Regulation of RYR2 by sarcoplasmic reticulum Ca(2+).

scientific article

Regulation of RYR2 by sarcoplasmic reticulum Ca(2+). is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1111/1440-1681.12364
P698PubMed publication ID25603835

P2093author name stringPeter P Jones
Joe Z Zhang
Helen M M Waddell
P2860cites workThe arrhythmogenic human HRC point mutation S96A leads to spontaneous Ca(2+) release due to an impaired ability to buffer store Ca(2+)Q24297159
Calsequestrin 2 and arrhythmiasQ24300626
The Ser96Ala variant in histidine-rich calcium-binding protein is associated with life-threatening ventricular arrhythmias in idiopathic dilated cardiomyopathyQ24311983
The role of calsequestrin, triadin, and junctin in conferring cardiac ryanodine receptor responsiveness to luminal calciumQ24319842
Abnormal calcium cycling and cardiac arrhythmias associated with the human Ser96Ala genetic variant of histidine-rich calcium-binding proteinQ24338370
Crystal structure of calsequestrin from rabbit skeletal muscle sarcoplasmic reticulumQ27758879
A missense mutation in a highly conserved region of CASQ2 is associated with autosomal recessive catecholamine-induced polymorphic ventricular tachycardia in Bedouin families from IsraelQ28204838
Calsequestrin 2 (CASQ2) mutations increase expression of calreticulin and ryanodine receptors, causing catecholaminergic polymorphic ventricular tachycardiaQ28235110
Complex formation between junctin, triadin, calsequestrin, and the ryanodine receptor. Proteins of the cardiac junctional sarcoplasmic reticulum membraneQ28248323
Calcium sparks: elementary events underlying excitation-contraction coupling in heart muscleQ28256108
RyR2 mutations linked to ventricular tachycardia and sudden death reduce the threshold for store-overload-induced Ca2+ release (SOICR)Q28278038
Enhanced store overload-induced Ca2+ release and channel sensitivity to luminal Ca2+ activation are common defects of RyR2 mutations linked to ventricular tachycardia and sudden deathQ28278262
Ca2+ stores regulate ryanodine receptor Ca2+ release channels via luminal and cytosolic Ca2+ sitesQ28292368
Ablation of triadin causes loss of cardiac Ca2+ release units, impaired excitation-contraction coupling, and cardiac arrhythmiasQ28511129
Histidine-rich Ca binding protein: a regulator of sarcoplasmic reticulum calcium sequestration and cardiac functionQ28584988
Regulation of myocardial function by histidine-rich, calcium-binding proteinQ28585120
Termination of cardiac Ca2+ sparks: role of intra-SR [Ca2+], release flux, and intra-SR Ca2+ diffusionQ42087741
Ryanodine receptor current amplitude controls Ca2+ sparks in cardiac muscleQ42273475
Ca²+ spark-dependent and -independent sarcoplasmic reticulum Ca²+ leak in normal and failing rabbit ventricular myocytesQ42852603
Luminal Ca2+ controls termination and refractory behavior of Ca2+-induced Ca2+ release in cardiac myocytesQ44128029
Quantitative assessment of the SR Ca2+ leak-load relationshipQ44167973
Abnormal Ca2+ release, but normal ryanodine receptors, in canine and human heart failureQ44232551
Ca2+ scraps: local depletions of free [Ca2+] in cardiac sarcoplasmic reticulum during contractions leave substantial Ca2+ reserveQ44468965
Modelling cardiac calcium sparks in a three-dimensional reconstruction of a calcium release unitQ44920191
Effects of calsequestrin over-expression on excitation-contraction coupling in isolated rabbit cardiomyocytesQ46507223
Catecholaminergic polymorphic ventricular tachycardia-related mutations R33Q and L167H alter calcium sensitivity of human cardiac calsequestrinQ46654993
Endoplasmic reticulum Ca2+ measurements reveal that the cardiac ryanodine receptor mutations linked to cardiac arrhythmia and sudden death alter the threshold for store-overload-induced Ca2+ release.Q46841648
Regulation of calcium channel in sarcoplasmic reticulum by calsequestrin.Q54032085
Regulation of the gating of the sheep cardiac sarcoplasmic reticulum Ca(2+)-release channel by luminal Ca2+.Q54033992
Regulation of Ca2+ signaling in transgenic mouse cardiac myocytes overexpressing calsequestrinQ28590847
Polymerization of calsequestrin. Implications for Ca2+ regulationQ31132192
