Molecular basis of hair cell loss

scientific article

Molecular basis of hair cell loss is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1008871568
P356DOI10.1007/S00441-015-2113-Z
P698PubMed publication ID25676005

P2093author name stringDavid N Furness
P2860cites workDeath pathways in noise-damaged outer hair cellsQ23910294
Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosisQ24798477
Regulation of the intrinsic apoptosis pathway by reactive oxygen speciesQ26995793
Functional hair cell mechanotransducer channels are required for aminoglycoside ototoxicityQ27331620
Endonuclease G is an apoptotic DNase when released from mitochondriaQ28206238
Apoptosis-inducing factor (AIF): a novel caspase-independent death effector released from mitochondriaQ28218562
Aminoglycoside ototoxicityQ28221225
A microRNA component of the p53 tumour suppressor networkQ28305330
Nitric oxide: promoter or suppressor of programmed cell death?Q28394862
Age-related cochlear hair cell loss is enhanced in mice lacking copper/zinc superoxide dismutaseQ28504993
Two classes of outer hair cells along the tonotopic axis of the cochleaQ28508990
TNFα induces survival through the FLIP-L-dependent activation of the MAPK/ERK pathwayQ28580836
Membrane disruption: an early event of hair cell apoptosis induced by exposure to intense noiseQ30412661
Oxidative stresses and mitochondrial dysfunction in age-related hearing lossQ30433206
Receptor-interacting protein kinases modulate noise-induced sensory hair cell deathQ30436802
Inner ear supporting cells: rethinking the silent majority.Q30439408
Human cochlea: anatomical characteristics and their relevance for cochlear implantationQ38050303
Hearing loss and deafness in the pediatric population: causes, diagnosis, and rehabilitationQ38102263
Systems biology of death receptor networks: live and let die.Q38215866
Necroptosis, in vivo detection in experimental disease modelsQ38243739
N-Acetyl-cysteine against noise-induced temporary threshold shift in male workersQ38371813
Anatomy of cochlear innervationQ39838457
Cisplatin-induced apoptosis in auditory cells: role of death receptor and mitochondrial pathwaysQ40689887
Proapoptotic Bax and Bak proteins form stable protein-permeable pores of tunable sizeQ41955014
Cell death in the inner ear associated with aging is apoptosis?Q42434955
Gentamicin-induced hair cell death is not dependent on the apoptosis receptor Fas.Q42437793
Cochlear cultures as a model system for studying aminoglycoside induced ototoxicityQ42472001
Microslicing of the resin-embedded cochlea in comparison with the surface preparation technique for analysis of hair cell number and morphologyQ42502818
Differential vulnerability of basal and apical hair cells is based on intrinsic susceptibility to free radicalsQ42503821
Low dose oxidative stress induces mitochondrial damage in hair cellsQ42513871
Trichostatin A protects against cisplatin-induced ototoxicity by regulating expression of genes related to apoptosis and synaptic functionQ42712060
Trimethyltin chloride induced chloride secretion across rat distal colonQ43233635
The role of macrophages in the disposal of degeneration products within the organ of corti after acoustic overstimulationQ43655715
Cisplatin otoprotection using transtympanic L-N-acetylcysteine: a pilot randomized study in head and neck cancer patientsQ44242814
Degeneration of sensory outer hair cells following pharmacological blockade of cochlear KCNQ channels in the adult guinea pig.Q44489167
Dose and time-dependent protection of the antioxidant N-L-acetylcysteine against impulse noise traumaQ44906311
Topical application of the antiapoptotic TAT-FNK protein prevents aminoglycoside-induced ototoxicityQ45876050
Stimulation of free radical formation by aminoglycoside antibioticsQ46166059
Outer hair cell loss and supporting cell expansion following chronic gentamicin treatmentQ46242957
Intense noise induces formation of vasoactive lipid peroxidation products in the cochleaQ46265724
Noise-induced hearing loss (NIHL) as a target of oxidative stress-mediated damage: cochlear and cortical responses after an increase in antioxidant defense.Q46345303
Morphological changes to the stereociliary bundles in the guinea pig cochlea after kanamycin treatmentQ46353363
Macrophage contribution to the response of the rat organ of Corti to amikacin.Q46533785
Qualitative and quantitative changes in the guinea pig organ of Corti after pure tone acoustic overstimulationQ46816186
AIF and endoG translocation in noise exposure induced hair cell deathQ46920722
A protein derived from the fusion of TAT peptide and FNK, a Bcl-x(L) derivative, prevents cochlear hair cell death from aminoglycoside ototoxicity in vivoQ48227895
Inhibition of H3K4me2 Demethylation Protects Auditory Hair Cells from Neomycin-Induced ApoptosisQ48598921
The composition and role of cross links in mechanoelectrical transduction in vertebrate sensory hair cellsQ50357231
Noise-induced alterations in cochlear mechanics, electromotility, and cochlear amplificationQ50357914
Mitochondria-targeted antioxidant MitoQ reduces gentamicin-induced ototoxicityQ50426038
A putative role of p53 pathway against impulse noise induced damage as demonstrated by protection with pifithrin-alpha and a Src inhibitorQ50426103
Cell death after co-administration of cisplatin and ethacrynic acidQ50461970
Reduction of noise-induced hearing loss using L-NAC and salicylate in the chinchilla.Q50494195
Mechanism of cisplatin ototoxicity: antioxidant system.Q50519742
Effect of absence of cochlear outer hair cells on behavioural auditory thresholdQ52313819
Apoptosis of guinea pig cochlear hair cells following chronic aminoglycoside treatment.Q52530430
Protective role of NecroX-5 against neomycin-induced hair cell damage in zebrafish.Q53316232
Protective effect of NecroX, a novel necroptosis inhibitor, on gentamicin-induced ototoxicity.Q53371567
Fas ligand expression in the organ of Corti.Q54761650
The development, distribution and density of the plasma membrane calcium ATPase 2 calcium pump in rat cochlear hair cellsQ30451399
Efficacy of three drugs for protecting against gentamicin-induced hair cell and hearing lossesQ30452815
Apoptosis in acquired and genetic hearing impairment: the programmed death of the hair cellQ30461482
Relative time course of degeneration of different cochlear structures in the CD/1 mouse model of accelerated agingQ30465212
Gentamicin rapidly inhibits mitochondrial metabolism in high-frequency cochlear outer hair cellsQ30466528
Differential expression of apoptosis-related genes in the cochlea of noise-exposed ratsQ30480619
Apoptosis-related genes change their expression with age and hearing loss in the mouse cochleaQ30482886
Rapid hair cell loss: a mouse model for cochlear lesionsQ30490976
Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis.Q30491795
Caspase-independent pathways of hair cell death induced by kanamycin in vivoQ30499344
Intense noise-induced apoptosis in hair cells of guinea pig cochleaeQ33180225
Oxidative stress-induced apoptosis of cochlear sensory cells: otoprotective strategiesQ33861807
ER-mitochondrial calcium flow underlies vulnerability of mechanosensory hair cells to damageQ33906624
Brain-specific knockdown of miR-29 results in neuronal cell death and ataxia in miceQ33929052
Impaired clearance of apoptotic cells in chronic inflammatory diseases: therapeutic implicationsQ33984427
Alternative cell death mechanisms in development and beyondQ34362382
The sensory and motor roles of auditory hair cellsQ34478832
NAC for noise: from the bench top to the clinicQ34573552
Mechanisms of cisplatin-induced ototoxicity and preventionQ34582682
Damage of the basilar membrane by acoustic stimulationQ34717333
Mitogen-activated protein kinase pathways in redox signalingQ35011377
Crosstalk of reactive oxygen species and NF-κB signalingQ35347850
The anticancer drug cisplatin induces an intrinsic apoptotic pathway inside the inner ear.Q36171348
Supporting sensory transduction: cochlear fluid homeostasis and the endocochlear potentialQ36542382
miRNAs and apoptosis: RNAs to die for.Q36617814
Identifying microRNAs involved in degeneration of the organ of corti during age-related hearing loss.Q36805707
Different uptake of gentamicin through TRPV1 and TRPV4 channels determines cochlear hair cell vulnerabilityQ36809706
Myc-induced AMPK-phospho p53 pathway activates Bak to sensitize mitochondrial apoptosisQ36855285
Proteomic analysis of the balance between survival and cell death responses in cisplatin-mediated ototoxicityQ36943536
Life and death by death receptorsQ37233180
Molecular biology of Bax and Bak activation and actionQ37824965
Ca2+ homeostasis defects and hereditary hearing loss.Q37893568
Deciphering the rules of programmed cell death to improve therapy of cancer and other diseasesQ37921609
Age-related hearing loss: quality of care for quality of lifeQ37989909
P433issue1
P304page(s)387-399
P577publication date2015-02-13
P1433published inCell and Tissue ResearchQ1524113
P1476titleMolecular basis of hair cell loss
P478volume361

