GC box binding induces phosphorylation of Sp1 by a DNA-dependent protein kinase

scientific article published on October 1990

GC box binding induces phosphorylation of Sp1 by a DNA-dependent protein kinase is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/0092-8674(90)90296-Q
P698PubMed publication ID2170018

P50authorStephen P JacksonQ37392575
P2093author name stringTjian R
Lees-Miller S
MacDonald JJ
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
P304page(s)155-165
P577publication date1990-10-01
P1433published inCellQ655814
P1476titleGC box binding induces phosphorylation of Sp1 by a DNA-dependent protein kinase
P478volume63

Reverse relations

cites work (P2860)
Q477734743β-hydroxy-5-ene Steroid dehydrogenase gene expression regulation in porcine granulosa cells : Differential effect of FSH and LH on gene transcription
Q367004385-Azacytidine treatment of HA-A melanoma cells induces Sp1 activity and concomitant transforming growth factor alpha expression
Q42483800A 300 bp 5’ -upstream sequence of a differentiation-dependent rabbit K3 keratin gene can serve as a keratinocyte-specific promoter
Q35997819A Drosophila protein homologous to the human p70 Ku autoimmune antigen interacts with the P transposable element inverted repeats
Q38346848A GT-rich sequence binding the transcription factor Sp1 is crucial for high expression of the human type VII collagen gene (COL7A1) in fibroblasts and keratinocytes
Q30373188A conserved heptapeptide restrains the activity of the yeast heat shock transcription factor.
Q41523522A fungal mating type protein that regulates sexual and asexual development contains a POU-related domain
Q36646897A novel cis-acting element controlling the rat CYP2D5 gene and requiring cooperativity between C/EBP beta and an Sp1 factor
Q41065598A retinoblastoma susceptibility gene product, RB, targeting protease is regulated through the cell cycle
Q36187399A role for Sp and nuclear receptor transcription factors in a cardiac hypertrophic growth program
Q24548846A tale of three fingers: the family of mammalian Sp/XKLF transcription factors
Q41846633A transcriptionally active form of GAL4 is phosphorylated and associated with GAL80
Q41116450A unique cathepsin-like protease isolated from CV-1 cells is involved in rapid degradation of retinoblastoma susceptibility gene product, RB, and transcription factor SP1.
Q31134431A universal framework for regulatory element discovery across all genomes and data types
Q43183225ABF1 is a phosphoprotein and plays a role in carbon source control of COX6 transcription in Saccharomyces cerevisiae
Q71859930ATP depletion affects the phosphorylation state, ligand binding, and nuclear transport of the 4 S polycyclic aromatic hydrocarbon-binding protein in rat hepatoma cells
Q41368190Absence of p350 subunit of DNA-activated protein kinase from a radiosensitive human cell line
Q31468454Acceleration of thrombomodulin gene transcription by retinoic acid: retinoic acid receptors and Sp1 regulate the promoter activity through interactions with two different sequences in the 5'-flanking region of human gene
Q40641526Activation of CTP:phosphocholine cytidylyltransferase alpha expression during the S phase of the cell cycle is mediated by the transcription factor Sp1.
Q40975184Activation of Sp1 and its functional co-operation with serum amyloid A-activating sequence binding factor in synoviocyte cells trigger synergistic action of interleukin-1 and interleukin-6 in serum amyloid A gene expression
Q38336655Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity
Q38333075Alternative pathway for induction of human immunodeficiency virus gene expression: involvement of the general transcription machinery.
Q33885523An alternatively spliced form of the transcription factor Sp1 containing only a single glutamine-rich transactivation domain
Q36684796An autonomous chromatin/DNA-PK mechanism for localized DNA damage signaling in mammalian cells
Q38320530An enhanced epithelial response of a papillomavirus promoter to transcriptional activators
Q40988914Analysis of the promoter of the luteinizing hormone/human chorionic gonadotropin receptor gene in neuroendocrine cells
Q38314250Anomalous interaction of Sp1 and specific binding of an E-box-binding protein with the regulatory elements of the Na,K-ATPase alpha 2 subunit gene promoter
Q36366579Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death
Q41583234Association between Polymorphisms of the AKT1 Gene Promoter and Risk of the Alzheimer's Disease in a Chinese Han Population with Type 2 Diabetes
Q24651154Association of p107 with Sp1: genetically separable regions of p107 are involved in regulation of E2F- and Sp1-dependent transcription
Q33851925Autostimulation of the Epstein-Barr virus BRLF1 promoter is mediated through consensus Sp1 and Sp3 binding sites
Q26827232Beyond DNA repair: DNA-PK function in cancer
Q34000499Bifurcated converging pathways for high Ca2+- and TGFbeta-induced inhibition of growth of normal human keratinocytes
Q38332157Biglycan gene expression in the human leiomyosarcoma cell line SK-UT-1. Basal and protein kinase A-induced transcription involves binding of Sp1-like/Sp3 proteins in the proximal promoter region
Q41092576Butyrate activates the WAF1/Cip1 gene promoter through Sp1 sites in a p53-negative human colon cancer cell line
Q33855602CREB binding protein coordinates the function of multiple transcription factors including nuclear factor I to regulate phosphoenolpyruvate carboxykinase (GTP) gene transcription
Q30983401Cell cycle regulated phosphorylation of RPA-32 occurs within the replication initiation complex
Q24650233Cell cycle-regulated association of E2F1 and Sp1 is related to their functional interaction
Q33782614Cellular transcription factors enhance herpes simplex virus type 1 oriS-dependent DNA replication.
