Agonistic autoantibodies directed against G-protein-coupled receptors and their relationship to cardiovascular diseases

scientific article published on 29 April 2014

Agonistic autoantibodies directed against G-protein-coupled receptors and their relationship to cardiovascular diseases is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1009516804
P356DOI10.1007/S00281-014-0425-9
P698PubMed publication ID24777744
P5875ResearchGate publication ID261956356

P50authorGerd WallukatQ63288594
Ingolf SchimkeQ56959779
P2860cites workAutoantibodies against G-protein-coupled receptors modulate heart mast cellsQ80278334
Autoantibodies against the serotoninergic 5-HT4 receptor and congenital heart block: a reassessmentQ80357088
Beta 1-adrenergic receptor autoantibodies mediate dilated cardiomyopathy by agonistically inducing cardiomyocyte apoptosisQ80589402
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Sera from patients with type 2 diabetes contain agonistic autoantibodies against G protein-coupled receptorsQ84289582
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Role of anti-β1 adrenergic antibodies from patients with periodontitis in cardiac dysfunctionQ85014063
Targeting anti-beta-1-adrenergic receptor antibodies for dilated cardiomyopathyQ27000434
Autoantibodies against muscarinic type 3 receptor in Sjögren's syndrome inhibit aquaporin 5 traffickingQ27323059
Potential relevance of alpha(1)-adrenergic receptor autoantibodies in refractory hypertensionQ28575913
Reduced oxidative stress in parallel to improved cardiac performance one year after selective removal of anti-beta 1-adrenoreceptor autoantibodies in patients with idiopathic dilated cardiomyopathy: data of a preliminary studyQ30989751
Autoantibodies to muscarinic acetylcholine receptors found in patients with primary biliary cirrhosisQ33720002
Patients with preeclampsia develop agonistic autoantibodies against the angiotensin AT1 receptorQ33848380
Ligand-specific conformation of extracellular loop-2 in the angiotensin II type 1 receptorQ33855316
Agonist-induced increase in apparent β-adrenergic receptor sizeQ33955321
Autoantibodies against the beta- and muscarinic receptors in cardiomyopathyQ33974796
Toxicological evaluation of oligonucleotide therapeuticsQ34182586
Agonistic autoantibodies as vasodilators in orthostatic hypotension: a new mechanismQ34244290
Antibodies to the α1-adrenergic receptor cause vascular impairments in rat brain as demonstrated by magnetic resonance angiographyQ34364148
Autoantibodies activating human beta1-adrenergic receptors are associated with reduced cardiac function in chronic heart failure.Q34491578
Molecular mechanisms of anti-G-protein-coupled receptor autoantibodiesQ34574047
Autoantibodies against muscarinic receptors in breast cancer: their role in tumor angiogenesisQ34608685
Immunoglobulin adsorption in patients with idiopathic dilated cardiomyopathyQ34646571
Receptor-activating autoantibodies and disease: preeclampsia and beyondQ35707881
Location and nature of the residues important for ligand recognition in G-protein coupled receptorsQ35896272
Beta 1-adrenergic receptor-directed autoimmunity as a cause of dilated cardiomyopathy in rats.Q36548874
Identification of antibodies with muscarinic cholinergic activity in human Chagas' disease: pathological implicationsQ58843978
Distinct patterns of autoantibodies against G-protein-coupled receptors in Chagas' cardiomyopathy and megacolon: their potential impact for early risk assessment in asymptomatic Chagas' patientsQ58844042
A circulating IgG in Chagas' disease which binds to beta-adrenoceptors of myocardium and modulates their activityQ58846968
Autoantibodies against the beta-adrenergic receptor in human myocarditis and dilated cardiomyopathy: beta-adrenergic agonism without desensitizationQ67700979
Autoantibodies to β-adrenergic receptors with antiadrenergic activity from patients with allergic asthmaQ68257393
Influence of anti-beta-receptor antibodies on cardiac adenylate cyclase in patients with idiopathic dilated cardiomyopathyQ68463587
Dilated cardiomyopathy defines serum autoantibodies against G-protein-coupled cardiovascular receptorsQ71186954
Functional autoimmune epitope on alpha 1-adrenergic receptors in patients with malignant hypertensionQ71662795
Anti-beta 1-adrenoceptor autoantibodies with chronotropic activity from the serum of patients with dilated cardiomyopathy: mapping of epitopes in the first and second extracellular loopsQ71694608
