Inner ear supporting cells: rethinking the silent majority.

scientific article

Inner ear supporting cells: rethinking the silent majority. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.SEMCDB.2013.03.009
P932PMC publication ID4005836
P698PubMed publication ID23545368

P50authorGuoqiang WanQ63070009
P2093author name stringGabriel Corfas
Jennifer S Stone
P2860cites workSupporting sensory transduction: cochlear fluid homeostasis and the endocochlear potentialQ36542382
Regulation of cell fate in the sensory epithelia of the inner ear.Q36629867
Notch signalling pathway mediates hair cell development in mammalian cochleaQ22009040
Mammalian cochlear supporting cells can divide and trans-differentiate into hair cellsQ22251095
Tricellulin is a tight-junction protein necessary for hearingQ24337885
Structure, expression, and functional analysis of a Na(+)-dependent glutamate/aspartate transporter from rat brainQ24563212
Gene disruption of p27(Kip1) allows cell proliferation in the postnatal and adult organ of cortiQ24648170
Expression of Delta1 and Serrate1 (Jagged1) in the mouse inner earQ28143721
Math1 gene transfer generates new cochlear hair cells in mature guinea pigs in vivoQ28178896
Hey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of CortiQ28507372
Loss of Fgfr3 leads to excess hair cell development in the mouse organ of CortiQ28508562
The role of Math1 in inner ear development: Uncoupling the establishment of the sensory primordium from hair cell fate determinationQ28510708
Otoancorin, an inner ear protein restricted to the interface between the apical surface of sensory epithelia and their overlying acellular gels, is defective in autosomal recessive deafness DFNB22.Q28512415
Math1: an essential gene for the generation of inner ear hair cellsQ28513764
Hes1 is a negative regulator of inner ear hair cell differentiationQ28571952
Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesisQ28574686
Discrete cellular and subcellular localization of glutamine synthetase and the glutamate transporter GLAST in the rat vestibular end organQ28583043
p27(Kip1) links cell proliferation to morphogenesis in the developing organ of CortiQ28585281
Sox2 is required for sensory organ development in the mammalian inner earQ28585583
Smaller inner ear sensory epithelia in Neurog 1 null mice are related to earlier hair cell cycle exitQ28585974
Hey2 functions in parallel with Hes1 and Hes5 for mammalian auditory sensory organ developmentQ28587058
Math1 regulates development of the sensory epithelium in the mammalian cochleaQ28588010
A mouse model for human deafness DFNB22 reveals that hearing impairment is due to a loss of inner hair cell stimulation.Q28590148
Targeted disruption of otog results in deafness and severe imbalanceQ28592378
Hes1 and Hes5 activities are required for the normal development of the hair cells in the mammalian inner earQ28592816
Identification of Vangl2 and Scrb1 as planar polarity genes in mammalsQ28593071
The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner-ear sensory hair cellsQ28593180
Non-syndromic vestibular disorder with otoconial agenesis in tilted/mergulhador mice caused by mutations in otopetrin 1Q28593287
Fibroblast growth factor signaling regulates pillar cell development in the organ of cortiQ28594385
The human deafness-associated connexin 30 T5M mutation causes mild hearing loss and reduces biochemical coupling among cochlear non-sensory cells in knock-in miceQ28748215
Dual embryonic origin of the mammalian otic vesicle forming the inner ear.Q29395212
Over half the hair cells in the mouse utricle first appear after birth, with significant numbers originating from early postnatal mitotic production in peripheral and striolar growth zonesQ30416938
Atoh1 expression and function during auditory hair cell regeneration in post-hatch chickensQ30418494
PTK7 regulates myosin II activity to orient planar polarity in the mammalian auditory epitheliumQ30418906
Variations in shape-sensitive restriction points mirror differences in the regeneration capacities of avian and mammalian earsQ30430743
