Tumor suppressor p16INK4a--modulator of glycomic profile and galectin-1 expression to increase susceptibility to carbohydrate-dependent induction of anoikis in pancreatic carcinoma cells

scientific article published on 29 May 2007

Tumor suppressor p16INK4a--modulator of glycomic profile and galectin-1 expression to increase susceptibility to carbohydrate-dependent induction of anoikis in pancreatic carcinoma cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/J.1742-4658.2007.05851.X
P698PubMed publication ID17535296
P5875ResearchGate publication ID6301309

P50authorThomas GressQ59785425
Magnus von Knebel DoeberitzQ87739754
Hans-Joachim GabiusQ38321355
Sabine AndréQ40339401
Bertram WiedenmannQ41604544
P2093author name stringJürgen Kopitz
Shin-Ichiro Nishimura
Malte Buchholz
Hiroaki Nakagawa
Kisaburo Deguchi
Wolfgang Kemmner
Stefan Rosewicz
Corina Böck
Hugo Sanchez-Ruderisch
Katharia M Detjen
Pia Forberich
P2860cites workEffect of 5-azacytidine and galectin-1 on growth and differentiation of the human b lymphoma cell line bl36Q24805197
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
Overexpression of pRB in human pancreatic carcinoma cells: function in chemotherapy-induced apoptosisQ27824780
Transcriptional regulation of the human beta-1,4-galactosyltransferase V gene in cancer cells: essential role of transcription factor Sp1Q28272913
Human galectin-2: novel inducer of T cell apoptosis with distinct profile of caspase activationQ28281057
Beta1,4-galactosyltransferase V functions as a positive growth regulator in gliomaQ28295914
Polylactosamine synthesis and branch formation of N-glycans in beta1,4-galactosyltransferase-1-deficient miceQ28507513
A focused microarray approach to functional glycomics: transcriptional regulation of the glycomeQ30800594
Determination of modulation of ligand properties of synthetic complex-type biantennary N-glycans by introduction of bisecting GlcNAc in silico, in vitro and in vivo.Q31033747
Carbohydrate-carbohydrate binding of ganglioside to integrin alpha(5) modulates alpha(5)beta(1) function.Q31705382
Deletion of mouse embryo fibroblast N-acetylglucosaminyltransferase V stimulates alpha5beta1 integrin expression mediated by the protein kinase C signaling pathwayQ45198893
Synthesis of poly-N-acetyllactosamine in core 2 branched O-glycans. The requirement of novel beta-1,4-galactosyltransferase IV and beta-1,3-n-acetylglucosaminyltransferaseQ46525727
Galectin-1 interacts with the {alpha}5{beta}1 fibronectin receptor to restrict carcinoma cell growth via induction of p21 and p27.Q46654963
Carbohydrate chain of ganglioside GM1 as a ligand: identification of the binding strategies of three 15 mer peptides and their divergence from the binding modes of growth-regulatory galectin-1 and cholera toxinQ46789100
Complex N-glycans are the major ligands for galectin-1, -3, and -8 on Chinese hamster ovary cellsQ46828658
Galectin-8 binds specific beta1 integrins and induces polarized spreading highlighted by asymmetric lamellipodia in Jurkat T cellsQ46861486
The acceptor substrate specificity of human beta4-galactosyltransferase V indicates its potential function in O-glycosylationQ48197881
Galectin-1 modulates human glioblastoma cell migration into the brain through modifications to the actin cytoskeleton and levels of expression of small GTPasesQ48543365
Influence of type of linkage and spacer on the interaction of beta-galactoside-binding proteins with immobilized affinity ligandsQ48759283
Galectin-1 is highly expressed in human gliomas with relevance for modulation of invasion of tumor astrocytes into the brain parenchymaQ48958266
Activation of human endothelial cells by tumor necrosis factor-α results in profound changes in the expression of glycosylation-related genesQ57261985
Glycosyldisulfides from dynamic combinatorial libraries as O-glycoside mimetics for plant and endogenous lectins: their reactivities in solid-phase and cell assays and conformational analysis by molecular dynamics simulationsQ33247129
Discovery of galectin ligands in fully randomized combinatorial one-bead-one-compound (glyco)peptide librariesQ33263168
Eukaryotic glycosylation: whim of nature or multipurpose tool?Q33608239
A secreted type of beta 1,6-N-acetylglucosaminyltransferase V (GnT-V) induces tumor angiogenesis without mediation of glycosylation: a novel function of GnT-V distinct from the original glycosyltransferase activityQ34116588
The asialoglycoprotein receptor clears glycoconjugates terminating with sialic acid alpha 2,6GalNAcQ34144756
