The last 59 amino acids of Smoothened cytoplasmic tail directly bind the protein kinase Fused and negatively regulate the Hedgehog pathway.

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The last 59 amino acids of Smoothened cytoplasmic tail directly bind the protein kinase Fused and negatively regulate the Hedgehog pathway. is …
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scholarly articleQ13442814

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P356DOI10.1016/J.YDBIO.2006.10.042
P698PubMed publication ID17182028
P5875ResearchGate publication ID6618345

P50authorSandra ClaretQ79444699
P2093author name stringAmira Brigui
Anne Plessis
Matthieu Sanial
Séverine Martin-Lannerée
Laurent Daviet
Tristan Piolot
Sébastien Malpel
P2860cites workHedgehog signal transduction proteins: contacts of the Fused kinase and Ci transcription factor with the kinesin-related protein Costal2.Q24806020
Posttranscriptional regulation of smoothened is part of a self-correcting mechanism in the Hedgehog signaling systemQ28138502
Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2Q28186976
Differential regulation of Hedgehog target gene transcription by Costal2 and Suppressor of FusedQ28238347
The Hedgehog response network: sensors, switches, and routersQ28267648
Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebratesQ28285927
Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transductionQ28297904
Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2Q28299947
The protein-protein interaction map of Helicobacter pyloriQ28484787
Identification of a Functional Interaction between the Transmembrane Protein Smoothened and the Kinesin-Related Protein Costal2Q28634848
Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothenedQ28646558
Suppressor of fused links fused and Cubitus interruptus on the hedgehog signalling pathwayQ28646646
Extensive phosphorylation of Smoothened in Hedgehog pathway activationQ28770067
Developmental roles and clinical significance of hedgehog signalingQ29614988
Protein interaction mapping: a Drosophila case studyQ33211911
Mosaic analysis with a repressible cell marker (MARCM) for Drosophila neural developmentQ33943141
The sonic hedgehog signaling system as a bistable genetic switchQ34185516
Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tailQ34274372
Hedgehog signalling in cancer formation and maintenanceQ34291589
The carboxyl-terminal domain of the protein kinase fused can function as a dominant inhibitor of hedgehog signalingQ34301702
Oligomerization of G protein-coupled receptors: past, present, and futureQ35546811
GPCR-interacting proteins (GIPs): nature and functionsQ35922926
Hedgehog signaling in pancreas development and diseaseQ36390442
CKI, there's more than one: casein kinase I family members in Wnt and Hedgehog signalingQ36397808
Ras-Raf interaction: two-hybrid analysisQ36786557
The Kinesin-related protein Costal2 associates with membranes in a Hedgehog-sensitive, Smoothened-independent mannerQ36860490
Phosphorylation of the fused protein kinase in response to signaling from hedgehogQ37633421
Cooperative requirement of the Gli proteins in neurogenesisQ38324359
Altered localization of Drosophila Smoothened protein activates Hedgehog signal transductionQ39895375
Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptusQ40445473
Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I.Q40477646
Hedgehog-stimulated phosphorylation of the kinesin-related protein Costal2 is mediated by the serine/threonine kinase fusedQ40740015
Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expressionQ40933908
Biological activity of soluble wingless protein in cultured Drosophila imaginal disc cellsQ41479991
Functional domains and sub-cellular distribution of the Hedgehog transducing protein Smoothened in DrosophilaQ42462438
smoothened encodes a receptor-like serpentine protein required for hedgehog signallingQ42633905
Expression of engrailed proteins in arthropods, annelids, and chordatesQ42642893
Genetic dissection of the Drosophila Cubitus interruptus signaling complexQ43690110
Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by HedgehogQ44605502
Multiple Cos2/Ci interactions regulate Ci subcellular localization through microtubule dependent and independent mechanismsQ44828940
Proteolysis That Is Inhibited by Hedgehog Targets Cubitus interruptus Protein to the Nucleus and Converts It to a RepressorQ44894172
A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patchedQ46395235
Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2.Q46727624
Costal2, a novel kinesin-related protein in the Hedgehog signaling pathwayQ46906896
The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signalQ47070614
Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein SlimbQ47070747
A putative serine/threonine protein kinase encoded by the segment-polarity fused gene of DrosophilaQ47070991
Identification of a tetrameric hedgehog signaling complexQ47071804
Smoothened translates Hedgehog levels into distinct responsesQ47745429
Modulation of the Suppressor of fused protein regulates the Hedgehog signaling pathway in Drosophila embryo and imaginal discs.Q52028620
Notch and Wingless modulate the response of cells to Hedgehog signalling in the Drosophila wing.Q52116733
Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus.Q52178240
Modulation of Hedgehog target gene expression by the Fused serine-threonine kinase in wing imaginal discs.Q52181380
The fu gene discriminates between pathways to control dpp expression in Drosophila imaginal discs.Q52202098
The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathwaysQ52207516
Expression of crumbs confers apical character on plasma membrane domains of ectodermal epithelia of Drosophila.Q52537316
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectSmoothened Dmel_CG11561Q29814209
Fused Dmel_CG6551Q29815568
P304page(s)121-133
P577publication date2006-11-03
P1433published inDevelopmental BiologyQ3025402
P1476titleThe last 59 amino acids of Smoothened cytoplasmic tail directly bind the protein kinase Fused and negatively regulate the Hedgehog pathway
P478volume303