Increased Ca2+ sensitivity of the ryanodine receptor mutant RyR2R4496C underlies catecholaminergic polymorphic ventricular tachycardiaQ33551271
Ca2+ blinks: rapid nanoscopic store calcium signalingQ33844840
Ca sparks do not explain all ryanodine receptor-mediated SR Ca leak in mouse ventricular myocytesQ33858455
Sarcoplasmic reticulum lumenal Ca2+ has access to cytosolic activation and inactivation sites of skeletal muscle Ca2+ release channelQ34017877
Microscopic spiral waves reveal positive feedback in subcellular calcium signalingQ34020114
Abnormal intrastore calcium signaling in chronic heart failureQ34048060
Differences in the regulation of RyR2 from human, sheep, and rat by Ca²⁺ and Mg²⁺ in the cytoplasm and in the lumen of the sarcoplasmic reticulumQ34088867
Theory of excitation-contraction coupling in cardiac muscleQ34091617
Regulation of cardiac muscle Ca2+ release channel by sarcoplasmic reticulum lumenal Ca2+Q34169317
Regulation of the cardiac ryanodine receptor channel by luminal Ca2+ involves luminal Ca2+ sensing sitesQ34169533
Potentiation of fractional sarcoplasmic reticulum calcium release by total and free intra-sarcoplasmic reticulum calcium concentrationQ34172221
Control of sarcoplasmic reticulum Ca2+ release by stochastic RyR gating within a 3D model of the cardiac dyad and importance of induction decay for CICR terminationQ34346767
Extraction of sub-microscopic Ca fluxes from blurred and noisy fluorescent indicator images with a detailed model fitting approachQ34611091
The ryanodine receptor store-sensing gate controls Ca2+ waves and Ca2+-triggered arrhythmiasQ34725308
The conformation of calsequestrin determines its ability to regulate skeletal ryanodine receptorsQ34829628
Calcium cycling in congestive heart failureQ34863566
Catecholaminergic-induced arrhythmias in failing cardiomyocytes associated with human HRCS96A variant overexpression.Q35395953
Abnormal termination of Ca2+ release is a common defect of RyR2 mutations associated with cardiomyopathiesQ35936858
Loss of luminal Ca2+ activation in the cardiac ryanodine receptor is associated with ventricular fibrillation and sudden deathQ36156989
Calsequestrin determines the functional size and stability of cardiac intracellular calcium stores: Mechanism for hereditary arrhythmiaQ36161627
Triadin binding to the C-terminal luminal loop of the ryanodine receptor is important for skeletal muscle excitation contraction couplingQ36296083
Modulation of SR Ca release by luminal Ca and calsequestrin in cardiac myocytes: effects of CASQ2 mutations linked to sudden cardiac death.Q36791253
Luminal Mg2+, a key factor controlling RYR2-mediated Ca2+ release: cytoplasmic and luminal regulation modeled in a tetrameric channelQ36908938
A mutation in calsequestrin, CASQ2D307H, impairs Sarcoplasmic Reticulum Ca2+ handling and causes complex ventricular arrhythmias in miceQ37278605
Luminal Ca(2+) activation of cardiac ryanodine receptors by luminal and cytoplasmic domainsQ37405229
Isolation of a calcium-sequestering protein from sarcoplasmic reticulumQ37477859
Ryanodine receptor assembly: A novel systems biology approach to 3D mappingQ37799093
Proteins within the intracellular calcium store determine cardiac RyR channel activity and cardiac outputQ38004648
Functional interaction between calsequestrin and ryanodine receptor in the heartQ38056435
Calcium release from the sarcoplasmic reticulumQ39860313
Increased susceptibility to isoproterenol-induced cardiac hypertrophy and impaired weight gain in mice lacking the histidine-rich calcium-binding proteinQ41077372
Luminal calcium regulation of calcium release from sarcoplasmic reticulumQ41125879
Regulation of current flow through ryanodine receptors by luminal Ca2+.Q41602511
Dynamic calcium movement inside cardiac sarcoplasmic reticulum during releaseQ41905623
P433issue6
P1104number of pages7
P304page(s)720-726
P577publication date2015-06-01
P1433published inClinical and Experimental Pharmacology and PhysiologyQ5133807
P1476titleRegulation of RYR2 by sarcoplasmic reticulum Ca(2+).
P478volume42

Reverse relations

cites work (P2860)
Q55516329Inhibition of Sarco-Endoplasmic Reticulum Ca2+ ATPase Extends the Lifespan in C. elegans Worms.
Q39700708Oxidation of RyR2 Has a Biphasic Effect on the Threshold for Store Overload-Induced Calcium Release