Targeted Mass Spectrometry Approach Enabled Discovery of O-Glycosylated Insulin and Related Signaling Peptides in Mouse and Human Pancreatic Islets.

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Targeted Mass Spectrometry Approach Enabled Discovery of O-Glycosylated Insulin and Related Signaling Peptides in Mouse and Human Pancreatic Islets. is …
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scholarly articleQ13442814

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P356DOI10.1021/ACS.ANALCHEM.7B01926
P932PMC publication ID6314835
P698PubMed publication ID28726377

P50authorQing YuQ59554347
Lingjun LiQ61467148
Rahul DasQ85828829
P2093author name stringYang Liu
Alan D Attie
Matthew S Glover
Mark P Keller
Xudong Shi
Alejandra Canales
P2860cites workElectron-Transfer/Higher-Energy Collision Dissociation (EThcD)-Enabled Intact Glycopeptide/Glycoproteome Characterization.Q50898017
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Toward full peptide sequence coverage by dual fragmentation combining electron-transfer and higher-energy collision dissociation tandem mass spectrometry.Q55056794
Concanavalin A microspheres for a self-regulating insulin delivery systemQ68041187
In vitro effects of glycosylated insulin in perfused liver and hindquarter in ratsQ68200966
Physical stabilization of insulin by glycosylationQ72151320
Structure of the 22-residue somatostatin from catfish. An O-glycosylated peptide having multiple formsQ72590849
Somatostatin inhibits insulin and glucagon secretion via two receptors subtypes: an in vitro study of pancreatic islets from somatostatin receptor 2 knockout miceQ73310120
Polypeptide hormonesQ74229526
Effective use of mass spectrometry for glycan and glycopeptide structural analysisQ26864820
Biochemistry and molecular cell biology of diabetic complicationsQ28131781
Contulakin-G, an O-glycosylated invertebrate neurotensinQ28375469
Proinsulin processing in the diabetic Goto-Kakizaki ratQ28572019
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Skyline: an open source document editor for creating and analyzing targeted proteomics experimentsQ30080030
Extended O-GlcNAc on HLA Class-I-Bound Peptides.Q30356689
An O-glycosylated neuroexcitatory conus peptideQ31974125
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Peptides in the brain: mass spectrometry-based measurement approaches and challengesQ33634384
Endogenous peptide discovery of the rat circadian clock: a focused study of the suprachiasmatic nucleus by ultrahigh performance tandem mass spectrometry.Q33697760
Post-translationally modified neuropeptides from Conus venomsQ33734580
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Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistryQ34603412
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Improving data quality and preserving HCD-generated reporter ions with EThcD for isobaric tag-based quantitative proteomics and proteome-wide PTM studiesQ36342472
Adaptive evolution of the insulin two-gene system in mouseQ36515711
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Proteases for processing proneuropeptides into peptide neurotransmitters and hormonesQ37053834
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GPR171 is a hypothalamic G protein-coupled receptor for BigLEN, a neuropeptide involved in feedingQ37218344
Vertebrate protein glycosylation: diversity, synthesis and functionQ37601831
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Metabolic stress, IAPP and islet amyloidQ38038652
Regulation of insulin secretion in human pancreatic isletsQ38043096
Alpha-Ketoisocaproate-induced hypersecretion of insulin by islets from diabetes-susceptible miceQ38329857
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Distinctive MS/MS Fragmentation Pathways of Glycopeptide-Generated Oxonium Ions Provide Evidence of the Glycan Structure.Q38932357
The chemistry and biochemistry of insulinQ40011145
Post-translational proteolysis in polypeptide hormone biosynthesisQ40329431
Antibodies to post-translationally modified insulin in type 1 diabetesQ40561404
Preparation and biological properties of glycosylated insulinQ41556308
Assignment of saccharide identities through analysis of oxonium ion fragmentation profiles in LC-MS/MS of glycopeptides.Q44456274
Obesity and diabetes in transgenic mice expressing proSAAS.Q44793939
Higher energy collision dissociation (HCD) product ion-triggered electron transfer dissociation (ETD) mass spectrometry for the analysis of N-linked glycoproteinsQ47380481
Studies on the conversion of proinsulin to insulin. I. Conversion in vitro with trypsin and carboxypeptidase B.Q47737213
P433issue17
P407language of work or nameEnglishQ1860
P921main subjectglycosylationQ898365
P304page(s)9184-9191
P577publication date2017-07-20
P1433published inAnalytical ChemistryQ485223
P1476titleTargeted Mass Spectrometry Approach Enabled Discovery of O-Glycosylated Insulin and Related Signaling Peptides in Mouse and Human Pancreatic Islets
P478volume89

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cites work (P2860)
Q98611535An atlas of O-linked glycosylation on peptide hormones reveals diverse biological roles
Q101126208Electron-Based Dissociation Is Needed for O-Glycopeptides Derived from OpeRATOR Proteolysis
Q90669713Isolation and characterization of glycosylated neuropeptides
Q52316238Neuropeptidomics of the Rat Habenular Nuclei.
Q96160474Optimal Dissociation Methods Differ for N- and O-glycopeptides
Q47111216The Role of Electron Transfer Dissociation in Modern Proteomics
Q57665965The benefits of hybrid fragmentation methods for glycoproteomics

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