Epigenetic influences on sensory regeneration: histone deacetylases regulate supporting cell proliferation in the avian utricleQ30432406
Supporting cells eliminate dying sensory hair cells to maintain epithelial integrity in the avian inner ear.Q30433076
Cisplatin ototoxicity blocks sensory regeneration in the avian inner earQ30434857
Differential distribution of stem cells in the auditory and vestibular organs of the inner ear.Q30440778
Proliferative responses to growth factors decline rapidly during postnatal maturation of mammalian hair cell epitheliaQ30443396
Shape change controls supporting cell proliferation in lesioned mammalian balance epitheliumQ30443443
Fgf signaling regulates development and transdifferentiation of hair cells and supporting cells in the basilar papillaQ30452881
Inner hair cells are not required for survival of spiral ganglion neurons in the adult cochleaQ30453628
Regenerated hair cells can originate from supporting cell progeny: evidence from phototoxicity and laser ablation experiments in the lateral line systemQ30456826
EGFR signaling is required for regenerative proliferation in the cochlea: conservation in birds and mammalsQ30457709
Apoptosis in acquired and genetic hearing impairment: the programmed death of the hair cellQ30461482
MYC gene delivery to adult mouse utricles stimulates proliferation of postmitotic supporting cells in vitroQ30461978
Vezatin, an integral membrane protein of adherens junctions, is required for the sound resilience of cochlear hair cellsQ30463528
Replacement of hair cells after laser microbeam irradiation in cultured organs of corti from embryonic and neonatal mice.Q30464878
TAK1 expression in the cochlea: a specific marker for adult supporting cellsQ30465209
Inhibition of Notch activity promotes nonmitotic regeneration of hair cells in the adult mouse utriclesQ30468270
An RT-PCR analysis of mRNA for growth factor receptors in damaged and control sensory epithelia of rat utriclesQ30469058
Mature mice lacking Rbl2/p130 gene have supernumerary inner ear hair cells and supporting cells.Q30472107
Position-dependent patterning of spontaneous action potentials in immature cochlear inner hair cellsQ30472648
ErbB expression: the mouse inner ear and maturation of the mitogenic response to heregulinQ30473444
Effects of DAPT and Atoh1 overexpression on hair cell production and hair bundle orientation in cultured Organ of Corti from neonatal ratsQ30473592
CD44 is a marker for the outer pillar cells in the early postnatal mouse inner ear.Q30474323
A disorganized innervation of the inner ear persists in the absence of ErbB2.Q30475830
Nonneuronal cells regulate synapse formation in the vestibular sensory epithelium via erbB-dependent BDNF expressionQ30476197
Gap junctional hemichannel-mediated ATP release and hearing controls in the inner earQ30476549
Cell-specific inducible gene recombination in postnatal inner ear supporting cells and gliaQ30476683
Hesr1 and Hesr2 may act as early effectors of Notch signaling in the developing cochleaQ30481816
Notch regulation of progenitor cell behavior in quiescent and regenerating auditory epithelium of mature birds.Q30483576
ATP release through connexin hemichannels and gap junction transfer of second messengers propagate Ca2+ signals across the inner earQ30484892
Integration of a retrograde signal during synapse formation by glia-secreted TGF-β ligandQ36709333
Expression of Math1 and HES5 in the cochleae of wildtype and Jag2 mutant miceQ36824504
The development of the reticular lamina in the hamster: an examination of transitory features and their functional rolesQ36877305
Non-sensory cells in the deafened organ of Corti: approaches for repairQ36950155
Brain-derived neurotrophic factor and neurotrophin 3 mRNAs in the peripheral target fields of developing inner ear ganglia.Q37257997
Role of glial cells in the formation and maintenance of synapsesQ37636837
Planar cell polarity: keeping hairs straight is not so simpleQ37698284
Sensory regeneration in the vertebrate inner ear: differences at the levels of cells and speciesQ37757414
Planar cell polarity in the inner ear.Q38058904
