Neu differentiation factor stimulates phosphorylation and activation of the Sp1 transcription factor

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Neu differentiation factor stimulates phosphorylation and activation of the Sp1 transcription factor is …
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scholarly articleQ13442814

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P356DOI10.1128/MCB.19.3.1961
P932PMC publication ID83989
P698PubMed publication ID10022883

P2093author name stringR Seger
Y Yarden
I Alroy
L Soussan
P2860cites workO-glycosylation of eukaryotic transcription factors: implications for mechanisms of transcriptional regulationQ24296741
Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulinQ24305421
Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expressionQ24337872
Isolation of the neu/HER-2 stimulatory ligand: a 44 kd glycoprotein that induces differentiation of mammary tumor cellsQ24337943
Identification of heregulin, a specific activator of p185erbB2Q24338146
Neural expression and chromosomal mapping of Neu differentiation factor to 8p12-p21Q24563427
Cloning by recognition site screening of two novel GT box binding proteins: a family of Sp1 related genesQ24629049
Association of p107 with Sp1: genetically separable regions of p107 are involved in regulation of E2F- and Sp1-dependent transcriptionQ24651154
Synergistic activation by the glutamine-rich domains of human transcription factor Sp1Q28245874
Analysis of the DNA-binding and activation properties of the human transcription factor AP-2Q28271397
The MAPK signaling cascadeQ28292599
Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domainQ28295806
Vulval development in Caenorhabditis elegansQ28305017
Neuregulins are concentrated at nerve-muscle synapses and activate ACh-receptor gene expressionQ28591878
ErbB-3 and ErbB-4 function as the respective low and high affinity receptors of all Neu differentiation factor/heregulin isoformsQ28609136
Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactionsQ28609149
Induction of acetylcholine receptor gene expression by ARIA requires activation of mitogen-activated protein kinaseQ30468691
Heregulin-stimulated acetylcholine receptor gene expression in muscle: requirement for MAP kinase and evidence for a parallel inhibitory pathway independent of electrical activityQ33886118
Implication of a multisubunit Ets-related transcription factor in synaptic expression of the nicotinic acetylcholine receptorQ33888892
Muscle-specific expression of the acetylcholine receptor alpha-subunit gene requires both positive and negative interactions between myogenic factors, Sp1 and GBF factors.Q34042866
Krox-20 controls myelination in the peripheral nervous systemQ34324119
ARIA, a protein that stimulates acetylcholine receptor synthesis, is a member of the neu ligand familyQ34361950
Functional interactions between the retinoblastoma (Rb) protein and Sp-family members: superactivation by Rb requires amino acids necessary for growth suppressionQ34396889
Neuregulins and their receptors: a versatile signaling module in organogenesis and oncogenesisQ34431223
Spacing of palindromic half sites as a determinant of selective STAT (signal transducers and activators of transcription) DNA binding and transcriptional activityQ34532143
A glutamine-rich hydrophobic patch in transcription factor Sp1 contacts the dTAFII110 component of the Drosophila TFIID complex and mediates transcriptional activationQ34920038
Isolation and characterization of the mouse acetylcholine receptor delta subunit gene: identification of a 148-bp cis-acting region that confers myotube-specific expressionQ36221143
Osteocalcin gene promoter-binding factors are tissue-specific nuclear matrix componentsQ36224079
Sequential requirement of hepatocyte growth factor and neuregulin in the morphogenesis and differentiation of the mammary glandQ36236069
The regulation of transcription by phosphorylationQ36377421
Transcriptional repression of the interleukin-2 gene by vitamin D3: direct inhibition of NFATp/AP-1 complex formation by a nuclear hormone receptorQ36555534
Tyrosine dephosphorylation of nuclear proteins mimics transforming growth factor beta 1 stimulation of alpha 2(I) collagen gene expressionQ36556324
The serum-inducible mouse gene Krox-24 encodes a sequence-specific transcriptional activatorQ36715241
Characterization of the functional role of E-box elements for the transcriptional activity of rat acetylcholine receptor epsilon-subunit and gamma-subunit gene promoters in primary muscle cell culturesQ36723290
Dephosphorylation of Sp1 by protein phosphatase 1 is involved in the glucose-mediated activation of the acetyl-CoA carboxylase geneQ36802936
The retinoblastoma gene product regulates Sp1-mediated transcriptionQ36816438
A reciprocal cell-cell interaction mediated by NT-3 and neuregulins controls the early survival and development of sympathetic neuroblastsQ37264951
Distinct isoforms of neuregulin are expressed in mesenchymal and neuronal cells during mouse developmentQ37558638
Transforming Growth Factor β Activates the Promoter of Cyclin-dependent Kinase Inhibitor p15 through an Sp1 Consensus SiteQ38289403
Transforming growth factor-beta stimulates alpha 2(I) collagen gene expression through a cis-acting element that contains an Sp1-binding siteQ38308029
Measurement of the binding of transcription factor Sp1 to a single GC box recognition sequenceQ38344881
Binding and functional effects of transcriptional factor Sp1 on the murine interleukin-6 promotorQ38360074
Binding of phosphorylated Sp1 protein to tandem Sp1 binding sites regulates alpha2 integrin gene core promoter activity.Q38504246
Sp1-mediated transcriptional activation is repressed by Sp3Q40792899
Epidermal egr-like zinc finger protein of Drosophila participates in myotube guidance.Q41064451
Histone deacetylase inhibitor activates the WAF1/Cip1 gene promoter through the Sp1 sitesQ41066638
The role of the transcription factor Sp1 in regulating the expression of the WAF1/CIP1 gene in U937 leukemic cellsQ41239623
Epidermal growth factor stimulation of the human gastrin promoter requires Sp1.Q41359086
Regulation of the acetylcholine receptor epsilon subunit gene by recombinant ARIA: an in vitro model for transynaptic gene regulationQ41372354
There must be 50 ways to rule the signal: the case of the Drosophila EGF receptorQ41420670
The ErbB signaling network in embryogenesis and oncogenesis: signal diversification through combinatorial ligand-receptor interactionsQ41554100
GC box binding induces phosphorylation of Sp1 by a DNA-dependent protein kinaseQ41718635
Negative regulation of human c-fos expression by the retinoblastoma gene productQ41724715
Distinct regions of Sp1 modulate DNA binding and transcriptional activationQ42018379
Remarkable similarities between yeast and mammalian protein phosphatasesQ43482559
Neu differentiation factor: a transmembrane glycoprotein containing an EGF domain and an immunoglobulin homology unitQ44744920
Different activation domains of Sp1 govern formation of multimers and mediate transcriptional synergismQ46405351
The regulation of Krox-20 expression reveals important steps in the control of peripheral glial cell development.Q52200195
Neu differentiation factor is a neuron-glia signal and regulates survival, proliferation, and maturation of rat Schwann cell precursors.Q52206462
Cell type- and differentiation-dependent expression from the mouse acetylcholine receptor epsilon-subunit promoter.Q52222556
Modulation of transcription factor Sp1 by cAMP-dependent protein kinase.Q52553797
Nonmyogenic factors bind nicotinic acetylcholine receptor promoter elements required for response to denervationQ64382071
Tyrphostins IV--highly potent inhibitors of EGF receptor kinase. Structure-activity relationship study of 4-anilidoquinazolinesQ71702568
Sp1 Is Phosphorylated and Its DNA Binding Activity Down-regulated upon Terminal Differentiation of the LiverQ71823770
Transcriptional regulation of the elastin gene by insulin-like growth factor-I involves disruption of Sp1 binding. Evidence for the role of Rb in mediating Sp1 binding in aortic smooth muscle cellsQ72645576
Protein kinase CK2 down-regulates glucose-activated expression of the acetyl-CoA carboxylase geneQ73063764
Casein kinase II-mediated phosphorylation of the C terminus of Sp1 decreases its DNA binding activityQ73343226
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
P304page(s)1961-1972
P577publication date1999-03-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleNeu differentiation factor stimulates phosphorylation and activation of the Sp1 transcription factor
P478volume19