Glycohistochemistry: the why and how of detection and localization of endogenous lectins.Q34205805
Homodimeric galectin-7 (p53-induced gene 1) is a negative growth regulator for human neuroblastoma cellsQ34247078
Expression of N-acetylglucosaminyltransferase v is associated with prognosis and histology in non-small cell lung cancersQ34304814
Genetic complementation reveals a novel human congenital disorder of glycosylation of type II, due to inactivation of the Golgi CMP-sialic acid transporterQ34372978
Elevated beta1,4-galactosyltransferase I in highly metastatic human lung cancer cells. Identification of E1AF as important transcription activatorQ34378390
Transcriptional regulation of N-acetylglucosaminyltransferase V by the src oncogeneQ34433644
N-acetylglucosaminyltransferase V and beta1-6 branching N-linked oligosaccharides are associated with good prognosis of patients with bladder cancerQ34517727
Plant lectins: occurrence, biochemistry, functions and applications.Q34959357
Leukocyte adhesion deficiency II: therapy and genetic defectQ35022314
A genetic approach to Mammalian glycan functionQ35099563
Chemical biology of the sugar codeQ35790497
The glycan code of the endoplasmic reticulum: asparagine-linked carbohydrates as protein maturation and quality-control tagsQ36153965
GalNAc-alpha-O-benzyl inhibits NeuAcalpha2-3 glycosylation and blocks the intracellular transport of apical glycoproteins and mucus in differentiated HT-29 cells.Q36255476
Mitogenic leukoagglutinin from Phaseolus vulgaris binds to a pentasaccharide unit in N-acetyllactosamine-type glycoprotein glycansQ36285557
A novel function for the tumor suppressor p16(INK4a): induction of anoikis via upregulation of the alpha(5)beta(1) fibronectin receptorQ36293774
Cell surface glycans: the why and how of their functionality as biochemical signals in lectin-mediated information transferQ36393405
Cell surface alpha 2,6 sialylation affects adhesion of breast carcinoma cellsQ38289793
Negative regulation of neuroblastoma cell growth by carbohydrate-dependent surface binding of galectin-1 and functional divergence from galectin-3.Q38299041
Interaction profile of galectin-5 with free saccharides and mammalian glycoproteins: probing its fine specificity and the effect of naturally clustered ligand presentation.Q38314956
alpha2,3/alpha2,6-Sialylation of N-glycans: non-synonymous signals with marked developmental regulation in bovine reproductive tractsQ38317619
Galectins bind to the multivalent glycoprotein asialofetuin with enhanced affinities and a gradient of decreasing binding constantsQ38321186
Gene expression profiling of mouse postnatal cerebellar development using oligonucleotide microarrays designed to detect differences in glycoconjugate expressionQ38325711
Introduction of extended LEC14-type branching into core-fucosylated biantennary N-glycanQ38328250
The her-2/neu oncogene stimulates the transcription of N-acetylglucosaminyltransferase V and expression of its cell surface oligosaccharide productsQ38331805
Rapid cell senescence-associated changes in galactosylation of N-linked oligosaccharides in human lung adenocarcinoma A549 cellsQ38340807
Unique conformer selection of human growth-regulatory lectin galectin-1 for ganglioside GM1 versus bacterial toxinsQ38346834
Galectin-3 precipitates as a pentamer with synthetic multivalent carbohydrates and forms heterogeneous cross-linked complexesQ38346878
First demonstration of differential inhibition of lectin binding by synthetic tri- and tetravalent glycoclusters from cross-coupling of rigidified 2-propynyl lactoside.Q38347052
Animal lectinsQ38348817
Ras oncogene directs expression of a differentially sialylated, functionally altered β1 integrinQ38349173
Comparative cross-linking activities of lactose-specific plant and animal lectins and a natural lactose-binding immunoglobulin G fraction from human serum with asialofetuinQ38350784
Mucin synthesis. Conversion of R1-beta 1-3Gal-R2 to R1-beta 1-3(GlcNAc beta 1-6)Gal-R2 and of R1-beta 1-3GalNAc-R2 to R1-beta 1-3(GlcNAc beta 1-6)GalNAc-R2 by a beta 6-N-acetylglucosaminyltransferase in pig gastric mucosaQ38350817
Malignant cell glycoproteins and glycolipidsQ38613949
Branching mode in complex-type triantennary N-glycans as regulatory element of their ligand propertiesQ40297187
Down-regulation of the expression of beta1,4-galactosyltransferase V promotes integrin beta1 maturationQ40299989
Aberrant expression of N-acetylglucosaminyltransferase-IVa and IVb (GnT-IVa and b) in pancreatic cancerQ40325695
