The retinoblastoma susceptibility gene product/Sp1 signalling pathway is modulated by Ca2+/calmodulin kinases II and IV activity

scientific article published on 01 April 1999

The retinoblastoma susceptibility gene product/Sp1 signalling pathway is modulated by Ca2+/calmodulin kinases II and IV activity is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1012227522
P356DOI10.1038/SJ.ONC.1202634
P698PubMed publication ID10348351

P50authorChristian GaiddonQ50853709
P2093author name stringLoeffler JP
Antoine M
Boutillier AL
Sohm F
P2860cites workA simple phase-extraction assay for chloramphenicol acyltransferase activityQ67929718
Membrane depolarization and calcium induce c-fos transcription via phosphorylation of transcription factor CREBQ68454790
Cell cycle-dependent regulation of phosphorylation of the human retinoblastoma gene productQ69389791
The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory elementQ69535058
Casein kinase II-mediated phosphorylation of the C terminus of Sp1 decreases its DNA binding activityQ73343226
The retinoblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activityQ24299515
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nucleiQ27860728
Control of transcription factors by signal transduction pathways: the beginning of the endQ28209088
Inhibition of cell proliferation by p107, a relative of the retinoblastoma proteinQ28260016
The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformationQ29400446
E2F: a link between the Rb tumor suppressor protein and viral oncoproteinsQ29618375
A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcomaQ29618817
Transforming p21ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regionsQ34295503
Functional interactions between the retinoblastoma (Rb) protein and Sp-family members: superactivation by Rb requires amino acids necessary for growth suppressionQ34396889
The retinoblastoma protein is phosphorylated during specific phases of the cell cycleQ34507572
Sp3 encodes multiple proteins that differ in their capacity to stimulate or repress transcriptionQ34632672
Neuronal Ca2+/calmodulin-dependent protein kinasesQ35231384
Sp-1 binds promoter elements regulated by the RB protein and Sp-1-mediated transcription is stimulated by RB coexpressionQ36234059
Voltage-insensitive Ca2+ channels and Ca2+/calmodulin-dependent protein kinases propagate signals from endothelin-1 receptors to the c-fos promoterQ36563219
Calcium/calmodulin-dependent protein kinase types II and IV differentially regulate CREB-dependent gene expressionQ36665572
The retinoblastoma gene product regulates Sp1-mediated transcriptionQ36816438
Regulation of transforming growth factor beta 1 gene expression by the product of the retinoblastoma-susceptibility geneQ37474961
cAMP response element-binding protein is activated by Ca2+/calmodulin- as well as cAMP-dependent protein kinaseQ37529773
The regulation and function of c-fos and other immediate early genes in the nervous systemQ37583743
The retinoblastoma gene product RB stimulates Sp1-mediated transcription by liberating Sp1 from a negative regulatorQ38306731
Spontaneous Ca2+ spikes and waves in embryonic neurons: signaling systems for differentiationQ40389627
Regulation of transcription by the retinoblastoma proteinQ40485501
Calcium, calmodulin and cell cycle progressionQ40552394
The molecular mechanisms of neuronal apoptosisQ40588445
Calcium regulation of gene expression in neuronal cellsQ40623122
Integration of cell cycle control with transcriptional regulation by the retinoblastoma proteinQ40914618
Mechanisms controlling gene expression by nuclear calcium signals.Q41040151
A unique cathepsin-like protease isolated from CV-1 cells is involved in rapid degradation of retinoblastoma susceptibility gene product, RB, and transcription factor SP1.Q41116450
Ca2+/calmodulin kinase types II and IV regulate c-fos transcription in the AtT20 corticotroph cell line.Q41190992
Structural evidence for the authenticity of the human retinoblastoma geneQ41344591
Differential activation of CREB by Ca2+/calmodulin-dependent protein kinases type II and type IV involves phosphorylation of a site that negatively regulates activityQ41430917
Gene transfer into primary and established mammalian cell lines with lipopolyamine-coated DNA.Q41580007
GC box binding induces phosphorylation of Sp1 by a DNA-dependent protein kinaseQ41718635
Negative regulation of human c-fos expression by the retinoblastoma gene productQ41724715
Multiple sequence elements in the c-fos promoter mediate induction by cAMP.Q42800062
CREB: a Ca(2+)-regulated transcription factor phosphorylated by calmodulin-dependent kinasesQ45137410
Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiationQ46219366
Human retinoblastoma susceptibility gene: cloning, identification, and sequenceQ48348004
Calcium controls gene expression via three distinct pathways that can function independently of the Ras/mitogen-activated protein kinases (ERKs) signaling cascadeQ48637359
P433issue17
P407language of work or nameEnglishQ1860
P921main subjectretinoblastomaQ500695
P304page(s)2762-2769
P577publication date1999-04-01
P1433published inOncogeneQ1568657
P1476titleThe retinoblastoma susceptibility gene product/Sp1 signalling pathway is modulated by Ca2+/calmodulin kinases II and IV activity
P478volume18

Reverse relations

cites work (P2860)
Q24336107A calcium-dependent switch in a CREST-BRG1 complex regulates activity-dependent gene expression
Q33601704A novel role for calcium/calmodulin kinase II within the brainstem pedunculopontine tegmentum for the regulation of wakefulness and rapid eye movement sleep
Q37709331A ruthenium anticancer compound interacts with histones and impacts differently on epigenetic and death pathways compared to cisplatin.
Q53491968Ca2+/Calmodulin-dependent kinase II signaling causes skeletal overgrowth and premature chondrocyte maturation
Q38467060Capsaicin sensitizes TRAIL-induced apoptosis through Sp1-mediated DR5 up-regulation: Involvement of Ca2+ influx
Q54050681Caspase-dependent cleavage of the retinoblastoma protein is an early step in neuronal apoptosis
Q40890887Characterization of the human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus) oncogene, kaposin (ORF K12).
Q35604588Complex regulation of p73 isoforms after alteration of amyloid precursor polypeptide (APP) function and DNA damage in neurons
Q86191005Gold-phosphine-porphyrin as potential metal-based theranostics
Q37332892Identification of cholinergic and non-cholinergic neurons in the pons expressing phosphorylated cyclic adenosine monophosphate response element-binding protein as a function of rapid eye movement sleep.
Q44401729Involvement of calcium/calmodulin‐dependent protein kinase II in the induction of mPer1
Q40725364New human myelodysplastic cell line, TER-3: G-CSF specific downregulation of Ca2+/calmodulin-dependent protein kinase IV.
Q34364484Regulation of the DNA methylation machinery and its role in cellular transformation
Q53079276Silibinin sensitizes TRAIL-mediated apoptosis by upregulating DR5 through ROS-induced endoplasmic reticulum stress-Ca2+-CaMKII-Sp1 pathway
Q40759850Sp3 Represses Gene Expression via the Titration of Promoter-specific Transcription Factors
Q36673695Transcriptional activator TAp63 is upregulated in muscular atrophy during ALS and induces the pro-atrophic ubiquitin ligase Trim63.

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