High prevalence of antibodies against beta 1- and beta 2-adrenoceptors in patients with primary electrical cardiac abnormalitiesQ71745703
Agonistic effects of anti-peptide antibodies and autoantibodies directed against adrenergic and cholinergic receptors: absence of desensitizationQ71917946
Activation of cyclic AMP-dependent protein kinase in cardiomyocytes by anti-beta 1-adrenoceptor autoantibodies from patients with idiopathic dilated cardiomyopathyQ71917952
Modulation of beta1-adrenoceptor activity by domain-specific antibodies and heart failure-associated autoantibodiesQ73069755
Alpha 1-adrenergic receptor antibodies in patients with primary hypertensionQ73089177
Anti-SSA/Ro52 autoantibodies blocking the cardiac 5-HT4 serotoninergic receptor could explain neonatal lupus congenital heart blockQ73166166
Short-term hemodynamic effects of immunoadsorption in dilated cardiomyopathyQ73303001
Induction of cardiomyopathy in severe combined immunodeficiency mice by transfer of lymphocytes from patients with idiopathic dilated cardiomyopathyQ73470133
Autoantibodies against the second extracellular loop of beta1-adrenergic receptors predict ventricular tachycardia and sudden death in patients with idiopathic dilated cardiomyopathyQ73536358
AT(1) receptor agonistic antibodies from preeclamptic patients cause vascular cells to express tissue factorQ73815485
Protective effect of bisoprolol on beta-1 adrenoceptor peptide-induced autoimmune myocardial damage in rabbitsQ74031533
Autoantibodies against the angiotensin receptor (AT1) in patients with hypertensionQ74126541
Immunochemical and functional characterization of an agonist-like monoclonal antibody against the M2 acetylcholine receptorQ74267890
Autoantibodies against M2 muscarinic receptors in patients with cardiomyopathy display non-desensitized agonist-like effectsQ74589807
Specific removal of beta1-adrenergic autoantibodies from patients with idiopathic dilated cardiomyopathyQ78587830
Fc(gamma) receptors IIa on cardiomyocytes and their potential functional relevance in dilated cardiomyopathyQ80192209
Are Agonistic Autoantibodies against G-Protein Coupled Receptors Involved in the Development of Long-Term Side Effects of Tumor Chemotherapy?Q36744349
Aptamer binding and neutralization of β1-adrenoceptor autoantibodies: basics and a vision of its future in cardiomyopathy treatmentQ38027725
Immunoadsorption therapy for dilated cardiomyopathy and pulmonary arterial hypertensionQ38077335
Activating autoantibodies and cardiovascular diseaseQ38118625
Agonistic autoantibodies to the α(1) -adrenergic receptor and the β(2) -adrenergic receptor in Alzheimer's and vascular dementiaQ39409827
Aptamer neutralization of beta1-adrenoceptor autoantibodies isolated from patients with cardiomyopathiesQ39714169
Autoimmunity against the β2 adrenergic receptor and muscarinic-2 receptor in complex regional pain syndromeQ39721007
Immunoglobulin G from breast cancer patients in stage I stimulates muscarinic acetylcholine receptors in MCF7 cells and induces proliferation. Participation of nitric oxide synthase-derived nitric oxide.Q39739073
Effects of protein A immunoadsorption in patients with chronic dilated cardiomyopathy.Q39839980
Muscarinic receptors autoantibodies purified from mammary adenocarcinoma-bearing mice sera stimulate tumor progressionQ40266096
Direct evidence for a beta 1-adrenergic receptor-directed autoimmune attack as a cause of idiopathic dilated cardiomyopathyQ40841949
Autoantibodies to β2-Adrenergic Receptors: a Possible Cause of Adrenergic Hyporesponsiveness in Allergic Rhinitis and AsthmaQ40862381
Anti-M2 muscarinic receptor autoantibodies and idiopathic dilated cardiomyopathyQ41108919
Antiadrenergic and muscarinic receptor antibodies in Chagas' cardiomyopathyQ41108938
Removal of autoantibodies in dilated cardiomyopathy by immunoadsorptionQ41108977
Anti-peptide antibodies sensitive to the 'active' state of the beta2-adrenergic receptorQ41145655
A peptide derived from a beta2-adrenergic receptor transmembrane domain inhibits both receptor dimerization and activation.Q41186190
In vitro effects of reactive O2 species on the β-receptor-adenylyl cyclase systemQ42451088
Agonistic antibody to the alpha1-adrenergic receptor mobilizes intracellular calcium and induces phosphorylation of a cardiac 15-kDa proteinQ43291018