Transcription factors that control inner ear development and their potential for transdifferentiation and reprogramming.Q38060458
Immune cytokines and dexamethasone influence sensory regeneration in the avian vestibular peripheryQ38459138
Ultrastructure and immunohistochemical identification of the extracellular matrix of the chinchilla cochleaQ39498707
Nectins establish a checkerboard-like cellular pattern in the auditory epitheliumQ39498953
S100 is preferentially distributed in myelin-forming Schwann cellsQ41190193
Response of the flat cochlear epithelium to forced expression of Atoh1.Q41272077
Developmental morphology of the mouse inner ear. A scanning electron microscopic observationQ41402294
Eya1-Six1 interaction is sufficient to induce hair cell fate in the cochlea by activating Atoh1 expression in cooperation with Sox2.Q41485484
Overexpression of Math1 induces robust production of extra hair cells in postnatal rat inner earsQ41736617
Dynamic expression of Lgr5, a Wnt target gene, in the developing and mature mouse cochleaQ41820010
Fine structure of the ordinary lateral line organ. II. The lateral line canal organ of spotted shark, Mustelus manazoQ42444106
Direct transdifferentiation gives rise to the earliest new hair cells in regenerating avian auditory epitheliumQ42467678
All functional aquaporin-4 isoforms are expressed in the rat cochlea and contribute to the formation of orthogonal arrays of particlesQ42489136
Cell division in the gerbil cochlea after acoustic trauma.Q42498101
Lack of brain-derived neurotrophic factor hampers inner hair cell synapse physiology, but protects against noise-induced hearing loss.Q42508462
Inner ear defects and hearing loss in mice lacking the collagen receptor DDR1.Q42521637
Prox1 expression in rod precursors and Müller cells.Q43246846
The presynaptic function of mouse cochlear inner hair cells during development of hearing.Q43653395
The role of macrophages in the disposal of degeneration products within the organ of corti after acoustic overstimulationQ43655715
Transforming growth factor-alpha-induced cellular changes in organotypic cultures of juvenile, amikacin-treated rat organ of corti.Q43831609
FGFR3 expression during development and regeneration of the chick inner ear sensory epithelia.Q43849600
Robust generation of new hair cells in the mature mammalian inner ear by adenoviral expression of Hath1.Q44042846
Basic fibroblast growth factor inhibits cell proliferation in cultured avian inner ear sensory epitheliaQ44874030
Progression of hair cell ejection and molecular markers of apoptosis in the avian cochlea following gentamicin treatmentQ44920105
Atoh1 expression defines activated progenitors and differentiating hair cells during avian hair cell regenerationQ44924680
Impaired permeability to Ins(1,4,5)P3 in a mutant connexin underlies recessive hereditary deafnessQ45183609
Organization of cell junctions and cytoskeleton in the reticular lamina in normal and ototoxically damaged organ of CortiQ46230453
Pharmacological inhibition of Notch signaling in the mature guinea pig cochleaQ46244953
Expression of candidate markers for stem/progenitor cells in the inner ears of developing and adult GFAP and nestin promoter-GFP transgenic miceQ46273133
Hair cell recovery in the vestibular sensory epithelia of mature guinea pigsQ46544464
Vestibular hair cell regeneration and restoration of balance function induced by math1 gene transferQ46713382
Notch signaling regulates the extent of hair cell regeneration in the zebrafish lateral line.Q46729652
The fate of outer hair cells after acoustic or ototoxic insultsQ46763690
The origin of spontaneous activity in the developing auditory system.Q46922216
Differential expression of bone morphogenetic proteins in the developing vestibular and auditory sensory organs.Q48059028
In vitro electrophysiological study of spontaneous activity in neonatal mouse vestibular ganglion neurons during developmentQ48379570
Notch-Hes1 pathway contributes to the cochlear prosensory formation potentially through the transcriptional down-regulation of p27Kip1.Q48523482
