The stomach is a source of leptin

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The stomach is a source of leptin is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1002530180
P356DOI10.1038/29547
P698PubMed publication ID9723619

P2093author name stringGuerre-Millo M
Lehy T
Attoub S
Bado A
Kermorgant S
Laigneau JP
Lewin MJ
Le Marchand-Brustel Y
Levasseur S
Moizo L
Bortoluzzi MN
P2860cites workPositional cloning of the mouse obese gene and its human homologueQ22251285
Weight-reducing effects of the plasma protein encoded by the obese geneQ29617934
Effects of the obese gene product on body weight regulation in ob/ob miceQ29617935
Role of leptin in the neuroendocrine response to fastingQ29618866
Identification and expression cloning of a leptin receptor, OB-RQ29620255
Regulated expression of the obese gene product (leptin) in white adipose tissue and 3T3-L1 adipocytes.Q33881238
Degradation of cholecystokinin octapeptide, related fragments and analogs by human and rat plasma in vitro.Q34253816
Transient increase in obese gene expression after food intake or insulin administrationQ34296141
Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networksQ34301257
Characterization and inhibition of a cholecystokinin-inactivating serine peptidaseQ34375419
Abnormal splicing of the leptin receptor in diabetic miceQ34379335
Differential regulation of adipose tissue glucose transporters in genetic obesity (fatty rat). Selective increase in the adipose cell/muscle glucose transporter (GLUT 4) expressionQ35820828
Synergistic interaction between leptin and cholecystokinin to reduce short-term food intake in lean miceQ36587611
Leptin selectively decreases visceral adiposity and enhances insulin action.Q37376534
Synergy between leptin and cholecystokinin (CCK) to control daily caloric intakeQ38349671
Rapid inhibition of ob gene expression and circulating leptin levels in lean mice by the beta 3-adrenoceptor agonists BRL 35135A and ZD2079.Q38351489
Circulating leptin levels are modulated by fasting, cold exposure and insulin administration in lean but not Zucker (fa/fa) rats as measured by ELISA.Q38356285
Adipose-tissue-specific increase in glyceraldehyde-3-phosphate dehydrogenase activity and mRNA amounts in suckling pre-obese Zucker rats. Effect of weaningQ42067808
Overexpression of a constitutively active form of phosphatidylinositol 3-kinase is sufficient to promote Glut 4 translocation in adipocytesQ42523326
Effect of enteral versus parenteral nutrition on leptin gene expression and release into the circulationQ45106368
Activation of beta(3) adrenergic receptors suppresses leptin expression and mediates a leptin-independent inhibition of food intake in mice.Q51028526
Cholecystokinin elicits Satiety in Rats with Open Gastric FistulasQ54170533
Abdominal Vagotomy Blocks the Satiety Effect of Cholecystokinin in the RatQ70889240
Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humansQ73677617
P433issue6695
P407language of work or nameEnglishQ1860
P304page(s)790-793
P577publication date1998-08-01
P1433published inNatureQ180445
P1476titleThe stomach is a source of leptin
P478volume394

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Q46726593Leptin and CCK modulate complementary background conductances to depolarize cultured nodose neurons
Q33693969Leptin and Inflammation
Q52718110Leptin and Leptin Resistance in the Pathogenesis of Obstructive Sleep Apnea: A Possible Link to Oxidative Stress and Cardiovascular Complications.
Q38153628Leptin and adiponectin: emerging therapeutic targets in breast cancer
Q42388662Leptin and aging
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Q89859670Leptin and ghrelin expressions in the gastrointestinal tracts of calves and cows
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Q64922262Leptin and its actions on reproduction in males.
Q30813460Leptin and its receptor in normal human gastric mucosa and in Helicobacter pylori-associated gastritis
Q36470247Leptin and its role in hippocampal synaptic plasticity
Q34110892Leptin and leptin receptor genes in Atlantic salmon: Cloning, phylogeny, tissue distribution and expression correlated to long-term feeding status.
