Refining stability and dissolution rate of amorphous drug formulations

scientific article published on 23 April 2014

Refining stability and dissolution rate of amorphous drug formulations is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1517/17425247.2014.911728
P698PubMed publication ID24754747

P50authorThomas RadesQ37828574
Petra Alexandra PriemelQ57041544
Line Hagner NielsenQ59544201
Riikka LaitinenQ114445996
Holger GrohganzQ39864868
Korbinian LöbmannQ40692383
P2093author name stringGuy Van den Mooter
Anette Mullertz
P2860cites workA theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailabilityQ28293773
Processing of carbamazepine-PEG 4000 solid dispersions with supercritical carbon dioxide: preparation, characterisation, and in vitro dissolutionQ30992178
Fast surface crystallization of amorphous griseofulvin below T g.Q33562887
Amorphous pharmaceutical solids: preparation, characterization and stabilizationQ34233896
Spatial confinement can lead to increased stability of amorphous indomethacinQ34240950
A mechanistic approach to understanding the factors affecting drug absorption: a review of fundamentalsQ34665881
Melt extrusion: from process to drug delivery technologyQ34793080
Glasses crystallize rapidly at free surfaces by growing crystals upwardQ34794288
Modification of the solid-state nature of sulfathiazole and sulfathiazole sodium by spray dryingQ35999134
Statistics on BCS classification of generic drug products approved between 2000 and 2011 in the USA.Q36331520
Mesoporous silicon: a platform for the delivery of therapeuticsQ36750143
Review: physical chemistry of solid dispersionsQ37643840
Application of mesoporous silicon dioxide and silicate in oral amorphous drug delivery systemsQ37942798
Studies on dissolution enhancement and mathematical modeling of drug release of a poorly water-soluble drug using water-soluble carriers.Q51933789
Influence of tablet dissolution on furosemide bioavailability: a bioequivalence study.Q52599984
A comparative study of the effect of spray drying and hot-melt extrusion on the properties of amorphous solid dispersions containing felodipine.Q54342599
Miniaturized screening of polymers for amorphous drug stabilization (SPADS): Rapid assessment of solid dispersion systemsQ57360710
In vitro and in vivo performance of novel supersaturated self-nanoemulsifying drug delivery systems (super-SNEDDS)Q58199076
Inhibition of surface crystallisation of amorphous indomethacin particles in physical drug–polymer mixturesQ59234458
Co-amorphous simvastatin and glipizide combinations show improved physical stability without evidence of intermolecular interactionsQ59234583
Effect of different preparation methods on the dissolution behaviour of amorphous indomethacinQ59234607
The impact of surface- and nano-crystallisation on the detected amorphous content and the dissolution behaviour of amorphous indomethacinQ59234647
Preparation of glass solutions of three poorly water soluble drugs by spray drying, melt extrusion and ball millingQ59235070
Stability of amorphous pharmaceutical solids: crystal growth mechanisms and effect of polymer additivesQ37995510
Mesoporous systems for poorly soluble drugsQ38044590
Solid dispersions: a strategy for poorly aqueous soluble drugs and technology updatesQ38050160
Drug precipitation-permeation interplay: supersaturation in an absorptive environmentQ39306982
Pharmaceutical Applications of Solid Dispersion SystemsQ40000294
Theoretical and practical approaches for prediction of drug-polymer miscibility and solubility.Q40294237
Characteristics and significance of the amorphous state in pharmaceutical systemsQ41323277
Effect of counterions on the properties of amorphous atorvastatin saltsQ41607145
Surface-enhanced crystallization of amorphous nifedipineQ42162153
Solubilities of crystalline drugs in polymers: an improved analytical method and comparison of solubilities of indomethacin and nifedipine in PVP, PVP/VA, and PVAcQ42979593
Precipitation of a poorly soluble model drug during in vitro lipolysis: characterization and dissolution of the precipitateQ43006891
Theoretical and experimental investigation on the solid solubility and miscibility of naproxen in poly(vinylpyrrolidone).Q43044276
Influence of preparation methods on solid state supersaturation of amorphous solid dispersions: a case study with itraconazole and eudragit e100.Q43145360
Aqueous film coating to reduce recrystallization of guaifenesin from hot-melt extruded acrylic matricesQ43251738
Oxidized mesoporous silicon microparticles for improved oral delivery of poorly soluble drugsQ43252837
Fusion processing of itraconazole solid dispersions by kinetisol dispersing: a comparative study to hot melt extrusionQ43291975
A theoretical and spectroscopic study of co-amorphous naproxen and indomethacinQ43753649
Evaluation of the structural determinants of polymeric precipitation inhibitors using solvent shift methods and principle component analysis.Q43782639
Characterization of carbamazepine-Gelucire 50/13 microparticles prepared by a spray-congealing process using ultrasounds.Q43938194
Evaluation of drug supersaturation by thermodynamic and kinetic approaches for the prediction of oral absorbability in amorphous pharmaceuticalsQ43957967
Biorelevant characterisation of amorphous furosemide salt exhibits conversion to a furosemide hydrate during dissolutionQ44183555
Stabilisation of amorphous drugs under high humidity using pharmaceutical thin films.Q44365106
Coamorphous repaglinide-saccharin with enhanced dissolutionQ44516449
A method to predict the equilibrium solubility of drugs in solid polymers near room temperature using thermal analysisQ44686991
Phase behavior of amorphous molecular dispersions I: Determination of the degree and mechanism of solid solubilityQ45117919
Preparation of an amorphous sodium furosemide salt improves solubility and dissolution rate and leads to a faster Tmax after oral dosing to ratsQ45394825
Cocrystallization and amorphization induced by drug-excipient interaction improves the physical properties of acyclovir.Q45398135
Amino acids as co-amorphous stabilizers for poorly water soluble drugs--Part 1: preparation, stability and dissolution enhancementQ45811011
Phase behavior of poly(vinylpyrrolidone) containing amorphous solid dispersions in the presence of moisture.Q45918887
Anomalous properties of spray dried solid dispersions.Q46004482
Enhanced dissolution rate and synchronized release of drugs in binary systems through formulation: Amorphous naproxen-cimetidine mixtures prepared by mechanical activationQ46069091
Amino acids as co-amorphous stabilizers for poorly water-soluble drugs--Part 2: molecular interactions.Q46318738
Improved physical stability of amorphous state through acid base interactionsQ46330466
Physical characterization and stability of amorphous indomethacin and ranitidine hydrochloride binary systems prepared by mechanical activationQ46471158
Physical state of poorly water soluble therapeutic molecules loaded into SBA-15 ordered mesoporous silica carriers: a case study with itraconazole and ibuprofenQ46481214
In situ amorphisation of indomethacin with Eudragit® E during dissolutionQ46546738
The effect of pressurized carbon dioxide as a temporary plasticizer and foaming agent on the hot stage extrusion process and extrudate properties of solid dispersions of itraconazole with PVP-VA 64.Q46683024
Construction of drug-polymer thermodynamic phase diagrams using Flory-Huggins interaction theory: identifying the relevance of temperature and drug weight fraction to phase separation within solid dispersionsQ47275244
Physical state and dissolution of ibuprofen formulated by co-spray drying with mesoporous silica: effect of pore and particle sizeQ47385833
Bulk, surface properties and water uptake mechanisms of salt/acid amorphous composite systems.Q50474793
Impact of process variables on the micromeritic and physicochemical properties of spray-dried microparticles--Part II. Physicochemical characterisation of spray-dried materials.Q50489339
Impact of process variables on the micromeritic and physicochemical properties of spray-dried porous microparticles, part I: introduction of a new morphology classification system.Q50489341
Precipitation in and supersaturation of contents of the upper small intestine after administration of two weak bases to fasted adults.Q51372033
Applications of supercritical fluids to enhance the dissolution behaviors of Furosemide by generation of microparticles and solid dispersions.Q51441001
Coamorphous drug systems: enhanced physical stability and dissolution rate of indomethacin and naproxen.Q51542358
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)977-989
P577publication date2014-04-23
P1433published inExpert Opinion on Drug DeliveryQ5421203
P1476titleRefining stability and dissolution rate of amorphous drug formulations
P478volume11

