review article | Q7318358 |
scholarly article | Q13442814 |
P2093 | author name string | I N Lavrik | |
P2860 | cites work | Mathematical modeling identifies inhibitors of apoptosis as mediators of positive feedback and bistability | Q21563509 |
Caspases: pharmacological manipulation of cell death | Q24536096 | ||
Regulation of CD95/Fas signaling at the DISC | Q26824629 | ||
Cell-to-cell variability in cell death: can systems biology help us make sense of it all? | Q27013063 | ||
Mechanism of procaspase-8 activation by c-FLIPL | Q27655368 | ||
The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex | Q28221276 | ||
Computational modelling of LY303511 and TRAIL-induced apoptosis suggests dynamic regulation of cFLIP | Q28393929 | ||
ON/OFF and beyond--a boolean model of apoptosis | Q28472140 | ||
Computational insights on the competing effects of nitric oxide in regulating apoptosis | Q28472789 | ||
Mathematical modelling of cell-fate decision in response to death receptor engagement | Q28473094 | ||
Modeling a snap-action, variable-delay switch controlling extrinsic cell death | Q28474253 | ||
Bistability in apoptosis by receptor clustering | Q28475785 | ||
Two CD95 (APO-1/Fas) signaling pathways | Q29619631 | ||
Systems analysis of apoptosis protein expression allows the case-specific prediction of cell death responsiveness of melanoma cells | Q30549646 | ||
Quantitative analysis of pathways controlling extrinsic apoptosis in single cells | Q33807797 | ||
Stoichiometry of the CD95 death-inducing signaling complex: experimental and modeling evidence for a death effector domain chain model | Q34032305 | ||
A death effector domain chain DISC model reveals a crucial role for caspase-8 chain assembly in mediating apoptotic cell death | Q34032310 | ||
Clinical application of a systems model of apoptosis execution for the prediction of colorectal cancer therapy responses and personalisation of therapy. | Q50507805 | ||
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XIAP discriminates between type I and type II FAS-induced apoptosis | Q34205704 | ||
The caspase-8 dimerization/dissociation balance is a highly potent regulator of caspase-8, -3, -6 signaling | Q34236748 | ||
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Enhancing apoptosis in TRAIL-resistant cancer cells using fundamental response rules | Q35551640 | ||
Fas death receptor signalling: roles of Bid and XIAP. | Q35657414 | ||
Lyapunov exponents and phase diagrams reveal multi-factorial control over TRAIL-induced apoptosis | Q35682077 | ||
Kinetics in signal transduction pathways involving promiscuous oligomerizing receptors can be determined by receptor specificity: apoptosis induction by TRAIL. | Q35863285 | ||
Proteasome inhibition can impair caspase-8 activation upon submaximal stimulation of apoptotic tumor necrosis factor-related apoptosis inducing ligand (TRAIL) signaling. | Q35922585 | ||
Life and death in peripheral T cells | Q36858872 | ||
Activation of executioner caspases is a predictor of progression-free survival in glioblastoma patients: a systems medicine approach | Q36907121 | ||
Death receptor signal transducers: nodes of coordination in immune signaling networks | Q37417486 | ||
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The role of the kinases RIP1 and RIP3 in TNF-induced necrosis | Q37721675 | ||
Systems biology of apoptosis signaling networks | Q37776839 | ||
It cuts both ways: reconciling the dual roles of caspase 8 in cell death and survival | Q37947994 | ||
Cellular FLICE-like inhibitory proteins (c-FLIPs): fine-tuners of life and death decisions | Q37981778 | ||
The emerging role of linear ubiquitination in cell signaling | Q37989135 | ||
Mathematical modeling of apoptosis | Q38117206 | ||
Caspase-8 activity has an essential role in CD95/Fas-mediated MAPK activation | Q39191656 | ||
A modular model of the apoptosis machinery | Q39429538 | ||
Modeling reveals that dynamic regulation of c-FLIP levels determines cell-to-cell distribution of CD95-mediated apoptosis | Q39591517 | ||
c-FLIP(L) is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis | Q39644966 | ||
Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis | Q39861453 | ||
Dynamics within the CD95 death-inducing signaling complex decide life and death of cells | Q40150581 | ||