Q34514792Leptin and leptin receptor in anterior pituitary function
Q77384735Leptin and reproduction
Q34548469Leptin and reproduction: a review
Q34566257Leptin and sweet taste
Q38291788Leptin and the obesity receptor (OB-R) in the small intestine and colon: a colocalization study
Q34514780Leptin and the pituitary
Q29615976Leptin and the regulation of body weight in mammals
Q34548531Leptin and the regulation of food intake, energy homeostasis and immunity with special focus on periparturient ruminants
Q33621147Leptin and the systems neuroscience of meal size control
Q34635461Leptin and the treatment of obesity: its current status
Q38337157Leptin and vascular endothelial growth factor regulate angiogenesis in tooth germs
Q42493271Leptin biosynthetic pathway in white adipocytes
Q82414120Leptin blockade attenuates sodium excretion in saline-loaded normotensive rats
Q43614898Leptin decreases feeding and exploratory behaviour via interactions with CCK(1) receptors in the rat.
Q51538084Leptin depresses food intake in great tits (Parus major).
Q48821592Leptin expression in the rat ovary depends on estrous cycle
Q36236092Leptin gene polymorphisms and their phenotypic associations
Q37778403Leptin gene therapy in the fight against diabetes
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Q48598724Leptin inhibits swallowing in rats
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Q35044712Leptin potentiates IFN-gamma-induced expression of nitric oxide synthase and cyclo-oxygenase-2 in murine macrophage J774A.1.
Q51540859Leptin production by the stomach is up-regulated in obese (fa/fa) Zucker rats.
Q40437556Leptin promoter mutations affect leptin levels and performance traits in dairy cows
Q38294084Leptin promotes cell survival and activates Jurkat T lymphocytes by stimulation of mitogen-activated protein kinase.
Q28540838Leptin promotes wound healing in the oral mucosa
Q28544888Leptin promotes wound healing in the skin
Q38287422Leptin receptor (Ob-R) expression is induced in peripheral blood mononuclear cells by in vitro activation and in vivo in HIV-infected patients.
Q30814506Leptin receptor expression in nodose ganglion cells projecting to the rat gastric fundus.
Q36530544Leptin receptor signaling is required for high-fat diet-induced atrophic gastritis in mice
Q28568855Leptin receptors are developmentally regulated in rat pituitary and hypothalamus
Q38308960Leptin reduces body weight gain in neonatal rats
Q42947348Leptin regulates MMP-2, TIMP-1 and collagen synthesis via p38 MAPK in HL-1 murine cardiomyocytes
Q39411088Leptin regulates sugar and amino acids transport in the human intestinal cell line Caco-2.
Q35360626Leptin secretion and leptin receptor in the human stomach
Q47180159Leptin serum concentration, food intake and body weight in rats whose mothers were exposed to malnutrition during lactation.
Q36576492Leptin signaling and Alzheimer's disease
Q55093422Leptin signaling axis specifically associates with clinical prognosis and is multifunctional in regulating cancer progression.
Q35630443Leptin signaling in the hypothalamus: emphasis on energy homeostasis and leptin resistance
Q38703387Leptin signalling pathways in hypothalamic neurons
Q38347729Leptin stimulates the oxidative burst in control monocytes but attenuates the oxidative burst in monocytes from HIV-infected patients
Q35598189Leptin stimulates the proliferation of human colon cancer cells in vitro but does not promote the growth of colon cancer xenografts in nude mice or intestinal tumorigenesis in Apc(Min/+) mice
Q40289740Leptin transcriptionally enhances peptide transporter (hPepT1) expression and activity via the cAMP-response element-binding protein and Cdx2 transcription factors.
Q36101219Leptin, adiponectin and pulmonary diseases
Q34635545Leptin, gut, and food intake
Q77350106Leptin, obesity, and liver disease
Q36849442Leptin, resistin and visfatin: the missing link between endocrine metabolic disorders and immunity
Q37351155Leptin-cytokine crosstalk in breast cancer.
