green fluorescent proteins in living cells: E-cadherin forms oligomers on the free cell surface.Q40184226
Sustained activation of N-WASP through phosphorylation is essential for neurite extensionQ40690235
Segmental differentiations of cell junctions in the vascular endothelium. Arteries and veinsQ41202146
Stress fibers in the splenic sinus endothelium in situ: molecular structure, relationship to the extracellular matrix, and contractilityQ41506130
Segmental differentiations of cell junctions in the vascular endothelium. The microvasculatureQ41946630
Tyrosine phosphorylation of cortactin is required for H2O2-mediated injury of human endothelial cellsQ42798181
Protein kinase C modifications of VE-cadherin, p120, and β-catenin contribute to endothelial barrier dysregulation induced by thrombinQ44436281
Interaction of cortactin and Arp2/3 complex is required for sphingosine-1-phosphate-induced endothelial cell remodeling.Q44970192
Sac-1004, a novel vascular leakage blocker, enhances endothelial barrier through the cAMP/Rac/cortactin pathway.Q46036444
Tyrosine phosphorylation of VE-cadherin prevents binding of p120- and beta-catenin and maintains the cellular mesenchymal stateQ46096039
Sphingosine-1-phosphate signaling regulates lamellipodia localization of cortactin complexes in endothelial cellsQ46896285
Involvement of cortactin and phosphotyrosine proteins in cell-cell contact formation in cultured bovine corneal endothelial cellsQ46901553
VE-cadherin-p120 interaction is required for maintenance of endothelial barrier functionQ48215842
Identification of CD146 as a component of the endothelial junction involved in the control of cell-cell cohesion.Q52544714
A two-tiered mechanism for stabilization and immobilization of E-cadherin.Q52691482
N-WASP regulates the epithelial junctional actin cytoskeleton through a non-canonical post-nucleation pathway.Q53230630
Genetic manipulation of endothelial cells by viral vectorsQ64375057
Mechanisms of cytoskeletal regulation: modulation of aortic endothelial cell protein band 4.1 by the extracellular matrixQ68878250
Desmoplakin expression and organization at human umbilical vein endothelial cell-to-cell junctionsQ71654032
Lamellipodia protrusion: moving interactions of vinculin and Arp2/3Q73148439
Characterization of human vascular endothelial cadherin glycansQ78167679
Endothelial cell barrier enhancement by ATP is mediated by the small GTPase Rac and cortactinQ79852053
Regulation of endothelial barrier function during flow-induced conversion to an arterial phenotypeQ80389191
Platelet-endothelial cell adhesion molecule-1 (CD31), a scaffolding molecule for selected catenin family members whose binding is mediated by different tyrosine and serine/threonine phosphorylationQ22254051
Transcriptional profiling reveals a critical role for tyrosine phosphatase VE-PTP in regulation of VEGFR2 activity and endothelial cell morphogenesisQ24315718
The LIM protein Ajuba is recruited to cadherin-dependent cell junctions through an association with alpha-cateninQ24316094
Recruitment of the Arp2/3 complex to vinculin: coupling membrane protrusion to matrix adhesionQ24324823
Diversity of the cadherin family: evidence for eight new cadherins in nervous tissueQ24337166
VE-PTP and VE-cadherin ectodomains interact to facilitate regulation of phosphorylation and cell contactsQ24534512
The uvomorulin-anchorage protein alpha catenin is a vinculin homologueQ24560521
Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly.Q24608988
Deconstructing the cadherin-catenin-actin complexQ24609677
Regulation of cell-cell adhesion by the cadherin-catenin complexQ24609784
Stabilizing the VE-cadherin-catenin complex blocks leukocyte extravasation and vascular permeabilityQ24634777
A novel endothelial-specific membrane protein is a marker of cell-cell contactsQ24642987
Interaction of alpha-actinin with the cadherin/catenin cell-cell adhesion complex via alpha-cateninQ24672506