Analysis of CD95 threshold signaling: triggering of CD95 (FAS/APO-1) at low concentrations primarily results in survival signaling | Q40161643 | ||
The role of CAP3 in CD95 signaling: new insights into the mechanism of procaspase-8 activation | Q40369810 | ||
Rapid turnover of c-FLIPshort is determined by its unique C-terminal tail | Q40424237 | ||
Selective knockdown of the long variant of cellular FLICE inhibitory protein augments death receptor-mediated caspase-8 activation and apoptosis. | Q40448034 | ||
Mathematical modeling reveals threshold mechanism in CD95-induced apoptosis | Q40516096 | ||
Caspase-8 cleaves its substrates from the plasma membrane upon CD95-induced apoptosis | Q41218122 | ||
Systems analysis of effector caspase activation and its control by X-linked inhibitor of apoptosis protein | Q41834899 | ||
A new C-terminal cleavage product of procaspase-8, p30, defines an alternative pathway of procaspase-8 activation | Q41873399 | ||
The chains of death: a new view on caspase-8 activation at the DISC. | Q43245304 | ||
Single-cell fluorescence resonance energy transfer analysis demonstrates that caspase activation during apoptosis is a rapid process. Role of caspase-3. | Q43966285 | ||
Systems modelling methodology for the analysis of apoptosis signal transduction and cell death decisions. | Q44087102 | ||
Fas/CD95-induced chemokines can serve as "find-me" signals for apoptotic cells | Q45834959 | ||
Dynamics of outer mitochondrial membrane permeabilization during apoptosis. | Q46167523 | ||
tBid interaction with cardiolipin primarily orchestrates mitochondrial dysfunctions and subsequently activates Bax and Bak. | Q46428278 | ||
Bistability analyses of a caspase activation model for receptor-induced apoptosis | Q47316430 | ||
P275 | copyright license | Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported | Q15643954 |
P6216 | copyright status | copyrighted | Q50423863 |
P921 | main subject | peptide | Q172847 |
membrane protein | Q423042 | ||
systems biology | Q815297 | ||
signal transduction | Q828130 | ||
apoptotic process | Q14599311 | ||
transport protein | Q2111029 | ||
cell surface receptor | Q2476074 | ||
biomedical investigative technique | Q66648976 | ||
apoptosis regulatory proteins | Q76931142 | ||
P304 | page(s) | e1259 | |
P577 | publication date | 2014-05-29 | |
P1433 | published in | Cell Death and Disease | Q2197222 |
P1476 | title | Systems biology of death receptor networks: live and let die. | |
P478 | volume | 5 |
Q54965678 | A guide to automated apoptosis detection: How to make sense of imaging flow cytometry data. |
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Q46685680 | Berbamine inhibited the growth of prostate cancer cells in vivo and in vitro via triggering intrinsic pathway of apoptosis |
Q38260863 | Cell death controlling complexes and their potential therapeutic role |
Q26767369 | Crosstalk between Autophagy and Apoptosis: Potential and Emerging Therapeutic Targets for Cardiac Diseases |
Q92783852 | Dissecting DISC regulation via pharmacological targeting of caspase-8/c-FLIPL heterodimer |
Q59132736 | Evaluating the Remote Control of Programmed Cell Death, with or without a Compensatory Cell Proliferation |
Q26773368 | FLIP the Switch: Regulation of Apoptosis and Necroptosis by cFLIP |
Q91329978 | Long and short isoforms of c-FLIP act as control checkpoints of DED filament assembly |
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Q36008004 | MicroRNA-106a functions as an oncogene in human gastric cancer and contributes to proliferation and metastasis in vitro and in vivo |
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Q37706731 | Sensitization of glycoengineered interferon-β1a-resistant cancer cells by cFLIP inhibition for enhanced anti-cancer therapy. |
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Q47233391 | The role of the Fas/FasL signaling pathway in environmental toxicant-induced testicular cell apoptosis: An update |
Q40539016 | Vasopressin Impairment During Sepsis Is Associated with Hypothalamic Intrinsic Apoptotic Pathway and Microglial Activation |
Q34377287 | p53 Family and Cellular Stress Responses in Cancer |
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