| scholarly article | Q13442814 |
| P356 | DOI | 10.1002/IJC.29081 |
| P698 | PubMed publication ID | 25130873 |
| P50 | author | Julien Ablain | Q63588995 |
| Hugues de Thé | Q33103207 | ||
| P2860 | cites work | Bexarotene is effective and safe for treatment of refractory advanced-stage cutaneous T-cell lymphoma: multinational phase II-III trial results | Q43594172 |
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| Distinct interactions of PML-RARalpha and PLZF-RARalpha with co-repressors determine differential responses to RA in APL. | Q54147247 | ||
| Single-agent liposomal all-trans retinoic acid can cure some patients with untreated acute promyelocytic leukemia: an update of The University of Texas M. D. Anderson Cancer Center Series. | Q54592312 | ||
| PML nuclear bodies | Q22065791 | ||
| Identification of a retinoic acid responsive element in the retinoic acid receptor beta gene | Q24300919 | ||
| Amino-terminal protein-protein interaction motif (POZ-domain) is responsible for activities of the promyelocytic leukemia zinc finger-retinoic acid receptor-alpha fusion protein | Q24308811 | ||
| Role of the polycomb repressive complex 2 in acute promyelocytic leukemia | Q24309258 | ||
| Small ubiquitin-like modifier-2 modification of retinoic acid receptor-alpha regulates its subcellular localization and transcriptional activity | Q24310064 | ||
| RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation | Q24320385 | ||
| The retinoic acid synthesis gene ALDH1a2 is a candidate tumor suppressor in prostate cancer | Q24323885 | ||
| The histone demethylase PHF8 governs retinoic acid response in acute promyelocytic leukemia | Q24337153 | ||
| A human retinoic acid receptor which belongs to the family of nuclear receptors | Q24339631 | ||
| The ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein | Q24523980 | ||
| Rearrangements of the retinoic acid receptor alpha and promyelocytic leukemia zinc finger genes resulting from t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia | Q24597732 | ||
| Retinoic acid synthesis and signaling during early organogenesis | Q24642848 | ||
| SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor alpha (RARalpha) and PLZF-RARalpha oncoproteins associated with acute promyelocytic leukemia | Q24653689 | ||
| The nuclear receptor superfamily: the second decade | Q27860725 | ||
| Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML | Q28118823 | ||
| Two critical hits for promyelocytic leukemia | Q28139515 | ||
| Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently | Q28208673 | ||
| Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor | Q28217975 | ||
| The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus | Q28241824 | ||
| Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17 | Q28255789 | ||
| Role of the histone deacetylase complex in acute promyelocytic leukaemia | Q28263534 | ||
| Identification of a receptor for the morphogen retinoic acid | Q28280559 | ||
| Acquisition of oncogenic potential by RAR chimeras in acute promyelocytic leukemia through formation of homodimers. | Q41745269 | ||
| PML-RAR{alpha} and Dnmt3a1 cooperate in vivo to promote acute promyelocytic leukemia | Q42029082 | ||
| Rearrangements and aberrant expression of the retinoic acid receptor alpha gene in acute promyelocytic leukemias | Q42220357 | ||
| The tumor suppressor Pml regulates cell fate in the developing neocortex | Q42447614 | ||
| Arsenic trioxide as an inducer of apoptosis and loss of PML/RAR alpha protein in acute promyelocytic leukemia cells | Q42545311 | ||
| PML/RARA oxidation and arsenic binding initiate the antileukemia response of As2O3. | Q42978007 | ||
| Oncogenic and cell survival properties of the retinoic acid metabolizing enzyme, CYP26A1. | Q43236391 | ||
| Combined effect of all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia cells in vitro and in vivo | Q43513950 | ||
| The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR | Q28300893 | ||
| Role of promyelocytic leukemia (PML) sumolation in nuclear body formation, 11S proteasome recruitment, and As2O3-induced PML or PML/retinoic acid receptor alpha degradation | Q28367104 | ||
| Positive and negative regulation of granulopoiesis by endogenous RARalpha | Q28510557 | ||
| Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation | Q28586404 | ||
| PML depletion disrupts normal mammary gland development and skews the composition of the mammary luminal cell progenitor pool | Q28590200 | ||
| The origin and evolution of mutations in acute myeloid leukemia | Q29614630 | ||
| Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia | Q29615735 | ||
| Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia | Q29616211 | ||
| Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies | Q29620390 | ||
| Retinoic acid regulates aberrant nuclear localization of PML-RAR alpha in acute promyelocytic leukemia cells | Q29620736 | ||
| A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein | Q29620737 | ||
| Retinoic acid and arsenic synergize to eradicate leukemic cells in a mouse model of acute promyelocytic leukemia | Q33178068 | ||
