PPARγ mediates innate immunity by regulating the 1α,25-dihydroxyvitamin D3 induced hBD-3 and cathelicidin in human keratinocytes

scientific article published on October 23, 2010

PPARγ mediates innate immunity by regulating the 1α,25-dihydroxyvitamin D3 induced hBD-3 and cathelicidin in human keratinocytes is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.JDERMSCI.2010.09.008
P953full work available at URLhttps://api.elsevier.com/content/article/PII:S0923181110002987?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0923181110002987?httpAccept=text/plain
P698PubMed publication ID20970965

P2093author name stringYasushi Hanakawa
Koji Hashimoto
Satoshi Hirakawa
Koji Sayama
Yuji Shirakata
Mikiko Tohyama
Sho Tokumaru
Xiuju Dai
Lujun Yang
P2860cites workThe role of chromatin during transcriptionQ27860995
Peroxisome proliferator-activated receptors, coactivators, and downstream targetsQ28186488
Upregulated expression of human β defensin-1 and -3 mRNA during differentiation of keratinocyte immortalized cell lines, HaCaT and PHK16-0bQ28202089
Peroxisome proliferator-activated receptors in cutaneous biologyQ28202926
Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3Q28258765
The SRC family of nuclear receptor coactivatorsQ33860695
Cutting edge: 1,25-dihydroxyvitamin D3 is a direct inducer of antimicrobial peptide gene expressionQ34550324
Signal transduction and nuclear responses in Staphylococcus aureus-induced expression of human beta-defensin 3 in skin keratinocytesQ35220350
Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanismQ35613903
Cutaneous defense mechanisms by antimicrobial peptidesQ36176418
Human beta-defensinsQ36482561
The role of antimicrobial peptides in human skin and in skin infectious diseasesQ37265026
Histone acetylation in keratinocytes enables control of the expression of cathelicidin and CD14 by 1,25-dihydroxyvitamin D3.Q40066275
Regulation of the CAMP gene by 1,25(OH)2D3 in various tissuesQ40157575
A dominant-negative peroxisome proliferator-activated receptor gamma (PPARgamma) mutant is a constitutive repressor and inhibits PPARgamma-mediated adipogenesisQ40899355
Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways.Q41205566
Troglitazone improves psoriasis and normalizes models of proliferative skin disease: ligands for peroxisome proliferator-activated receptor-gamma inhibit keratinocyte proliferationQ43503202
Topical treatment with thiazolidinediones, activators of peroxisome proliferator-activated receptor-gamma, normalizes epidermal homeostasis in a murine hyperproliferative disease modelQ44255006
1alpha,25-dihydroxyvitamin D3 stimulates activator protein 1 DNA-binding activity by a phosphatidylinositol 3-kinase/Ras/MEK/extracellular signal regulated kinase 1/2 and c-Jun N-terminal kinase 1-dependent increase in c-Fos, Fra1, and c-Jun expressQ44369492
All-trans-retinoic acid induces interleukin-8 via the nuclear factor-kappaB and p38 mitogen-activated protein kinase pathways in normal human keratinocytes.Q45195283
PPAR gamma is an important transcription factor in 1 alpha,25-dihydroxyvitamin D3-induced involucrin expressionQ46852546
Control of the innate epithelial antimicrobial response is cell-type specific and dependent on relevant microenvironmental stimuliQ46961436
Nuclear translocation of phosphorylated STAT3 is essential for vascular endothelial growth factor-induced human dermal microvascular endothelial cell migration and tube formationQ47745076
New mechanisms of skin innate immunity: ASK1-mediated keratinocyte differentiation regulates the expression of β-defensins, LL37, and TLR2Q57267045
Inhibition of the 1,25-dihydroxyvitamin D3-induced increase in vitamin D receptor (VDR) levels and binding of VDR-retinoid X receptor (RXR) to a direct repeat (DR)-3 type response element by an RXR-specific ligand in human keratinocyte culturesQ74546237
STAT5a/PPARgamma pathway regulates involucrin expression in keratinocyte differentiationQ79849784
Induction of keratinocyte migration via transactivation of the epidermal growth factor receptor by the antimicrobial peptide LL-37Q81245806
Defective killing of Staphylococcus aureus in atopic dermatitis is associated with reduced mobilization of human beta-defensin-3Q81419219
Vitamin D induces the antimicrobial protein hCAP18 in human skinQ81688994
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectinnate immune responseQ428253
keratinocyteQ1473931
P304page(s)179-186
P577publication date2010-10-23
P1433published inJournal of Dermatological ScienceQ15749351
P1476titlePPARγ mediates innate immunity by regulating the 1α,25-dihydroxyvitamin D3 induced hBD-3 and cathelicidin in human keratinocytes
P478volume60

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cites work (P2860)
Q360051031,25-Dihydroxyvitamin-D3 Induces Avian β-Defensin Gene Expression in Chickens
Q35170224Cathelicidin antimicrobial protein, vitamin D, and risk of death in critically ill patients
Q35070462High transcript levels of vitamin D receptor are correlated with higher mRNA expression of human beta defensins and IL-10 in mucosa of HIV-1-exposed seronegative individuals
Q37336016Impaired innate mucosal immunity in aged mice permits prolonged Streptococcus pneumoniae colonization.
Q42479062Pseudoceramide stimulates peroxisome proliferator-activated receptor-α expression in a murine model of atopic dermatitis: molecular basis underlying the anti-inflammatory effect and the preventive effect against steroid-induced barrier impairment
Q34425809Randomized controlled trial of calcitriol in severe sepsis
Q36655079Regulation of antimicrobial peptide gene expression by nutrients and by-products of microbial metabolism
Q24562747The retinoid X receptors and their ligands
Q50147154Vitamin D and the Pathophysiology of Inflammatory Skin Diseases
Q58614683Vitamin D: Nutrient, Hormone, and Immunomodulator
Q50111769Β-defensins - Underestimated peptides in influenza combat

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