Q42832755Characteristics of the intron involvement in the mitogen-induced expression of Zfp-36.
Q42156669Characterization and functional analysis of the 5'-flanking region of the mouse 20alpha-hydroxysteroid dehydrogenase gene
Q36686048Characterization of a family of Arabidopsis zinc finger protein cDNAs
Q33937292Characterization of a zinc finger DNA-binding protein expressed specifically in Petunia petals and seedlings
Q53761571Characterization of promoter elements directing Mona/Gads molecular adapter expression in T and myelomonocytic cells: involvement of the AML-1 transcription factor.
Q28271679Characterization of the human alpha 1(VI) collagen promoter and its comparison with human alpha 2(VI) promoters
Q36556726Characterization of the human granulocyte-macrophage colony-stimulating factor gene promoter: an AP1 complex and an Sp1-related complex transactivate the promoter activity that is suppressed by a YY1 complex
Q32077500Characterization of the murine gene of gC1qBP, a novel cell protein that binds the globular heads of C1q, vitronectin, high molecular weight kininogen and factor XII.
Q40963135Cleavage of transcription factor SP1 by caspases during anti-IgM-induced B-cell apoptosis
Q38306814Cloning and characterization of 5'-flanking region of mouse prostacyclin synthase gene
Q24337872Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression
Q40411319Compilation of vertebrate-encoded transcription factors
Q47316946Computational characterization of chromatin domain boundary-associated genomic elements
Q50315355Cooperation of Sp1 and p300 in the induction of the CDK inhibitor p21WAF1/CIP1 during NGF-mediated neuronal differentiation
Q33779441Correlated high expression of FXR and Sp1 in cancer cells confers a poor prognosis for pancreatic cancer: A study based on TCGA and tissue microarray
Q41596688Cryo-EM structure of human DNA-PK holoenzyme
Q28361370Cyclin A-CDK phosphorylates Sp1 and enhances Sp1-mediated transcription
Q68045281DNA binding activity of the Arabidopsis G-box binding factor GBF1 is stimulated by phosphorylation by casein kinase II from broccoli
Q47070264DNA binding specificities of YPF1, a Drosophila homolog to the DNA binding subunit of human DNA-dependent protein kinase, Ku.
Q37730186DNA damage enhances melanogenesis
Q90055320DNA dependent protein kinase (DNA-PK) enhances HIV transcription by promoting RNA polymerase II activity and recruitment of transcription machinery at HIV LTR
Q40930040DNA double-strand break repair and V(D)J recombination: involvement of DNA-PK.
Q39002684DNA looping and Sp1 multimer links: a mechanism for transcriptional synergism and enhancement
Q45715501DNA looping between sites for transcriptional activation: self-association of DNA-bound Sp1
Q64389910DNA-PK Deficiency in Alzheimer's Disease
Q33892330DNA-PK and P38 MAPK: A Kinase Collusion in Alzheimer's Disease?
Q92408727DNA-PK as an Emerging Therapeutic Target in Cancer
Q90628309DNA-PK, Nuclear mTOR, and the Androgen Pathway in Prostate Cancer
Q38852980DNA-PKcs-Mediated Transcriptional Regulation Drives Prostate Cancer Progression and Metastasis
Q56567850DNA-activated protein kinase in Raji Burkitt's lymphoma cells
Q41082640DNA-dependent phosphorylation of histone H2A.X during nucleosome assembly in Xenopus laevis oocytes: involvement of protein phosphorylation in nucleosome spacing.
Q35603296DNA-dependent protein kinase (Ku protein-p350 complex) assembles on double-stranded DNA.
Q34868235DNA-dependent protein kinase activity is absent in xrs-6 cells: implications for site-specific recombination and DNA double-strand break repair
Q36998015DNA-dependent protein kinase and DNA repair: relevance to Alzheimer's disease
Q24337388DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product
Q24522560DNA-dependent protein kinase phosphorylation of IkappaB alpha and IkappaB beta regulates NF-kappaB DNA binding properties
Q34519398DNA-dependent protein kinase specifically represses promoter-directed transcription initiation by RNA polymerase I.
Q46922132DNase I-resistant DNA-dependent protein kinase activity in Xenopus oocytes
Q38332241Delayed secondary glucocorticoid response elements. Unusual nucleotide motifs specify glucocorticoid receptor binding to transcribed regions of alpha 2u-globulin DNA
Q36802936Dephosphorylation of Sp1 by protein phosphatase 1 is involved in the glucose-mediated activation of the acetyl-CoA carboxylase gene
Q36688944Developmental expression of Sp1 in the mouse
Q40656165Differential Gene Expression in Human Glioma Cells: Correlation With Presence or Absence of DNA-Dependent Protein Kinase
Q37572384Differential accumulation of transcripts encoding protein kinase homologs in greening pea seedlings
Q46221774Differential activation of the rat phenylethanolamine N-methyltransferase gene by Sp1 and Egr-1.
