Clinical significance of cancerous inhibitor of protein phosphatase 2A in human cancers

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Clinical significance of cancerous inhibitor of protein phosphatase 2A in human cancers is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1002/IJC.29431
P698PubMed publication ID25628223
P5875ResearchGate publication ID270911862

P2093author name stringJohn E Pimanda
Anchit Khanna
P2860cites workCIP2A expression is increased in prostate cancerQ21198842
Constitutive induction of p-Erk1/2 accompanied by reduced activities of protein phosphatases 1 and 2A and MKP3 due to reactive oxygen species during cellular senescenceQ24306834
Identification of PP2A complexes and pathways involved in cell transformationQ24316472
CIP2A inhibits PP2A in human malignanciesQ24319683
CHK1 inhibitors in combination chemotherapy: thinking beyond the cell cycleQ24622357
Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domainQ24794765
Differential responses to doxorubicin-induced phosphorylation and activation of Akt in human breast cancer cells.Q24813382
Molecular pathways: harnessing E2F1 regulation for prosenescence therapy in p53-defective cancer cellsQ26852510
Chk1 targeting reactivates PP2A tumor suppressor activity in cancer cellsQ28299365
CIP2A promotes proliferation of spermatogonial progenitor cells and spermatogenesis in miceQ28590389
A phase 2 study of bortezomib in relapsed, refractory myelomaQ33348702
Ethoxysanguinarine Induces Inhibitory Effects and Downregulates CIP2A in Lung Cancer Cells.Q33636463
Overexpression of CIP2A is an independent prognostic indicator in nasopharyngeal carcinoma and its depletion suppresses cell proliferation and tumor growth.Q33712856
Targeting c-MYC by antagonizing PP2A inhibitors in breast cancerQ33835127
Autoantibody response to a novel tumor-associated antigen p90/CIP2A in breast cancer immunodiagnosisQ33895872
CIP2A is Overexpressed in Non-Small Cell Lung Cancer and Correlates with Poor PrognosisQ34138056
Cloning and characterization of a novel 90 kDa 'companion' auto-antigen of p62 overexpressed in cancer.Q34138916
Therapy-Induced Senescence in CancerQ34212773
Cancerous inhibitor of protein phosphatase 2A mediates bortezomib-induced autophagy in hepatocellular carcinoma independent of proteasomeQ34577215
A tumor suppressor role for PP2A-B56alpha through negative regulation of c-Myc and other key oncoproteinsQ34609728
Modelling Myc inhibition as a cancer therapyQ34811008
MYC-dependent regulation and prognostic role of CIP2A in gastric cancer.Q34983172
CIP2A is associated with human breast cancer aggressivityQ34996768
CIP2A influences survival in colon cancer and is critical for maintaining Myc expressionQ35009096
High CIP2A immunoreactivity is an independent prognostic indicator in early-stage tongue cancerQ35034737
Cancerous inhibitor of PP2A is targeted by natural compound celastrol for degradation in non-small-cell lung cancer.Q35055737
Prognostic role of CIP2A expression in serous ovarian cancerQ35263210
CIP2A is a target of bortezomib in human triple negative breast cancer cellsQ36245640
Involvement of PP2A in viral and cellular transformationQ36318172
CIP2A protein expression in high-grade, high-stage bladder cancerQ36530648
Senescence sensitivity of breast cancer cells is defined by positive feedback loop between CIP2A and E2F1.Q36609038
Regulation of cell adhesion by PP2A and SV40 small tumor antigen: an important link to cell transformationQ36637948
Cancerous inhibitor of protein phosphatase 2A determines bortezomib-induced apoptosis in leukemia cellsQ36805842
Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumorsQ36972697
Multiple pathways regulated by the tumor suppressor PP2A in transformationQ37105971
Pro-senescence therapy for cancer treatmentQ37893959
Phosphatases: providing safe passage through mitotic exitQ37900486
The role and therapeutic potential of Ser/Thr phosphatase PP2A in apoptotic signalling networks in human cancer cellsQ37980870
Cancerous inhibitor of protein phosphatase 2A, an emerging human oncoprotein and a potential cancer therapy target.Q38160825
Oncogenic nexus of cancerous inhibitor of protein phosphatase 2A (CIP2A): an oncoprotein with many handsQ38228491
Increase in CIP2A expression is associated with doxorubicin resistance.Q38478005
CIP2A mediates erlotinib-induced apoptosis in non-small cell lung cancer cells without EGFR mutation.Q38982120
Expression and prognostic significance of CIP2A in cutaneous malignant melanomaQ39039799
Bortezomib congeners induce apoptosis of hepatocellular carcinoma via CIP2A inhibition.Q39043713
CIP2A is overexpressed in osteosarcoma and regulates cell proliferation and invasionQ39098575
CIP2A is a predictor of survival and a novel therapeutic target in bladder urothelial cell carcinomaQ39218849
Inhibition of CIP2A determines erlotinib-induced apoptosis in hepatocellular carcinomaQ39239414
Expression and prognostic significance of CIP2A mRNA in hepatocellular carcinoma and nontumoral liver tissues.Q39358186
CIP2A-mediated Akt activation plays a role in bortezomib-induced apoptosis in head and neck squamous cell carcinoma cellsQ39395326
Therapeutic implications for the induced levels of Chk1 in Myc-expressing cancer cellsQ39470889
Efficacy of CHK inhibitors as single agents in MYC-driven lymphoma cellsQ39490308
Cancerous inhibitor of protein phosphatase 2A is overexpressed in cervical cancer and upregulated by human papillomavirus 16 E7 oncoproteinQ39541598
ETS1 mediates MEK1/2-dependent overexpression of cancerous inhibitor of protein phosphatase 2A (CIP2A) in human cancer cellsQ39569073
Bortezomib sensitizes HCC cells to CS-1008, an antihuman death receptor 5 antibody, through the inhibition of CIP2A.Q39577867
CIP2A mediates effects of bortezomib on phospho-Akt and apoptosis in hepatocellular carcinoma cellsQ39664633
Cancer cell sensitivity to bortezomib is associated with survivin expression and p53 status but not cancer cell typesQ39748970
CIP2A expression is elevated in cervical cancerQ39757518
c-Myc depletion inhibits proliferation of human tumor cells at various stages of the cell cycleQ42115767
CIP2A signature reveals the MYC dependency of CIP2A-regulated phenotypes and its clinical association with breast cancer subtypesQ42500610
Clinical implications of CIP2A protein expression in breast cancerQ43448302
CIP2A expression is associated with altered expression of epithelial-mesenchymal transition markers and predictive of poor prognosis in pancreatic ductal adenocarcinomaQ43459677
Identification of a c-Jun N-terminal kinase-2-dependent signal amplification cascade that regulates c-Myc levels in ras transformation.Q44938943
CIP2A with survivin protein expressions in human non-small-cell lung cancer correlates with prognosisQ45278609
CIP2A is a predictor of poor prognosis in colon cancerQ48733192
CIP2A overexpression is associated with c-Myc expression in colorectal cancer.Q50969099
PP2A impaired activity is a common event in acute myeloid leukemia and its activation by forskolin has a potent anti-leukemic effect.Q53275436
Mutational analysis of MYC in common epithelial cancers and acute leukemias.Q53592467
CIP2A is highly expressed in hepatocellular carcinoma and predicts poor prognosis.Q54298803
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)525-532
P577publication date2015-01-13
P1433published inInternational Journal of CancerQ332492
P1476titleClinical significance of cancerous inhibitor of protein phosphatase 2A in human cancers
P478volume138