Specific binding of a hexanucleotide to HIV-1 reverse transcriptase: a novel class of bioactive molecules

scientific article published on 12 October 2006

Specific binding of a hexanucleotide to HIV-1 reverse transcriptase: a novel class of bioactive molecules is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/NAR/GKL533
P932PMC publication ID1635251
P698PubMed publication ID17038335
P5875ResearchGate publication ID6757768

P50authorDina GrohmannQ91312357
P2093author name stringGeorg Sczakiel
Winfried Wünsche
Sandra D Laufer
Tobias Restle
Alessandra Mescalchin
P2860cites workStructure of HIV-2 reverse transcriptase at 2.35-A resolution and the mechanism of resistance to non-nucleoside inhibitors.Q24540388
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UCSF Chimera--a visualization system for exploratory research and analysisQ27860666
Docking essential dynamics eigenstructuresQ28258497
Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivativesQ28323202
Combinatorially selected guanosine-quartet structure is a potent inhibitor of human immunodeficiency virus envelope-mediated cell fusionQ28368943
Role of Pr160gag-pol in mediating the selective incorporation of tRNA(Lys) into human immunodeficiency virus type 1 particlesQ28646824
Use of organic cosmotropic solutes to crystallize flexible proteins: application to T7 RNA polymerase and its complex with the inhibitor T7 lysozymeQ30429048
Adaptive recognition by nucleic acid aptamersQ30836242
NMR spectroscopy techniques for screening and identifying ligand binding to protein receptorsQ30887851
Aptamers: an emerging class of therapeuticsQ33211036
Isolation of virus-neutralizing RNAs from a large pool of random sequencesQ33704732
An improved method to determine cell viability by simultaneous staining with fluorescein diacetate-propidium iodideQ34043489
Multiparameter single-molecule fluorescence spectroscopy reveals heterogeneity of HIV-1 reverse transcriptase:primer/template complexes.Q34761256
Antivirals and antiviral strategiesQ35889586
High affinity ligands from in vitro selection: complex targets.Q35974349
Intramers and aptamers: applications in protein-function analyses and potential for drug screeningQ36002329
Cloning and expression of the gene for bacteriophage T7 RNA polymeraseQ36266166
Aptamers--basic research, drug development, and clinical applicationsQ36311540
High-affinity ssDNA inhibitors of the reverse transcriptase of type 1 human immunodeficiency virusQ36679059
Disruption of HIV-1 integrase-DNA complexes by short 6-oxocytosine-containing oligonucleotidesQ38292574
HIV-1 reverse transcriptase-pseudoknot RNA aptamer interaction has a binding affinity in the low picomolar range coupled with high specificityQ38313513
Refined model for primer/template binding by HIV-1 reverse transcriptase: pre-steady-state kinetic analyses of primer/template binding and nucleotide incorporation events distinguish between different binding modes depending on the nature of the nucQ38320371
Combinatorial selection of high affinity RNA ligands to live African trypanosomesQ38326105
Analysis of the polymerization kinetics of homodimeric EIAV p51/51 reverse transcriptase implies the formation of a polymerase active site identical to heterodimeric EIAV p66/51 reverse transcriptaseQ38333840
HIV-1 integrase complexes with DNA dissociate in the presence of short oligonucleotides conjugated to acridineQ38339273
Endogenous expression of a high-affinity pseudoknot RNA aptamer suppresses replication of HIV-1.Q38362885
Mutations in the primer grip of human immunodeficiency virus type 1 reverse transcriptase impair proviral DNA synthesis and virion maturation.Q39580647
Rapid and simple purification of T7 RNA polymeraseQ40503593
Phenotypic analysis of the sensitivity of HIV-1 to inhibitors of the reverse transcriptase, protease, and integrase using a self-inactivating virus vector systemQ40796655
The structure of HIV-1 reverse transcriptase complexed with an RNA pseudoknot inhibitorQ41971165
Temperature-dependent equilibrium between the open and closed conformation of the p66 subunit of HIV-1 reverse transcriptase revealed by site-directed spin labelling.Q42632779
Expression of the heterodimeric form of human immunodeficiency virus type 2 reverse transcriptase in Escherichia coli and characterization of the enzyme.Q43611277
Co-expression of the subunits of the heterodimer of HIV-1 reverse transcriptase in Escherichia coli.Q54726149
Sequences within Pr160gag-pol affecting the selective packaging of primer tRNA(Lys3) into HIV-1Q73910219
P433issue19
P407language of work or nameEnglishQ1860
P304page(s)5631-5637
P577publication date2006-10-12
P1433published inNucleic Acids ResearchQ135122
P1476titleSpecific binding of a hexanucleotide to HIV-1 reverse transcriptase: a novel class of bioactive molecules
P478volume34

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cites work (P2860)
Q90153498Click Chemistry-Based Two-Component System for Efficient Inhibition of Human Immunodeficiency Virus (HIV) Reverse Transcriptase (RT)
Q30155408Functional binding of hexanucleotides to 3C protease of hepatitis A virus
Q34756615Novel HIV-1 reverse transcriptase inhibitors.
Q37833455Oligomeric nucleic acids as antivirals.
Q38337802Specific recognition of proteins by array-bound hexanucleotides