The conditional inactivation of the beta-catenin gene in endothelial cells causes a defective vascular pattern and increased vascular fragilityQ24675378
Involvement of ZO-1 in Cadherin-based Cell Adhesion through Its Direct Binding to α Catenin and Actin FilamentsQ24678389
Crystal structure of Arp2/3 complexQ27636380
Biochemical and Structural Definition of the l-Afadin- and Actin-binding Sites of alpha -CateninQ27638447
Cellular motility driven by assembly and disassembly of actin filamentsQ27860676
Focal adhesion kinase regulation of N-WASP subcellular localization and functionQ28118737
The functional importance of multiple actin isoformsQ28251664
CD44 interaction with ankyrin and IP3 receptor in lipid rafts promotes hyaluronan-mediated Ca2+ signaling leading to nitric oxide production and endothelial cell adhesion and proliferationQ28253388
Phosphorylation of caveolin-1 regulates oxidant-induced pulmonary vascular permeability via paracellular and transcellular pathwaysQ28256714
Alpha 1(E)-catenin is an actin-binding and -bundling protein mediating the attachment of F-actin to the membrane adhesion complexQ28289996
Mammalian formin-1 participates in adherens junctions and polymerization of linear actin cablesQ28507974
Cortactin regulates cell migration through activation of N-WASPQ28594449
The WASP-WAVE protein network: connecting the membrane to the cytoskeletonQ29616493
The ARP2/3 complex: an actin nucleator comes of ageQ29617347
Intercalated disc protein, mXinα, suppresses p120-catenin-induced branching phenotype via its interactions with p120-catenin and cortactinQ30009949
Physical mechanisms of signal integration by WASP family proteins.Q30156827
α-Actinin-4/FSGS1 is required for Arp2/3-dependent actin assembly at the adherens junctionQ30426063
Cortactin deficiency is associated with reduced neutrophil recruitment but increased vascular permeability in vivoQ30428570
Mechanotransduction in vascular physiology and atherogenesisQ30439086
p120 catenin regulates lamellipodial dynamics and cell adhesion in cooperation with cortactinQ30444077
p120-Catenin regulates leukocyte transmigration through an effect on VE-cadherin phosphorylationQ30483820
Adherens junctions connect stress fibres between adjacent endothelial cellsQ30493870
Phosphorylation of VE-cadherin controls endothelial phenotypes via p120-catenin coupling and Rac1 activationQ30497938
Release of cellular tension signals self-restorative ventral lamellipodia to heal barrier micro-wounds.Q30539318
Localized RhoA GTPase activity regulates dynamics of endothelial monolayer integrityQ30557918
ARP2/3-mediated junction-associated lamellipodia control VE-cadherin-based cell junction dynamics and maintain monolayer integrityQ30564169
Switched at birth: a new family for PECAM-1.Q31936284
Endothelial adherens junctions and the actin cytoskeleton: an 'infinity net'?Q33551077
alpha-Catenin as a tension transducer that induces adherens junction developmentQ33572769
Role of actin and myosin in the control of paracellular permeability in pig, rat and human vascular endotheliumQ33731066
p120-Catenin regulates clathrin-dependent endocytosis of VE-cadherinQ34099519
Cadherin-directed actin assembly: E-cadherin physically associates with the Arp2/3 complex to direct actin assembly in nascent adhesive contactsQ34117282
Update on pulmonary edema: the role and regulation of endothelial barrier functionQ34381569
INF2 Is a WASP homology 2 motif-containing formin that severs actin filaments and accelerates both polymerization and depolymerization.Q34544252
Tubedown associates with cortactin and controls permeability of retinal endothelial cells to albuminQ34780430
The role of endothelial cell lateral junctions during leukocyte traffickingQ34862153
Cortactin: a multifunctional regulator of cellular invasivenessQ34891306
Arp2/3 complex is bound and activated by two WASP proteinsQ35170778
The Drosophila blood brain barrier is maintained by GPCR-dependent dynamic actin structuresQ35210797
