| scholarly article | Q13442814 |
| review article | Q7318358 |
| P50 | author | Gideon Davies | Q18342394 |
| Spencer Williams | Q42690198 | ||
| Andrew James Thompson | Q43144579 | ||
| Gaetano Speciale | Q55978955 | ||
| P2860 | cites work | Mechanistic insights into glycosidase chemistry | Q37192688 |
| Structural analyses of enzymes involved in the O-GlcNAc modification | Q37568546 | ||
| Increasing O-GlcNAc levels: An overview of small-molecule inhibitors of O-GlcNAcase. | Q37576207 | ||
| Treating lysosomal storage diseases with pharmacological chaperones: from concept to clinics | Q37668227 | ||
| Developing inhibitors of glycan processing enzymes as tools for enabling glycobiology. | Q38027408 | ||
| Transition States, analogues, and drug development | Q38069211 | ||
| Mechanistic insights into the 1,3-xylanases: useful enzymes for manipulation of algal biomass | Q38328114 | ||
| Reassessment of acarbose as a transition state analogue inhibitor of cyclodextrin glycosyltransferase | Q38330289 | ||
| Transition state analog inhibitors and enzyme catalysis | Q39106066 | ||
| Reaction of beta-d-Glucosidase A3 from Aspergillus wentii with d-Glucal | Q41131388 | ||
| On the antiperiplanar lone pair hypothesis and its application to catalysis by glycosidases | Q41581419 | ||
| Chemical insight into the emergence of influenza virus strains that are resistant to Relenza | Q42272438 | ||
| Use of peptide aldehydes to generate transition-state analogs of elastase | Q44335259 | ||
| Binding Energy and Catalysis: The Implications for Transition-State Analogs and Catalytic Antibodies. | Q45964704 | ||
| Structural insights into the catalytic mechanism of Trypanosoma cruzi trans-sialidase | Q47640497 | ||
| Mechanism of Agrobacterium beta-glucosidase: kinetic analysis of the role of noncovalent enzyme/substrate interactions. | Q52321039 | ||
| Molecular mechanism of the glycosylation step catalyzed by Golgi alpha-mannosidase II: a QM/MM metadynamics investigation. | Q52705531 | ||
| Recent Insights into Inhibition, Structure, and Mechanism of Configuration-Retaining Glycosidases. | Q52715067 | ||
| Aldehydes as Inhibitors of Papain | Q54636763 | ||
| Substrate Distortion by a Lichenase Highlights the Different Conformational Itineraries Harnessed by Related Glycoside Hydrolases | Q60238228 | ||
| Common Inhibition of Both β-Glucosidases and β-Mannosidases by Isofagomine Lactam Reflects Different Conformational Itineraries for Pyranoside Hydrolysis | Q60238249 | ||
| Role of sugar hydroxyl groups in glycoside hydrolysis. Cleavage mechanism of deoxyglucosides and related substrates by beta-glucosidase A3 from Aspergillus wentii | Q71541016 | ||
| Glycosidase mechanisms: anatomy of a finely tuned catalyst | Q73364193 | ||
| Insights into mucopolysaccharidosis I from the structure and action of α-L-iduronidase | Q24336251 | ||
| Sugar ring distortion in the glycosyl-enzyme intermediate of a family G/11 xylanase | Q27618055 | ||
| Catalysis and specificity in enzymatic glycoside hydrolysis: a 2,5B conformation for the glycosyl-enzyme intermediate revealed by the structure of the Bacillus agaradhaerens family 11 xylanase | Q27618772 | ||
| A structural view of the action of Escherichia coli (lacZ) beta-galactosidase | Q27636550 | ||
| Distortion of a cellobio-derived isofagomine highlights the potential conformational itinerary of inverting beta-glucosidases | Q27641245 | ||
| The Cellvibrio japonicus Mannanase CjMan26C Displays a Unique exo-Mode of Action That Is Conferred by Subtle Changes to the Distal Region of the Active Site | Q27652206 | ||
| Mechanistic insights into a Ca2+-dependent family of α-mannosidases in a human gut symbiont | Q27659017 | ||
| Analysis of a New Family of Widely Distributed Metal-independent α-Mannosidases Provides Unique Insight into the Processing of N -Linked Glycans | Q27667236 | ||
| Structural and mechanistic insight into N-glycan processing by endo-α-mannosidase | Q27676550 | ||