Q36430308Dimerization and DNA binding alter phosphorylation of Fos and Jun.
Q40628182Down-regulation of Sp1 activity through modulation of O-glycosylation by treatment with a low glucose mimetic, 2-deoxyglucose.
Q38332848Down-regulation of cytochrome P450 1A1 gene promoter by oxidative stress. Critical contribution of nuclear factor 1.
Q42507009Downregulation of constitutive and heavy metal-induced metallothionein-I expression by nuclear factor I.
Q38355367Dual regulation of ets-activated gene expression by SP1
Q35185681Dynamic interplay between O-glycosylation and O-phosphorylation of nucleocytoplasmic proteins: a new paradigm for metabolic control of signal transduction and transcription
Q37596389E1BF is an essential RNA polymerase I transcription factor with an intrinsic protein kinase activity that can modulate rRNA gene transcription
Q52952533Effects of interferon alpha on vascular endothelial growth factor gene transcription and tumor angiogenesis.
Q41647864Elements in the first intron of the alpha 1(I) collagen gene interact with Sp1 to regulate gene expression
Q36098859Enhanced phosphorylation of transcription factor sp1 in response to herpes simplex virus type 1 infection is dependent on the ataxia telangiectasia-mutated protein
Q41103802Epidermal growth factor and okadaic acid stimulate Sp1 proteolysis
Q43559925Epidermal growth factor induction of apolipoprotein A-I is mediated by the Ras-MAP kinase cascade and Sp1.
Q41359086Epidermal growth factor stimulation of the human gastrin promoter requires Sp1.
Q77513314Equine SCID: mechanistic analysis and comparison with murine SCID
Q33702830Equine severe combined immunodeficiency: a defect in V(D)J recombination and DNA-dependent protein kinase activity.
Q34332767Evidence that Sp1 positively and Sp3 negatively regulate and androgen does not directly regulate functional tumor suppressor 15-lipoxygenase 2 (15-LOX2) gene expression in normal human prostate epithelial cells
Q48707674Exogenously expressed human Ku70 stabilizes Ku80 in Xenopus oocytes and induces heterologous DNA-PK catalytic activity
Q71938503Expression analysis of an Arabidopsis C2H2 zinc finger protein gene
Q28272631Expression and characterization of recombinant caveolin. Purification by polyhistidine tagging and cholesterol-dependent incorporation into defined lipid membranes
Q73088388Function for p300 and not CBP in the apoptotic response to DNA damage
Q36644772Functional analysis of the V gamma 3 promoter of the murine gamma delta T-cell receptor
Q40043461Functional dissection of the human spumaretrovirus transactivator identifies distinct classes of dominant-negative mutants.
Q28590355Functional interaction between DNA-PK and c-Abl in response to DNA damage
Q38333206Functional recognition of the neuronal tyrosine hydroxylase cAMP regulatory element in different cell types
Q37629590GAL4 is phosphorylated as a consequence of transcriptional activation
Q52550218Gap junctional communication modulates gene transcription by altering the recruitment of Sp1 and Sp3 to connexin-response elements in osteoblast promoters.
Q33802472Gene for the catalytic subunit of mouse DNA-dependent protein kinase maps to the scid locus
Q35851299Gene regulation by Sp1 and Sp3.
Q38352191Genomic structure and expression of the murine Hmgi-c gene
Q44534309Glucose metabolism in cancer: importance of transcription factor-DNA interactions within a short segment of the proximal region og the type II hexokinase promoter
Q41074637Glucose regulates the promoter activity of aldolase A and pyruvate kinase M2 via dephosphorylation of Sp1.
Q30656360Glycosylation of the murine estrogen receptor-alpha
Q42822980Growth/cell cycle regulation of Sp1 phosphorylation
Q30615171HIV-1-associated central nervous system dysfunction
Q39376722Hepatitis C virus promotes expression of the 3β-hydroxysterol δ24-reductase through Sp1.
Q36935311Hormone-induced progesterone receptor phosphorylation consists of sequential DNA-independent and DNA-dependent stages: analysis with zinc finger mutants and the progesterone antagonist ZK98299.
Q30450287Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53.
Q36774702Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, and the human Ku autoantigen
Q35845633Human cytomegalovirus upregulates NF-kappa B activity by transactivating the NF-kappa B p105/p50 and p65 promoters
Q40066208Human immunodeficiency virus type 1 Tat-mediated trans activation correlates with the phosphorylation state of a cellular TAR RNA stem-binding factor.
Q48070725Human mineralocorticoid receptor genomic structure and identification of expressed isoforms
Q28378156Hydrogen peroxide: a link between acetaldehyde-elicited alpha1(I) collagen gene up-regulation and oxidative stress in mouse hepatic stellate cells
Q42461521Hypoxia regulates beta-enolase and pyruvate kinase-M promoters by modulating Sp1/Sp3 binding to a conserved GC element
Q28577792Identification of DNA-dependent protein kinase as a cofactor for the forkhead transcription factor FoxA2
Q40260459Identification of a hydrogen peroxide-induced PP1-JNK1-Sp1 signaling pathway for gene regulation
Q41104472Identification of a minimal promoter element of the mouse epidermal growth factor gene
Q47773747Identification of two distinct Sp1- and RBF-1-like nuclear factors that bind to the upstream region of the human angiotensinogen promoter
Q38291982In vivo footprinting of the human 11beta-hydroxysteroid dehydrogenase type 2 promoter: evidence for cell-specific regulation by Sp1 and Sp3.
