Inhibition of CRM1-mediated nucleocytoplasmic transport: triggering human melanoma cell apoptosis by perturbing multiple cellular pathways

scientific article

Inhibition of CRM1-mediated nucleocytoplasmic transport: triggering human melanoma cell apoptosis by perturbing multiple cellular pathways is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1042858379
P356DOI10.1038/JID.2012.233
P698PubMed publication ID22832492
P5875ResearchGate publication ID230567972

P2093author name stringChristine Wagner
Gaurav Pathria
Stephan N Wagner
P2860cites workML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomasQ24290531
Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanomaQ24597152
Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulationQ24629474
Rewired ERK-JNK signaling pathways in melanomaQ24683737
Inhibition of Mutated, Activated BRAF in Metastatic MelanomaQ27860458
Genomic analysis of metastasis reveals an essential role for RhoCQ28144278
The mammalian Mog1 protein is a guanine nucleotide release factor for RanQ28144428
Identification of a signal for rapid export of proteins from the nucleusQ29547742
Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanomaQ29614282
Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3KQ29614757
Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNAQ29620175
The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domainQ29620270
A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES maskingQ33890625
PI3K/Akt-sensitive MEK-independent compensatory circuit of ERK activation in ER-positive PI3K-mutant T47D breast cancer cellsQ33945648
NESbase version 1.0: a database of nuclear export signalsQ34169526
CBS9106 is a novel reversible oral CRM1 inhibitor with CRM1 degrading activityQ34207970
Nucleocytoplasmic transport: Ran, beta and beyondQ34446326
Expression of the nuclear export protein chromosomal region maintenance/exportin 1/Xpo1 is a prognostic factor in human ovarian cancerQ34756429
Nuclear transport and cancer: from mechanism to interventionQ35633427
The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functionsQ36360691
Identification of nuclear export inhibitors with potent anticancer activity in vivoQ37081966
CRM1-mediated nuclear export of proteins and drug resistance in cancerQ37320237
Gene expression changes in an animal melanoma model correlate with aggressiveness of human melanoma metastasesQ37375070
Mdm2-mediated ubiquitylation: p53 and beyond.Q37508606
ERK and cell death: mechanisms of ERK-induced cell death--apoptosis, autophagy and senescenceQ37618297
Polo-like kinase 1 is a potential therapeutic target in human melanomaQ39528323
Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6Q39576878
Phospho-ERK staining is a poor indicator of the mutational status of BRAF and NRAS in human melanoma.Q40005196
Recurrent patterns of dual RB and p53 pathway inactivation in melanomaQ40340097
Subcellular localization determines the protective effects of activated ERK2 against distinct apoptogenic stimuli in myeloid leukemia cells.Q40549982
Leptomycin B stabilizes and activates p53 in primary prostatic epithelial cells and induces apoptosis in the LNCaP cell lineQ40675789
Nuclear export of MAP kinase (ERK) involves a MAP kinase kinase (MEK)-dependent active transport mechanismQ40895714
Effects on normal fibroblasts and neuroblastoma cells of the activation of the p53 response by the nuclear export inhibitor leptomycin B.Q40911261
Expression and targeting of the apoptosis inhibitor, survivin, in human melanomaQ40912648
Survivin withdrawal by nuclear export failure as a physiological switch to commit cells to apoptosis.Q42066929
Differential regulation of c-Jun by ERK and JNK during PC12 cell differentiation.Q42650781
Involvement of protein phosphatase 2A nuclear accumulation and subsequent inactivation of activator protein-1 in leptomycin B-inhibited cyclin D1 expressionQ42796003
Anticancer therapy: boosting the bang of Bim.Q43252624
Cytoplasmic localization of mitogen-activated protein kinase kinase directed by its NH2-terminal, leucine-rich short amino acid sequence, which acts as a nuclear export signalQ45300833
Expression of CRM1 in human gliomas and its significance in p27 expression and clinical prognosis.Q45941482
Cytoplasmic retention of peroxide-activated ERK provides survival in primary cultures of rat hepatocytes.Q46552226
The Karyopherin proteins, Crm1 and Karyopherin beta1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation.Q46668855
Sef is a spatial regulator for Ras/MAP kinase signalingQ47235238
Fisetin: a natural fist against melanoma?Q48872219
hPEBP4 resists TRAIL-induced apoptosis of human prostate cancer cells by activating Akt and deactivating ERK1/2 pathways.Q53581949
Nuclear export is essential for the tumor-promoting activity of survivin.Q53588764
RSK and MSK in MAP kinase signallingQ58328419
Aberrant nucleocytoplasmic localization of the retinoblastoma tumor suppressor protein in human cancer correlates with moderate/poor tumor differentiationQ58376144
A comparison of the activity, sequence specificity, and CRM1-dependence of different nuclear export signalsQ73598439
CRM1-mediated nuclear export determines the cytoplasmic localization of the antiapoptotic protein SurvivinQ77851227
P433issue12
P407language of work or nameEnglishQ1860
P304page(s)2780-2790
P577publication date2012-07-26
P1433published inJournal of Investigative DermatologyQ3186921
P1476titleInhibition of CRM1-mediated nucleocytoplasmic transport: triggering human melanoma cell apoptosis by perturbing multiple cellular pathways
P478volume132

Reverse relations

cites work (P2860)
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