Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts

scientific article published on 01 March 1998

Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0960-9822(98)70137-X
P698PubMed publication ID9512419

P2093author name stringB B McConnell
G Peters
S Brookes
M Starborg
P2860cites workCloning of senescent cell-derived inhibitors of DNA synthesis using an expression screenQ48084448
Cell-surface receptor for ecotropic murine retroviruses is a basic amino-acid transporter.Q50798159
Differential growth state‐dependent regulation of plasminogen activator inhibitor type‐1 expression in senescent IMR‐90 human diploid fibroblastsQ71825118
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4aQ24324559
A biomarker that identifies senescent human cells in culture and in aging skin in vivoQ24562644
Regulation of p16CDKN2 expression and its implications for cell immortalization and senescenceQ24650807
Inhibition of pRb phosphorylation and cell-cycle progression by a 20-residue peptide derived from p16CDKN2/INK4AQ28289708
Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell lineQ29547239
The serial cultivation of human diploid cell strainsQ29547356
Production of high-titer helper-free retroviruses by transient transfectionQ29547802
Inhibitors of mammalian G1 cyclin-dependent kinasesQ29547907
Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblastsQ35927191
Replicative senescence: the human fibroblast comes of age.Q37951214
Origins of G1 arrest in senescent human fibroblastsQ40422559
Replicative senescence: implications for in vivo aging and tumor suppressionQ41003046
Induction of senescence in human malignant glioma cells by p16INK4A.Q41098516
Accumulation of p16INK4a in mouse fibroblasts as a function of replicative senescence and not of retinoblastoma gene statusQ41098520
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)351-354
P577publication date1998-03-01
P1433published inCurrent BiologyQ1144851
P1476titleInhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts
P478volume8