High expression of N-acetylglucosaminyltransferase V in favorable neuroblastomas: Involvement of its effect on apoptosisQ40331560
Hypersialylation of beta1 integrins, observed in colon adenocarcinoma, may contribute to cancer progression by up-regulating cell motilityQ40414546
Ras oncogene induces beta-galactoside alpha2,6-sialyltransferase (ST6Gal I) via a RalGEF-mediated signal to its housekeeping promoterQ40517981
Galectin-3 augments K-Ras activation and triggers a Ras signal that attenuates ERK but not phosphoinositide 3-kinase activityQ40543716
Transfection of 2,6 and 2,3-sialyltransferase genes and GlcNAc-transferase genes into human glioma cell line U-373 MG affects glycoconjugate expression and enhances cell deathQ40547157
Persubstituted cyclodextrin-based glycoclusters as inhibitors of protein-carbohydrate recognition using purified plant and mammalian lectins and wild-type and lectin-gene-transfected tumor cells as targetsQ40597683
Regulation on the expression and N-glycosylation of integrins by N-acetylglucosaminyltransferase VQ40629726
The ST6Gal I sialyltransferase selectively modifies N-glycans on CD45 to negatively regulate galectin-1-induced CD45 clustering, phosphatase modulation, and T cell deathQ40681367
Hyposialylation of integrins stimulates the activity of myeloid fibronectin receptorsQ40721464
FosB gene products trigger cell proliferation and morphological alteration with an increased expression of a novel processed form of galectin-1 in the rat 3Y1 embryo cell line.Q40735153
Occurrence of oligosialic acids on integrin alpha 5 subunit and their involvement in cell adhesion to fibronectinQ40797420
Galectins-1 and -3 and their ligands in tumor biology. Non-uniform properties in cell-surface presentation and modulation of adhesion to matrix glycoproteins for various tumor cell lines, in biodistribution of free and liposome-bound galectins and iQ40930082
Down-regulation of beta1,4-galactosyltransferase gene expression by cell-cycle suppressor gene p16.Q40975647
Galectin-1 is a major receptor for ganglioside GM1, a product of the growth-controlling activity of a cell surface ganglioside sialidase, on human neuroblastoma cells in cultureQ41036890
A crucial role for T-bet in selectin ligand expression in T helper 1 (Th1) cellsQ42090258
New aspects of galectin functionality in nuclei of cultured bone marrow stromal and epidermal cells: biotinylated galectins as tool to detect specific binding sitesQ42453087
Determination of structural and functional overlap/divergence of five proto-type galectins by analysis of the growth-regulatory interaction with ganglioside GM1 in silico and in vitro on human neuroblastoma cellsQ42639630
Evidence for stimulation of tumor proliferation in cell lines and histotypic cultures by clinically relevant low doses of the galactoside-binding mistletoe lectin, a component of proprietary extractsQ43570944
Cutting edge: differential requirements for Stat4 in expression of glycosyltransferases responsible for selectin ligand formation in Th1 cellsQ43664728
Germ cell survival through carbohydrate-mediated interaction with Sertoli cellsQ43845917
Lectin localization in human nerve by biochemically defined lectin-binding glycoproteins, neoglycoprotein and lectin-specific antibodyQ44041022
Galectin-1(L11A) predicted from a computed galectin-1 farnesyl-binding pocket selectively inhibits Ras-GTP.Q44883110
Loss of disialyl Lewis(a), the ligand for lymphocyte inhibitory receptor sialic acid-binding immunoglobulin-like lectin-7 (Siglec-7) associated with increased sialyl Lewis(a) expression on human colon cancers.Q44961886
Growth-regulatory human galectin-1: crystallographic characterisation of the structural changes induced by single-site mutations and their impact on the thermodynamics of ligand bindingQ45100720
Dimeric galectin-1 binds with high affinity to alpha2,3-sialylated and non-sialylated terminal N-acetyllactosamine units on surface-bound extended glycans.Q45158458
P433issue13
P407language of work or nameEnglishQ1860
P921main subjectpancreatic carcinomaQ18556536
P304page(s)3233-3256
P577publication date2007-05-29
P1433published inFEBS JournalQ1388041
P1476titleTumor suppressor p16INK4a--modulator of glycomic profile and galectin-1 expression to increase susceptibility to carbohydrate-dependent induction of anoikis in pancreatic carcinoma cells
P478volume274

Reverse relations

cites work (P2860)
Q33810026A regulatory network of two galectins mediates the earliest steps of avian limb skeletal morphogenesis.
