Alpha-Ketoisocaproate-induced hypersecretion of insulin by islets from diabetes-susceptible mice

scientific article

Alpha-Ketoisocaproate-induced hypersecretion of insulin by islets from diabetes-susceptible mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1152/AJPENDO.00573.2004
P698PubMed publication ID15741243
P5875ResearchGate publication ID7993159

P2093author name stringBrian L Frey
Lloyd M Smith
Alan D Attie
Michael R Shortreed
Mary E Rabaglia
Mark P Gray-Keller
P2860cites workOverexpression and characterization of the human mitochondrial and cytosolic branched-chain aminotransferasesQ28262954
Hyperinsulinism and hyperammonemia in infants with regulatory mutations of the glutamate dehydrogenase geneQ28269681
Diazoxide restores beta3-adrenergic receptor function in diet-induced obesity and diabetesQ33181164
Dominantly inherited hyperinsulinism caused by a mutation in the sulfonylurea receptor type 1.Q37270892
Insulin resistance and hypersecretion in obesity. European Group for the Study of Insulin Resistance (EGIR).Q37371843
Overexpression of constitutively activated glutamate dehydrogenase induces insulin secretion through enhanced glutamate oxidationQ40628216
Distinguishing Features of Leucine and α-Ketoisocaproate Sensing in Pancreatic β-CellsQ40655102
A high fasting plasma insulin concentration predicts type 2 diabetes independent of insulin resistance: evidence for a pathogenic role of relative hyperinsulinemia.Q40734688
L-leucine and a nonmetabolized analogue activate pancreatic islet glutamate dehydrogenaseQ41614642
Basal insulin hypersecretion in insulin-resistant Zucker diabetic and Zucker fatty rats: role of enhanced fuel metabolismQ42475368
Insulin secretion and insulin sensitivity in relation to glucose tolerance: lessons from the Botnia StudyQ42489566
Diazoxide treatment at onset preserves residual insulin secretion in adults with autoimmune diabetesQ42523946
The elevation of glutamate content and the amplification of insulin secretion in glucose-stimulated pancreatic islets are not causally relatedQ44043453
Differences between mouse and rat pancreatic islets: succinate responsiveness, malic enzyme, and anaplerosisQ44058319
Regulation of leucine-stimulated insulin secretion and glutamine metabolism in isolated rat isletsQ44223858
A new subtype of autosomal dominant diabetes attributable to a mutation in the gene for sulfonylurea receptor 1.Q44297979
Fasting hyperinsulinemia is a predictor of increased body weight gain and obesity in Pima Indian childrenQ44496940
Improved beta-cell survival and reduced insulitis in a type 1 diabetic rat model after treatment with a beta-cell-selective K(ATP) channel opener.Q44816765
Interaction between BTBR and C57BL/6J genomes produces an insulin resistance syndrome in (BTBR x C57BL/6J) F1 mice.Q50917448
Genetic obesity unmasks nonlinear interactions between murine type 2 diabetes susceptibility loci.Q51552683
The influence of genetic background on the expression of the obese (ob) gene in the mouseQ53909983
Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis.Q53920238
Hyperinsulinemia in a normal population as a predictor of non-insulin-dependent diabetes mellitus, hypertension, and coronary heart disease: the Barilla factory revisited.Q54081357
P433issue2
P921main subjectpreproinsulinQ7240673
P304page(s)E218-24
P577publication date2005-03-01
P1433published inAmerican Journal of Physiology - Endocrinology and MetabolismQ15765671
P1476titleAlpha-Ketoisocaproate-induced hypersecretion of insulin by islets from diabetes-susceptible mice
P478volume289

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cites work (P2860)
Q36586611A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibility
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Q34132510Cholecystokinin is up-regulated in obese mouse islets and expands beta-cell mass by increasing beta-cell survival
Q42503904Enhanced mitochondrial metabolism may account for the adaptation to insulin resistance in islets from C57BL/6J mice fed a high-fat diet
Q34132215FoxM1 is up-regulated by obesity and stimulates beta-cell proliferation
Q46932225Fuel-induced amplification of insulin secretion in mouse pancreatic islets exposed to a high sulfonylurea concentration: role of the NADPH/NADP+ ratio
Q33657409Genetic validation of whole-transcriptome sequencing for mapping expression affected by cis-regulatory variation
Q36272452Global Identification of Protein Post-translational Modifications in a Single-Pass Database Search
Q35794958Glucagon-Like Peptide-1 Regulates Cholecystokinin Production in β-Cells to Protect From Apoptosis
Q36309626Hippocampal Transcriptomic and Proteomic Alterations in the BTBR Mouse Model of Autism Spectrum Disorder
Q41314328Hypothalamic regulation of glucose-stimulated insulin secretion
Q34510196Integrative analysis of a cross-loci regulation network identifies App as a gene regulating insulin secretion from pancreatic islets
Q87929725Islet proteomics reveals genetic variation in dopamine production resulting in altered insulin secretion
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Q34737010Mechanisms of disease:Molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes
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Q37400761Metabolomics applied to diabetes research: moving from information to knowledge
Q37403962Nutrient modulation of insulin secretion
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Q39086901Oxo-4-methylpentanoic acid directs the metabolism of GABA into the Krebs cycle in rat pancreatic islets
Q41553184PWD/PhJ mice have a genetically determined increase in nutrient-stimulated insulin secretion
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Q36217634The Transcription Factor Nfatc2 Regulates β-Cell Proliferation and Genes Associated with Type 2 Diabetes in Mouse and Human Islets
Q39643761The dicarboxylate carrier plays a role in mitochondrial malate transport and in the regulation of glucose-stimulated insulin secretion from rat pancreatic beta cells
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Q33883478The mitochondrial 2-oxoglutarate carrier is part of a metabolic pathway that mediates glucose- and glutamine-stimulated insulin secretion
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Q28291461Transamination Is Required for α-Ketoisocaproate but Not Leucine to Stimulate Insulin Secretion*

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