Specific immunoadsorption therapy using a tryptophan column in patients with refractory heart failure due to dilated cardiomyopathyQ43626109
Autoantibodies against the beta1 adrenoceptor from patients with dilated cardiomyopathy prolong action potential duration and enhance contractility in isolated cardiomyocytesQ43670106
Decreased oxidative stress in patients with idiopathic dilated cardiomyopathy one year after immunoglobulin adsorptionQ43672370
Anti-β-adrenoceptors autoimmunity causing 'idiopathic' arrhythmias and cardiomyopathyQ43835988
Therapeutic use of muscarinic acetylcholine receptor peptide to prevent mice chagasic cardiac dysfunctionQ44264613
Maternal autoantibodies from preeclamptic patients activate angiotensin receptors on human trophoblast cellsQ44320558
AT1 receptor agonistic antibodies from preeclamptic patients stimulate NADPH oxidaseQ44385661
Beta1-adrenoceptor antibodies induce apoptosis in adult isolated cardiomyocytesQ44392529
Effects of the serum gamma globulin fraction of patients with allergic asthma and dilated cardiomyopathy on chronotropic beta adrenoceptor function in cultured neonatal rat heart myocytesQ44657870
Angiotensin II type 1-receptor activating antibodies in renal-allograft rejectionQ45259438
Antibodies to beta 1 and beta 2 adrenoreceptors in Chagas' diseaseQ46161530
From agonist to antagonist: Fab fragments of an agonist-like monoclonal anti-beta(2)-adrenoceptor antibody behave as antagonistsQ46208108
Maternal autoantibodies from preeclamptic patients activate angiotensin receptors on human mesangial cells and induce interleukin-6 and plasminogen activator inhibitor-1 secretionQ46344658
Functional epitope of muscarinic type 3 receptor which interacts with autoantibodies from Sjogren's syndrome patients.Q46653992
Effect of chagasic sera on the rat isolated atrial preparation: immunological, morphological and function aspectsQ46790587
Transfer of rabbit autoimmune cardiomyopathy into severe combined immunodeficiency miceQ47211148
Agonistic AT1 receptor autoantibodies and monocyte stimulation in hypertensive patients*1Q47447775
Renal ischemia and transplantation predispose to vascular constriction mediated by angiotensin II type 1 receptor-activating antibodiesQ47630949
Complete elimination of cardiodepressant IgG3 autoantibodies by immunoadsorption in patients with severe heart failureQ48186336
Ig apheresis for the treatment of severe DCM patientsQ48309211
Economic evaluation and survival analysis of immunoglobulin adsorption in patients with idiopathic dilated cardiomyopathy.Q50749673
Peptides derived from cardiovascular G-protein-coupled receptors induce morphological cardiomyopathic changes in immunized rabbits.Q50957107
Effects of immunoadsorption and subsequent immunoglobulin G substitution on cardiopulmonary exercise capacity in patients with dilated cardiomyopathy.Q51772854
Anti-beta1-adrenergic receptor autoantibodies in patients with chronic Chagas heart disease.Q51798355
Long-term benefits of immunoadsorption in β(1)-adrenoceptor autoantibody-positive transplant candidates with dilated cardiomyopathy.Q52887237
Involvement of functional autoantibodies against vascular receptors in systemic sclerosis.Q52900457
Distinct patterns of autoantibodies against G-protein-coupled receptors in Chagas' cardiomyopathy and megacolon. Their potential impact for early risk assessment in asymptomatic Chagas' patients.Q52905846
Agonistic anti-beta1-adrenergic receptor autoantibodies from cardiomyopathy patients reduce the beta1-adrenergic receptor expression in neonatal rat cardiomyocytes.Q52991955
Autoantibodies in Sjögren's syndrome patients acutely inhibit muscarinic receptor function.Q53407460
Pro-apoptotic effect of anti-β1-adrenergic receptor antibodies in periodontitis patients.Q54474836
Interaction of human chagasic IgG with the second extracellular loop of the human heart muscarinic acetylcholine receptor: functional and pathological implicationsQ58843227
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectcardiovascular diseaseQ389735
autoantibodyQ785022
G protein-coupled receptorQ38173
P304page(s)351-363
P577publication date2014-04-29
P1433published inSeminars in ImmunopathologyQ15724576
P1476titleAgonistic autoantibodies directed against G-protein-coupled receptors and their relationship to cardiovascular diseases
P478volume36

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cites work (P2860)
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