Immunocytochemical localization of a high-affinity glutamate-aspartate transporter, GLAST, in the rat and guinea-pig cochleaQ48577992
Specialized membrane domains for water transport in glial cells: high-resolution immunogold cytochemistry of aquaporin-4 in rat brain.Q48823528
Sox2 and JAGGED1 expression in normal and drug-damaged adult mouse inner ear.Q30490970
Influence of supporting cells on neuronal degeneration after hair cell lossQ30492612
Developmental regulation of spontaneous activity in the Mammalian cochleaQ30492955
Expression of Prox1 during mouse cochlear developmentQ30492966
Differential expression of unconventional myosins in apoptotic and regenerating chick hair cells confirms two regeneration mechanisms.Q30494211
Analysis of connexin subunits required for the survival of vestibular hair cellsQ30496805
Induction of cell proliferation in mammalian inner-ear sensory epithelia by transforming growth factor alpha and epidermal growth factorQ30530875
Targeted ablation of connexin26 in the inner ear epithelial gap junction network causes hearing impairment and cell deathQ30578611
Expression of p75NTR and its associated protein NADE in the rat cochleaQ30656023
A claudin-9-based ion permeability barrier is essential for hearing.Q33495556
Gipc1 has a dual role in Vangl2 trafficking and hair bundle integrity in the inner ear.Q33793330
Mutations in the gene encoding tight junction claudin-14 cause autosomal recessive deafness DFNB29.Q33932144
Molecular mechanisms of recovery from vestibular damage in mammals: recent advancesQ33935238
Claudin 14 knockout mice, a model for autosomal recessive deafness DFNB29, are deaf due to cochlear hair cell degenerationQ33967701
Notch signaling in the development of the inner ear: lessons from DrosophilaQ34069543
Restrictions in cell cycle progression of adult vestibular supporting cells in response to ectopic cyclin D1 expressionQ34071932
Gap junction-mediated intercellular biochemical coupling in cochlear supporting cells is required for normal cochlear functionsQ34084948
Deafness and renal tubular acidosis in mice lacking the K-Cl co-transporter Kcc4.Q34125574
The auditory hair cell ribbon synapse: from assembly to functionQ34282892
Regulation of cellular calcium in vestibular supporting cells by otopetrin 1Q34430287
Roles of fibroblast growth factors in the inner ear.Q34577340
Missense mutations in Otopetrin 1 affect subcellular localization and inhibition of purinergic signaling in vestibular supporting cellsQ34612758
Planar cell polarity in the inner ear: how do hair cells acquire their oriented structure?Q34968724
Hair cell regeneration: winging our way towards a sound future.Q35069014
Control of excitatory CNS synaptogenesis by astrocyte-secreted proteins Hevin and SPARCQ35164836
The role of connexins in human disease.Q35201418
Cell adhesion molecules during inner ear and hair cell development, including notch and its ligandsQ35607422
Age-dependent in vivo conversion of mouse cochlear pillar and Deiters' cells to immature hair cells by Atoh1 ectopic expressionQ35986490
Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptorsQ36058143
Wnt-responsive Lgr5-expressing stem cells are hair cell progenitors in the cochleaQ36160283
A myelin proteolipid protein-LacZ fusion protein is developmentally regulated and targeted to the myelin membrane in transgenic miceQ36233433
Atoh1 directs the formation of sensory mosaics and induces cell proliferation in the postnatal mammalian cochlea in vivoQ36336938
Fibroblast growth factor receptor 3 regulates microtubule formation and cell surface mechanical properties in the developing organ of CortiQ36480557
The growth of cochlear fibers and the formation of their synaptic endings in the avian inner ear: a study with the electron microscopeQ36493938
Immunolocalization of the calcium binding S100A1, S100A5 and S100A6 proteins in the dog cochlea during postnatal developmentQ48952789
Expression of the Sox10 gene during mouse inner ear developmentQ49159530
Expression and function of Sox21 during mouse cochlea development.Q50435198
Vestibular dysfunction of patients with mutations of Connexin 26.Q50471916