Reverse relations

cites work (P2860)
Q114864269A Novel Curcumin-Based Drug Powder Inhalation Medicine for Chronic Obstructive Pulmonary Disease
Q57353648Characterization of amorphous solid dispersions
Q58691868Co-Amorphous Simvastatin-Nifedipine with Enhanced Solubility for Possible Use in Combination Therapy of Hypertension and Hypercholesterolemia
Q88741018Confinement of Amorphous Lactose in Pores Formed Upon Co-Spray Drying With Nanoparticles
Q57785804Dual mechanism of microenvironmental pH modulation and foam melt extrusion to enhance performance of HPMCAS based amorphous solid dispersion
Q51284615Gastrointestinal and Systemic Monitoring of Posaconazole in Humans After Fasted and Fed State Administration of a Solid Dispersion.
Q92891800Identification and investigation of the vibrational properties of crystalline and co-amorphous drugs with Raman and terahertz spectroscopy
Q51105115On the inherent properties of Soluplus and its application in ibuprofen solid dispersions generated by microwave-quench cooling technology.
Q38907190Porous calcium carbonate as a carrier material to increase the dissolution rate of poorly soluble flavouring compounds.
Q59234241Properties of the Sodium Naproxen-Lactose-Tetrahydrate Co-Crystal upon Processing and Storage.
Q38856865Rational excipient selection for co-amorphous formulations
Q37371404Stable Colloidal Drug Aggregates Catch and Release Active Enzymes
Q36408457The Binary System of Ibuprofen-Nicotinamide Under Nanoscale Confinement: From Cocrystal to Coamorphous State.
Q38644728The Precipitation Behavior of Poorly Water-Soluble Drugs with an Emphasis on the Digestion of Lipid Based Formulations.
Q38856754The role of the carrier in the formulation of pharmaceutical solid dispersions. Part II: amorphous carriers.

Search more.