Mechanism of Nef-induced CD4 endocytosis: Nef connects CD4 with the mu chain of adaptor complexes

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Mechanism of Nef-induced CD4 endocytosis: Nef connects CD4 with the mu chain of adaptor complexes is …
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scholarly articleQ13442814

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P356DOI10.1093/EMBOJ/17.9.2472
P3181OpenCitations bibliographic resource ID653029
P932PMC publication ID1170589
P698PubMed publication ID9564030
P5875ResearchGate publication ID13716489

P2093author name stringD Trono
J L Carpentier
M Foti
V Piguet
A Mangasarian
Y L Chen
P2860cites workEndocytosis of major histocompatibility complex class I molecules is induced by the HIV–1 Nef proteinQ22251058
Serine phosphorylation-independent downregulation of cell-surface CD4 by nefQ22251290
Human immunodeficiency virus type 1 Nef and p56lck protein-tyrosine kinase interact with a common element in CD4 cytoplasmic tailQ24310700
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinasesQ24319848
Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domainQ24336240
Regulatory interactions in the recognition of endocytic sorting signals by AP-2 complexesQ24336247
Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signalingQ24532104
The beta 1 and beta 2 subunits of the AP complexes are the clathrin coat assembly componentsQ24564302
Nef-mediated clathrin-coated pit formationQ24678715
Association and colocalization of Eps15 with adaptor protein-2 and clathrinQ24683892
The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunitQ27860669
A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chainsQ27913878
The AP-3 adaptor complex is essential for cargo-selective transport to the yeast vacuole.Q27930544
Interaction of Shc with adaptor protein adaptinsQ28277206
The ear of alpha-adaptin interacts with the COOH-terminal domain of the Eps 15 proteinQ28281593
Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipientsQ28284190
Interaction of tyrosine-based sorting signals with clathrin-associated proteinsQ28290076
Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infectionQ28304773
Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptorsQ29615768
Importance of the nef gene for maintenance of high virus loads and for development of AIDSQ29618369
Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptorQ29618735
Signal-dependent membrane protein trafficking in the endocytic pathwayQ29622948
The CD4 determinant for downregulation by HIV-1 Nef directly binds to Nef. Mapping of the Nef binding surface by NMR.Q30176862
The HIV-1 Nef protein acts as a connector with sorting pathways in the Golgi and at the plasma membraneQ34418242
Human immunodeficiency virus type 1 Nef protein inhibits activation pathways in peripheral blood mononuclear cells and T-cell lines.Q35835206
Human immunodeficiency virus type 1 Nef-induced down-modulation of CD4 is due to rapid internalization and degradation of surface CD4.Q36625495
Analyzing protein-protein interactions using two-hybrid systemQ36787579
Endocytosis and transcytosisQ37828723
Nef-CD4 physical interaction sensed with the yeast two-hybrid systemQ38361343
Receptor-mediated endocytosis: concepts emerging from the LDL receptor systemQ39461911
Human immunodeficiency virus type 1 Nef induces accumulation of CD4 in early endosomesQ39868503
The role of clathrin, adaptors and dynamin in endocytosisQ40647427
Internalization and recycling of CD4 transfected into HeLa and NIH3T3 cellsQ40822207
Myristoylation-dependent binding of HIV-1 Nef to CD4.Q41022468
Mutational analysis of HIV-1 Nef: identification of two mutants that are temperature-sensitive for CD4 downregulationQ41225968
Role of beta-arrestin in mediating agonist-promoted G protein-coupled receptor internalizationQ41238228
Differential endocytosis of CD4 in lymphocytic and nonlymphocytic cellsQ41692782
The appendage domain of the AP-2 subunit is not required for assembly or invagination of clathrin-coated pitsQ42075246
Regulation and function of the CD3gamma DxxxLL motif: a binding site for adaptor protein-1 and adaptor protein-2 in vitro.Q42831149
Endocytosis of beta 2 integrins by stimulated human neutrophils analyzed by flow cytometryQ46170959
HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes.Q54148550
Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2Q56908447
HIV F/3' orf encodes a phosphorylated GTP-binding protein resembling an oncogene productQ59048755
Clathrin domains involved in recognition by assembly protein AP-2Q67986737
Down-modulation of MHC-I in a CD4+ T cell line, CEM-E5, after HIV-1 infectionQ69375431
Structural determinants of interaction of tyrosine-based sorting signals with the adaptor medium chainsQ71763363
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectendocytosisQ189814
P304page(s)2472-2481
P577publication date1998-05-01
P1433published inThe EMBO JournalQ1278554
P1476titleMechanism of Nef-induced CD4 endocytosis: Nef connects CD4 with the mu chain of adaptor complexes
P478volume17