The molecular origin of anti-DNA antibodies.

scientific article

The molecular origin of anti-DNA antibodies. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.3109/08830188909086988
P698PubMed publication ID2491158

P50authorSamuel M. BeharQ42397777
P2093author name stringB Diamond
M D Scharff
S Corbet
P2860cites workSomatic generation of antibody diversityQ29616439
Avidity of anti-DNA antibodies in serum and IgG glomerular eluates from patients with systemic lupus erythematosus. Association of high avidity antinative DNA antibody with glomerulonephritisQ30449890
Somatic diversification of the S107 (T15) VH11 germ-line gene that encodes the heavy-chain variable region of antibodies to double-stranded DNA in (NZB x NZW)F1 miceQ33578476
Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouseQ34380142
High frequency of autoantibodies bearing cross-reactive idiotopes among hybridomas using VH7183 genes prepared from normal and autoimmune murine strainsQ34566686
Anti-DNA autoantibody-producing hybridomas of normal human lymphoid cell originQ34613899
Somatic diversification of S107 from an antiphosphocholine to an anti-DNA autoantibody is due to a single base change in its heavy chain variable regionQ34619489
Homology of the NH2-terminal amino acid sequences of the heavy and light chains of human monoclonal lupus autoantibodies containing the dominant 16/6 idiotypeQ34624483
Human and murine phosphorycholine-binding immunoglobulins: conserved subgroup and first hypervariable region of heavy chainsQ35006299
Antigen-binding mutants of mouse myeloma cellsQ35053978
The Three-Dimensional Structure of a Phosphorylcholine-Binding Mouse Immunoglobulin Fab and the Nature of the Antigen Binding SiteQ35114867
Isolation of hybridomas expressing a specific heavy chain variable region gene segment by using a screening technique that detects mRNA sequences in whole cell lysatesQ36257696
Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutininQ36261566
Somatic mutation in a cultured mouse myeloma cell affects antigen bindingQ36283076
Single amino acid substitution altering antigen-binding specificityQ36287596
Polymorphism in immunoglobulin heavy chains suggesting gene conversionQ36296681
Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusionsQ36302303
Anti-phosphorylcholine antibodies of the T15 idiotype are optimally protective against Streptococcus pneumoniaeQ36346976
Induction of murine autoimmune disease by chronic polyclonal B cell activationQ36347616
Immunochemical similarities between monoclonal antibacterial Waldenstrom's macroglobulins and monoclonal anti-DNA lupus autoantibodiesQ36350070
Diversity in the germline antibody repertoire. Molecular evolution of the T15 VN gene familyQ36351376
Variable region sequences of murine IgM anti-IgG monoclonal autoantibodies (rheumatoid factors). A structural explanation for the high frequency of IgM anti-IgG B cellsQ36352229
A single germline VH gene segment of normal A/J mice encodes autoantibodies characteristic of systemic lupus erythematosusQ36352279
A human monoclonal macroglobulin with specificity for alpha(2----8)-linked poly-N-acetyl neuraminic acid, the capsular polysaccharide of group B meningococci and Escherichia coli K1, which crossreacts with polynucleotides and with denatured DNAQ36352307
Variable region sequences of murine IgM anti-IgG monoclonal autoantibodies (rheumatoid factors). II. Comparison of hybridomas derived by lipopolysaccharide stimulation and secondary protein immunization.Q36353493
Isolation and characterization of a light chain variable region gene for human rheumatoid factorsQ36354253
Point mutations cause the somatic diversification of IgM and IgG2a antiphosphorylcholine antibodiesQ36354592
Inter- and intraclonal diversity in the antibody response to influenza hemagglutininQ36355399
Interaction and sequence diversity among T15 VH genes in CBA/J miceQ36355441
Antibody diversity: somatic hypermutation of rearranged VH genesQ36587415
Somatic mutation of the T15 heavy chain gives rise to an antibody with autoantibody specificityQ37568701
Three-dimensional structure of antibodiesQ38189045
The genetic origin of autoantibodiesQ38257739
V genes encoding autoantibodies: molecular and phenotypic characteristicsQ39468473
Evolution of antibody variable region structure during the immune responseQ39658887
Mutation drift and repertoire shift in the maturation of the immune responseQ39658890
Timing, genetic requirements and functional consequences of somatic hypermutation during B-cell development.Q39658899
Somatic mutation in anti-phosphorylcholine antibodiesQ39658903
Studies on the somatic instability of immunoglobulin genes in vivo and in cultured cellsQ39658906
Immunopathogenesis of systemic lupus erythematosusQ39870333
CH Isotype 'Switching' During Normal B-Lymphocyte DevelopmentQ40076387
Idiotypic networks and other preconceived ideasQ40182559
Structural basis of antibody functionQ40204572
Two kappa immunoglobulin genes are expressed in the myeloma S107.Q45154465
A single VH gene segment encodes the immune response to phosphorylcholine: somatic mutation is correlated with the class of the antibodyQ48409127
Variability in the Lambda Light Chain Sequences of Mouse AntibodyQ52832029
Somatic mutation and the maturation of immune response to 2-phenyl oxazoloneQ58019387
Use of anti-idiotypic antibodies to explore genetic mechanisms of production of anti-DNA antibodiesQ59032652
The role of clonal selection and somatic mutation in autoimmunityQ59082893
P433issue1
P304page(s)23-42
P577publication date1989-01-01
P1433published inInternational Reviews of ImmunologyQ6052764
P1476titleThe molecular origin of anti-DNA antibodies
P478volume5

Reverse relations

cites work (P2860)
Q26824461A model for lupus brain disease
Q37410508Amelioration of lupus-like autoimmune disease in NZB/WF1 mice after treatment with a blocking monoclonal antibody specific for complement component C5.
Q67464544Cryptic T cell epitopes in polymorphic immunoglobulin regions: Evidence for positive repertoire selection during fetal development
Q46500837IRF3-dependent type I interferon response in B cells regulates CpG-mediated antibody production
Q72771976Lack of connectivity between the induced and autoimmune repertoires of lpr/lpr mice
Q40393393The Genetic Basis of Autoimmune Disease in MRL-lpr/lpr Mice
Q87773324The immunoglobulin heavy chain 3' regulatory region superenhancer controls mouse B1 B-cell fate and late VDJ repertoire diversity

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