| scholarly article | Q13442814 |
| P2093 | author name string | Trono D | |
| Krause L | |||
| Chen YL | |||
| Aiken C | |||
| P433 | issue | 1 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | mutational analysis | Q1955810 |
| P304 | page(s) | 293-300 | |
| P577 | publication date | 1996-03-01 | |
| P1433 | published in | Virology | Q7934867 |
| P1476 | title | Mutational analysis of HIV-1 Nef: identification of two mutants that are temperature-sensitive for CD4 downregulation | |
| P478 | volume | 217 |
| Q37110624 | A basic patch on alpha-adaptin is required for binding of human immunodeficiency virus type 1 Nef and cooperative assembly of a CD4-Nef-AP-2 complex |
| Q36424087 | A diacidic motif in human immunodeficiency virus type 1 Nef is a novel determinant of binding to AP-2 |
| Q38316915 | Activation of p21-activated kinase 2 and its association with Nef are conserved in murine cells but are not sufficient to induce an AIDS-like disease in CD4C/HIV transgenic mice |
| Q34434761 | Ataxia-telangiectasia-mutated (ATM) protein can enhance human immunodeficiency virus type 1 replication by stimulating Rev function |
| Q24321956 | Binding of HIV-1 Nef to a novel thioesterase enzyme correlates with Nef-mediated CD4 down-regulation |
| Q24324674 | Binding of c-Raf1 kinase to a conserved acidic sequence within the carboxyl-terminal region of the HIV-1 Nef protein |
| Q36015423 | CD4 and MHC-I downregulation are conserved in primary HIV-1 Nef alleles from brain and lymphoid tissues, but Pak2 activation is highly variable |
| Q36538938 | CD4 and major histocompatibility complex class I downregulation by the human immunodeficiency virus type 1 nef protein in pediatric AIDS progression |
| Q33333829 | Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef- and Vpu-inhibitable manner |
| Q40777827 | Deletion of N-terminal myristoylation site of HIV Nef abrogates both MHC-1 and CD4 down-regulation |
| Q39606016 | Direct in vitro binding of full-length human immunodeficiency virus type 1 Nef protein to CD4 cytoplasmic domain |
| Q34302168 | Dynamic evolution of the human immunodeficiency virus type 1 pathogenic factor, Nef. |
| Q40056813 | Endocytic sorting motif interactions involved in Nef-mediated downmodulation of CD4 and CD3. |
| Q33837307 | Genetic and functional diversity of human immunodeficiency virus type 1 subtype B Nef primary isolates |
| Q35861175 | HIV-1 Env and Nef Cooperatively Contribute to Plasmacytoid Dendritic Cell Activation via CD4-Dependent Mechanisms |
| Q44807433 | HIV-1 Nef enhances both membrane expression and virion incorporation of Env products. A model for the Nef-dependent increase of HIV-1 infectivity |
| Q51986948 | HIV-1 Nef mutations abrogating downregulation of CD4 affect other Nef functions and show reduced pathogenicity in transgenic mice. |
| Q22253302 | HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes |
| Q38830464 | HIV-1 Nef: Taking Control of Protein Trafficking |
| Q36926697 | HIV-1 Nef: at the crossroads |
| Q27681494 | How HIV-1 Nef hijacks the AP-2 clathrin adaptor to downregulate CD4 |
| Q37232786 | Human immunodeficiency virus type 1 Nef protein targets CD4 to the multivesicular body pathway. |
| Q33768829 | Inhibition of human immunodeficiency virus type 1 by triciribine involves the accessory protein nef |
| Q34283497 | Interaction of HIV-1 Nef protein with the host protein Alix promotes lysosomal targeting of CD4 receptor. |
| Q24682806 | Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity |
| Q24323265 | Interactions between HIV1 Nef and vacuolar ATPase facilitate the internalization of CD4 |
| Q24533226 | Mechanism of Nef-induced CD4 endocytosis: Nef connects CD4 with the mu chain of adaptor complexes |
| Q37183848 | Mechanisms of HIV-1 Nef function and intracellular signaling |
| Q41384498 | Nef and PAK: virulence factor and cellular accomplice |
| Q40008941 | Nef does not affect the efficiency of human immunodeficiency virus type 1 fusion with target cells |
| Q30175880 | Nef-induced CD4 and major histocompatibility complex class I (MHC-I) down-regulation are governed by distinct determinants: N-terminal alpha helix and proline repeat of Nef selectively regulate MHC-I trafficking |
| Q22009370 | Nef-induced CD4 degradation: a diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of beta-COP in endosomes |
| Q33851483 | Nef-induced CD4 downregulation: a diacidic sequence in human immunodeficiency virus type 1 Nef does not function as a protein sorting motif through direct binding to beta-COP. |
| Q33800544 | Nef-induced major histocompatibility complex class I down-regulation is functionally dissociated from its virion incorporation, enhancement of viral infectivity, and CD4 down-regulation |
| Q34999681 | Nef-mediated downregulation of CD4 enhances human immunodeficiency virus type 1 replication in primary T lymphocytes |
| Q92666235 | Potent Enhancement of HIV-1 Replication by Nef in the Absence of SERINC3 and SERINC5 |
| Q30176531 | Refined solution structure and backbone dynamics of HIV-1 Nef. |
| Q30415417 | Role of Coatomer Protein I in Virus Replication |
| Q36857108 | Role of Nef in HIV-1 replication and pathogenesis |
| Q34203170 | Self-association of the Lentivirus protein, Nef |
| Q40242493 | Specific and distinct determinants mediate membrane binding and lipid raft incorporation of HIV-1(SF2) Nef. |
| Q97905448 | Structural basis of CD4 downregulation by HIV-1 Nef |
| Q56907580 | Structural similarity of two T cell signaling regulators suggests a conserved and interactive mechanism of immunosuppression |
| Q24522550 | Structure--function relationships in HIV-1 Nef. |
| Q30175300 | The HIV Nef protein alters Ca(2+) signaling in myelomonocytic cells through SH3-mediated protein-protein interactions |
| Q40703608 | The HIV-1 Nef protein and phagocyte NADPH oxidase activation |
| Q24645110 | The Nef protein of HIV-1 associates with rafts and primes T cells for activation |
| Q24673997 | The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix |
| Q30167954 | The pathogenicity of human immunodeficiency virus (HIV) type 1 Nef in CD4C/HIV transgenic mice is abolished by mutation of its SH3-binding domain, and disease development is delayed in the absence of Hck. |
| Q33783315 | The proteolytic cleavage of human immunodeficiency virus type 1 Nef does not correlate with its ability to stimulate virion infectivity. |
| Q34415192 | Use of the two-hybrid system to identify cellular partners of the HIV1 Nef protein. |
| Q37412098 | Viral factors in non-progression |
| Q33785282 | Virion incorporation of human immunodeficiency virus type 1 Nef is mediated by a bipartite membrane-targeting signal: analysis of its role in enhancement of viral infectivity. |
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