bcl-2 induction of urokinase plasminogen activator receptor expression in human cancer cells through Sp1 activation: involvement of ERK1/ERK2 activity

scientific article published on December 2003

bcl-2 induction of urokinase plasminogen activator receptor expression in human cancer cells through Sp1 activation: involvement of ERK1/ERK2 activity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M308938200
P698PubMed publication ID14660675

P2093author name stringMaurizio Fanciulli
Gabriella Zupi
Gabriella Fibbi
Daniela Trisciuoglio
Donatella Del Bufalo
Uwe Zangemeister-Wittke
Angela Iervolino
Antonio Candiloro
P2860cites workUp-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of functionQ28140184
Cyclin A-CDK phosphorylates Sp1 and enhances Sp1-mediated transcriptionQ28361370
Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesisQ29617644
Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cellsQ29618480
Expression and regulatory function of the transcription factor Sp1 in the uterine endometrium at early pregnancy: implications for epithelial phenotypeQ30841456
Sp1 and krüppel-like factor family of transcription factors in cell growth regulation and cancerQ33952921
Neu differentiation factor stimulates phosphorylation and activation of the Sp1 transcription factorQ33957454
Mithramycin inhibits SP1 binding and selectively inhibits transcriptional activity of the dihydrofolate reductase gene in vitro and in vivoQ34209261
Sp1 phosphorylation by Erk 2 stimulates DNA bindingQ34489381
Mithramycin blocks protein binding and function of the SV40 early promoterQ34575253
Mitochondrial reactive oxygen species in cell death signalingQ34648823
The role of the Bcl-2 protein family in cancerQ35091123
Transcriptional regulation of basic fibroblast growth factor gene by p53 in human glioblastoma and hepatocellular carcinoma cellsQ35758725
Reduced O glycosylation of Sp1 is associated with increased proteasome susceptibilityQ36568052
The role of urokinase-type plasminogen activator in aggressive tumor cell behaviorQ37835073
Increased Sp1 phosphorylation as a mechanism of hepatocyte growth factor (HGF/SF)-induced vascular endothelial growth factor (VEGF/VPF) transcriptionQ38359760
The Sp1 transcription factor contributes to the tumor necrosis factor-induced expression of the angiogenic factor thymidine phosphorylase in human colon carcinoma cellsQ38360146
Hypoxic induction of interleukin-8 gene expression in human endothelial cellsQ40335593
Treatment of melanoma cells with a bcl-2/bcl-xL antisense oligonucleotide induces antiangiogenic activityQ40615175
Bcl-2 overexpression in human melanoma cells increases angiogenesis through VEGF mRNA stabilization and HIF-1-mediated transcriptional activityQ40707392
Urokinase-type plasminogen activator and its receptor: new targets for anti-metastatic therapy?Q40731569
bcl-2 over-expression enhances NF-kappaB activity and induces mmp-9 transcription in human MCF7(ADR) breast-cancer cellsQ40890870
ERK activation upon hypoxia: involvement in HIF-1 activationQ40898952
Epidermal growth factor and okadaic acid stimulate Sp1 proteolysisQ41103802
Urokinase-Type Plasminogen Activator Overexpression Enhances the Invasive Capacity of Endothelial CellsQ41111732
Induction of vascular endothelial growth factor by tumor necrosis factor alpha in human glioma cells. Possible roles of SP-1.Q41151821
Selective localization of receptors for urokinase amino-terminal fragment at substratum contact sites of an in vitro-established line of human epidermal cellsQ41592577
Role and localization of urokinase receptor in the formation of new microvascular structures in fibrin matricesQ42113244
Induction of apoptosis in small-cell lung cancer cells by an antisense oligodeoxynucleotide targeting the Bcl-2 coding sequenceQ42441665
Nonsteroidal anti-inflammatory drugs inhibit matrix metalloproteinase-2 via suppression of the ERK/Sp1-mediated transcriptionQ42522960
Binding of Sp1 to the proximal promoter links constitutive expression of the human uPA gene and invasive potential of PC3 cells.Q42526967
Growth/cell cycle regulation of Sp1 phosphorylationQ42822980
Hypoxic induction of human vascular endothelial growth factor expression through c-Src activationQ42826789
Hydrogen peroxide stimulates extracellular signal-regulated protein kinases in pulmonary arterial smooth muscle cellsQ47708473
Regulation of macrophage production of vascular endothelial growth factor (VEGF) by hypoxia and transforming growth factor beta-1.Q48024877
Modulation of transcription factor Sp1 by cAMP-dependent protein kinase.Q52553797
Angiogenic potential of prostate carcinoma cells overexpressing bcl-2.Q54022940
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectplasminogenQ107129060
P304page(s)6737-6745
P577publication date2003-12-01
P1433published inJournal of Biological ChemistryQ867727
P1476titlebcl-2 induction of urokinase plasminogen activator receptor expression in human cancer cells through Sp1 activation: involvement of ERK1/ERK2 activity
P478volume279

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