Q45182797Leptin-induced satiation mediated by abdominal vagal afferents
Q89664105Leptin-mediated differential regulation of microsomal triglyceride transfer protein in the intestine and liver affects plasma lipids
Q36923681Leptin-sensitive sensory nerves innervate white fat.
Q56169405Leptin: a review of its peripheral actions and interactions
Q37161458Leptin: linking obesity, the metabolic syndrome, and cardiovascular disease
Q36208881Limits to sustained energy intake IX: a review of hypotheses
Q35597659Liquid calories and the failure of satiety: how good is the evidence?
Q38308924Long form leptin receptor mRNA expression in the brain, pituitary, and other tissues in the pig.
Q45989469Long-Term Intake of a High-Protein Diet Affects Body Phenotype, Metabolism, and Plasma Hormones in Mice.
Q47175179Long-lived weight-reduced αMUPA mice show higher and longer maternal-dependent postnatal leptin surge
Q50853632Long-term changes in leptin, chemerin and ghrelin levels following different bariatric surgery procedures: Roux-en-Y gastric bypass and sleeve gastrectomy.
Q38316186Luminal leptin activates mucin-secreting goblet cells in the large bowel
Q40729024Luminal leptin enhances CD147/MCT-1-mediated uptake of butyrate in the human intestinal cell line Caco2-BBE.
Q28570063Luminal leptin inhibits L-glutamine transport in rat small intestine: involvement of ASCT2 and B0AT1
Q35149198Making sense of gut contents
Q42042991Mechanisms of action of leptin in preventing gastric ulcer
Q38828407Metabolic Actions of the Type 1 Cholecystokinin Receptor: Its Potential as a Therapeutic Target
Q37922651Metabolic surgery-principles and current concepts
Q44644600Mice body weight gain is prevented after naked human leptin cDNA transfer into skeletal muscle by electroporation
Q74329657Modulation by leptin of proliferation and apoptosis in vascular endothelial cells
Q44054580Modulation of exocrine pancreatic secretion by leptin through CCK(1)-receptors and afferent vagal fibres in the rat.
Q40984477Modulation of intestinal L-glutamate transport by luminal leptin.
Q47814167Molecular cloning and expression of leptin in gray and harbor seal blubber, bone marrow, and lung and its potential role in marine mammal respiratory physiology
Q38311370Molecular cloning and properties of the chicken leptin-receptor (CLEPR) gene.
Q64243637Molecular dynamic (MD) studies on Gln233Arg (rs1137101) polymorphism of leptin receptor gene and associated variations in the anthropometric and metabolic profiles of Saudi women
Q38077483Molecular mechanisms of central leptin resistance in obesity
Q37045211Mother and Infant Body Mass Index, Breast Milk Leptin and Their Serum Leptin Values.
Q28086792Multifaceted interplay among mediators and regulators of intestinal glucose absorption: potential impacts on diabetes research and treatment
Q37133618Neural systems controlling the drive to eat: mind versus metabolism
Q33592561Neuropeptide Y: a key molecule in anorexia and cachexia in wasting disorders?
Q37469981Obesity, inflammation, and liver cancer
Q34290268Olfaction under metabolic influences.
Q57107664Oral Nanoparticles Exhibit Specific High-Efficiency Intestinal Uptake and Lymphatic Transport
Q48268063Orexin-A (hypocretin-1) impairs Morris water maze performance and CA1-Schaffer collateral long-term potentiation in rats
Q38309409Overexpression of gastric leptin precedes adipocyte leptin during high-fat diet and is linked to 5HT-containing enterochromaffin cells.