Q47864390Adhesion/growth-regulatory galectins in the human eye: localization profiles and tissue reactivities as a standard to detect disease-associated alterations
Q38004594Beyond glycoproteins as galectin counterreceptors: tumor-effector T cell growth control via ganglioside GM1 [corrected].
Q46505356Cell-type-specific expression of murine multifunctional galectin-3 and its association with follicular atresia/luteolysis in contrast to pro-apoptotic galectins-1 and -7.
Q42837584Clicked and long spaced galactosyl- and lactosylcalix[4]arenes: new multivalent galectin-3 ligands
Q36304002Clinical implication of the serum galectin-1 expression in epithelial ovarian cancer patients
Q53270597Colonic carcinogenesis along different genetic routes: glycophenotyping of tumor cases separated by microsatellite instability/stability.
Q51768317Combining carbohydrate substitutions at bioinspired positions with multivalent presentation towards optimising lectin inhibitors: case study with calixarenes.
Q38312051Conformational selection in glycomimetics: human galectin-1 only recognizes syn-Ψ-type conformations of β-1,3-linked lactose and its C-glycosyl derivative.
Q38071660Context-dependent multifunctionality of galectin-1: a challenge for defining the lectin as therapeutic target
Q41334598Contribution of galectin-1, a glycan-binding protein, to gastrointestinal tumor progression
Q50847552Copy-number variation of functional galectin genes: studying animal galectin-7 (p53-induced gene 1 in man) and tandem-repeat-type galectins-4 and -9.
Q38337529Cyclic neoglycodecapeptides: how to increase their inhibitory activity and selectivity on lectin/toxin binding to a glycoprotein and cells
Q45988156Defining the potential of aglycone modifications for affinity/selectivity enhancement against medically relevant lectins: synthesis, activity screening, and HSQC-based NMR analysis.
Q46095235Detection of galectin-3 in patients with inflammatory bowel diseases: new serum marker of active forms of IBD?
Q34676070Emerging role of alpha2,6-sialic acid as a negative regulator of galectin binding and function
Q27685442Fine-tuning of prototype chicken galectins: structure of CG-2 and structure-activity correlations
Q88580977From glycophenotyping by (plant) lectin histochemistry to defining functionality of glycans by pairing with endogenous lectins
Q42688469Functional interplay between ganglioside GM1 and cross-linking galectin-1 induces axon-like neuritogenesis via integrin-based signaling and TRPC5-dependent Ca²⁺ influx
Q30436202Galectin fingerprinting in naso-sinusal diseases
Q38294225Galectin-1 Couples Glycobiology to Inflammation in Osteoarthritis through the Activation of an NF-κB-Regulated Gene Network
Q38339024Galectin-1 sensitizes carcinoma cells to anoikis via the fibronectin receptor α5β1-integrin.
Q89207834Galectin-8 induces functional disease markers in human osteoarthritis and cooperates with galectins-1 and -3
Q33902518Galectins as tools for glycan mapping in histology: comparison of their binding profiles to the bovine zona pellucida by confocal laser scanning microscopy
Q39052321Galectins: their network and roles in immunity/tumor growth control
Q35180105Ganglioside GM1 deficiency in effector T cells from NOD mice induces resistance to regulatory T-cell suppression
Q37690232Glycophenotyping of osteoarthritic cartilage and chondrocytes by RT-qPCR, mass spectrometry, histochemistry with plant/human lectins and lectin localization with a glycoprotein
Q57825182Human Galectins Induce Conversion of Dermal Fibroblasts into Myofibroblasts and Production of Extracellular Matrix: Potential Application in Tissue Engineering and Wound Repair
Q61454627Human galectins as sensors for apoptosis/necrosis-associated surface changes of granulocytes and lymphocytes
Q57901365Human osteoarthritic knee cartilage: fingerprinting of adhesion/growth-regulatory galectins in vitro and in situ indicates differential upregulation in severe degeneration
Q33605492Hydrodynamic properties of human adhesion/growth-regulatory galectins studied by fluorescence correlation spectroscopy
Q35723085Hypoxia Up-Regulates Galectin-3 in Mammary Tumor Progression and Metastasis
Q37809484In search of a solution to the sphinx-like riddle of GM1.
