Mitochondrial homeostasis molecules: regulation by a trio of recessive Parkinson's disease genes

scientific article published on 12 December 2014

Mitochondrial homeostasis molecules: regulation by a trio of recessive Parkinson's disease genes is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.5607/EN.2014.23.4.345
P932PMC publication ID4276805
P698PubMed publication ID25548534
P5875ResearchGate publication ID270291214

P2093author name stringJi-Soo Kim
Ji-Young Han
Jin H Son
P2860cites workMitochondrial BCL-2 inhibits AMBRA1-induced autophagyQ24294358
PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's diseaseQ24294809
Ubiquitin is phosphorylated by PINK1 to activate parkinQ24296532
PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motilityQ24296955
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1Q24297155
Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNAQ24299860
Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagyQ24300975
Parkin interacts with Ambra1 to induce mitophagyQ24313512
Mitochondrial complex I deficiency in Parkinson's diseaseQ69370277
Mitochondrial dysfunction in Parkinson's diseaseQ80228162
Parkin is recruited selectively to impaired mitochondria and promotes their autophagyQ24317471
Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagyQ24339224
Mitochondrial biology and Parkinson's diseaseQ26824090
Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolismQ28266830
Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1Q28300820
Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1Q28506681
The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in miceQ28591283
PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondriaQ28592217
Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stressQ28592727
PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncouplingQ28593164
Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress.Q28593258
Mitochondrial dysfunction and oxidative damage in parkin-deficient miceQ28593859
Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutantsQ29615627
Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkinQ29615684
Metabolic control through the PGC-1 family of transcription coactivatorsQ29616509
PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activityQ29617292
PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65Q29622844
p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondriaQ34269257
Voltage-dependent anion channels (VDACs) recruit Parkin to defective mitochondria to promote mitochondrial autophagyQ34305642
Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase ParkinQ35783335
Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic functionQ36042047
PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagyQ36476931
Rescue of PINK1 protein null-specific mitochondrial complex IV deficits by ginsenoside Re activation of nitric oxide signalingQ36492752
A novel PGC-1α isoform in brain localizes to mitochondria and associates with PINK1 and VDAC.Q37069425
The Parkinson-associated protein PINK1 interacts with Beclin1 and promotes autophagyQ39754547
Synergistic activation of the human MnSOD promoter by DJ-1 and PGC-1alpha: regulation by SUMOylation and oxidationQ39952558
Mitochondrial dysfunction, peroxidation damage and changes in glutathione metabolism in PARK6.Q40201823
Parkin enhances mitochondrial biogenesis in proliferating cellsQ40322753
Parkin mediates proteasome-dependent protein degradation and rupture of the outer mitochondrial membraneQ42235376
How could Parkin-mediated ubiquitination of mitofusin promote mitophagy?Q42943868
The antioxidant Trolox helps recovery from the familial Parkinson's disease-specific mitochondrial deficits caused by PINK1- and DJ-1-deficiency in dopaminergic neuronal cellsQ43965888
Effect of coenzyme Q10 on the mitochondrial function of skin fibroblasts from Parkinson patientsQ44894243
Mitochondrial complex I and II activities of lymphocytes and platelets in Parkinson's diseaseQ48595004
Respiratory chain abnormalities in skeletal muscle from patients with Parkinson's diseaseQ48673461
P275copyright licenseCreative Commons Attribution-NonCommercial 3.0 UnportedQ18810331
P6216copyright statuscopyrightedQ50423863
P433issue4
P921main subjectParkinson's diseaseQ11085
P304page(s)345-351
P577publication date2014-12-12
P1433published inExperimental neurobiologyQ26842060
P1476titleMitochondrial homeostasis molecules: regulation by a trio of recessive Parkinson's disease genes
P478volume23

Reverse relations

cites work (P2860)
Q26740364Chaperone-Mediated Autophagy and Mitochondrial Homeostasis in Parkinson's Disease
Q38649157Does PGC1α/FNDC5/BDNF Elicit the Beneficial Effects of Exercise on Neurodegenerative Disorders?
Q48271930Effects of eldepryl on glial cell proliferation and activation in the substantia nigra and striatum in a rat model of Parkinson's disease
Q38811976Fire and water: Tumor cell adaptation to metabolic conditions
Q53453128Mitochondrial Dysfunction in Parkinson's Disease.

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