Q36014224Overexpression of the obesity hormone leptin in human colorectal cancer
Q42816086PAP/HIP protein is an obesogenic factor
Q22010039Pancreatic function in CCK-deficient mice: adaptation to dietary protein does not require CCK
Q47450510Partial cloning and localization of leptin and leptin receptor in the mammary gland of the Egyptian water buffalo
Q28364469PepT1-mediated epithelial transport of dipeptides and cephalexin is enhanced by luminal leptin in the small intestine
Q60660385Perinatal expression of leptin in rat stomach
Q31890451Perioperative response of leptin and the tumor necrosis factor alpha system in morbidly obese patients. Influence of cortisol inhibition by etomidate
Q38320730Peripheral gastric leptin modulates brain stem neuronal activity in neonates
Q35204654Peripheral mechanisms in appetite regulation
Q36166645Peripheral neural targets in obesity
Q48400142Peripheral oxytocin activates vagal afferent neurons to suppress feeding in normal and leptin-resistant mice: a route for ameliorating hyperphagia and obesity
Q36753785Peripheral tissue-brain interactions in the regulation of food intake
Q44859567Physiological and neurobiological elements of food intake
Q33828756Physiological roles of the leptin endocrine system: differences between mice and humans
Q35595597Plasma ghrelin following cure of Helicobacter pylori
Q34320676Plasma leptin and exercise: recent findings
Q73428363Plasma leptin and exercise: recent findings
Q36497073Plasma leptin and ghrelin concentrations in patients with Crohn's disease
Q73389540Plasma leptin and thyroxine of mink (Mustela vison) vary with gender, diet and subchronic exposure to PCBs
Q74141528Plasma leptin is independently associated with the intima-media thickness of the common carotid artery
Q43141708Plasma leptin, insulin, and neuropeptide Y response to feeding in newborn infants
Q35605865Plasma levels of leptin and mammographic density among postmenopausal women: a cross-sectional study
Q51561515Plasma plasminogen activator inhibitor-I is associated with plasma leptin irrespective of body mass index, body fat mass, and plasma insulin and metabolic parameters in premenopausal women.
Q39270817Plasticity of vagal afferent signaling in the gut.
Q38719266Polymorphisms in Lep and Lepr Genes in Infants: Correlation with Serum Leptin Values in the First 6 Months of Life.
Q30940391Positive regulatory control loop between gut leptin and intestinal GLUT2/GLUT5 transporters links to hepatic metabolic functions in rodents
Q37753300Postnatal development of hypothalamic leptin receptors
Q35124551Postnatal leptin is necessary for maturation of numerous organs in newborn rats
Q35770446Potential prognostic value of leptin receptor in hepatocellular carcinoma
Q38292853Potential role of leptin in endochondral ossification
Q35884329Probiotic treatment reduces appetite and glucose level in the zebrafish model.
Q34381500Pulling strings below the surface: hormone receptor signaling through inhibition of protein tyrosine phosphatases
Q51043300Purifying selection on leptin genes in teleosts may be due to poikilothermy.
Q40280686RNA interference targeting leptin gene effect on hepatic stellate cells
Q48596358Rapid inhibition of neural excitability in the nucleus tractus solitarii by leptin: implications for ingestive behaviour
Q40287500Receptor-Mediated Transcytosis of Leptin through Human Intestinal Cells In Vitro
Q37119776Reduced intestinal absorption of dipeptides via PepT1 in mice with diet-induced obesity is associated with leptin receptor down-regulation.
Q35691135Regulation of Appetite, Body Composition, and Metabolic Hormones by Vasoactive Intestinal Polypeptide (VIP)
Q36944823Regulation of food intake: the gastric X/A-like endocrine cell in the spotlight
Q59613881Regulation of intestinal growth in response to variations in energy supply and demand.
Q43263217Regulation of leptin distribution between plasma and cerebrospinal fluid by cholecystokinin receptors
Q34450454Regulation of leptin production
Q73056782Regulation of leptin secretion: effects of aging on daily patterns of serum leptin and food consumption
Q90059997Relationship between Helicobacter pylori infection and obesity in Chinese adults: A systematic review with meta-analysis
Q55022523Relationships of H. pylori infection and its related gastroduodenal morbidity with metabolic syndrome: a large cross-sectional study.