| Retinoic acid and arsenic trioxide for acute promyelocytic leukemia | Q33409020 | ||
| Arsenic trioxide controls the fate of the PML-RARalpha oncoprotein by directly binding PML. | Q33551142 | ||
| Comprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYC | Q33560429 | ||
| Single-agent arsenic trioxide in the treatment of newly diagnosed acute promyelocytic leukemia: long-term follow-up data | Q33636371 | ||
| Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia | Q33836409 | ||
| The induction of differentiation in teratocarcinoma stem cells by retinoic acid | Q33851753 | ||
| Treatment of high-risk neuroblastoma with intensive chemotherapy, radiotherapy, autologous bone marrow transplantation, and 13-cis-retinoic acid. Children's Cancer Group | Q33876841 | ||
| p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal | Q33953631 | ||
| PML/RARalpha and FLT3-ITD induce an APL-like disease in a mouse model | Q34032333 | ||
| PML-RARalpha/RXR Alters the Epigenetic Landscape in Acute Promyelocytic Leukemia. | Q34099047 | ||
| Retinoic acid signalling during development | Q34253095 | ||
| PML nuclear bodies: dynamic sensors of DNA damage and cellular stress | Q34346231 | ||
| Pathways of retinoic acid- or arsenic trioxide-induced PML/RARalpha catabolism, role of oncogene degradation in disease remission | Q34435558 | ||
| The incidence of acute promyelocytic leukemia appears constant over most of a human lifespan, implying only one rate limiting mutation | Q34508181 | ||
| All-trans retinoic acid/As2O3 combination yields a high quality remission and survival in newly diagnosed acute promyelocytic leukemia | Q34546653 | ||
| Use of all-trans retinoic acid plus arsenic trioxide as an alternative to chemotherapy in untreated acute promyelocytic leukemia | Q34563645 | ||
| PML targeting eradicates quiescent leukaemia-initiating cells | Q34591761 | ||
| Dimerization-induced corepressor binding and relaxed DNA-binding specificity are critical for PML/RARA-induced immortalization | Q34658550 | ||
| New role for granulocyte colony-stimulating factor-induced extracellular signal-regulated kinase 1/2 in histone modification and retinoic acid receptor α recruitment to gene promoters: relevance to acute promyelocytic leukemia cell differentiation. | Q35102049 | ||
| Cancer revoked: oncogenes as therapeutic targets | Q35118737 | ||
| The role of corepressors in transcriptional regulation by nuclear hormone receptors | Q35672518 | ||
| Mechanism of the nuclear receptor molecular switch | Q35846738 | ||
| Rara haploinsufficiency modestly influences the phenotype of acute promyelocytic leukemia in mice | Q35866178 | ||
| A PMLRARalpha transgene initiates murine acute promyelocytic leukemia | Q36049975 | ||
| Tumor-suppressive effect of the retinoic acid receptor beta in human epidermoid lung cancer cells | Q36084691 | ||
| RARgamma is critical for maintaining a balance between hematopoietic stem cell self-renewal and differentiation | Q36238093 | ||
| RARalpha-PLZF overcomes PLZF-mediated repression of CRABPI, contributing to retinoid resistance in t(11;17) acute promyelocytic leukemia | Q36276965 | ||
| Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid | Q36390529 | ||
| Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia | Q36515569 | ||
| Retinoic acid receptor beta mediates the growth-inhibitory effect of retinoic acid by promoting apoptosis in human breast cancer cells | Q36557548 | ||
| Molecular pathways: current role and future directions of the retinoic acid pathway in cancer prevention and treatment | Q36745391 | ||
| Uncoupling RARA transcriptional activation and degradation clarifies the bases for APL response to therapies | Q36750049 | ||
| Acute leukemia with promyelocytic features in PML/RARalpha transgenic mice | Q36771988 | ||
| Retinoic acid induces proteasome-dependent degradation of retinoic acid receptor alpha (RARalpha) and oncogenic RARalpha fusion proteins | Q36774571 | ||
| Protein kinases and the proteasome join in the combinatorial control of transcription by nuclear retinoic acid receptors | Q36806030 | ||
| Vitamin A and retinoid signaling: genomic and nongenomic effects | Q36920549 | ||
| Hidden abnormalities and novel classification of t(15;17) acute promyelocytic leukemia (APL) based on genomic alterations | Q37109353 | ||
| Long-term efficacy and safety of all-trans retinoic acid/arsenic trioxide-based therapy in newly diagnosed acute promyelocytic leukemia | Q37117735 | ||
| The PRC1 Polycomb group complex interacts with PLZF/RARA to mediate leukemic transformation | Q37200691 | ||
| Regulation of human hematopoietic stem cell self-renewal by the microenvironment's control of retinoic acid signaling | Q37218410 | ||
| Impairment of p53 acetylation, stability and function by an oncogenic transcription factor | Q37258978 | ||
| Acquired, nonrandom chromosomal abnormalities associated with the development of acute promyelocytic leukemia in transgenic mice | Q37292292 | ||
| PML nuclear bodies in the pathogenesis of acute promyelocytic leukemia: active players or innocent bystanders? | Q37410162 | ||