Reverse relations

cites work (P2860)
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Q34017130FOXO3a mediates signaling crosstalk that coordinates ubiquitin and atrogin-1/MAFbx expression during glucocorticoid-induced skeletal muscle atrophy
Q38294385GC box-binding transcription factors control the neuronal specific transcription of the cyclin-dependent kinase 5 regulator p35.
Q33967189Grb2 and Shc adapter proteins play distinct roles in Neu (ErbB-2)-induced mammary tumorigenesis: implications for human breast cancer
Q34479560HER-2/neu represses the metastasis suppressor RECK via ERK and Sp transcription factors to promote cell invasion
Q24336095Heregulin regulates the ability of the ErbB3-binding protein Ebp1 to bind E2F promoter elements and repress E2F-mediated transcription
Q31807876Heregulin upregulates the expression of nitric oxide synthase (NOS)-1 in rat cerebellar granule neurons via the ErbB4 receptor
Q38321481Identification by in vivo genomic footprinting of a transcriptional switch containing NF-kappaB and Sp1 that regulates the IkappaBalpha promoter
Q40837890Identification of novel, functional genetic variants in the human matrix metalloproteinase-2 gene: role of Sp1 in allele-specific transcriptional regulation
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Q40816857Nuclear factor 1 interferes with Sp1 binding through a composite element on the rat poly(ADP-ribose) polymerase promoter to modulate its activity in vitro
Q42435325Oxidative stress regulates vascular endothelial growth factor-A gene transcription through Sp1- and Sp3-dependent activation of two proximal GC-rich promoter elements
Q39240987PMA stimulates MUC5B gene expression through an Sp1-based mechanism in airway epithelial cells
Q37244649Regulation of transcription factors and repression of Sp1 by prolactin signaling through the short isoform of its cognate receptor
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Q52596037Sp1 and the ets-related transcription factor complex GABP alpha/beta functionally cooperate to activate the utrophin promoter.
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Q38347131bcl-2 induction of urokinase plasminogen activator receptor expression in human cancer cells through Sp1 activation: involvement of ERK1/ERK2 activity

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