Cisplatin otoprotection using transtympanic L-N-acetylcysteine: a pilot randomized study in head and neck cancer patients

scientific article published in October 2013

Cisplatin otoprotection using transtympanic L-N-acetylcysteine: a pilot randomized study in head and neck cancer patients is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/LARY.24360
P698PubMed publication ID23946126

P2093author name stringJohn Yoo
Eric Winquist
Kevin Fung
Lorne S Parnes
Varagur Venkatesan
Jason Franklin
Denise Lewis
Douglas Angel
Scott J Hamilton
P2860cites workAnalysis of risk factors for cisplatin-induced ototoxicity in patients with testicular cancerQ30486848
Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: three meta-analyses of updated individual data. MACH-NC Collaborative Group. Meta-Analysis of Chemotherapy on Head and Neck Cancer.Q30591228
Cisplatin, fluorouracil, and docetaxel in unresectable head and neck cancerQ33377142
Application of antioxidants and other agents to prevent cisplatin ototoxicityQ33777748
Intratympanic steroids for inner ear disorders: a reviewQ35013597
Comparison of five agents in protecting the cochlea against the ototoxic effects of cisplatin in the hamsterQ36891791
Clinical pharmacokinetics of N-acetylcysteineQ37713718
Intravenous acetylcysteine for the treatment of acetaminophen overdoseQ37815203
Cisplatin rescue therapy: experience with sodium thiosulfate, WR2721, and diethyldithiocarbamateQ37903232
Acetaminophen and acetylcysteine dose and duration: past, present and future.Q37982762
Oral vs intratympanic corticosteroid therapy for idiopathic sudden sensorineural hearing loss: a randomized trial.Q38490567
Concurrent chemoradiotherapy in the management of squamous cell cancer of the oropharynx: current standards and future directionsQ40163496
Cisplatin-induced ototoxicity: the effect of pigmentation and inhibitory agentsQ40892797
Cisplatin-induced ototoxicity: audiometric findings and experimental cochlear pathologyQ42436551
Effect of 4-methylthiobenzoic acid on cisplatin-induced ototoxicity in the rat.Q42472901
D-Methionine protects against cisplatin damage to the stria vascularisQ42480391
Effects of alpha-tocopherol on cisplatin-induced ototoxicity in guinea pigsQ42497488
Round window application of D-methionine provides complete cisplatin otoprotectionQ42522966
D-methionine provides excellent protection from cisplatin ototoxicity in the rat.Q42527795
Differential damage to auditory neurons and hair cells by ototoxins and neuroprotection by specific neurotrophins in rat cochlear organotypic culturesQ42552469
Round window membrane delivery of L-methionine provides protection from cisplatin ototoxicity without compromising chemotherapeutic efficacyQ43639242
L-n-acetyl-cysteine protection against cisplatin-induced auditory neuronal and hair cell toxicityQ43745674
4-Methylthiobenzoic acid reduces cisplatin nephrotoxicity in rats without compromising anti-tumour activity.Q43917100
Round window application of D-methionine, sodium thiosulfate, brain-derived neurotrophic factor, and fibroblast growth factor-2 in cisplatin-induced ototoxicityQ44729016
Protection against cisplatin-induced ototoxicity by N-acetylcysteine in a rat modelQ44952944
Prevention of cisplatin ototoxicity using transtympanic N-acetylcysteine and lactateQ45152818
Changes in the stria vascularis of the guinea pig due to cis-platinumQ46264909
Protection against cisplatin-induced toxicities by N-acetylcysteine and sodium thiosulfate as assessed at the molecular, cellular, and in vivo levelsQ46542133
Cisplatin and fluorouracil alone or with docetaxel in head and neck cancerQ46932585
Introduction to sample size determination and power analysis for clinical trialsQ47281427
Transtympanic injections of N-acetylcysteine for the prevention of cisplatin-induced ototoxicity: a feasible method with promising efficacyQ48208401
cis-platinum ototoxicity in childrenQ48661276
Ototoxic protection of sodium thiosulfate: daily vs constant infusion.Q50479115
Local application of sodium thiosulfate prevents cisplatin-induced hearing loss in the guinea pig.Q50482976
Ototoxicity caused by cisplatin is ameliorated by melatonin and other antioxidants.Q50497431
Mechanism of cisplatin ototoxicity: antioxidant system.Q50519742
Cisplatin: evaluation of its ototoxic potential.Q53744914
Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer.Q53794992
High-dose cisplatin in patients with advanced malignancies.Q53855067
Postoperative Concurrent Radiotherapy and Chemotherapy for High-Risk Squamous-Cell Carcinoma of the Head and NeckQ56532861
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectcisplatinQ412415
head and neck cancerQ1783924
head and neck carcinomaQ18554836
neck cancerQ18966654
P304page(s)E87-94
P577publication date2013-10-01
P1433published inThe LaryngoscopeQ15755068
P1476titleCisplatin otoprotection using transtympanic L-N-acetylcysteine: a pilot randomized study in head and neck cancer patients
P478volume124