Q53682346Increased expression of distinct galectins in multiple sclerosis lesions.
Q37412929Inhibition of human retinal pigment epithelial cell attachment, spreading, and migration by the human lectin galectin-1.
Q47677002Integrin β1 is bound to galectin-1 in human trophoblast
Q38180146Introduction to glycopathology: the concept, the tools and the perspectives
Q38332609Lectins: getting familiar with translators of the sugar code
Q39045114Lipid glycosylation: a primer for histochemists and cell biologists
Q42507266Loss of adhesion/growth-regulatory galectin-9 from squamous cell epithelium in head and neck carcinomas
Q26749071Multivalent Carbohydrate-Lectin Interactions: How Synthetic Chemistry Enables Insights into Nanometric Recognition
Q27688879Natural single amino acid polymorphism (F19Y) in human galectin-8: detection of structural alterations and increased growth-regulatory activity on tumor cells
Q50564014Network monitoring of adhesion/growth-regulatory galectins: localization of the five canonical chicken proteins in embryonic and maturing bone and cartilage and their introduction as histochemical tools.
Q38978059Open Wound Healing In Vivo: Monitoring Binding and Presence of Adhesion/Growth-Regulatory Galectins in Rat Skin during the Course of Complete Re-Epithelialization
Q41873777Preliminary X-ray crystallographic analysis of an engineered variant of human chimera-type galectin-3 with a shortened N-terminal domain.
Q33791981Proteomics in pancreatic cancer research
Q41016662Regulatory Impact of Amniotic Membrane Transplantation on Presence of Adhesion/Growth-Regulatory Galectins-1 and -7 in Corneal Explants from Acanthamoeba Keratitis Patients: Clinical Note.
Q38288649Sialylation of beta1 integrins blocks cell adhesion to galectin-3 and protects cells against galectin-3-induced apoptosis
Q57664399Smooth muscle actin-expressing stromal fibroblasts in head and neck squamous cell carcinoma: Increased expression of galectin-1 and induction of poor prognosis factors
Q35559685Structural aspects of binding of α-linked digalactosides to human galectin-1
Q41183639Structural significance of galectin design: impairment of homodimer stability by linker insertion and partial reversion by ligand presence.
Q38766179Sweet complementarity: the functional pairing of glycans with lectins
Q33928742Symmetric dithiodigalactoside: strategic combination of binding studies and detection of selectivity between a plant toxin and human lectins.
Q44484616Synthetic polyamine BPA-C8 inhibits TGF-β1-mediated conversion of human dermal fibroblast to myofibroblasts and establishment of galectin-1-rich extracellular matrix in vitro
Q51237398Teaming up synthetic chemistry and histochemistry for activity screening in galectin-directed inhibitor design.
Q38096239The third dimension of reading the sugar code by lectins: design of glycoclusters with cyclic scaffolds as tools with the aim to define correlations between spatial presentation and activity.
Q35904166Thermodynamic Switch in Binding of Adhesion/Growth Regulatory Human Galectin-3 to Tumor-Associated TF Antigen (CD176) and MUC1 Glycopeptides.
Q54389574Toward comprehensive analysis of the galectin network in chicken: unique diversity of galectin-3 and comparison of its localization profile in organs of adult animals to the other four members of this lectin family.
Q54657364Tumor suppressor p16 INK4a: Downregulation of galectin-3, an endogenous competitor of the pro-anoikis effector galectin-1, in a pancreatic carcinoma model.
Q35890610Tumor-Associated Glycans and Immune Surveillance
Q54486460Tumour suppressor p16(INK4a) - anoikis-favouring decrease in N/O-glycan/cell surface sialylation by down-regulation of enzymes in sialic acid biosynthesis in tandem in a pancreatic carcinoma model.
Q39264263Upregulation of IL-6, IL-8 and CXCL-1 production in dermal fibroblasts by normal/malignant epithelial cells in vitro: Immunohistochemical and transcriptomic analyses.
Q37296108VHL-dependent regulation of a β-dystroglycan glycoform and glycogene expression in renal cancer
Q46695812Versatile strategy for the synthesis of biotin-labelled glycans, their immobilization to establish a bioactive surface and interaction studies with a lectin on a biochip

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