Canagliflozin, a sodium glucose co-transporter 2 inhibitor, for the management of type 2 diabetes

scientific article published on August 2014

Canagliflozin, a sodium glucose co-transporter 2 inhibitor, for the management of type 2 diabetes is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.3810/HP.2014.08.1122
P698PubMed publication ID25255411

P2093author name stringStephen Brunton
Timothy S Reid
P2860cites workFirst human dose-escalation study with remogliflozin etabonate, a selective inhibitor of the sodium-glucose transporter 2 (SGLT2), in healthy subjects and in subjects with type 2 diabetes mellitusQ21195757
Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD).Q22241288
Ipragliflozin and other sodium-glucose cotransporter-2 (SGLT2) inhibitors in the treatment of type 2 diabetes: preclinical and clinical dataQ30612949
SGLT2 inhibition--a novel strategy for diabetes treatmentQ34117872
Role of the kidney in normal glucose homeostasis and in the hyperglycaemia of diabetes mellitus: therapeutic implicationsQ34120717
Dose-ranging effects of canagliflozin, a sodium-glucose cotransporter 2 inhibitor, as add-on to metformin in subjects with type 2 diabetesQ34227891
Efficacy and safety of canagliflozin monotherapy in subjects with type 2 diabetes mellitus inadequately controlled with diet and exerciseQ34646948
Efficacy and safety of canagliflozin in patients with type 2 diabetes mellitus inadequately controlled with metformin and sulphonylurea: a randomised trialQ34804900
Sodium glucose cotransporter 2 inhibitors as a new treatment for diabetes mellitus.Q35011476
Lower baseline glycemia reduces apparent oral agent glucose-lowering efficacy: a meta-regression analysisQ36578983
Efficacy and safety of canagliflozin in subjects with type 2 diabetes and chronic kidney diseaseQ36845771
Canagliflozin compared with sitagliptin for patients with type 2 diabetes who do not have adequate glycemic control with metformin plus sulfonylurea: a 52-week randomized trialQ37106527
Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitusQ37141727
Characterization of renal glucose reabsorption in response to dapagliflozin in healthy subjects and subjects with type 2 diabetesQ37193454
Empagliflozin as add-on to metformin plus sulfonylurea in patients with type 2 diabetes: a 24-week, randomized, double-blind, placebo-controlled trialQ37278239
Efficacy and safety of canagliflozin compared with placebo and sitagliptin in patients with type 2 diabetes on background metformin monotherapy: a randomised trialQ37302078
Renal sodium-glucose transport: role in diabetes mellitus and potential clinical implicationsQ37439364
Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patientsQ37524302
Familial renal glucosuria and SGLT2: from a mendelian trait to a therapeutic target.Q37645623
Canagliflozin, a sodium glucose co-transporter 2 inhibitor, improves model-based indices of beta cell function in patients with type 2 diabetesQ37692849
Sodium-glucose co-transport inhibitors: progress and therapeutic potential in type 2 diabetes mellitusQ37703184
Biology of human sodium glucose transportersQ37870037
Role of sodium-glucose cotransporter 2 (SGLT 2) inhibitors in the treatment of type 2 diabetes.Q37878715
The role of the kidneys in glucose homeostasis: a new path towards normalizing glycaemia.Q37940036
Canagliflozin: a review of its use in patients with type 2 diabetes mellitusQ38212007
Renal hemodynamic effect of sodium-glucose cotransporter 2 inhibition in patients with type 1 diabetes mellitusQ38439475
Urinary tract infection in randomized phase III studies of canagliflozin, a sodium glucose co-transporter 2 inhibitorQ43599025
Efficacy and safety of canagliflozin versus glimepiride in patients with type 2 diabetes inadequately controlled with metformin (CANTATA-SU): 52 week results from a randomised, double-blind, phase 3 non-inferiority trialQ43804231
Genital mycotic infections with canagliflozin, a sodium glucose co-transporter 2 inhibitor, in patients with type 2 diabetes mellitus: a pooled analysis of clinical studiesQ44438668
Efficacy and safety of canagliflozin treatment in older subjects with type 2 diabetes mellitus: a randomized trialQ44452805
Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetesQ45124469
Efficacy and safety of empagliflozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor, as add-on to metformin in type 2 diabetes with mild hyperglycaemiaQ45442620
Renal glucose excretion and tubular reabsorption rate related to blood glucose in subjects with type 2 diabetes with a critical reappraisal of the "renal glucose threshold" model.Q46024197
Vulvovaginitis and balanitis in patients with diabetes treated with dapagliflozinQ46401612
Effects of exenatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylureaQ46458866
Glucose transporters in human renal proximal tubular cells isolated from the urine of patients with non-insulin-dependent diabetesQ46818617
Rationale, design, and baseline characteristics of the Canagliflozin Cardiovascular Assessment Study (CANVAS)--a randomized placebo-controlled trialQ47909934
Urinary tract infections in patients with diabetes treated with dapagliflozinQ48016891
Pharmacokinetics and pharmacodynamics of canagliflozin, a sodium glucose co-transporter 2 inhibitor, in subjects with type 2 diabetes mellitus.Q50996678
Long-term efficacy and safety of canagliflozin monotherapy in patients with type 2 diabetes inadequately controlled with diet and exercise: findings from the 52-week CANTATA-M study.Q51333570
Long-term efficacy of dapagliflozin in patients with type 2 diabetes mellitus receiving high doses of insulin: a randomized trial.Q51359456
Canagliflozin improves glycaemic control over 28 days in subjects with type 2 diabetes not optimally controlled on insulin.Q51362851
Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with glimepiride: a randomized, 24-week, double-blind, placebo-controlled trial.Q51372081
Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, in patients with type 2 diabetes mellitus inadequately controlled on glimepiride alone or on glimepiride and metformin.Q51468797
Renal glucose excretion as a function of blood glucose concentration in subjects with type 2 diabetes--results of a hyperglycaemic glucose clamp study.Q51943358
From victim to ally: the kidney as an emerging target for the treatment of diabetes mellitusQ57479460
P433issue3
P407language of work or nameEnglishQ1860
P921main subjecttype 2 diabetesQ3025883
P304page(s)96-108
P577publication date2014-08-01
P1433published inHospital PracticeQ5908551
P1476titleCanagliflozin, a sodium glucose co-transporter 2 inhibitor, for the management of type 2 diabetes
P478volume42

Reverse relations

cites work (P2860)
Q33665173Canagliflozin as an Initial Therapy in Drug-Naïve Subjects with Type 2 Diabetes Mellitus: A Potential Involvement of Atherogenic Lipids in its Glycemic Efficacy
Q38573559Canagliflozin: a sodium glucose co-transporter 2 inhibitor for the treatment of type 2 diabetes mellitus
Q55407978Characterization of Metabolic Parameters in Responders and Nonresponders Treated with Canagliflozin Monotherapy in Drug-naive Subjects with Type 2 Diabetes.
Q57462258Two Glucose-Lowering Mechanisms of Canagliflozin Depending on Body Weight Changes in Drug-Naïve Subjects with Type 2 Diabetes
Q26786524What's next after metformin? focus on sulphonylurea: add-on or combination therapy

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