| Analysis of Keystone Enzyme in Agar Hydrolysis Provides Insight into the Degradation (of a Polysaccharide from) Red Seaweeds | Q27677860 | ||
| Human α-l-iduronidase uses its own N -glycan as a substrate-binding and catalytic module | Q27679724 | ||
| Structural snapshots illustrate the catalytic cycle of β-galactocerebrosidase, the defective enzyme in Krabbe disease | Q27680741 | ||
| Combined Inhibitor Free-Energy Landscape and Structural Analysis Reports on the Mannosidase Conformational Coordinate | Q27680888 | ||
| The reaction coordinate of a bacterial GH47 α-mannosidase: a combined quantum mechanical and structural approach | Q27682479 | ||
| Active site plasticity within the glycoside hydrolase NagZ underlies a dynamic mechanism of substrate distortion | Q27683501 | ||
| Influenza neuraminidase operates via a nucleophilic mechanism and can be targeted by covalent inhibitors | Q27684045 | ||
| Mechanism-based covalent neuraminidase inhibitors with broad-spectrum influenza antiviral activity | Q27684054 | ||
| X-ray crystallographic studies of family 11 xylanase Michaelis and product complexes: implications for the catalytic mechanism | Q27688881 | ||
| Bacterial chitobiase structure provides insight into catalytic mechanism and the basis of Tay-Sachs disease | Q27732881 | ||
| The conformational free energy landscape of beta-D-glucopyranose. Implications for substrate preactivation in beta-glucoside hydrolases | Q28240539 | ||
| Mycobacterium tuberculosis strains possess functional cellulases | Q28487153 | ||
| Rational design of potent sialidase-based inhibitors of influenza virus replication | Q29616647 | ||
| The carbohydrate-active enzymes database (CAZy) in 2013 | Q29617118 | ||
| The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design. | Q30356303 | ||
| Turnover is rate-limited by deglycosylation for Micromonospora viridifaciens sialidase-catalyzed hydrolyses: conformational implications for the Michaelis complex | Q34164726 | ||
| Conformational analyses of the reaction coordinate of glycosidases | Q34216875 | ||
| Emerging principles for the therapeutic exploitation of glycosylation. | Q34395447 | ||
| Thiooligosaccharides as tools for structural biology | Q34518281 | ||
| How sugars pucker: electronic structure calculations map the kinetic landscape of five biologically paramount monosaccharides and their implications for enzymatic catalysis. | Q35075956 | ||
| Covalent inhibitors of glycosidases and their applications in biochemistry and biology | Q37171562 | ||
| P921 | main subject | enzyme | Q8047 |
| biomedical investigative technique | Q66648976 | ||
| P304 | page(s) | 1-13 | |
| P577 | publication date | 2014-07-10 | |
| 2014-10-01 | |||
| P1433 | published in | Current Opinion in Structural Biology | Q15758416 |
| P1476 | title | Dissecting conformational contributions to glycosidase catalysis and inhibition | |
| P478 | volume | 28 |
| Q41162446 | 1,6-Cyclophellitol Cyclosulfates: A New Class of Irreversible Glycosidase Inhibitor |
| Q41063159 | A Bacteroidetes locus dedicated to fungal 1,6-β-glucan degradation: Unique substrate conformation drives specificity of the key endo-1,6-β-glucanase. |
| Q48027369 | A front-face 'SNi synthase' engineered from a retaining 'double-SN2' hydrolase. |
| Q40347230 | A β-Mannanase with a Lysozyme-like Fold and a Novel Molecular Catalytic Mechanism |
| Q48786307 | Ab initio modelling of the anomeric and exo anomeric effects in 2-methoxytetrahydropyran and 2-methoxythiane corrected for intramolecular BSSE. |
| Q34557558 | Activity-based probes for functional interrogation of retaining β-glucuronidases |
| Q92667389 | Adaptation of Syntenic Xyloglucan Utilization Loci of Human Gut Bacteroidetes to Polysaccharide Side Chain Diversity |
| Q38714993 | An evolutionarily distinct family of polysaccharide lyases removes rhamnose capping of complex arabinogalactan proteins |