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cites work (P2860)
Q58692000A Role for p53 in the Adaptation to Glutamine Starvation through the Expression of SLC1A3
Q30828170A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19(ARF)-p53 signaling
Q28510048Ablation of PRMT6 reveals a role as a negative transcriptional regulator of the p53 tumor suppressor
Q34467363Absence of p16INK4a and truncation of ARF tumor suppressors in chickens.
Q34199776Aging, cellular senescence, and cancer
Q33819277Analysis of Gene Expression in Human Dermal Fibroblasts Treated with Senescence-Modulating COX Inhibitors
Q40089139BS69 is involved in cellular senescence through the p53-p21Cip1 pathway.
Q34286570Biallelic mutations in p16(INK4a) confer resistance to Ras- and Ets-induced senescence in human diploid fibroblasts
Q35040426Branched-chain amino acids enhance premature senescence through mammalian target of rapamycin complex I-mediated upregulation of p21 protein
Q33540071CDK inhibition and cancer therapy
Q88532138CDK inhibitors for muscle stem cell differentiation and self-renewal
Q36532424CDKN2B-AS1 genotype-glaucoma feature correlations in primary open-angle glaucoma patients from the United States
Q35118727Cancer and ageing: rival demons?
Q38112116Cardiac stem cells in patients with heart disease
Q39686197Cell cycle arrest by human cytomegalovirus 86-kDa IE2 protein resembles premature senescence
Q35097387Cell senescence and hypermitogenic arrest
Q28609756Cellular response to oncogenic ras involves induction of the Cdk4 and Cdk6 inhibitor p15(INK4b)
Q34903039Cellular senescence and organismal ageing in the absence of p21(CIP1/WAF1) in ku80(-/-) mice
Q33953067Cellular senescence and protein degradation: breaking down cancer
Q37828383Cellular senescence as a target in cancer control
Q34421790Cellular senescence as a tumor-suppressor mechanism
Q40266725Characterization of the activities of p21Cip1/Waf1 promoter-driven reporter systems during camptothecin-induced senescence-like state of BHK-21 cells
Q41980817Contrasting behavior of the p18INK4c and p16INK4a tumor suppressors in both replicative and oncogene-induced senescence
Q40533302Contribution of p16(INK4a) to replicative senescence of human fibroblasts
Q24292698Contribution of p16INK4a and p21CIP1 pathways to induction of premature senescence of human endothelial cells: permissive role of p53
Q39445352Control of replicative life span in human cells: barriers to clonal expansion intermediate between M1 senescence and M2 crisis
Q22008677Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest
Q92054489DNA damage in human skin and the capacities of natural compounds to modulate the bystander signalling
Q33872220Decreasing expression of the G1-phase inhibitors, p21Cip1 and p16INK4a, promotes division of corneal endothelial cells from older donors
Q33957508Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts
Q33638597Differentiation-related changes in the cell cycle traverse.
Q38335920Direct control of caveolin-1 expression by FOXO transcription factors
Q33859300Discovering novel chemotherapeutic drugs for the third millennium
Q53388774Effects of p21 deletion in mouse models of premature aging.
Q35680797Effects of p21Waf1/Cip1/Sdi1 on cellular gene expression: implications for carcinogenesis, senescence, and age-related diseases
Q33855451Epigenetic aspects of cellular senescence
Q24675583Epstein-Barr virus LMP1 blocks p16INK4a-RB pathway by promoting nuclear export of E2F4/5
Q38908051Evidence for a CDK4-dependent checkpoint in a conditional model of cellular senescence
Q27692024Examination of the expanding pathways for the regulation of p21 expression and activity
Q34025754Four faces of cellular senescence.
Q34801705From the Hayflick mosaic to the mosaics of ageing. Role of stress-induced premature senescence in human ageing
Q30322978Functional evaluation of tumour-specific variants of p16INK4a/CDKN2A: correlation with protein structure information.
Q34076841Genes involved in senescence and immortalization
Q53544041Genetic cooperation between p21Cip1 and INK4 inhibitors in cellular senescence and tumor suppression.
Q90590903Genistein inhibits proliferation and induces senescence in neonatal mouse pituitary gland explant cultures
Q34982499Gerosuppression in confluent cells
Q36210880Growth inhibition by miR-519 via multiple p21-inducing pathways
Q40565411Histone deacetylase inhibitors induce a senescence-like state in human cells by a p16-dependent mechanism that is independent of a mitotic clock
Q42827551Human fibroblast replicative senescence can occur in the absence of extensive cell division and short telomeres
Q39647398INK4a-deficient human diploid fibroblasts are resistant to RAS-induced senescence
Q28200729Id proteins in cell cycle control and cellular senescence
Q40768898Identification and sequencing of the Syrian Golden hamster (Mesocricetus auratus) p16(INK4a) and p15(INK4b) cDNAs and their homozygous gene deletion in cheek pouch and pancreatic tumor cells.
Q39444837Induced expression of p16(INK4a) inhibits both CDK4- and CDK2-associated kinase activity by reassortment of cyclin-CDK-inhibitor complexes
Q39681563Induction of extracellular matrix-remodeling genes by the senescence-associated protein APA-1
Q33958412Induction of p21(WAF1/CIP1) and inhibition of Cdk2 mediated by the tumor suppressor p16(INK4a)
Q39734867Inhibitor of differentiation 1 (ID1) promotes cell survival and proliferation of prostate epithelial cells
Q35332453Insulin-like growth factor binding protein-6 delays replicative senescence of human fibroblasts.
Q35918432Intense myocyte formation from cardiac stem cells in human cardiac hypertrophy