Q39022599Resistin and Visfatin Expression in HCT-116 Colorectal Cancer Cell Line
Q47730674Resistin is expressed in different rat tissues and is regulated in a tissue- and gender-specific manner
Q35074649Rhythmic, reciprocal ghrelin and leptin signaling: new insight in the development of obesity
Q48616904Role of ghrelin and leptin in predicting the severity of acute pancreatitis
Q35161166Role of leptin as an immunomodulator of blood mononuclear cells: mechanisms of action
Q34895005Role of leptin in bone growth: central player or peripheral supporter?
Q35841647Role of leptin in farm animals: a review.
Q28190087Role of leptin in the stomach and the pancreas
Q32078337Role of leptin in ulcer healing
Q40621896Role of leptin present in maternal milk in the control of energy balance during the post-natal period
Q51758245Salivary and serum leptin concentrations in patients with chronic periodontitis.
Q43708502Seasonal changes in serum leptin, food intake, and body weight in photoentrained woodchucks
Q38319671Secretion of soluble leptin receptors by exocrine and endocrine cells of the gastric mucosa
Q61316840Secretory granules of endocrine and chief cells of human stomach mucosa contain leptin
Q47359132Serum Leptin, Obestatin, and Ghrelin Levels and Gastric Emptying Rates of Liquid and Solid Meals in Non-obese Rats with Roux-en-Y Bypass Surgery or Prosthesis Placement: Implications for the Role of Vagal Afferents.
Q42588440Serum leptin and body mass index in children with H pylori infection
Q47163438Serum leptin and skeletal differences between obese and non-obese patients with chronic obstructive pulmonary disease
Q47966942Serum leptin is not correlated with body fat in severe food restriction
Q35582841Serum leptin levels in gastric cancer patients and the relationship with insulin resistance
Q38288153Sex-associated differences in the leptin and ghrelin systems related with the induction of hyperphagia under high-fat diet exposure in rats
Q60660388Sexual dimorphism in age-related changes in UCP2 and leptin gene expression in subcutaneous adipose tissue in humans
Q58607131Signaling Pathways Induced by Leptin during Epithelial⁻Mesenchymal Transition in Breast Cancer
Q40442341Similarities and differences in the transcriptional regulation of the leptin gene promoter in gastric and adipose cells
Q38818508Sleep, circadian rhythm and body weight: parallel developments
Q34478453Small bowel review: normal physiology part 1.
Q48361828Steroidogenic genes expressions are repressed by high levels of leptin and the JAK/STAT signaling pathway in MA-10 Leydig cells.
Q36700872Stimulation of leptin secretion by insulin
Q33186670Structure of cholecystokinin receptor binding sites and mechanism of activation/inactivation by agonists/antagonists.
Q44431140Study of association between atrophic gastritis and body mass index: a cross-sectional study in 10,197 Japanese subjects
Q46379427Study of hypothalamic leptin receptor expression in low-birth-weight piglets and effects of leptin supplementation on neonatal growth and development
Q36083581Susceptibility of gastric cancer according to leptin and leptin receptor gene polymorphisms in Korea
Q38025921Sympathoinhibitory signals from the gut and obesity-related hypertension
Q34056736Synergistic interaction between CCK and leptin to regulate food intake
Q34719817Synergistic interaction between leptin and cholecystokinin in the rat nodose ganglia is mediated by PI3K and STAT3 signaling pathways: implications for leptin as a regulator of short term satiety
Q59823590Systemic administration of lipopolysaccharide increases plasma leptin levels
Q33996305Systemic leptin dose-dependently increases STAT3 phosphorylation within hypothalamic and hindbrain nuclei
Q38311710Systemic stress increases serum leptin level
Q92856540The Effects of Leptin on Glial Cells in Neurological Diseases
Q37655073The Leptin Receptor Complex: Heavier Than Expected?
