| scholarly article | Q13442814 |
| P356 | DOI | 10.1074/JBC.M512710200 |
| P8608 | Fatcat ID | release_vhrvjnsq4renfpgqdk3fkf3noy |
| P698 | PubMed publication ID | 16407193 |
| P50 | author | Paul Jolicoeur | Q3371543 |
| Kalle Saksela | Q30158253 | ||
| P2093 | author name string | Zaher Hanna | |
| Patrick Vincent | |||
| Denis Kay | |||
| Elena Priceputu | |||
| P2860 | cites work | Activation of Vav by Nef induces cytoskeletal rearrangements and downstream effector functions | Q22010220 |
| Identification of the Nef-associated kinase as p21-activated kinase 2 | Q22010961 | ||
| Endocytosis of major histocompatibility complex class I molecules is induced by the HIV–1 Nef protein | Q22251058 | ||
| Mechanism for down-regulation of CD28 by Nef. | Q24291079 | ||
| PAK kinases are directly coupled to the PIX family of nucleotide exchange factors | Q24313368 | ||
| Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain | Q24336554 | ||
| Mutation of a conserved residue (D123) required for oligomerization of human immunodeficiency virus type 1 Nef protein abolishes interaction with human thioesterase and results in impairment of Nef biological functions | Q24524045 | ||
| Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling | Q24532104 | ||
| Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling | Q24682031 | ||
| Multisite autophosphorylation of p21-activated protein kinase gamma-PAK as a function of activation | Q28119004 | ||
| p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis | Q28141296 | ||
| Phosphorylation of p85 beta PIX, a Rac/Cdc42-specific guanine nucleotide exchange factor, via the Ras/ERK/PAK2 pathway is required for basic fibroblast growth factor-induced neurite outgrowth | Q28201468 | ||
| Basic fibroblast growth factor stimulates activation of Rac1 through a p85 betaPIX phosphorylation-dependent pathway | Q28209505 | ||
| Negative control of the Myc protein by the stress-responsive kinase Pak2 | Q28241326 | ||
| Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients | Q28284190 | ||
| Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection | Q28304773 | ||
| Lentivirus Nef specifically activates Pak2. | Q28647353 | ||
| Importance of the nef gene for maintenance of high virus loads and for development of AIDS | Q29618369 | ||
| Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement | Q30014848 | ||
| The pathogenicity of human immunodeficiency virus (HIV) type 1 Nef in CD4C/HIV transgenic mice is abolished by mutation of its SH3-binding domain, and disease development is delayed in the absence of Hck. | Q30167954 | ||
| Simian immunodeficiency virus containing mutations in N-terminal tyrosine residues and in the PxxP motif in Nef replicates efficiently in rhesus macaques | Q30168517 | ||
| The conserved core of human immunodeficiency virus type 1 Nef is essential for association with Lck and for enhanced viral replication in T-lymphocytes | Q30175324 | ||
| SH3-Domain binding function of HIV-1 Nef is required for association with a PAK-related kinase | Q30176003 | ||
| Association of simian immunodeficiency virus Nef with cellular serine/threonine kinases is dispensable for the development of AIDS in rhesus macaques | Q30176465 | ||
| SH3-mediated Hck tyrosine kinase activation and fibroblast transformation by the Nef protein of HIV-1. | Q30176471 | ||
| Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef- and Vpu-inhibitable manner | Q33333829 | ||
| The numerous effector functions of Nef. | Q33635872 | ||
| HIV: a new role for Nef in the spread of HIV. | Q33664665 | ||
| The downregulation of CD4 and MHC-I by primate lentiviruses: a paradigm for the modulation of cell surface receptors | Q33683328 | ||
| The Nef-mediated AIDS-like disease of CD4C/human immunodeficiency virus transgenic mice is associated with increased Fas/FasL expression on T cells and T-cell death but is not prevented in Fas-, FasL-, tumor necrosis factor receptor 1-, or interleuk | Q33780442 | ||
| Pathogenic conversion of live attenuated simian immunodeficiency virus vaccines is associated with expression of truncated Nef | Q33798199 | ||
| Unusual polymorphisms in human immunodeficiency virus type 1 associated with nonprogressive infection | Q33803970 | ||
| Genetic and functional diversity of human immunodeficiency virus type 1 subtype B Nef primary isolates | Q33837307 | ||
| Human immunodeficiency virus type 1 Nef selectively associates with a catalytically active subpopulation of p21-activated kinase 2 (PAK2) independently of PAK2 binding to Nck or beta-PIX | Q33931747 | ||
| HIV and SIV Nef modulate signal transduction and protein sorting in T cells | Q34170887 | ||
| Expression of simian immunodeficiency virus nef in immune cells of transgenic mice leads to a severe AIDS-like disease | Q34335218 | ||
| Nef proteins from simian immunodeficiency virus-infected chimpanzees interact with p21-activated kinase 2 and modulate cell surface expression of various human receptors | Q34436944 | ||
| p21-activated kinase 1 (Pak1) regulates cell motility in mammalian fibroblasts | Q36256616 | ||
| Expression of the type 1 human immunodeficiency virus Nef protein in T cells prevents antigen receptor-mediated induction of interleukin 2 mRNA. | Q37532727 | ||
| In vitro binding and phosphorylation of human immunodeficiency virus type 1 Nef protein by serine/threonine protein kinase | Q38294973 | ||
| p21-activated kinase 1 plays a critical role in cellular activation by Nef. | Q39451991 | ||
