| scholarly article | Q13442814 |
| P6179 | Dimensions Publication ID | 1046514453 |
| P356 | DOI | 10.1038/NATURE03179 |
| P698 | PubMed publication ID | 15616566 |
| P2093 | author name string | Chao Tong | |
| Bing Wang | |||
| Liping Luo | |||
| Jin Jiang | |||
| Jianhang Jia | |||
| P2860 | cites work | Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2 | Q28186976 |
| Degrading Ci: who is Cul-pable? | Q28201909 | ||
| Hedgehog signaling in animal development: paradigms and principles | Q28208463 | ||
| Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened | Q28646558 | ||
| Protein kinase recognition sequence motifs | Q29620224 | ||
| The specification of neuronal identity by graded Sonic Hedgehog signalling. | Q33707747 | ||
| The COE transcription factor Collier is a mediator of short-range Hedgehog-induced patterning of the Drosophila wing | Q33865508 | ||
| Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail | Q34274372 | ||
| Dual pathways for induction of wingless expression by protein kinase A and Hedgehog in Drosophila embryos | Q37367286 | ||
| Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction | Q39895375 | ||
| Protein kinase A antagonizes Hedgehog signaling by regulating both the activator and repressor forms of Cubitus interruptus | Q40445861 | ||
| Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells. | Q42438994 | ||
| Protein kinase A and hedgehog signaling in Drosophila limb development | Q42489490 | ||
| smoothened encodes a receptor-like serpentine protein required for hedgehog signalling | Q42633905 | ||
| Determinants on simian virus 40 large T antigen are important for recognition and phosphorylation by casein kinase I | Q44810908 | ||
| Isolation and characterization of Drosophila cAMP-dependent protein kinase genes. | Q45993141 | ||
| cAMP-dependent protein kinase and hedgehog act antagonistically in regulating decapentaplegic transcription in Drosophila imaginal discs | Q46510555 | ||
| The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal | Q47070614 | ||
| Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus | Q47070663 | ||
| Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator | Q47070726 | ||
| Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1. | Q47071799 | ||
| Visualization of gene expression in living adult Drosophila. | Q52199397 | ||
| The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways | Q52207516 | ||
| Heritable gene silencing in Drosophila using double-stranded RNA. | Q52581458 | ||
| Signal transduction by cAMP-dependent protein kinase A in Drosophila limb patterning | Q59067876 | ||
| Function of protein kinase A in hedgehog signal transduction and Drosophila imaginal disc development | Q72571346 | ||
| P433 | issue | 7020 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | phosphorylation | Q242736 |
| Protein kinase, cAMP-dependent, regulatory subunit type 1 Dmel_CG42341 | Q29809915 | ||
| Protein kinase, cAMP-dependent, catalytic subunit 1 Dmel_CG4379 | Q29813918 | ||
| Smoothened Dmel_CG11561 | Q29814209 | ||
| Hedgehog Dmel_CG4637 | Q29814574 | ||
| Casein kinase Ialpha Dmel_CG2028 | Q29819873 | ||
| P304 | page(s) | 1045-1050 | |
| P577 | publication date | 2004-12-01 | |
| P1433 | published in | Nature | Q180445 |
| P1476 | title | Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I. | |
| P478 | volume | 432 |
| Q35204277 | A broadly conserved g-protein-coupled receptor kinase phosphorylation mechanism controls Drosophila smoothened activity |
| Q46123280 | A cell based, high throughput assay for quantitative analysis of Hedgehog pathway activation using a Smoothened activation sensor |
| Q40122689 | A cytoplasmic PPPSP motif determines megalin's phosphorylation and regulates receptor's recycling and surface expression |
| Q29618700 | A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation |
| Q35748326 | A screen for X-linked mutations affecting Drosophila photoreceptor differentiation identifies Casein kinase 1α as an essential negative regulator of wingless signaling |
| Q36515873 | A screen for modifiers of hedgehog signaling in Drosophila melanogaster identifies swm and mts. |
| Q90292778 | Activation of Smoothened in the Hedgehog pathway unexpectedly increases Gαs-dependent cAMP levels in Drosophila |