Reverse relations

cites work (P2860)
Q61447782A randomized controlled trial to test the efficacy of trans-tympanic injections of a sodium thiosulfate gel to prevent cisplatin-induced ototoxicity in patients with head and neck cancer
Q38582633A systematic review and meta-analysis of the efficacy and safety of N-acetylcysteine in preventing aminoglycoside-induced ototoxicity: implications for the treatment of multidrug-resistant TB.
Q28543956Apaf-1 inhibitors protect from unwanted cell death in in vivo models of kidney ischemia and chemotherapy induced ototoxicity
Q54698100Biological Activities and Potential Oral Applications of N-Acetylcysteine: Progress and Prospects.
Q38937722Bromelain and N-acetylcysteine inhibit proliferation and survival of gastrointestinal cancer cells in vitro: significance of combination therapy
Q37641278Cisplatin-induced mitochondrial dysfunction is associated with impaired cognitive function in rats
Q42281143Dose escalation study of intravenous and intra-arterial N-acetylcysteine for the prevention of oto- and nephrotoxicity of cisplatin with a contrast-induced nephropathy model in patients with renal insufficiency.
Q33847686Early investigational drugs for hearing loss
Q40470161Evidence of the presence of nucleic acids and β-glucan in the matrix of non-typeable Haemophilus influenzae in vitro biofilms.
Q30434847In vitro efficacy of N-acetylcysteine on bacteria associated with chronic suppurative otitis media
Q92499700Interventions for cisplatin-induced hearing loss in children and adolescents with cancer
Q91625343Mechanisms of Cisplatin-Induced Ototoxicity and Prevention
Q38353200Molecular basis of hair cell loss
Q36213831N-Acetyl-l-Cysteine and Cysteamine as New Strategies against Mixed Biofilms of Nonencapsulated Streptococcus pneumoniae and Nontypeable Haemophilus influenzae
Q28397956N-acetyl-cysteine prevents age-related hearing loss and the progressive loss of inner hair cells in γ-glutamyl transferase 1 deficient mice
Q91625325Otoprotectants: From Research to Clinical Application
Q26773384Oxidative Stress and Inflammation in Hepatic Diseases: Therapeutic Possibilities of N-Acetylcysteine
Q39348472Paradoxical roles of dual oxidases in cancer biology.
Q38866435Potentiation of chemotherapeutics by bromelain and N-acetylcysteine: sequential and combination therapy of gastrointestinal cancer cells
Q58762727Preparing for the incoming wave of biosimilars in oncology
Q26825493Prevention and restoration of hearing loss associated with the use of cisplatin
Q92183813Prevention of cisplatin-induced ototoxicity in children and adolescents with cancer: a clinical practice guideline
Q47716828Progress in the Development of Preventative Drugs for Cisplatin-Induced Hearing Loss.
Q42369948Protein Synthesis Inhibition and Activation of the c-Jun N-Terminal Kinase Are Potential Contributors to Cisplatin Ototoxicity
Q46941571Targeted amelioration of cisplatin-induced ototoxicity in guinea pigs
Q49936568The Development of a Nano-based Approach to Alleviate Cisplatin-Induced Ototoxicity
Q36064041The Protective Effect of Chrysin Against Cisplatin İnduced Ototoxicity in Rats
Q28535147Ups and downs of Viagra: revisiting ototoxicity in the mouse model