The cytoskeletal mechanisms of cell-cell junction formation in endothelial cellsQ35672305
α-Catenin uses a novel mechanism to activate vinculinQ35801858
Vinculin associates with endothelial VE-cadherin junctions to control force-dependent remodelingQ35839771
Study of the actin cytoskeleton in live endothelial cells expressing GFP-actinQ35841488
Magic touch: how does cell-cell adhesion trigger actin assembly?Q35935761
p120-Catenin prevents neutrophil transmigration independently of RhoA inhibition by impairing Src dependent VE-cadherin phosphorylationQ36175619
The molecular organization of endothelial cell to cell junctions: differential association of plakoglobin, beta-catenin, and alpha-catenin with vascular endothelial cadherin (VE-cadherin)Q36235299
Vinculin is part of the cadherin-catenin junctional complex: complex formation between alpha-catenin and vinculinQ36255361
Cytoskeleton assembly at endothelial cell-cell contacts is regulated by alphaII-spectrin-VASP complexesQ36404914
EPLIN mediates linkage of the cadherin catenin complex to F-actin and stabilizes the circumferential actin beltQ36423364
The multiple languages of endothelial cell-to-cell communicationQ36429966
A WAVE2-Arp2/3 actin nucleator apparatus supports junctional tension at the epithelial zonula adherens.Q36433801
PKCα activation of p120-catenin serine 879 phospho-switch disassembles VE-cadherin junctions and disrupts vascular integrity.Q36456320
Tissue organization by cadherin adhesion molecules: dynamic molecular and cellular mechanisms of morphogenetic regulationQ36567245
Neural Wiskott-Aldrich syndrome protein (N-WASP)-mediated p120-catenin interaction with Arp2-Actin complex stabilizes endothelial adherens junctions.Q36596294
p120-catenin: Past and presentQ36686745
Adhesion and signaling molecules controlling the transmigration of leukocytes through endotheliumQ36877349
Cortactin in tumor invasivenessQ37135990
p120-catenin inhibits VE-cadherin internalization through a Rho-independent mechanismQ37146677
Actin-related protein2/3 complex regulates tight junctions and terminal differentiation to promote epidermal barrier formationQ37218402
Cell adhesion dynamics at endothelial junctions: VE-cadherin as a major playerQ37326058
The actin cytoskeleton in endothelial cell phenotypesQ37333152
"Developmental mechanics": cellular patterns controlled by adhesion, cortical tension and cell divisionQ37464773
Cortactin: Coordinating adhesion and the actin cytoskeleton at cellular protrusionsQ37479450
Formin-binding proteins: modulators of formin-dependent actin polymerizationQ37546275
Vascular integrity mediated by vascular endothelial cadherin and regulated by sphingosine 1-phosphate and angiopoietin-1.Q37616962
Regulation of endothelial permeability via paracellular and transcellular transport pathwaysQ37690727
Adherens junction: molecular architecture and regulationQ37748230
WASH, WHAMM and JMY: regulation of Arp2/3 complex and beyondQ37796281
Actin dynamics at intracellular membranes: the Spir/formin nucleator complexQ37815647
Functions of p120ctn isoforms in cell-cell adhesion and intracellular signalingQ37971582
Cortactin in cell migration and cancer at a glanceQ38008316
Cadherin junctions and their cytoskeleton(s).Q38057857
The regulation and functional impact of actin assembly at cadherin cell-cell adhesions.Q38075353
Caveolae as plasma membrane sensors, protectors and organizers.Q38076024
Roles of cadherins and catenins in cell-cell adhesion and epithelial cell polarityQ38088469
The role of VE-cadherin in vascular morphogenesis and permeability controlQ38088474
p120 catenin: an essential regulator of cadherin stability, adhesion-induced signaling, and cancer progression.Q38088489
Endothelial adherens junctions at a glanceQ38115518
Actin filament dynamics and endothelial cell junctions: the Ying and Yang between stabilization and motionQ38197107
