Nef-induced CD4 degradation: a diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of beta-COP in endosomes

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Nef-induced CD4 degradation: a diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of beta-COP in endosomes is …
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scholarly articleQ13442814

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P356DOI10.1016/S0092-8674(00)80715-1
P8608Fatcat IDrelease_h65263jgavgw5k3cpx7565y5pi
P3181OpenCitations bibliographic resource ID2579362
P698PubMed publication ID10199403

P2093author name stringD Trono
F Gu
J Gruenberg
J L Carpentier
M Foti
N Demaurex
V Piguet
P2860cites workCoupling of coat assembly and vesicle budding to packaging of putative cargo receptorsQ22008843
Endocytosis of major histocompatibility complex class I molecules is induced by the HIV–1 Nef proteinQ22251058
Serine phosphorylation-independent downregulation of cell-surface CD4 by nefQ22251290
Interactions between HIV1 Nef and vacuolar ATPase facilitate the internalization of CD4Q24323265
Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domainQ24336240
Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domainQ24336554
Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signalingQ24532104
Mechanism of Nef-induced CD4 endocytosis: Nef connects CD4 with the mu chain of adaptor complexesQ24533226
In migrating fibroblasts, recycling receptors are concentrated in narrow tubules in the pericentriolar area, and then routed to the plasma membrane of the leading lamellaQ24657613
An endosomal beta COP is involved in the pH-dependent formation of transport vesicles destined for late endosomesQ24671983
Multivesicular endosomes containing internalized EGF-EGF receptor complexes mature and then fuse directly with lysosomesQ24672025
Nef-mediated clathrin-coated pit formationQ24678715
Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivityQ24682806
A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chainsQ27913878
Coatomer is essential for retrieval of dilysine-tagged proteins to the endoplasmic reticulumQ27938624
Association of coatomer proteins with the beta-receptor for platelet-derived growth factorQ28242587
PACS-1 defines a novel gene family of cytosolic sorting proteins required for trans-Golgi network localizationQ28278951
Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipientsQ28284190
A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptorQ28288514
A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4Q28288524
Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infectionQ28304773
Coatomer interaction with di-lysine endoplasmic reticulum retention motifsQ28609806
A Role for Acidic Residues in Di-leucine Motif-based Targeting to the Endocytic PathwayQ28612864
The solution structure of HIV-1 Nef reveals an unexpected fold and permits delineation of the binding surface for the SH3 domain of Hck tyrosine protein kinaseQ28647550
Importance of the nef gene for maintenance of high virus loads and for development of AIDSQ29618369
The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brainQ29618472
Signal transduction by lymphocyte antigen receptorsQ29619894
Nef-induced CD4 and major histocompatibility complex class I (MHC-I) down-regulation are governed by distinct determinants: N-terminal alpha helix and proline repeat of Nef selectively regulate MHC-I traffickingQ30175880
The CD4 determinant for downregulation by HIV-1 Nef directly binds to Nef. Mapping of the Nef binding surface by NMR.Q30176862
The cytoplasmic domain of P-selectin contains a sorting determinant that mediates rapid degradation in lysosomesQ30442254
Tubular early endosomal networks in AtT20 and other cellsQ33404259
New COP1-binding motifs involved in ER retrievalQ33890112
The HIV-1 Nef protein acts as a connector with sorting pathways in the Golgi and at the plasma membraneQ34418242
Nef interacts with the mu subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I moleculesQ34468033
Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesisQ35845204
Characterization of the early endosome and putative endocytic carrier vesicles in vivo and with an assay of vesicle fusion in vitroQ36220495
Structural requirements and sequence motifs for polarized sorting and endocytosis of LDL and Fc receptors in MDCK cells.Q36234444
ADP-ribosylation factor 6 regulates a novel plasma membrane recycling pathwayQ36273935
Functional dissection of COP-I subunits in the biogenesis of multivesicular endosomesQ36274983
A lysosomal targeting signal in the cytoplasmic tail of the beta chain directs HLA-DM to MHC class II compartments.Q36382769
Human immunodeficiency virus type 1 Nef-induced down-modulation of CD4 is due to rapid internalization and degradation of surface CD4.Q36625495
The role of clathrin, adaptors and dynamin in endocytosisQ40647427
A lipid associated with the antiphospholipid syndrome regulates endosome structure and functionQ41056430
Inhibition of endosome function in CHO cells bearing a temperature-sensitive defect in the coatomer (COPI) component epsilon-COP.Q41067848
Mutational analysis of HIV-1 Nef: identification of two mutants that are temperature-sensitive for CD4 downregulationQ41225968
Targeting of a lysosomal membrane protein: a tyrosine-containing endocytosis signal in the cytoplasmic tail of lysosomal acid phosphatase is necessary and sufficient for targeting to lysosomes.Q41229177
Linking cargo to vesicle formation: receptor tail interactions with coat proteins.Q41566699
An alpha-helical signal in the cytosolic domain of the interleukin 2 receptor beta chain mediates sorting towards degradation after endocytosisQ42805931
Beta-COP is essential for biosynthetic membrane transport from the endoplasmic reticulum to the Golgi complex in vivoQ45345741
Nef--an adaptor adaptor?Q47686975
The role of endosomes and lysosomes in MHC class II functioningQ47927773
HIV-1 regulatory/accessory genes: keys to unraveling viral and host cell biologyQ47956025
HIV-1 auxiliary proteins: making connections in a dying cellQ47964324
HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes.Q54148550
Myristoylation-enhanced binding of the HIV-1 Nef protein to T cell skeletal matrix.Q54649040
EndocytosisQ57374715
The mannose 6-phosphate receptor and the biogenesis of lysosomesQ57960197
HIV F/3' orf encodes a phosphorylated GTP-binding protein resembling an oncogene productQ59048755
Budding from Golgi membranes requires the coatomer complex of non-clathrin coat proteinsQ59068188
Cytoplasmic coat proteins involved in endosome functionQ70787141
Endocytosis and lysosomal targeting of epidermal growth factor receptors are mediated by distinct sequences independent of the tyrosine kinase domainQ72591871
HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localizationQ72610545
Mechanism of acidification of the trans-Golgi network (TGN). In situ measurements of pH using retrieval of TGN38 and furin from the cell surfaceQ74088770
Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic miceQ77470803
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)63-73
P577publication date1999-04-02
P1433published inCellQ655814
P1476titleNef-induced CD4 degradation: a diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of beta-COP in endosomes
P478volume97

Reverse relations

cites work (P2860)
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