Q38334993Increased expression of DNA-dependent protein kinase confers resistance to adriamycin
Q40819762Independent repression of a GC-rich housekeeping gene by Sp1 and MAZ involves the same cis-elements
Q74194228Induction of p21WAF1 expression via Sp1-binding sites by tamoxifen in estrogen receptor-negative lung cancer cells
Q39879958Induction of the transcription factor Sp1 during human cytomegalovirus infection mediates upregulation of the p65 and p105/p50 NF-kappaB promoters
Q38336378Induction of transforming growth factor-beta receptor type II expression in estrogen receptor-positive breast cancer cells through SP1 activation by 5-aza-2'-deoxycytidine
Q44542035Inhibition of MG-63 cell cycle progression by synthetic vitamin D3 analogs mediated by p27, Cdk2, cyclin E, and the retinoblastoma protein
Q40092239Inhibition of estrogen receptor beta-mediated human telomerase reverse transcriptase gene transcription via the suppression of mitogen-activated protein kinase signaling plays an important role in 15-deoxy-Delta(12,14)-prostaglandin J(2)-induced apo
Q73692153Inhibition of phosphatidylinositol 3-kinase by c-Abl in the genotoxic stress response
Q28566805Insulin dynamically regulates calmodulin gene expression by sequential o-glycosylation and phosphorylation of sp1 and its subcellular compartmentalization in liver cells
Q38348517Insulin-Like Growth Factor I Increases Rat Peptide YY Promoter Activity through Sp1 Binding Sites
Q34365204Interaction between HIV-1 Tat and DNA-PKcs modulates HIV transcription and class switch recombination
Q36664841Interaction of several related GC-box- and GT-box-binding proteins with the intronic enhancer is required for differential expression of the gb110 gene in embryonal carcinoma cells
Q44560864Interaction of the transcription factor Sp1 with the nuclear pore protein p62 requires the C-terminal domain of p62.
Q34989577Intracellular glycosylation and development
Q42435349Involvement of two Sp1 elements in basal endothelial prostaglandin H synthase-1 promoter activity
Q36413193KLF8 promotes tumorigenesis, invasion and metastasis of colorectal cancer cells by transcriptional activation of FHL2.
Q34078665Leptin increases tissue inhibitor of metalloproteinase I (TIMP-1) gene expression by a specificity protein 1/signal transducer and activator of transcription 3 mechanism
Q33964319Life and death decisions: regulation of apoptosis by proteolysis of signaling molecules
Q24318363Ligand and DNA-dependent phosphorylation of human progesterone receptor in vitro
Q36730819Linking DNA Damage and Hormone Signaling Pathways in Cancer
Q44044712Lipopolysaccharide down-regulates Sp1 binding activity by promoting Sp1 protein dephosphorylation and degradation
Q42797017Localization and hormonal stimulation of phosphorylation sites in the LNCaP-cell androgen receptor
Q55019234Long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 promotes lung adenocarcinoma by directly interacting with specificity protein 1.
Q38503777MFP1, a novel plant filament-like protein with affinity for matrix attachment region DNA.
Q38855197Measles Virus Infection Inactivates Cellular Protein Phosphatase 5 with Consequent Suppression of Sp1 and c-Myc Activities
Q33900903Mechanism of action in thalidomide teratogenesis
Q33737143Mechanisms and control of embryonic genome activation in mammalian embryos
Q37261167Mechanisms of decreased expression of transforming growth factor-beta receptor type I at late stages of HPV16-mediated transformation
Q40317888Mithramycin targets sp1 and the androgen receptor transcription level-potential therapeutic role in advanced prostate cancer
Q33782959Modulation of Sp1 phosphorylation by human immunodeficiency virus type 1 Tat.
Q52553797Modulation of transcription factor Sp1 by cAMP-dependent protein kinase.
Q38082670Molecular basis of etiological implications in Alzheimer's disease: focus on neuroinflammation
Q29620376Molecular cloning and functional analysis of Drosophila TAF110 reveal properties expected of coactivators
Q78165328Molecular mechanism for cooperation between Sp1 and steroidogenic factor-1 (SF-1) to regulate bovine CYP11A gene expression
Q40204866Molecular mechanisms of transactivation and doxorubicin-mediated repression of survivin gene in cancer cells
Q34174972Molecular pathways in virus-induced cytokine production
Q35793477Multiple positive and negative elements regulate human brain creatine kinase gene expression
Q52189175Multiple transcriptional elements in the avian type X collagen gene. Identification of Sp1 family proteins as regulators for high level expression in hypertrophic chondrocytes.