Q40738994Iron chelation-induced senescence-like growth arrest in hepatocyte cell lines: association of transforming growth factor beta1 (TGF-beta1)-mediated p27Kip1 expression.
Q40881096LMP1 of Epstein-Barr virus suppresses cellular senescence associated with the inhibition of p16INK4a expression
Q77614144Limits to lifespan
Q40876849Long-term cultured IL-2-dependent T cell lines demonstrate p16(INK4a) overexpression, normal pRb/p53, and upregulation of cyclins E or D2.
Q34250440Loss of retinoblastoma but not p16 function allows bypass of replicative senescence in human fibroblasts
Q36557934Magnesium deficiency accelerates cellular senescence in cultured human fibroblasts
Q34056462MicroRNA profiling in human diploid fibroblasts uncovers miR-519 role in replicative senescence
Q37113691Microtubule binding and disruption and induction of premature senescence by disorazole C(1).
Q41566495Misidentified Human Gene Functions with Mouse Models: The Case of the Retinoblastoma Gene Family in Senescence.
Q40901754Mitogen stimulation cooperates with telomere shortening to activate DNA damage responses and senescence signaling
Q53632631Molecular signature of oncogenic ras-induced senescence.
Q36460808NSun2 delays replicative senescence by repressing p27 (KIP1) translation and elevating CDK1 translation
Q24294537Nek4 regulates entry into replicative senescence and the response to DNA damage in human fibroblasts
Q28203134Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence
Q35833994Oxidative stress in aging human skin
Q35201220PML is induced by oncogenic ras and promotes premature senescence
Q22003910Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling
Q42917409Real-time in vivo imaging of p16gene expression: a new approach to study senescence stress signaling in living animals
Q33961286Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14(ARF) tumor suppressor
Q34665706Regulation of senescence in cancer and aging
Q35019590Replicative senescence and senescence-like state induced in cancer-derived cells
Q28210023Repression of p15INK4b expression by Myc through association with Miz-1
Q35561999Reversal of human cellular senescence: roles of the p53 and p16 pathways
Q40758263Role of cyclin-dependent kinase inhibitors in the growth arrest at senescence in human prostate epithelial and uroepithelial cells
Q34012414Role of p14(ARF) in replicative and induced senescence of human fibroblasts
Q38082328Senescence and aging: the critical roles of p53.
Q35210205Senescence of human fibroblasts induced by oncogenic Raf.
Q53584741Senescence of human skin-derived precursors regulated by Akt-FOXO3-p27(KIP¹)/p15(INK⁴b) signaling.
Q35549516Smurf2-mediated ubiquitination and degradation of Id1 regulates p16 expression during senescence
Q43594592Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus.
Q30843774Telomere shortening is an in vivo marker of myocyte replication and aging
Q92783649The Multifaceted p21 (Cip1/Waf1/CDKN1A) in Cell Differentiation, Migration and Cancer Therapy
Q34966683The Werner syndrome helicase protein is required for cell proliferation, immortalization, and tumorigenesis in Scaffold attachment factor B1 deficient mice
Q33889383The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.
Q28587433The ink4a/arf tumor suppressors cooperate with p21cip1/waf in the processes of mouse epidermal differentiation, senescence, and carcinogenesis
Q22009397The p16(INK4a) tumour suppressor protein inhibits alphavbeta3 integrin-mediated cell spreading on vitronectin by blocking PKC-dependent localization of alphavbeta3 to focal contacts
Q54317457The p16INK4a/CDKN2A tumor suppressor and its relatives.
Q24557451The p400 E1A-associated protein is a novel component of the p53 --> p21 senescence pathway
Q36347895The retinoblastoma protein selectively represses E2F1 targets via a TAAC DNA element during cellular senescence
Q47439670The role of replicative senescence in chronic allograft nephropathy.
Q34918305The transcriptional cofactor MCAF1/ATF7IP is involved in histone gene expression and cellular senescence
Q54383317Transcriptional activation of p21(WAF¹/CIP¹) is mediated by increased DNA binding activity and increased interaction between p53 and Sp1 via phosphorylation during replicative senescence of human embryonic fibroblasts.
Q40887241Translation of p15.5INK4B, an N-terminally extended and fully active form of p15INK4B, is initiated from an upstream GUG codon
Q35378363Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype
Q24337508Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor
Q33965486Uncoupling between phenotypic senescence and cell cycle arrest in aging p21-deficient fibroblasts
Q49175511WSB1 overcomes oncogene-induced senescence by targeting ATM for degradation
Q35585808What has senescence got to do with cancer?
Q36994782ZNF313 is a novel cell cycle activator with an E3 ligase activity inhibiting cellular senescence by destabilizing p21(WAF1.).
Q39325305ZRF1 controls oncogene-induced senescence through the INK4-ARF locus
Q33962054mTOR Signaling from Cellular Senescence to Organismal Aging
Q28115122miR-543 and miR-590-3p regulate human mesenchymal stem cell aging via direct targeting of AIMP3/p18
Q73673952p16 INK4a can initiate an autonomous senescence program
Q21092220p16(INK4a) translation suppressed by miR-24
Q40879237p21Waf1/Cip1/Sdi1-induced growth arrest is associated with depletion of mitosis-control proteins and leads to abnormal mitosis and endoreduplication in recovering cells
Q91645670p53 Isoforms in Cellular Senescence- and Ageing-Associated Biological and Physiological Functions

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