| Q28535420 | Activation of Smurf E3 ligase promoted by smoothened regulates hedgehog signaling through targeting patched turnover |
| Q92686162 | Activation of hedgehog signaling associates with early disease progression in chronic lymphocytic leukemia |
| Q35033814 | Activation of heterotrimeric G proteins by Smoothened |
| Q37638143 | Activation of the hedgehog-signaling pathway in human cancer and the clinical implications |
| Q37686591 | An essential role for Grk2 in Hedgehog signalling downstream of Smoothened |
| Q47398587 | An intracellular activation of Smoothened that is independent of Hedgehog stimulation in Drosophila |
| Q42367827 | Apontic directly activates hedgehog and cyclin E for proper organ growth and patterning |
| Q37343914 | Atrophin-Rpd3 complex represses Hedgehog signaling by acting as a corepressor of CiR. |
| Q39150566 | CK1 in Developmental Signaling: Hedgehog and Wnt. |
| Q54940982 | Casein kinase 1α: biological mechanisms and theranostic potential. |
| Q34333526 | Casein kinase 2 promotes Hedgehog signaling by regulating both smoothened and Cubitus interruptus |
| Q89677012 | Chondroitin sulfate proteoglycan Windpipe modulates Hedgehog signaling in Drosophila |
| Q35108046 | Clinical implications of hedgehog signaling pathway inhibitors |
| Q50128926 | Comparative genomic analysis of intracranial germ cell tumors - the preliminary study focused on Sonic Hedgehog signaling pathway. |
| Q27021981 | Decoding the phosphorylation code in Hedgehog signal transduction |
| Q45060865 | Developmental shaping of dendritic arbors in Drosophila relies on tightly regulated intra-neuronal activity of protein kinase A (PKA). |
| Q48718646 | Differential susceptibility of midbrain and spinal cord patterning to floor plate defects in the talpid2 mutant. |
| Q36393098 | Disruption of the PACAP gene promotes medulloblastoma in ptc1 mutant mice. |
| Q44577268 | Drosophila miR-5 suppresses Hedgehog signaling by directly targeting Smoothened |
| Q42489576 | Dual degradation signals control Gli protein stability and tumor formation |
| Q95936696 | Dual functions of Rack1 in regulating Hedgehog pathway |
| Q27328908 | Dynamic interpretation of hedgehog signaling in the Drosophila wing disc |
| Q38193041 | Endocytosis and signaling during development |
| Q37890182 | Endothelial differentiation: molecular mechanisms of specification and heterogeneity |
| Q38516787 | Factor interaction analysis for chromosome 8 and DNA methylation alterations highlights innate immune response suppression and cytoskeletal changes in prostate cancer |
| Q35917072 | Fused-Costal2 protein complex regulates Hedgehog-induced Smo phosphorylation and cell-surface accumulation |
| Q42077575 | G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila |
| Q59792326 | Hedgehog Signaling in Cancer: A Prospective Therapeutic Target for Eradicating Cancer Stem Cells |
| Q92225035 | Hedgehog Signaling: An Achilles' Heel in Cancer |
| Q35089052 | Hedgehog activates fused through phosphorylation to elicit a full spectrum of pathway responses |
| Q36923126 | Hedgehog in the Drosophila testis niche: what does it do there? |
| Q36211158 | Hedgehog induces formation of PKA-Smoothened complexes to promote Smoothened phosphorylation and pathway activation |
| Q50043204 | Hedgehog reciprocally controls trafficking of Smo and Ptc through the Smurf family of E3 ubiquitin ligases. |
| Q34706637 | Hedgehog regulates smoothened activity by inducing a conformational switch |
| Q36002803 | Hedgehog secretion and signal transduction in vertebrates |
| Q27318288 | Hedgehog signaling acts with the temporal cascade to promote neuroblast cell cycle exit |
| Q37350250 | Hedgehog signaling in development and cancer. |
| Q90256025 | Hedgehog signaling promotes lipolysis in adipose tissue through directly regulating Bmm/ATGL lipase |
| Q41200769 | Hedgehog signalling is required for cell survival in Drosophila wing pouch cells |
| Q34830946 | Hedgehog-induced phosphorylation by CK1 sustains the activity of Ci/Gli activator |
| Q34526612 | Hedgehog-regulated atypical PKC promotes phosphorylation and activation of Smoothened and Cubitus interruptus in Drosophila |
| Q34130143 | Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila |
| Q36610082 | Hh-induced Smoothened conformational switch is mediated by differential phosphorylation at its C-terminal tail in a dose- and position-dependent manner |
| Q41980171 | Hippo signaling regulates Yorkie nuclear localization and activity through 14-3-3 dependent and independent mechanisms |
| Q42912953 | Hrs promotes ubiquitination and mediates endosomal trafficking of smoothened in Drosophila hedgehog signaling |
| Q58452335 | Human Receptors Patched and Smoothened Partially Transduce Hedgehog Signal When Expressed inDrosophilaCells |
| Q34321378 | Ihog and Boi are essential for Hedgehog signaling in Drosophila. |
| Q34341729 | Ihog and Boi elicit Hh signaling via Ptc but do not aid Ptc in sequestering the Hh ligand |
| Q36836283 | Implications of hedgehog signaling antagonists for cancer therapy |
| Q36417421 | Important genes in the pathogenesis of 5q- syndrome and their connection with ribosomal stress and the innate immune system pathway |
| Q81195403 | Inhibition of in vitro RNA binding and replicase activity by phosphorylation of the p33 replication protein of Cucumber necrosis tombusvirus |
| Q33778665 | Inhibition of the nuclear import of cubitus interruptus by roadkill in the presence of strong hedgehog signal |
| Q37809668 | International Union of Basic and Clinical Pharmacology. LXXX. The Class Frizzled Receptors |
| Q28591555 | Intraflagellar transport, cilia, and mammalian Hedgehog signaling: analysis in mouse embryonic fibroblasts |
| Q35015160 | Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium |
| Q28593489 | Loss of the serine/threonine kinase fused results in postnatal growth defects and lethality due to progressive hydrocephalus |
| Q51991109 | Manipulations of PKA in chick limb development reveal roles in digit patterning including a positive role in Sonic Hedgehog signaling. |
| Q33899466 | Mechanism and evolution of cytosolic Hedgehog signal transduction |
| Q37923514 | Mechanisms of Hedgehog signalling in cancer |
| Q97553945 | Miga mediated endoplasmic reticulum-mitochondria contact sites regulate neuronal homeostasis |
| Q36088405 | Molecular Characterization of Bovine SMO Gene and Effects of Its Genetic Variations on Body Size Traits in Qinchuan Cattle (Bos taurus). |
| Q61934982 | Molecular and immunohistochemical investigation of protein kinase a regulatory subunit type 1A (PRKAR1A) in odontogenic myxomas |
| Q37771779 | Molecular mechanisms of endothelial differentiation |
| Q35919920 | PI(4)P Promotes Phosphorylation and Conformational Change of Smoothened through Interaction with Its C-terminal Tail |
| Q42033728 | PP4 and PP2A regulate Hedgehog signaling by controlling Smo and Ci phosphorylation |
| Q34574774 | Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling |
| Q46973015 | Phosphorylation of frizzled-3. |
| Q81195396 | Phosphorylation of the p33 replication protein of Cucumber necrosis tombusvirus adjacent to the RNA binding site affects viral RNA replication |
| Q45416432 | Phosphorylation of viral RNA-dependent RNA polymerase and its role in replication of a plus-strand RNA virus. |
| Q28306716 | Phosphorylation regulates OLIG2 cofactor choice and the motor neuron-oligodendrocyte fate switch |
| Q28287724 | Plant viral movement proteins: agents for cell-to-cell trafficking of viral genomes |
| Q46073381 | Plasmodesmal-associated protein kinase in tobacco and Arabidopsis recognizes a subset of non-cell-autonomous proteins |
| Q28512810 | Protein kinase A acts at the basal body of the primary cilium to prevent Gli2 activation and ventralization of the mouse neural tube |
| Q36209723 | Protein kinase A and casein kinases mediate sequential phosphorylation events in the circadian negative feedback loop |
| Q98623343 | Protein phosphatase 4 promotes Hedgehog signaling through dephosphorylation of Suppressor of fused |
| Q35868275 | RACK1 promotes non-small-cell lung cancer tumorigenicity through activating sonic hedgehog signaling pathway |
| Q37114945 | Recent progress in the study of Hedgehog signaling |
| Q42807908 | Regulation of Gli1 localization by the cAMP/protein kinase A signaling axis through a site near the nuclear localization signal |
| Q38933688 | Regulation of Hedgehog Signalling Inside and Outside the Cell. |