Q41551864Murine monoclonal antibodies specific for conserved and non-conserved antigenic determinants of the human and murine Ku autoantigens
Q40062939Mutual functional antagonism of the simian virus 40 T antigen and the hepatitis B virus trans activator
Q41094353Nerve growth factor induces transcription of the p21 WAF1/CIP1 and cyclin D1 genes in PC12 cells by activating the Sp1 transcription factor
Q43746975Nerve growth factor uses Ras/ERK and phosphatidylinositol 3-kinase cascades to up-regulate the N-methyl-D-aspartate receptor 1 promoter
Q33957454Neu differentiation factor stimulates phosphorylation and activation of the Sp1 transcription factor
Q73302869Neuroadaptational changes in DNA binding of stimulatory protein-1 and nuclear factor-kB gene transcription factors during ethanol dependence
Q38302177Novel Sp family-like transcription factors are present in adult insect cells and are involved in transcription from the polyhedrin gene initiator promoter
Q37587479Novel clustering of Sp1 transcription factor binding sites at the transcription initiation site of the human muscle phosphofructokinase P1 promoter
Q36650759Nuclear factor I and epithelial cell-specific transcription of human papillomavirus type 16
Q41069200Nuclear factor I family members regulate the transcription of surfactant protein-C.
Q35805048Nuclear receptor-mediated transactivation through interaction with Sp proteins
Q38306064Nuclear receptors modulate the interaction of Sp1 and GC-rich DNA via ternary complex formation
Q24644353O glycosylation of an Sp1-derived peptide blocks known Sp1 protein interactions
Q24324116O-GlcNAc modification of Sp1 inhibits the functional interaction between Sp1 and Oct1
Q38344855Oct-1, silencer sequence, and GC box regulate thyroid hormone receptor beta1 promoter
Q42476459Oncogene-mediated downregulation of RECK, a novel transformation suppressor gene
Q36683049Overexpression of Myc suppresses CCAAT transcription factor/nuclear factor 1-dependent promoters in vivo
Q39721518Overlapping DNA recognition motifs between Sp1 and a novel trans-acting factor within the wt1 tumour suppressor gene promoter
Q42435325Oxidative stress regulates vascular endothelial growth factor-A gene transcription through Sp1- and Sp3-dependent activation of two proximal GC-rich promoter elements
Q39240987PMA stimulates MUC5B gene expression through an Sp1-based mechanism in airway epithelial cells
Q35650808PP2B-mediated dephosphorylation of c-Jun C terminus regulates phorbol ester-induced c-Jun/Sp1 interaction in A431 cells
Q40966182Phenylethanolamine N-methyltransferase gene expression. Sp1 and MAZ potential for tissue-specific expression
Q44973219Phosphorylation of Sp1 by cyclin-dependent kinase 2 modulates the role of Sp1 in CTP:phosphocholine cytidylyltransferase alpha regulation during the S phase of the cell cycle
Q42443975Phosphorylation of human general transcription factors TATA-binding protein and transcription factor IIB by DNA-dependent protein kinase--synergistic stimulation of RNA polymerase II basal transcription in vitro
Q71118453Phosphorylation of the N-terminal domain of Xenopus TATA-box binding protein by DNA-dependent protein kinase depends on the C-terminal core domain
Q37162321Phosphorylation stimulates the transcriptional activity of the human beta 1 thyroid hormone nuclear receptor
Q54309389Polyadenylation of SV40 late pre-mRNA is dependent on phosphorylation of an essential component associated with the 3' end processing machinery
Q28291615Positive regulation of human α1 (I) collagen promoter activity by transcription factor Sp1
Q37496666Post-translational control of sp-family transcription factors
Q36098970Preferential integration of adeno-associated virus type 2 into a polypyrimidine/polypurine-rich region within AAVS1.
Q44044514Progesterone receptor activates its promoter activity in human endometrial stromal cells
Q28508848Promoter characterization of the human and mouse epilysin (MMP-28) genes
Q36710187Protein kinase Calpha-induced derepression of the human luteinizing hormone receptor gene transcription through ERK-mediated release of HDAC1/Sin3A repressor complex from Sp1 sites
Q33922189Protein phosphatase 2A: a definite player in viral and parasitic regulation
Q72243665Proteins of the Xenopus laevis zinc finger multigene family as targets for CK II phosphorylation
Q33784868Purification and characterization of a cellular protein that binds to the downstream activation sequence of the strict late UL38 promoter of herpes simplex virus type 1
Q40409914RNA binding properties and evoultionary conservation of the Xenopus multifinger protein Xfin
Q35986963RNA-dependent phosphorylation of a nuclear RNA binding protein
Q24336612RREB-1, a novel zinc finger protein, is involved in the differentiation response to Ras in human medullary thyroid carcinomas
Q34042822Rac1-mediated mitochondrial H2O2 generation regulates MMP-9 gene expression in macrophages via inhibition of SP-1 and AP-1
Q36568052Reduced O glycosylation of Sp1 is associated with increased proteasome susceptibility
Q30176052Regulation of DNA-dependent protein kinase by the Lyn tyrosine kinase
Q33587139Regulation of HIV-1 transcription in cells of the monocyte-macrophage lineage
Q24336551Regulation of Rad51 function by c-Abl in response to DNA damage
Q40625779Regulation of Tension-induced Mechanotranscriptional Signals by the Microtubule Network in Fibroblasts
Q55475411Regulation of brain fatty acid-binding protein expression by differential phosphorylation of nuclear factor I in malignant glioma cell lines.