Role of cadherins and plakoglobin in interendothelial adhesion under resting conditions and shear stressQ38341235
Pulmonary endothelial cell barrier enhancement by sphingosine 1-phosphate: roles for cortactin and myosin light chain kinaseQ38342964
Caveolin-1 opens endothelial cell junctions by targeting catenins.Q39465321
VE-PTP maintains the endothelial barrier via plakoglobin and becomes dissociated from VE-cadherin by leukocytes and by VEGF.Q39915486
P433issue2
P921main subjectendotheliumQ111140
P304page(s)125-135
P577publication date2014-03-01
P1433published inCell Adhesion and MigrationQ15817193
P1476titleDynamics between actin and the VE-cadherin/catenin complex: novel aspects of the ARP2/3 complex in regulation of endothelial junctions
P478volume8

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cites work (P2860)
Q92409782A Novel Microscopic Assay Reveals Heterogeneous Regulation of Local Endothelial Barrier Function
Q89078624Atorvastatin enhances endothelial adherens junctions through promoting VE-PTP gene transcription and reducing VE-cadherin-Y731 phosphorylation
Q63866071CMTM4 regulates angiogenesis by promoting cell surface recycling of VE-cadherin to endothelial adherens junctions.
Q38966854Contraction of endothelial cells: 40 years of research, but the debate still lives
Q58579198Cortical Actin Dynamics in Endothelial Permeability
Q83226379Endothelial EphB4 maintains vascular integrity and transport function in adult heart
Q42112829Endothelial monolayers and transendothelial migration depend on mechanical properties of the substrate
Q91792408Epithelial protein lost in neoplasm (EPLIN): Beyond a tumor suppressor
Q47101001Expression analysis of E-cad and vascular endothelial growth factor in triple-negative breast cancer patients of different ethnic groups in western China
Q28073354From basic mechanisms to clinical applications in heart protection, new players in cardiovascular diseases and cardiac theranostics: meeting report from the third international symposium on "New frontiers in cardiovascular research"
Q90488185Human brain microvascular endothelial cell pairs model tissue-level blood-brain barrier function
Q42725740Interleukin 2 Activates Brain Microvascular Endothelial Cells Resulting in Destabilization of Adherens Junctions
Q64084674Low-energy shock waves evoke intracellular Ca increases independently of sonoporation
Q36371672Meeting report from the 2nd International Symposium on New Frontiers in Cardiovascular Research. Protecting the cardiovascular system from ischemia: between bench and bedside
Q55309370Parallels between single cell migration and barrier formation: The case of RhoB and Rac1 trafficking.
Q64119466Placenta Transcriptome Profiling in Intrauterine Growth Restriction (IUGR)
Q48286660RhoA, RhoB and RhoC differentially regulate endothelial barrier function.
Q49871796Short interfering RNA-mediated silencing of actin-related protein 2/3 complex subunit 4 inhibits the migration of SW620 human colorectal cancer cells
Q91951062Silica nanomaterials induce organ injuries by Ca2+-ROS-initiated disruption of the endothelial barrier and triggering intravascular coagulation
Q27317056Spatiotemporal analysis of RhoA/B/C activation in primary human endothelial cells
Q97540667TIMP1 preserves the blood-brain barrier through interacting with CD63/integrin β 1 complex and regulating downstream FAK/RhoA signaling
Q33738604The ARP 2/3 complex mediates endothelial barrier function and recovery
Q51588682Traction force dynamics predict gap formation in activated endothelium.
Q37393447VE-cadherin involved in the pulmonary microvascular endothelial cell barrier injury induced by angiotensin II through modulating the cellular apoptosis and skeletal rearrangement
Q50278297Vascular Endothelial (VE)-Cadherin, Endothelial Adherens Junctions, and Vascular Disease
Q48106191YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular development

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