Transcriptional activation of p21(WAF¹/CIP¹) is mediated by increased DNA binding activity and increased interaction between p53 and Sp1 via phosphorylation during replicative senescence of human embryonic fibroblasts.

scientific article published on 21 January 2014

Transcriptional activation of p21(WAF¹/CIP¹) is mediated by increased DNA binding activity and increased interaction between p53 and Sp1 via phosphorylation during replicative senescence of human embryonic fibroblasts. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S11033-014-3094-9
P698PubMed publication ID24445528

P2093author name stringJong-Yeon Shin
Hyun-Seok Kim
Seong-Hoon Park
Jae-Bong Park
Jae-Yong Lee
Jaebong Kim
Sung Chan Kim
Min-Ju Kim
Hong-Jun Kang
Jee-In Heo
P2860cites workIncreased p53 Protein Associated with Aging in Human Diploid FibroblastsQ41354644
Increase in expression level of p21sdi1/cip1/waf1 with increasing division age in both normal and SV40-transformed human fibroblastsQ41361622
Microarray analysis of replicative senescenceQ41693910
GC box binding induces phosphorylation of Sp1 by a DNA-dependent protein kinaseQ41718635
Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblastsQ42815554
Activation of protein kinase G Increases the expression of p21CIP1, p27KIP1, and histidine triad protein 1 through Sp1.Q46507418
p21WAF/CIP1/SDI1 is upregulated due to increased mRNA stability during hydroxyurea-induced senescence of human fibroblastsQ46659874
Features of replicative senescence induced by direct addition of antennapedia-p16INK4A fusion protein to human diploid fibroblastsQ48025794
Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screenQ48084448
Transcriptional Regulation of the p21(WAF1/CIP1)GeneQ59119133
Association of CDKN2A/p16INK4A with human head and neck keratinocyte replicative senescence: relationship of dysfunction to immortality and neoplasia.Q67234417
Differential CDK-inhibitor gene expression in aging human diploid fibroblastsQ71256061
Arsenite induces p53 accumulation through an ATM-dependent pathway in human fibroblastsQ73263383
Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblastsQ74344707
Signaling to p53: breaking the MDM2-p53 circuitQ77430977
p53 is preferentially recruited to the promoters of growth arrest genes p21 and GADD45 during replicative senescence of normal human fibroblastsQ80208893
Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)Q24293520
Activation of the ATM kinase by ionizing radiation and phosphorylation of p53Q24311891
A biomarker that identifies senescent human cells in culture and in aging skin in vivoQ24562644
WAF1, a potential mediator of p53 tumor suppressionQ27861121
The double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitroQ28144828
A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1Q28203791
DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2Q28254119
The serial cultivation of human diploid cell strainsQ29547356
The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNAQ29615251
A DNA damage checkpoint response in telomere-initiated senescenceQ29615919
Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpointsQ29617405
Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replicationQ29617915
Oxygen sensitivity severely limits the replicative lifespan of murine fibroblastsQ29618748
The plant isoflavenoid genistein activates p53 and Chk2 in an ATM-dependent mannerQ31627070
Identification of phosphorylation sites on transcription factor Sp1 in response to DNA damage and its accumulation at damaged sitesQ33350921
ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase.Q33887607
Does oxidative damage to DNA increase with age?Q33943307
Increased activity of p53 in senescing fibroblastsQ33971254
The role of the cyclin-dependent kinase inhibitor p21 in apoptosis.Q34164259
p53 post-translational modification: deregulated in tumorigenesisQ34300569
The tumor suppressor p53 and histone deacetylase 1 are antagonistic regulators of the cyclin-dependent kinase inhibitor p21/WAF1/CIP1 gene.Q34888585
PML is induced by oncogenic ras and promotes premature senescenceQ35201220
Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblastsQ35927191
Proliferating cell nuclear antigen and p21 are components of multiple cell cycle kinase complexesQ37375698
Ultraviolet radiation, but not gamma radiation or etoposide-induced DNA damage, results in the phosphorylation of the murine p53 protein at serine-389Q37413761
Transcriptional regulation by post-transcriptional modification--role of phosphorylation in Sp1 transcriptional activityQ38029855
Sp1 plays a critical role in the transcriptional activation of the human cyclin-dependent kinase inhibitor p21(WAF1/Cip1) gene by the p53 tumor suppressor proteinQ38300297
Posttranslational modifications of p53 in replicative senescence overlapping but distinct from those induced by DNA damageQ39452086
Cataloging altered gene expression in young and senescent cells using enhanced differential displayQ40395446
Transcriptional activation of p21(waf1/cip1) by alkylphospholipids: role of the mitogen-activated protein kinase pathway in the transactivation of the human p21(waf1/cip1) promoter by Sp1.Q40595387
Oxygen accelerates the accumulation of mutations during the senescence and immortalization of murine cells in cultureQ40607065
Effect of extracellular signal-regulated kinase on p53 accumulation in response to cisplatinQ40859019
Sp3, but not Sp1, mediates the transcriptional activation of the p21/WAF1/Cip1 gene promoter by histone deacetylase inhibitor.Q40929256
Evidence that transcriptional activation by p53 plays a direct role in the induction of cellular senescence.Q41150575
P433issue4
P1104number of pages12
P304page(s)2397-2408
P577publication date2014-01-21
P1433published inMolecular Biology ReportsQ15752755
P1476titleTranscriptional activation of p21(WAF¹/CIP¹) is mediated by increased DNA binding activity and increased interaction between p53 and Sp1 via phosphorylation during replicative senescence of human embryonic fibroblasts.
P478volume41

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cites work (P2860)
Q35944207A Systematic Investigation into Aging Related Genes in Brain and Their Relationship with Alzheimer's Disease
Q48117209Depletion of B cell CLL/Lymphoma 11B Gene Expression Represses Glioma Cell Growth
Q34278867High dose ionizing radiation regulates micro RNA and gene expression changes in human peripheral blood mononuclear cells
Q43064484Identification of XBP1-u as a novel regulator of the MDM2/p53 axis using an shRNA library
Q61449898PDCD4 Knockdown Induces Senescence in Hepatoma Cells by Up-Regulating the p21 Expression
Q38219980Stressing mitosis to death
Q58261855Telomere length and telomerase activity are related with immortalization frequency but not with replicative senescence in mammalian embryonic fibroblasts, except human embryonic fibroblasts

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