| Q36041364 | Regulation of Hedgehog signaling by ubiquitination |
| Q36046503 | Regulation of Smoothened Phosphorylation and High-Level Hedgehog Signaling Activity by a Plasma Membrane Associated Kinase. |
| Q47145510 | Regulation of Smoothened Trafficking and Hedgehog Signaling by the SUMO Pathway |
| Q89180921 | Regulation of Smoothened ubiquitylation and cell surface expression through a Cul4-DDB1-Gβ E3 ubiquitin ligase complex |
| Q35179117 | Regulation of smoothened by Drosophila G-protein-coupled receptor kinases |
| Q42846647 | Regulation of wingless signaling by the CKI family in Drosophila limb development. |
| Q92757280 | Role of Protein Kinases in Hedgehog Pathway Control and Implications for Cancer Therapy |
| Q34153940 | Role of lipid metabolism in smoothened derepression in hedgehog signaling |
| Q33855672 | Role of the Drosophila non-visual ß-arrestin kurtz in hedgehog signalling. |
| Q37640295 | SUMO regulates the activity of Smoothened and Costal-2 in Drosophila Hedgehog signaling |
| Q36478223 | Sequential phosphorylation of smoothened transduces graded hedgehog signaling. |
| Q36897356 | Small-molecule modulators of Hh and Wnt signaling pathways |
| Q38088823 | Smoothened antagonists: a promising new class of antitumor agents |
| Q33359720 | Smoothened goes molecular: new pieces in the hedgehog signaling puzzle |
| Q36812361 | Smoothened oligomerization/higher order clustering in lipid rafts is essential for high Hedgehog activity transduction |
| Q36914895 | Smoothened regulates activator and repressor functions of Hedgehog signaling via two distinct mechanisms |
| Q36676046 | Smoothened regulation in response to Hedgehog stimulation |
| Q35131741 | Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2 |
| Q36992971 | Smoothened signaling in vertebrates is facilitated by a G protein-coupled receptor kinase |
| Q36387660 | Smoothened transduces Hedgehog signal by forming a complex with Evc/Evc2. |
| Q28478568 | Sonic Hedgehog dependent phosphorylation by CK1α and GRK2 is required for ciliary accumulation and activation of smoothened |
| Q27680954 | Structural insights into the role of the Smoothened cysteine-rich domain in Hedgehog signalling |
| Q37608723 | Suppressor of fused impedes Ci/Gli nuclear import by opposing Trn/Kapβ2 in Hedgehog signaling |
| Q50630293 | Switch of PKA substrates from Cubitus interruptus to Smoothened in the Hedgehog signalosome complex. |
| Q90438213 | Synaptojanin regulates Hedgehog signalling by modulating phosphatidylinositol 4-phosphate levels |
| Q35808842 | The G protein-coupled receptor regulatory kinase GPRK2 participates in Hedgehog signaling in Drosophila. |
| Q38052884 | The Hedgehog signal transduction network |
| Q38374713 | The Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phosphorylation |
| Q34070454 | The Kto-Skd complex can regulate ptc expression by interacting with Cubitus interruptus (Ci) in the Hedgehog signaling pathway |
| Q38829260 | The Orphan G Protein-coupled Receptor Gpr175 (Tpra40) Enhances Hedgehog Signaling by Modulating cAMP Levels |
| Q40015415 | The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control |
| Q52738410 | The complexities of G-protein-coupled receptor kinase function in Hedgehog signaling. |
| Q35038489 | The contributions of protein kinase A and smoothened phosphorylation to hedgehog signal transduction in Drosophila melanogaster |
| Q41138602 | The decoupling of Smoothened from Galphai proteins has little effect on Gli3 protein processing and Hedgehog-regulated chick neural tube patterning |
| Q47676569 | The deubiquitinase UCHL5/UCH37 positively regulates Hedgehog signaling by deubiquitinating Smoothened |
| Q41695885 | The emerging roles of phosphatases in Hedgehog pathway. |
| Q35655642 | The extracellular loops of Smoothened play a regulatory role in control of Hedgehog pathway activation |
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| Q38306371 | The last 59 amino acids of Smoothened cytoplasmic tail directly bind the protein kinase Fused and negatively regulate the Hedgehog pathway. |
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| Q28481326 | The nitric oxide-cyclic GMP pathway regulates FoxO and alters dopaminergic neuron survival in Drosophila |
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