| Disrupting surfaces of nef required for downregulation of CD4 and for enhancement of virion infectivity attenuates simian immunodeficiency virus replication in vivo | Q39539413 | ||
| Human immunodeficiency virus type 1 Nef-mediated downregulation of CD4 correlates with Nef enhancement of viral pathogenesis | Q39699492 | ||
| Nef associates with p21-activated kinase 2 in a p21-GTPase-dependent dynamic activation complex within lipid rafts. | Q40273924 | ||
| HIV accessory proteins: leading roles for the supporting cast. | Q40456339 | ||
| Rodent cells support key functions of the human immunodeficiency virus type 1 pathogenicity factor Nef | Q40471343 | ||
| Human immunodeficiency virus type 1 Nef activates p21-activated kinase via recruitment into lipid rafts | Q40572781 | ||
| The role of Nef in the replication cycle of the human and simian immunodeficiency viruses | Q40640655 | ||
| HIV-1 Nef associated PAK and PI3-kinases stimulate Akt-independent Bad-phosphorylation to induce anti-apoptotic signals | Q40770875 | ||
| CD4+ T cells from CD4C/HIVNef transgenic mice show enhanced activation in vivo with impaired proliferation in vitro but are dispensable for the development of a severe AIDS-like organ disease | Q40815028 | ||
| Inhibition of HIV-1 progeny virion release by cell-surface CD4 is relieved by expression of the viral Nef protein | Q40947083 | ||
| Identification of regions in HIV-1 Nef required for efficient downregulation of cell surface CD4. | Q41110573 | ||
| Nef and the Nef-associated kinase | Q41142054 | ||
| From negative factor to a critical role in virus pathogenesis: the changing fortunes of Nef. | Q41184642 | ||
| Human immunodeficiency virus type 1 Nef protein is incorporated into virus particles and specifically cleaved by the viral proteinase | Q41203484 | ||
| Mutational analysis of HIV-1 Nef: identification of two mutants that are temperature-sensitive for CD4 downregulation | Q41225968 | ||
| Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation | Q41269491 | ||
| HIV-1: is Nef a PAK animal? | Q41311839 | ||
| A conserved domain and membrane targeting of Nef from HIV and SIV are required for association with a cellular serine kinase activity | Q41333852 | ||
| The positive influence of Nef on viral infectivity | Q41338314 | ||
| Analysis of Nef-induced MHC-I endocytosis | Q41338324 | ||
| p21-activated protein kinase gamma-PAK suppresses programmed cell death of BALB3T3 fibroblasts | Q42830675 | ||
| In vivo mutational analysis of the N-terminal region of HIV-1 Nef reveals critical motifs for the development of an AIDS-like disease in CD4C/HIV transgenic mice | Q45046886 | ||
| Live attenuated, multiply deleted simian immunodeficiency virus causes AIDS in infant and adult macaques | Q45751494 | ||
| Association of simian immunodeficiency virus Nef with the T-cell receptor (TCR) zeta chain leads to TCR down-modulation | Q45752793 | ||
| Resistance of neonatal monkeys to live attenuated vaccine strains of simian immunodeficiency virus | Q45765427 | ||
| Activation of PAK by HIV and SIV Nef: importance for AIDS in rhesus macaques | Q46878044 | ||
| Functional and structural defects in HIV type 1 nef genes derived from pediatric long-term survivors | Q47807438 | ||
| HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes. | Q54148550 | ||
| The N-Terminus of Nef from HIV-1/SIV Associates with a Protein Complex Containing Lck and a Serine Kinase | Q57243844 | ||
| P433 | issue | 11 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | HIV/AIDS | Q12199 |
| P1104 | number of pages | 15 | |
| P304 | page(s) | 6940-6954 | |
| P577 | publication date | 2005-12-28 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | Activation of p21-activated kinase 2 and its association with Nef are conserved in murine cells but are not sufficient to induce an AIDS-like disease in CD4C/HIV transgenic mice | |
| P478 | volume | 281 |
| Q37410702 | Adult AIDS-like disease in a novel inducible human immunodeficiency virus type 1 Nef transgenic mouse model: CD4+ T-cell activation is Nef dependent and can occur in the absence of lymphophenia |
| Q36412750 | Compartmentalization of the gut viral reservoir in HIV-1 infected patients |
| Q42913149 | HIV-1 Nef Disrupts Maturation of CD4+ T Cells through CD4/Lck Modulation |
| Q27021639 | How HIV takes advantage of the cytoskeleton in entry and replication |
| Q42157622 | Human immunodeficiency virus type 1 Nef recruits the guanine exchange factor Vav1 via an unexpected interface into plasma membrane microdomains for association with p21-activated kinase 2 activity |
| Q39741159 | Lentiviral Nef proteins utilize PAK2-mediated deregulation of cofilin as a general strategy to interfere with actin remodeling |
| Q38260894 | Nef as a Proliferative Factor for Kidney Epithelial Cells in HIV-Associated Nephropathy |
| Q30441489 | Nef does not contribute to replication differences between R5 pre-AIDS and AIDS HIV-1 clones from patient ACH142 |
| Q39472336 | No detectable XMRV in subjects with chronic fatigue syndrome from Quebec |
| Q86190175 | Normal development and function but impaired memory phenotype of CD8⁺ T cells in transgenic mice expressing HIV-1 Nef in its natural target cells |
| Q40168499 | Primary human immunodeficiency virus type 1 nef alleles show major differences in pathogenicity in transgenic mice |
| Q42094434 | Selective expression of human immunodeficiency virus Nef in specific immune cell populations of transgenic mice is associated with distinct AIDS-like phenotypes |
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