Agonistic antibody to the alpha1-adrenergic receptor mobilizes intracellular calcium and induces phosphorylation of a cardiac 15-kDa protein

scientific article published on 15 August 2009

Agonistic antibody to the alpha1-adrenergic receptor mobilizes intracellular calcium and induces phosphorylation of a cardiac 15-kDa protein is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S11010-009-0224-0
P698PubMed publication ID19685172
P5875ResearchGate publication ID26746319

P2093author name stringHannelore Haase
Peter Karczewski
Marion Bimmler
Petra Hempel
P2860cites workDoes contractile Ca2+ control calcineurin-NFAT signaling and pathological hypertrophy in cardiac myocytes?Q37199523
Differential effects of sera from normotensive and hypertensive pregnant women on Ca(2+) metabolism in normal vasular smooth muscle cellsQ40872142
Anti-peptide antibodies sensitive to the 'active' state of the beta2-adrenergic receptorQ41145655
Differential sensitivity to isoprenaline of troponin I and phospholamban phosphorylation in isolated rat heartsQ41960967
Autoantibodies against the beta1 adrenoceptor from patients with dilated cardiomyopathy prolong action potential duration and enhance contractility in isolated cardiomyocytesQ43670106
Expression of alpha1-adrenergic receptor subtypes in heart cell cultureQ43788139
Autoantibodies against AT1-receptor and alpha1-adrenergic receptor in patients with hypertensionQ44162378
Modulation of intracellular Ca2+ via L-type calcium channels in heart cells by the autoantibody directed against the second extracellular loop of the α1-adrenoceptorsQ44431698
Effects of the serum gamma globulin fraction of patients with allergic asthma and dilated cardiomyopathy on chronotropic beta adrenoceptor function in cultured neonatal rat heart myocytesQ44657870
Antibodies from preeclamptic patients stimulate increased intracellular Ca2+ mobilization through angiotensin receptor activationQ45069619
Cardiac remodeling after long-term stimulation by antibodies against the alpha1-adrenergic receptor in ratsQ45216646
From agonist to antagonist: Fab fragments of an agonist-like monoclonal anti-beta(2)-adrenoceptor antibody behave as antagonistsQ46208108
Isoproterenol-induced phosphorylation of a 15-kilodalton sarcolemmal protein in intact myocardiumQ46407758
Phospholemman-phosphorylation mediates the beta-adrenergic effects on Na/K pump function in cardiac myocytesQ46588903
Angiotensin II-induced negative inotropy in rat ventricular myocytes: role of reactive oxygen species and p38 MAPK.Q46628023
Alpha 1-adrenergic stimulation is coupled to cardiac myocyte hypertrophyQ67913904
Alpha-adrenergic stimulation of sarcolemmal protein phosphorylation and slow responses in intact myocardiumQ68957999
Autoantibodies against beta-adrenoceptors in human idiopathic dilated cardiomyopathyQ69324044
Differentiation and behavior of isolated embryonic and neonatal heart cells in a chemically defined mediumQ71504585
Characterization of anti-peptide antibodies directed against an extracellular immunogenic epitope on the human alpha 1-adrenergic receptorQ71634185
Functional autoimmune epitope on alpha 1-adrenergic receptors in patients with malignant hypertensionQ71662795
Anti-beta 1-adrenoceptor autoantibodies with chronotropic activity from the serum of patients with dilated cardiomyopathy: mapping of epitopes in the first and second extracellular loopsQ71694608
Modulation of beta1-adrenoceptor activity by domain-specific antibodies and heart failure-associated autoantibodiesQ73069755
Alpha 1-adrenergic receptor antibodies in patients with primary hypertensionQ73089177
AT(1) receptor agonistic antibodies from preeclamptic patients cause vascular cells to express tissue factorQ73815485
Alpha1-adrenergic stress induces downregulation of Na+/Ca2+ exchanger in myocardial preparations from rabbits at physiological preloadQ79674398
Expression and phosphorylation of the na-pump regulatory subunit phospholemman in heart failureQ81059387
Potential relevance of alpha(1)-adrenergic receptor autoantibodies in refractory hypertensionQ28575913
Receptor subtype involved in alpha 1-adrenergic receptor-mediated Ca2+ signaling in cardiomyocytesQ28577006
Purification and complete sequence determination of the major plasma membrane substrate for cAMP-dependent protein kinase and protein kinase C in myocardiumQ33263494
Adrenergic and muscarinic receptors in the human heartQ33784373
Mapping of a functional autoimmune epitope on the beta 1-adrenergic receptor in patients with idiopathic dilated cardiomyopathyQ34263678
Insights into alpha1 adrenoceptor function in health and disease from transgenic animal studiesQ35096881
Angiotensin receptor agonistic autoantibodies induce pre-eclampsia in pregnant miceQ35701236
Agonistic AT(1) receptor autoantibody increases in serum of patients with refractory hypertension and improves Ca(2+) mobilization in cultured rat vascular smooth muscle cellsQ36295460
Signal transduction and regulation: are all alpha1-adrenergic receptor subtypes created equal?Q36671706
Regulation of cardiac Na+/Ca2+ exchanger by phospholemmanQ36796638
Multiple GPCR conformations and signalling pathways: implications for antagonist affinity estimates.Q36880896
P433issue1-2
P921main subjectphosphorylationQ242736
P304page(s)233-242
P577publication date2009-08-15
P1433published inMolecular and Cellular BiochemistryQ1573176
P1476titleAgonistic antibody to the alpha1-adrenergic receptor mobilizes intracellular calcium and induces phosphorylation of a cardiac 15-kDa protein
P478volume333

Reverse relations

cites work (P2860)
Q38207936Agonistic autoantibodies directed against G-protein-coupled receptors and their relationship to cardiovascular diseases
Q39409827Agonistic autoantibodies to the α(1) -adrenergic receptor and the β(2) -adrenergic receptor in Alzheimer's and vascular dementia
Q34364148Antibodies to the α1-adrenergic receptor cause vascular impairments in rat brain as demonstrated by magnetic resonance angiography
Q92479800Molecular mechanisms regulating immune responses in thromboangiitis obliterans: A comprehensive review
Q35707881Receptor-activating autoantibodies and disease: preeclampsia and beyond
Q41470145Synthesis and antihypertensive screening of new derivatives of quinazolines linked with isoxazole

Search more.