Q48962513Regulation of gene expression in the preimplantation mouse embryo: temporal and spatial patterns of expression of the transcription factor Sp1.
Q40650133Regulation of human CETP gene expression: role of SP1 and SP3 transcription factors at promoter sites -690, -629, and -37.
Q33871779Regulation of myelin basic protein gene transcription by Sp1 and Puralpha: evidence for association of Sp1 and Puralpha in brain
Q39920234Regulation of prion gene expression by transcription factors SP1 and metal transcription factor-1.
Q38297914Regulation of rat ornithine decarboxylase promoter activity by binding of transcription factor Sp1.
Q40321086Regulation of the ClC-2 lung epithelial chloride channel by glycosylation of SP1.
Q34922462Regulation of the activity of Sp1-related transcription factors.
Q44866187Regulation of the estrogen receptor alpha minimal promoter by Sp1, USF-1 and ERalpha
Q41030965Regulation of the human protein C inhibitor gene expression in HepG2 cells: role of Sp1 and AP2.
Q37244649Regulation of transcription factors and repression of Sp1 by prolactin signaling through the short isoform of its cognate receptor
Q38316453Repeated CT elements bound by zinc finger proteins control the absolute and relative activities of the two principal human c-myc promoters
Q38307585Repression of transforming growth factor-beta receptor type I promoter expression by Sp1 deficiency
Q33958593Repressive effect of Sp1 on the C/EBPalpha gene promoter: role in adipocyte differentiation
Q36661971Retinoic acid (RA) regulates 17beta-hydroxysteroid dehydrogenase type 2 expression in endometrium: interaction of RA receptors with specificity protein (SP) 1/SP3 for estradiol metabolism
Q40437555Retinoic acid activates human secretin gene expression by Sp proteins and nuclear factor I in neuronal SH-SY5Y cells
Q38943928Role of ATM in the formation of the replication compartment during lytic replication of Epstein-Barr virus in nasopharyngeal epithelial cells
Q40945744Role of Sp1 in cAMP-dependent transcriptional regulation of the bovine CYP11A gene.
Q44341044Role of an AP-2-like element in transcriptional regulation of mouse mu-opioid receptor gene
Q33930287Roles of the NFI/CTF gene family in transcription and development
Q36754616SMAD3/4-dependent transcriptional activation of the human type VII collagen gene (COL7A1) promoter by transforming growth factor beta.
Q39654285SP1 acts as a key factor, contributes to upregulation of ADAM23 expression under serum deprivation
Q53614802SP1 and SP3 mediate progesterone-dependent induction of the 17beta hydroxysteroid dehydrogenase type 2 gene in human endometrium.
Q24561996Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathways
Q48526211Sequence motif in control regions of the H+/K+ ATPase α and β subunit genes recognized by gastric specific nuclear protein(s)
Q36489011Serine/threonine phosphorylation regulates binding of C hnRNP proteins to pre-mRNA.
Q37363474Shear stress induction of the tissue factor gene
Q36562044Single-stranded-DNA binding alters human replication protein A structure and facilitates interaction with DNA-dependent protein kinase
Q42446615Site-directed mutagenesis of the ATM promoter: consequences for response to proliferation and ionizing radiation
Q39869550Sp proteins and Runx2 mediate regulation of matrix gla protein (MGP) expression by parathyroid hormone
Q40154381Sp-1 binds promoter elements that are regulated by retinoblastoma and regulate CTP:phosphocholine cytidylyltransferase-alpha transcription
Q71823770Sp1 Is Phosphorylated and Its DNA Binding Activity Down-regulated upon Terminal Differentiation of the Liver
Q41176384Sp1 activates and inhibits transcription from separate elements in the proximal promoter of the human adenine nucleotide translocase 2 (ANT2) gene.
Q55304865Sp1 activation of RNA polymerase II transcription complexes involves a heat-labile DNA-binding component.
Q34460815Sp1 and AP2 regulate but do not constitute TATA-less human TAF(II)55 core promoter activity
Q40920191Sp1 and NF-Y synergistically mediate the effect of vitamin D(3) in the p27(Kip1) gene promoter that lacks vitamin D response elements
Q28140115Sp1 and Smad proteins cooperate to mediate transforming growth factor-beta 1-induced alpha 2(I) collagen expression in human glomerular mesangial cells
Q38363336Sp1 and Sp3 activate the testis-specific histone H1t promoter through the H1t/GC-box
Q38355603Sp1 and Sp3 are involved in up-regulation of human deoxyribonuclease II transcription during differentiation of HL-60 cells.
Q38359975Sp1 and Sp3 transcription factors synergistically regulate HGF receptor gene expression in kidney
Q33952921Sp1 and krüppel-like factor family of transcription factors in cell growth regulation and cancer
Q38267908Sp1 and the 'hallmarks of cancer'.