Q48121093The correlation of serum levels of leptin, leptin receptor and NO x (NO 2 (-) and NO 3 (-)) in patients with obstructive sleep apnea syndrome
Q35131420The diffuse endocrine system: from embryogenesis to carcinogenesis.
Q51732634The effect of Helicobacter pylori and economic status on growth parameters and leptin, ghrelin, and insulin-like growth factor (IGF)-I concentrations in children.
Q40559114The effect of gender on Helicobacter felis‐mediated gastritis, epithelial cell proliferation, and apoptosis in the mouse model
Q78060115The effect of leptin on Lep expression is tissue-specific and nutritionally regulated
Q50937920The effects of periodontal therapy on serum and salivary leptin levels in chronic periodontitis patients with normal body mass index.
Q38331107The gingiva contains leptin and leptin receptor in health and disease
Q34621785The gut and food intake: an update for surgeons.
Q43545260The impact of insulin-dependent diabetes on ventilatory control in the mouse
Q35163929The ins and outs of leptin receptor activation
Q36776551The intake of a hyperlipidic diet stimulates the gastric leptin signalling pathway in female rats.
Q38303737The intake of physiological doses of leptin during lactation in rats prevents obesity in later life
Q26861527The integrative role of leptin, oestrogen and the insulin family in obesity-associated breast cancer: potential effects of exercise
Q36232613The neurobiology of human obesity
Q47893352The relation between serum leptin levels and max VO2 in male patients with type I diabetes and healthy sedentary males.
Q43650566The release of leptin and its effect on hormone release from human pituitary adenomas
Q21284847The role of "mixed" orexigenic and anorexigenic signals and autoantibodies reacting with appetite-regulating neuropeptides and peptides of the adipose tissue-gut-brain axis: relevance to food intake and nutritional status in patients with [...]
Q33656384The role of agouti-related protein in regulating body weight
Q35459617The role of gastrointestinal vagal afferent fibres in obesity
Q34599780The role of leptin and ghrelin in the regulation of food intake and body weight in humans: a review
Q28069664The role of leptin in central nervous system diseases
Q35605670The role of leptin in innate and adaptive immune responses
Q34335412The role of leptin in the respiratory system: an overview
Q35359964The role of long chain fatty acids in regulating food intake and cholecystokinin release in humans
Q38016990The role of the circadian clock system in nutrition and metabolism.
Q38303756The role of the vagus nerve in mediating the long-term anorectic effects of leptin
Q53473295The thymoprotective function of leptin is indirectly mediated via suppression of obesity.
Q34778864The vagus nerve, food intake and obesity
Q40804073Transcriptional regulation of the leptin gene promoter in rat GH3 pituitary and C6 glioma cells
Q35975648Transplantation of wild-type white adipose tissue normalizes metabolic, immune and inflammatory alterations in leptin-deficient ob/ob mice
Q38291754Treatment of obesity and diabetes in mice by transplant of gut cells engineered to produce leptin
Q37704860Type 2 diabetes, PUFAs, and vitamin D: their relation to inflammation
Q64257959Understanding Human Physiological Limitations and Societal Pressures in Favor of Overeating Helps to Avoid Obesity
Q35558049Unraveling the multiple roles of leptin in inflammation and autoimmunity
Q60804002Up-regulation of muscle UCP2 gene expression by a new β3-adrenoceptor agonist, trecadrine, in obese (cafeteria) rodents, but down-regulation in lean animals
Q50143070Vagal Interoceptive Modulation of Motivated Behavior
Q81534643Vagal and splanchnic afferent nerves are not essential for anorexia associated with abomasal parasitism in sheep
Q35587505Vagal control of satiety and hormonal regulation of appetite
Q83672360[Lipodystrophy. Mechanisms, clinical presentation, therapy]