Survival of adult spiral ganglion neurons requires erbB receptor signaling in the inner ear.Q50477414
New hair cells arise from supporting cell conversion in the acoustically damaged chick inner ear.Q50515888
Hair cell regeneration after acoustic trauma in adult Coturnix quail.Q50563874
Regeneration of sensory hair cells after acoustic trauma.Q50563884
The glutamate-aspartate transporter GLAST mediates glutamate uptake at inner hair cell afferent synapses in the mammalian cochlea.Q50727558
Delta-like 1 and lateral inhibition during hair cell formation in the chicken inner ear: evidence against cis-inhibition.Q50784299
Spatiotemporal expression of otogelin in the developing and adult mouse inner ear.Q51063688
Fgf8 induces pillar cell fate and regulates cellular patterning in the mammalian cochlea.Q51980744
A morphogenetic wave of p27Kip1 transcription directs cell cycle exit during organ of Corti development.Q52014319
Planar polarity of hair cells in the chick inner ear is correlated with polarized distribution of c-flamingo-1 protein.Q52052470
Increase in efficiency and reduction in Ca2+ dependence of exocytosis during development of mouse inner hair cells.Q52061934
Glial fibrillary acidic protein expression and promoter activity in the inner ear of developing and adult mice.Q52126259
Developmental and cellular expression pattern of epithelial sodium channel alpha, beta and gamma subunits in the inner ear of the rat.Q52140661
Cell production in the chicken cochlea.Q52247024
Cell cycle regulation in the inner ear sensory epithelia: role of cyclin D1 and cyclin-dependent kinase inhibitors.Q54713440
Postnatal development of type I and type II hair cells in the mouse utricle: acquisition of voltage-gated conductances and differentiated morphologyQ61782294
Intercellular junctions in the reticular lamina of the organ of CortiQ67867077
Synchronization of hair cell regeneration in the chick cochlea following noise damageQ67926321
The avian inner ear. Continuous production of hair cells in vestibular sensory organs, but not in the auditory papillaQ67993031
The embryonic and postnatal development of the inner ear of the mouseQ68637919
Ultrastructural evidence for hair cell regeneration in the mammalian inner earQ70619029
Post-translational modifications of tubulin suggest that dynamic microtubules are present in sensory cells and stable microtubules are present in supporting cells of the mammalian cochleaQ71119581
Identification of the timing of S phase and the patterns of cell proliferation during hair cell regeneration in the chick cochleaQ72001365
Development of the inner ear of the mouse: a radioautographic study of terminal mitosesQ72334432
Mammalian vestibular hair cell regenerationQ72485240
Analysis of temporal and spatial patterns of rat vestibular hair cell differentiation by tritiated thymidine radioautographyQ72530276
Hair and supporting-cell differentiation during the development of the avian inner earQ72645925
Expression of Glial Fibrillary Acidic Protein in Immature OligodendrogliaQ72721299
Induction of cell proliferation in avian inner ear sensory epithelia by insulin-like growth factor-I and insulinQ73216109
Pattern formation in the basilar papilla: evidence for cell rearrangementQ73542533
Dynamic patterns of neurotrophin 3 expression in the postnatal mouse inner earQ79502596
Reciprocal regulation of presynaptic and postsynaptic proteins in bipolar spiral ganglion neurons by neurotrophinsQ80235036
Multiple roles of Notch signaling in cochlear developmentQ80390441
Transforming growth factor-activated kinase 1 induced in spinal astrocytes contributes to mechanical hypersensitivity after nerve injuryQ80755004
P433issue5
P304page(s)448-459
P577publication date2013-03-29
P1433published inSeminars in Cell & Developmental BiologyQ14330411
P1476titleInner ear supporting cells: rethinking the silent majority
P478volume24

Reverse relations

cites work (P2860)
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Q33649267microRNA-224 regulates Pentraxin 3, a component of the humoral arm of innate immunity, in inner ear inflammation

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