| Differentiation therapy of acute myeloid leukemia: past, present and future | Q37495367 | ||
| Mouse retinoic acid receptor alpha 2 isoform is transcribed from a promoter that contains a retinoic acid response element | Q37619937 | ||
| Retinoids, Retinoic Acid Receptors, and Cancer | Q37809078 | ||
| Revisiting the differentiation paradigm in acute promyelocytic leukemia | Q37858862 | ||
| The drug-induced degradation of oncoproteins: an unexpected Achilles' heel of cancer cells? | Q38010165 | ||
| Arsenic degrades PML or PML-RARalpha through a SUMO-triggered RNF4/ubiquitin-mediated pathway | Q39992451 | ||
| Genomewide array-based comparative genomic hybridization analysis of acute promyelocytic leukemia | Q40328303 | ||
| PML-RARA-RXR oligomers mediate retinoid and rexinoid/cAMP cross-talk in acute promyelocytic leukemia cell differentiation | Q40564729 | ||
| Leukocytosis and the retinoic acid syndrome in patients with acute promyelocytic leukemia treated with arsenic trioxide | Q40618562 | ||
| Control of normal cell differentiation and the phenotypic reversion of malignancy in myeloid leukaemia | Q40683687 | ||
| Esterification of all-trans-retinol in normal human epithelial cell strains and carcinoma lines from oral cavity, skin and breast: reduced expression of lecithin:retinol acyltransferase in carcinoma lines | Q40844636 | ||
| Evidence of epigenetic changes affecting the chromatin state of the retinoic acid receptor beta2 promoter in breast cancer cells | Q40891228 | ||
| P433 | issue | 10 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | tretinoin | Q29417 |
| leukemia | Q29496 | ||
| P304 | page(s) | 2262-2272 | |
| P577 | publication date | 2014-08-14 | |
| P1433 | published in | International Journal of Cancer | Q332492 |
| P1476 | title | Retinoic acid signaling in cancer: The parable of acute promyelocytic leukemia | |
| P478 | volume | 135 |
| Q37611247 | Antagonizing Retinoic Acid Receptors Increases Myeloid Cell Production by Cultured Human Hematopoietic Stem Cells |
| Q53232370 | Cancer research in France. |
| Q26785497 | Cancer stem cells are the cause of drug resistance in multiple myeloma: fact or fiction? |
| Q88913331 | Cell dynamics during differentiation therapy with all-trans retinoic acid in acute promyelocytic leukemia |
| Q33839179 | Diverse Regulation of Vitamin D Receptor Gene Expression by 1,25-Dihydroxyvitamin D and ATRA in Murine and Human Blood Cells at Early Stages of Their Differentiation |
| Q92432180 | Epigenetic loss of AOX1 expression via EZH2 leads to metabolic deregulations and promotes bladder cancer progression |
| Q27853287 | Impaired aldehyde dehydrogenase 1 subfamily member 2A-dependent retinoic acid signaling is related with a mesenchymal-like phenotype and an unfavorable prognosis of head and neck squamous cell carcinoma |
| Q64990535 | Manipulation of Epithelial Differentiation by HPV Oncoproteins. |
| Q50581791 | Modulating epigenetic memory through vitamins and TET: implications for regenerative medicine and cancer treatment. |
| Q49986992 | NLS-RARα is a novel transcriptional factor |
| Q40351225 | NRF2 Mediates Neuroblastoma Proliferation and Resistance to Retinoic Acid Cytotoxicity in a Model of In Vitro Neuronal Differentiation. |
| Q38922128 | Nuclear retinoid receptors and pregnancy: placental transfer, functions, and pharmacological aspects |
| Q92511137 | PTPN14 degradation by high-risk human papillomavirus E7 limits keratinocyte differentiation and contributes to HPV-mediated oncogenesis |
| Q45970621 | Plant homeodomain finger protein 2 as a novel IKAROS target in acute lymphoblastic leukemia. |
| Q27322080 | Preclinical mouse cancer models: a maze of opportunities and challenges |
| Q38752325 | Prognostic factors in acute promyelocytic leukemia: strategies to define high-risk patients |
| Q37707093 | RXRα ligand Z-10 induces PML-RARα cleavage and APL cell apoptosis through disrupting PML-RARα/RXRα complex in a cAMP-independent manner |
| Q90585361 | Retinoic Acid Receptor-β Is Downregulated in Hepatocellular Carcinoma and Cirrhosis and Its Expression Inhibits Myosin-Driven Activation and Durotaxis in Hepatic Stellate Cells |
| Q91727275 | Retinoic Acid Receptors in Acute Myeloid Leukemia Therapy |
| Q91529341 | Retinoic acid and arsenic trioxide induce lasting differentiation and demethylation of target genes in APL cells |
| Q33688613 | Retinoic acid receptor alpha drives cell cycle progression and is associated with increased sensitivity to retinoids in T-cell lymphoma |
| Q37673265 | Role of Vitamin A/Retinoic Acid in Regulation of Embryonic and Adult Hematopoiesis |
| Q93156286 | The Impact of Flt3 Gene Mutations in Acute Promyelocytic Leukemia: A Meta-Analysis |
| Q47990678 | The short isoform of PML-RARα activates the NRF2/HO-1 pathway through a direct interaction with NRF2. |
| Q37699371 | Tracing anti-cancer and cancer-promoting actions of all-trans retinoic acid in breast cancer to a RARα epigenetic mechanism of mammary epithelial cell fate |
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