| Q57990887 | Benchmarking of density functionals for the kinetics and thermodynamics of the hydrolysis of glycosidic bonds catalyzed by glycosidases |
| Q91105935 | Biochemical characterisation of four rhamnosidases from thermophilic bacteria of the genera Thermotoga, Caldicellulosiruptor and Thermoclostridium |
| Q42256067 | Carba-cyclophellitols Are Neutral Retaining-Glucosidase Inhibitors. |
| Q48198854 | Carbohydrate anomalies in the PDB. |
| Q41701518 | Complex pectin metabolism by gut bacteria reveals novel catalytic functions. |
| Q64078609 | Conformational Itinerary of Sucrose During Hydrolysis by Retaining Amylosucrase |
| Q28818125 | Contribution of Shape and Charge to the Inhibition of a Family GH99 endo-α-1,2-Mannanase |
| Q27300714 | Detection of Active Mammalian GH31 α-Glucosidases in Health and Disease Using In-Class, Broad-Spectrum Activity-Based Probes |
| Q36155089 | Direct determination of protonation states and visualization of hydrogen bonding in a glycoside hydrolase with neutron crystallography |
| Q57047286 | Distinguishing the differences in beta-glycosylceramidase folds, dynamics, and actions informs therapeutic uses |
| Q90232603 | Enzymes from Marine Polar Regions and Their Biotechnological Applications |
| Q27698498 | Evidence for a boat conformation at the transition state of GH76 α-1,6-mannanases--key enzymes in bacterial and fungal mannoprotein metabolism |
| Q52619349 | Gluco-1 H-imidazole: A New Class of Azole-Type β-Glucosidase Inhibitor. |
| Q90395580 | Glucocerebrosidase: Functions in and Beyond the Lysosome |
| Q92073912 | Heparanase: A Challenging Cancer Drug Target |
| Q49642846 | Insights into the roles of non-catalytic residues in the active site of a GH10 xylanase with activity on cellulose |
| Q91968345 | Intrinsic dynamic behavior of enzyme:substrate complexes govern the catalytic action of β-galactosidases across clan GH-A |
| Q36724836 | Ligand-binding specificity and promiscuity of the main lignocellulolytic enzyme families as revealed by active-site architecture analysis |
| Q52668535 | Mechanism of the Escherichia coli MltE lytic transglycosylase, the cell-wall-penetrating enzyme for Type VI secretion system assembly. |
| Q64285134 | Molecular Basis of Broad Spectrum -Glycan Specificity and Processing of Therapeutic IgG Monoclonal Antibodies by Endoglycosidase S2 |
| Q57280155 | New irreversible α-L-iduronidase inhibitors and activity-based probes |
| Q89694690 | Rational Design of Mechanism-Based Inhibitors and Activity-Based Probes for the Identification of Retaining α-l-Arabinofuranosidases |
| Q34615790 | Recent advances in employing molecular modelling to determine the specificity of glycan-binding proteins. |
| Q58786771 | Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level |
| Q90691280 | Ring Puckering Landscapes of Glycosaminoglycan-Related Monosaccharides from Molecular Dynamics Simulations |
| Q34501966 | Structural characterization of human heparanase reveals insights into substrate recognition. |
| Q57050919 | Structure and function of a glycoside hydrolase family 8 endoxylanase from Teredinibacter turnerae |
| Q47340402 | Structure-guided engineering of the substrate specificity of a fungal β-glucuronidase toward triterpenoid saponins |
| Q35811933 | Synthesis of 2-deoxy-2,2-difluoro-α-maltosyl fluoride and its X-ray structure in complex with Streptomyces coelicolor GlgEI-V279S. |
| Q46412085 | The Impact of Heteromultivalency in Lectin Recognition and Glycosidase Inhibition: An Integrated Mechanistic Study |
| Q55325892 | The complete conformational free energy landscape of β-xylose reveals a two-fold catalytic itinerary for β-xylanases. |
| Q38843553 | Unusual active site location and catalytic apparatus in a glycoside hydrolase family. |
| Q27704029 | YihQ is a sulfoquinovosidase that cleaves sulfoquinovosyl diacylglyceride sulfolipids |
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