Reverse relations

cites work (P2860)
Q54962600Acute Noise Exposure Is Associated With Intrinsic Apoptosis in Murine Central Auditory Pathway.
Q30380086Auditory system: development, genetics, function, aging, and diseases.
Q27307804Characterization of ATPase Activity of P2RX2 Cation Channel
Q104135023Combinatorial Atoh1 and Gfi1 induction enhances hair cell regeneration in the adult cochlea
Q89574380Exosomes mediate sensory hair cell protection in the inner ear
Q27317317Functional development of mechanosensitive hair cells in stem cell-derived organoids parallels native vestibular hair cells.
Q35986030Natural Bizbenzoquinoline Derivatives Protect Zebrafish Lateral Line Sensory Hair Cells from Aminoglycoside Toxicity
Q77789888Novel QUEST MRI in vivo measurement of noise-induced oxidative stress in the cochlea
Q64115836OHC-TRECK: A Novel System Using a Mouse Model for Investigation of the Molecular Mechanisms Associated with Outer Hair Cell Death in the Inner Ear
Q88595779Osmotic stabilization prevents cochlear synaptopathy after blast trauma
Q47813284Peroxynitrite induces apoptosis of mouse cochlear hair cells via a Caspase-independent pathway in vitro
Q90084356Pleiotrophin increases neurite length and number of spiral ganglion neurons in vitro
Q28551590Prestin-Dependence of Outer Hair Cell Survival and Partial Rescue of Outer Hair Cell Loss in PrestinV499G/Y501H Knockin Mice
Q41170353Recent Advancements in the Regeneration of Auditory Hair Cells and Hearing Restoration
Q50315610Reduction of permanent hearing loss by local glucocorticoid application : Guinea pigs with acute acoustic trauma. German version
Q46407017Reduction of permanent hearing loss by local glucocorticoid application : Guinea pigs with acute acoustic trauma
Q27314582Regeneration of Sensory Hair Cells Requires Localized Interactions between the Notch and Wnt Pathways.
Q39015106Signaling in the Auditory System: Implications in Hair Cell Regeneration and Hearing Function

Search more.