Q71846440Sp1 binding activity increases in activated Ito cells
Q36563516Sp1 binding plays a critical role in Erb-B2- and v-ras-mediated downregulation of alpha2-integrin expression in human mammary epithelial cells
Q48037946Sp1 binds to the rat luteinizing hormone beta (LHbeta) gene promoter and mediates gonadotropin-releasing hormone-stimulated expression of the LHbeta subunit gene
Q40019025Sp1 binds two sites in the CD11c promoter in vivo specifically in myeloid cells and cooperates with AP1 to activate transcription
Q41040349Sp1 cooperates with the ets transcription factor, GABP, to activate the CD18 (beta2 leukocyte integrin) promoter
Q43628311Sp1 involvement in the 4beta-phorbol 12-myristate 13-acetate (TPA)-mediated increase in resistance to methotrexate in Chinese hamster ovary cells
Q31506685Sp1 phosphorylation regulates apoptosis via extracellular FasL-Fas engagement
Q34277377Sp1 phosphorylation regulates inducible expression of platelet-derived growth factor B-chain gene via atypical protein kinase C-zeta
Q41078917Sp1 protein contributes to airway-specific rat MUC 2 mucin gene transcription
Q28214220Sp1 transactivation of the TCL1 oncogene
Q42820210Sp1 transcriptional activity is up-regulated by phosphatase 2A in dividing T lymphocytes
Q45106628Sp1-mediated transcriptional activation from the dominant promoter of the rat alpha1B adrenergic receptor gene in DDT1MF-2 cells
Q40792899Sp1-mediated transcriptional activation is repressed by Sp3
Q40051439Specificity proteins Sp1 and Sp3 interact with the rat GTP cyclohydrolase I proximal promoter to regulate transcription
Q71743088Stimulation of a Ca(2+)-calmodulin-activated histone 3 arginine kinase in quiescent rat heart endothelial cells compared to actively dividing cells
Q41358623Stimulation of defective DNA transfer activity in recombination deficient SCID cell extracts by a 72-kDa protein from wild-type thymocytes
Q72465867Stimulation of the DNA-dependent protein kinase by RNA polymerase II transcriptional activator proteins
Q41279368Structural and functional analysis of the promoter of the murine V gamma 1.1 T cell receptor gene
Q30743798Structure of the rat glucose-dependent insulinotropic polypeptide receptor gene
Q34340811Suppression of heat-induced hsp70 expression by the 70-kDa subunit of the human Ku autoantigen
Q40932301Suppression of the poly(ADP-ribose) polymerase activity by DNA-dependent protein kinase in vitro
Q46427332Survivin enhances telomerase activity via up-regulation of specificity protein 1- and c-Myc-mediated human telomerase reverse transcriptase gene transcription
Q34046598Synergistic activation of the HTLV1 LTR Ets-responsive region by transcription factors Ets1 and Sp1.
Q37634102Targeting DNA Repair in Cancer: Beyond PARP Inhibitors.
Q35936421Targeting of Sp1 to a non-Sp1 site in the human neurofilament (H) promoter via an intermediary DNA-binding protein
Q24290251Tau promoter confers neuronal specificity and binds Sp1 and AP-2
Q33958084Temporal activation of the sea urchin late H1 gene requires stage-specific phosphorylation of the embryonic transcription factor SSAP
Q38074017Thalidomide-analogue biology: immunological, molecular and epigenetic targets in cancer therapy.
Q64389407The DNA-dependent protein kinase is inactivated by autophosphorylation of the catalytic subunit
Q41263744The DNA-dependent protein kinase, DNA-PK: 10 years and no ends in sight
Q28081821The DNA-dependent protein kinase: A multifunctional protein kinase with roles in DNA double strand break repair and mitosis
Q38348275The Nuclear Abundance of Transcription Factors Sp1 and Sp3 Depends on Biotin in Jurkat Cells
Q33778355The Sp-family of transcription factors
Q35019835The Sp1 family of transcription factors is involved in p27(Kip1)-mediated activation of myelin basic protein gene expression
Q38357200The Xenopus B2 factor involved in TFIIIA gene regulation is closely related to Sp1 and interacts in a complex with USF.
Q61806756The active role of the transcription factor Sp1 in NFATc2-mediated gene regulation in pancreatic cancer
Q40678312The core promoter region of the tumor necrosis factor alpha gene confers phorbol ester responsiveness to upstream transcriptional activators.
Q90113081The crucial role of DNA-dependent protein kinase and myelin transcription factor 1-like protein in the miR-141 tumor suppressor network
Q36567115The glutamine-rich activation domains of human Sp1 do not stimulate transcription in Saccharomyces cerevisiae.
Q36797980The human DNA-activated protein kinase phosphorylates simian virus 40 T antigen at amino- and carboxy-terminal sites
Q35980970The life and death of DNA-PK.
Q41150401The locus-specific enhancer activity of the class I major histocompatibility complex interferon-responsive element is associated with a gamma-interferon (IFN)-inducible factor distinct from STAT1alpha, p48, and IFN regulatory factor-1.
Q38289366The mouse p44 mitogen-activated protein kinase (extracellular signal-regulated kinase 1) gene. Genomic organization and structure of the 5'-flanking regulatory region
Q40959304The mycotoxin fumonisin B1 transcriptionally activates the p21 promoter through a cis-acting element containing two Sp1 binding sites
Q40816643The p38 mitogen-activated kinase pathway regulates the human interleukin-10 promoter via the activation of Sp1 transcription factor in lipopolysaccharide-stimulated human macrophages
Q36377421The regulation of transcription by phosphorylation
Q38306731The retinoblastoma gene product RB stimulates Sp1-mediated transcription by liberating Sp1 from a negative regulator
Q77811804The retinoblastoma susceptibility gene product/Sp1 signalling pathway is modulated by Ca2+/calmodulin kinases II and IV activity
Q49906238The role of DNA-PK in aging and energy metabolism
Q42514630The role of Sp1 and NF-kappa B in regulating CD40 gene expression
Q40886655The role of Sp1 in the differential expression of transforming growth factor-beta receptor type II in human breast adenocarcinoma MCF-7 cells
Q35830410The role of the non-homologous end-joining pathway in lymphocyte development
Q41239623The role of the transcription factor Sp1 in regulating the expression of the WAF1/CIP1 gene in U937 leukemic cells
Q38331207The transcription factor Sp1 regulates the myeloid-specific expression of the human hematopoietic cell kinase (HCK) gene through binding to two adjacent GC boxes within the HCK promoter-proximal region
Q42816689The transcription factor nuclear factor I mediates repression of the GLUT4 promoter by insulin
Q73694178The tumor suppressor protein p53 requires a cofactor to activate transcriptionally the human BAX promoter
Q40023447The von Hippel-Lindau tumor suppressor gene product interacts with Sp1 to repress vascular endothelial growth factor promoter activity
Q38314159Three clustered Sp1 sites are required for efficient transcription of the TATA-less promoter of the gene for insulin-like growth factor-binding protein-2 from the rat
Q40856128Transcription by RNA polymerase II in DNA-PK deficient scid mouse cells
Q38345845Transcription factor Sp1 is essential for early embryonic development but dispensable for cell growth and differentiation
Q38308326Transcription factor Sp1 is involved in the regulation of varicella-zoster virus glycoprotein E.
Q33781947Transcription factor Sp1 mediates cell-specific trans-activation of the human cytomegalovirus DNA polymerase gene promoter by immediate-early protein IE86 in glioblastoma U373MG cells.
Q44047589Transcription factor Sp1 phosphorylation induced by shear stress inhibits membrane type 1-matrix metalloproteinase expression in endothelium
Q38334009Transcription factors nuclear factor I and Sp1 interact with the murine collagen alpha 1 (I) promoter
Q33548739Transcription of human resistin gene involves an interaction of Sp1 with peroxisome proliferator-activating receptor gamma (PPARgamma)
Q36699178Transcription of the mouse secretory protease inhibitor p12 gene is activated by the developmentally regulated positive transcription factor Sp1
Q52877812Transcription of the vascular endothelial growth factor receptor-3 (VEGFR3) gene is regulated by the zinc finger proteins Sp1 and Sp3 and is under epigenetic control: transcription of vascular endothelial growth factor receptor 3.
Q38306196Transcriptional activation of human leukosialin (CD43) gene by Sp1 through binding to a GGGTGG motif
Q54383317Transcriptional activation of p21(WAF¹/CIP¹) is mediated by increased DNA binding activity and increased interaction between p53 and Sp1 via phosphorylation during replicative senescence of human embryonic fibroblasts.
Q38346995Transcriptional activation of the minimal human Proalpha1(I) collagen promoter: obligatory requirement for Sp1.
Q38296619Transcriptional analysis of acetylcholine receptor alpha 3 gene promoter motifs that bind Sp1 and AP2.
Q78732223Transcriptional control of the RECK metastasis/angiogenesis suppressor gene
Q41756422Transcriptional regulation by the Sp family proteins.
Q40779906Transcriptional regulation of cell-specific expression of the human cystathionine beta -synthase gene by differential binding of Sp1/Sp3 to the -1b promoter
Q24534075Transcriptional regulation of human 3'-phosphoadenosine 5'-phosphosulphate synthase 2
Q40607021Transcriptional regulation of multidrug resistance in breast cancer
Q34064174Transcriptional regulation of the LH beta gene by gonadotropin-releasing hormone and the protein kinase C system
Q36798033Transcriptional regulation of the gene coding for human protein C.
Q38361499Transcriptional repression of the RET proto-oncogene by a mitogen activated protein kinase-dependent signalling pathway
Q38289102Triggering of the human interleukin-6 gene by interferon-gamma and tumor necrosis factor-alpha in monocytic cells involves cooperation between interferon regulatory factor-1, NF kappa B, and Sp1 transcription factors
Q40060664Two synthetic Sp1-binding sites functionally substitute for the 21-base-pair repeat region to activate simian virus 40 growth in CV-1 cells
Q40115583Unusual Sp1-GC box interaction in a parvovirus promoter
Q40519651V(D)J recombination and double-strand break repair
Q37278595Zinc rapidly induces a metal response element-binding factor
Q40405852c-Jun is phosphorylated by the DNA-dependent protein kinase in vitro; definition of the minimal kinase recognition motif
Q36230959cis and trans elements differ among mouse strains with high and low extrahepatic complement factor B gene expression
Q35855782ras oncogene-dependent activation of the P4 promoter of minute virus of mice through a proximal P4 element interacting with the Ets family of transcription factors.

Search more.